Pentatricopeptide repeat domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IG13_LEIDO

TriTrypDb:

LdBPK_302900.1 , LdCL_300034600 , LDHU3_30.3860

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IG13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	425	429	PF00656	0.550
CLV_C14_Caspase3-7	493	497	PF00656	0.456
CLV_C14_Caspase3-7	603	607	PF00656	0.459
CLV_NRD_NRD_1	28	30	PF00675	0.409
CLV_NRD_NRD_1	39	41	PF00675	0.492
CLV_NRD_NRD_1	54	56	PF00675	0.667
CLV_NRD_NRD_1	640	642	PF00675	0.514
CLV_PCSK_KEX2_1	28	30	PF00082	0.420
CLV_PCSK_KEX2_1	39	41	PF00082	0.492
CLV_PCSK_KEX2_1	53	55	PF00082	0.666
CLV_PCSK_KEX2_1	640	642	PF00082	0.542
CLV_PCSK_PC7_1	50	56	PF00082	0.700
CLV_PCSK_SKI1_1	28	32	PF00082	0.422
CLV_PCSK_SKI1_1	308	312	PF00082	0.477
CLV_PCSK_SKI1_1	39	43	PF00082	0.499
CLV_PCSK_SKI1_1	652	656	PF00082	0.435
DEG_Nend_UBRbox_1	1	4	PF02207	0.599
DEG_SPOP_SBC_1	193	197	PF00917	0.472
DEG_SPOP_SBC_1	72	76	PF00917	0.620
DEG_SPOP_SBC_1	81	85	PF00917	0.571
DOC_CYCLIN_RxL_1	305	313	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	320	326	PF00134	0.417
DOC_MAPK_DCC_7	535	543	PF00069	0.495
DOC_MAPK_MEF2A_6	592	599	PF00069	0.513
DOC_PP4_FxxP_1	131	134	PF00568	0.582
DOC_PP4_FxxP_1	166	169	PF00568	0.565
DOC_USP7_MATH_1	386	390	PF00917	0.498
DOC_USP7_MATH_1	43	47	PF00917	0.564
DOC_USP7_MATH_1	431	435	PF00917	0.463
DOC_USP7_MATH_1	48	52	PF00917	0.719
DOC_USP7_MATH_1	504	508	PF00917	0.416
DOC_USP7_MATH_1	566	570	PF00917	0.535
DOC_USP7_MATH_1	586	590	PF00917	0.319
DOC_USP7_MATH_1	639	643	PF00917	0.545
DOC_USP7_MATH_1	81	85	PF00917	0.707
DOC_WW_Pin1_4	130	135	PF00397	0.578
DOC_WW_Pin1_4	221	226	PF00397	0.450
DOC_WW_Pin1_4	370	375	PF00397	0.392
DOC_WW_Pin1_4	60	65	PF00397	0.774
DOC_WW_Pin1_4	641	646	PF00397	0.467
DOC_WW_Pin1_4	656	661	PF00397	0.452
LIG_14-3-3_CanoR_1	128	132	PF00244	0.510
LIG_14-3-3_CanoR_1	150	157	PF00244	0.582
LIG_14-3-3_CanoR_1	161	169	PF00244	0.558
LIG_14-3-3_CanoR_1	183	193	PF00244	0.587
LIG_14-3-3_CanoR_1	387	393	PF00244	0.526
LIG_14-3-3_CanoR_1	441	449	PF00244	0.505
LIG_14-3-3_CanoR_1	55	64	PF00244	0.655
LIG_14-3-3_CterR_2	668	673	PF00244	0.500
LIG_Actin_WH2_2	13	30	PF00022	0.426
LIG_BRCT_BRCA1_1	162	166	PF00533	0.633
LIG_BRCT_BRCA1_1	630	634	PF00533	0.476
LIG_CaM_IQ_9	343	359	PF13499	0.521
LIG_eIF4E_1	289	295	PF01652	0.369
LIG_FHA_1	127	133	PF00498	0.673
LIG_FHA_1	193	199	PF00498	0.469
LIG_FHA_1	254	260	PF00498	0.403
LIG_FHA_1	331	337	PF00498	0.379
LIG_FHA_1	353	359	PF00498	0.523
LIG_FHA_1	395	401	PF00498	0.517
LIG_FHA_1	470	476	PF00498	0.491
LIG_FHA_1	653	659	PF00498	0.476
LIG_FHA_1	72	78	PF00498	0.606
LIG_FHA_2	32	38	PF00498	0.474
LIG_FHA_2	401	407	PF00498	0.505
LIG_FHA_2	474	480	PF00498	0.461
LIG_FHA_2	491	497	PF00498	0.376
LIG_FHA_2	601	607	PF00498	0.448
LIG_FHA_2	642	648	PF00498	0.395
LIG_LIR_Apic_2	129	134	PF02991	0.570
LIG_LIR_Apic_2	163	169	PF02991	0.573
LIG_LIR_Gen_1	364	374	PF02991	0.429
LIG_LIR_Gen_1	434	443	PF02991	0.412
LIG_LIR_LC3C_4	270	275	PF02991	0.406
LIG_LIR_Nem_3	364	369	PF02991	0.415
LIG_LIR_Nem_3	434	439	PF02991	0.405
LIG_LIR_Nem_3	442	446	PF02991	0.392
LIG_NRBOX	229	235	PF00104	0.426
LIG_NRBOX	6	12	PF00104	0.419
LIG_Rb_LxCxE_1	278	290	PF01857	0.499
LIG_REV1ctd_RIR_1	363	372	PF16727	0.367
LIG_SH2_CRK	436	440	PF00017	0.388
LIG_SH2_STAP1	418	422	PF00017	0.414
LIG_SH2_STAP1	613	617	PF00017	0.411
LIG_SH2_STAT3	350	353	PF00017	0.570
LIG_SH2_STAT5	220	223	PF00017	0.512
LIG_SH2_STAT5	297	300	PF00017	0.455
LIG_SH3_3	219	225	PF00018	0.403
LIG_SH3_3	290	296	PF00018	0.356
LIG_SH3_3	571	577	PF00018	0.439
LIG_SUMO_SIM_anti_2	397	403	PF11976	0.420
LIG_SUMO_SIM_par_1	472	479	PF11976	0.347
LIG_SxIP_EBH_1	165	177	PF03271	0.491
LIG_TRAF2_1	34	37	PF00917	0.537
LIG_UBA3_1	510	516	PF00899	0.347
LIG_WRC_WIRS_1	440	445	PF05994	0.355
MOD_CDK_SPxxK_3	641	648	PF00069	0.462
MOD_CK1_1	130	136	PF00069	0.442
MOD_CK1_1	184	190	PF00069	0.542
MOD_CK1_1	301	307	PF00069	0.410
MOD_CK1_1	457	463	PF00069	0.513
MOD_CK1_1	489	495	PF00069	0.384
MOD_CK1_1	503	509	PF00069	0.493
MOD_CK1_1	59	65	PF00069	0.728
MOD_CK1_1	79	85	PF00069	0.716
MOD_CK1_1	87	93	PF00069	0.672
MOD_CK2_1	31	37	PF00069	0.490
MOD_CK2_1	473	479	PF00069	0.457
MOD_DYRK1A_RPxSP_1	641	645	PF00069	0.534
MOD_DYRK1A_RPxSP_1	656	660	PF00069	0.564
MOD_GlcNHglycan	189	192	PF01048	0.653
MOD_GlcNHglycan	269	272	PF01048	0.393
MOD_GlcNHglycan	300	303	PF01048	0.397
MOD_GlcNHglycan	312	315	PF01048	0.330
MOD_GlcNHglycan	443	446	PF01048	0.475
MOD_GlcNHglycan	479	483	PF01048	0.392
MOD_GlcNHglycan	496	499	PF01048	0.414
MOD_GlcNHglycan	502	505	PF01048	0.372
MOD_GlcNHglycan	58	61	PF01048	0.688
MOD_GlcNHglycan	588	591	PF01048	0.414
MOD_GlcNHglycan	79	82	PF01048	0.752
MOD_GlcNHglycan	89	92	PF01048	0.777
MOD_GlcNHglycan	94	97	PF01048	0.679
MOD_GSK3_1	126	133	PF00069	0.599
MOD_GSK3_1	156	163	PF00069	0.773
MOD_GSK3_1	181	188	PF00069	0.444
MOD_GSK3_1	201	208	PF00069	0.287
MOD_GSK3_1	39	46	PF00069	0.613
MOD_GSK3_1	431	438	PF00069	0.446
MOD_GSK3_1	465	472	PF00069	0.463
MOD_GSK3_1	486	493	PF00069	0.487
MOD_GSK3_1	500	507	PF00069	0.572
MOD_GSK3_1	56	63	PF00069	0.565
MOD_GSK3_1	652	659	PF00069	0.469
MOD_GSK3_1	71	78	PF00069	0.717
MOD_GSK3_1	80	87	PF00069	0.647
MOD_N-GLC_1	611	616	PF02516	0.351
MOD_N-GLC_2	21	23	PF02516	0.384
MOD_NEK2_1	11	16	PF00069	0.514
MOD_NEK2_1	127	132	PF00069	0.597
MOD_NEK2_1	181	186	PF00069	0.460
MOD_NEK2_1	192	197	PF00069	0.534
MOD_NEK2_1	201	206	PF00069	0.236
MOD_NEK2_1	228	233	PF00069	0.383
MOD_NEK2_1	253	258	PF00069	0.445
MOD_NEK2_1	298	303	PF00069	0.447
MOD_NEK2_1	31	36	PF00069	0.295
MOD_NEK2_1	310	315	PF00069	0.271
MOD_NEK2_1	426	431	PF00069	0.472
MOD_NEK2_1	439	444	PF00069	0.286
MOD_NEK2_1	494	499	PF00069	0.465
MOD_NEK2_1	600	605	PF00069	0.458
MOD_NEK2_1	77	82	PF00069	0.782
MOD_NEK2_1	86	91	PF00069	0.697
MOD_NEK2_1	92	97	PF00069	0.564
MOD_NEK2_2	48	53	PF00069	0.607
MOD_PIKK_1	349	355	PF00454	0.514
MOD_PIKK_1	400	406	PF00454	0.452
MOD_PIKK_1	566	572	PF00454	0.525
MOD_PIKK_1	611	617	PF00454	0.383
MOD_PKA_1	39	45	PF00069	0.520
MOD_PKA_2	127	133	PF00069	0.641
MOD_PKA_2	149	155	PF00069	0.755
MOD_PKA_2	160	166	PF00069	0.573
MOD_PKA_2	182	188	PF00069	0.571
MOD_PKA_2	386	392	PF00069	0.520
MOD_PKA_2	39	45	PF00069	0.568
MOD_PKA_2	639	645	PF00069	0.487
MOD_Plk_1	394	400	PF00069	0.416
MOD_Plk_1	463	469	PF00069	0.516
MOD_Plk_1	628	634	PF00069	0.482
MOD_Plk_2-3	473	479	PF00069	0.491
MOD_Plk_4	11	17	PF00069	0.545
MOD_Plk_4	127	133	PF00069	0.498
MOD_Plk_4	229	235	PF00069	0.375
MOD_Plk_4	435	441	PF00069	0.401
MOD_Plk_4	454	460	PF00069	0.294
MOD_Plk_4	490	496	PF00069	0.447
MOD_ProDKin_1	130	136	PF00069	0.584
MOD_ProDKin_1	221	227	PF00069	0.450
MOD_ProDKin_1	370	376	PF00069	0.390
MOD_ProDKin_1	60	66	PF00069	0.774
MOD_ProDKin_1	641	647	PF00069	0.460
MOD_ProDKin_1	656	662	PF00069	0.443
MOD_SUMO_rev_2	389	393	PF00179	0.549
TRG_DiLeu_BaEn_1	354	359	PF01217	0.556
TRG_ENDOCYTIC_2	436	439	PF00928	0.393
TRG_ER_diArg_1	27	29	PF00400	0.406
TRG_ER_diArg_1	39	41	PF00400	0.492
TRG_ER_diArg_1	52	55	PF00400	0.668
TRG_ER_diArg_1	639	641	PF00400	0.547
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I481	Leptomonas seymouri	70%	98%
A0A0S4IPG5	Bodo saltans	35%	100%
A0A1X0P1H7	Trypanosomatidae	49%	100%
A0A3R7JPV2	Trypanosoma rangeli	49%	100%
A4HIM2	Leishmania braziliensis	85%	100%
A4I5W7	Leishmania infantum	100%	100%
C9ZR90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B161	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q704	Leishmania major	96%	100%
V5B7A2	Trypanosoma cruzi	49%	100%