LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Major Facilitator Superfamily, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Major Facilitator Superfamily, putative
Gene product:
major facilitator superfamily, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IG09_LEIDO
TriTrypDb:
LdBPK_310750.1 * , LdCL_310013200 , LDHU3_31.1100
Length:
979

Annotations

LeishMANIAdb annotations

Part of a gigantic, highly expanded family of Kinetoplastid transporters. Most similar to plant nodulins and animal monocarboxylate transporters.. Likely one of the main nutrient transporters in Kinetoplastida.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A0A3Q8IG09
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG09

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 5
GO:0022857 transmembrane transporter activity 2 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 131 135 PF00656 0.809
CLV_C14_Caspase3-7 145 149 PF00656 0.542
CLV_C14_Caspase3-7 427 431 PF00656 0.731
CLV_C14_Caspase3-7 509 513 PF00656 0.853
CLV_C14_Caspase3-7 534 538 PF00656 0.752
CLV_MEL_PAP_1 27 33 PF00089 0.624
CLV_NRD_NRD_1 127 129 PF00675 0.573
CLV_NRD_NRD_1 151 153 PF00675 0.460
CLV_NRD_NRD_1 370 372 PF00675 0.435
CLV_NRD_NRD_1 40 42 PF00675 0.655
CLV_NRD_NRD_1 633 635 PF00675 0.555
CLV_NRD_NRD_1 677 679 PF00675 0.543
CLV_NRD_NRD_1 894 896 PF00675 0.701
CLV_NRD_NRD_1 920 922 PF00675 0.487
CLV_NRD_NRD_1 933 935 PF00675 0.414
CLV_PCSK_KEX2_1 129 131 PF00082 0.487
CLV_PCSK_KEX2_1 13 15 PF00082 0.658
CLV_PCSK_KEX2_1 150 152 PF00082 0.362
CLV_PCSK_KEX2_1 369 371 PF00082 0.435
CLV_PCSK_KEX2_1 42 44 PF00082 0.632
CLV_PCSK_KEX2_1 633 635 PF00082 0.555
CLV_PCSK_KEX2_1 677 679 PF00082 0.543
CLV_PCSK_KEX2_1 894 896 PF00082 0.701
CLV_PCSK_KEX2_1 920 922 PF00082 0.487
CLV_PCSK_KEX2_1 933 935 PF00082 0.414
CLV_PCSK_PC1ET2_1 129 131 PF00082 0.487
CLV_PCSK_PC1ET2_1 13 15 PF00082 0.658
CLV_PCSK_PC1ET2_1 369 371 PF00082 0.435
CLV_PCSK_PC1ET2_1 42 44 PF00082 0.632
CLV_PCSK_SKI1_1 137 141 PF00082 0.540
CLV_PCSK_SKI1_1 154 158 PF00082 0.274
CLV_PCSK_SKI1_1 189 193 PF00082 0.615
CLV_PCSK_SKI1_1 303 307 PF00082 0.635
CLV_PCSK_SKI1_1 345 349 PF00082 0.435
CLV_PCSK_SKI1_1 461 465 PF00082 0.395
CLV_PCSK_SKI1_1 527 531 PF00082 0.524
CLV_PCSK_SKI1_1 771 775 PF00082 0.529
CLV_PCSK_SKI1_1 941 945 PF00082 0.568
DEG_SCF_SKP2-CKS1_1 397 404 PF00560 0.435
DEG_SPOP_SBC_1 542 546 PF00917 0.793
DOC_ANK_TNKS_1 405 412 PF00023 0.435
DOC_ANK_TNKS_1 510 517 PF00023 0.720
DOC_CYCLIN_RxL_1 524 534 PF00134 0.718
DOC_MAPK_gen_1 150 157 PF00069 0.657
DOC_MAPK_gen_1 369 377 PF00069 0.635
DOC_MAPK_gen_1 444 452 PF00069 0.710
DOC_MAPK_gen_1 524 532 PF00069 0.792
DOC_MAPK_gen_1 785 793 PF00069 0.715
DOC_MAPK_MEF2A_6 370 379 PF00069 0.635
DOC_MAPK_MEF2A_6 524 532 PF00069 0.866
DOC_MAPK_MEF2A_6 588 595 PF00069 0.824
DOC_MAPK_MEF2A_6 899 907 PF00069 0.529
DOC_PP1_RVXF_1 152 158 PF00149 0.575
DOC_PP1_RVXF_1 28 34 PF00149 0.869
DOC_PP2B_LxvP_1 422 425 PF13499 0.529
DOC_PP2B_LxvP_1 576 579 PF13499 0.861
DOC_PP2B_LxvP_1 72 75 PF13499 0.841
DOC_PP2B_LxvP_1 79 82 PF13499 0.733
DOC_PP2B_PxIxI_1 588 594 PF00149 0.812
DOC_PP4_FxxP_1 204 207 PF00568 0.529
DOC_SPAK_OSR1_1 152 156 PF12202 0.635
DOC_USP7_MATH_1 222 226 PF00917 0.529
DOC_USP7_MATH_1 425 429 PF00917 0.666
DOC_USP7_MATH_1 763 767 PF00917 0.519
DOC_USP7_MATH_1 799 803 PF00917 0.529
DOC_USP7_MATH_1 908 912 PF00917 0.529
DOC_USP7_UBL2_3 119 123 PF12436 0.811
DOC_WW_Pin1_4 17 22 PF00397 0.802
DOC_WW_Pin1_4 345 350 PF00397 0.635
DOC_WW_Pin1_4 398 403 PF00397 0.435
DOC_WW_Pin1_4 543 548 PF00397 0.780
DOC_WW_Pin1_4 661 666 PF00397 0.867
DOC_WW_Pin1_4 74 79 PF00397 0.812
DOC_WW_Pin1_4 880 885 PF00397 0.525
LIG_14-3-3_CanoR_1 30 34 PF00244 0.868
LIG_14-3-3_CanoR_1 361 368 PF00244 0.635
LIG_14-3-3_CanoR_1 48 56 PF00244 0.613
LIG_14-3-3_CanoR_1 588 594 PF00244 0.856
LIG_14-3-3_CanoR_1 656 665 PF00244 0.716
LIG_14-3-3_CanoR_1 677 687 PF00244 0.753
LIG_Actin_WH2_2 393 408 PF00022 0.445
LIG_AP2alpha_1 306 310 PF02296 0.405
LIG_APCC_ABBA_1 593 598 PF00400 0.827
LIG_APCC_ABBA_1 646 651 PF00400 0.705
LIG_BIR_II_1 1 5 PF00653 0.836
LIG_BRCT_BRCA1_1 836 840 PF00533 0.501
LIG_Clathr_ClatBox_1 529 533 PF01394 0.716
LIG_deltaCOP1_diTrp_1 716 721 PF00928 0.529
LIG_eIF4E_1 714 720 PF01652 0.635
LIG_FHA_1 108 114 PF00498 0.858
LIG_FHA_1 166 172 PF00498 0.529
LIG_FHA_1 24 30 PF00498 0.823
LIG_FHA_1 282 288 PF00498 0.521
LIG_FHA_1 388 394 PF00498 0.529
LIG_FHA_1 414 420 PF00498 0.426
LIG_FHA_1 59 65 PF00498 0.686
LIG_FHA_1 645 651 PF00498 0.851
LIG_FHA_1 689 695 PF00498 0.663
LIG_FHA_1 704 710 PF00498 0.502
LIG_FHA_1 722 728 PF00498 0.247
LIG_FHA_1 788 794 PF00498 0.627
LIG_FHA_1 837 843 PF00498 0.529
LIG_FHA_1 960 966 PF00498 0.746
LIG_FHA_2 10 16 PF00498 0.874
LIG_FHA_2 129 135 PF00498 0.703
LIG_FHA_2 143 149 PF00498 0.675
LIG_FHA_2 346 352 PF00498 0.635
LIG_FHA_2 473 479 PF00498 0.717
LIG_FHA_2 582 588 PF00498 0.779
LIG_FHA_2 627 633 PF00498 0.741
LIG_FHA_2 705 711 PF00498 0.672
LIG_FHA_2 843 849 PF00498 0.581
LIG_FHA_2 93 99 PF00498 0.800
LIG_IRF3_LxIS_1 160 165 PF10401 0.529
LIG_LIR_Apic_2 213 217 PF02991 0.635
LIG_LIR_Apic_2 681 687 PF02991 0.759
LIG_LIR_Apic_2 697 702 PF02991 0.543
LIG_LIR_Gen_1 296 306 PF02991 0.525
LIG_LIR_Gen_1 308 318 PF02991 0.291
LIG_LIR_Gen_1 651 662 PF02991 0.742
LIG_LIR_Gen_1 711 722 PF02991 0.519
LIG_LIR_LC3C_4 70 74 PF02991 0.741
LIG_LIR_Nem_3 173 178 PF02991 0.529
LIG_LIR_Nem_3 289 293 PF02991 0.529
LIG_LIR_Nem_3 296 301 PF02991 0.348
LIG_LIR_Nem_3 308 313 PF02991 0.291
LIG_LIR_Nem_3 651 657 PF02991 0.730
LIG_LIR_Nem_3 711 717 PF02991 0.561
LIG_LIR_Nem_3 837 843 PF02991 0.501
LIG_NRBOX 229 235 PF00104 0.529
LIG_Pex14_1 718 722 PF04695 0.529
LIG_Pex14_1 874 878 PF04695 0.441
LIG_Pex14_2 153 157 PF04695 0.635
LIG_Pex14_2 204 208 PF04695 0.529
LIG_Pex14_2 235 239 PF04695 0.532
LIG_Pex14_2 298 302 PF04695 0.529
LIG_Pex14_2 306 310 PF04695 0.340
LIG_REV1ctd_RIR_1 303 311 PF16727 0.435
LIG_SH2_CRK 654 658 PF00017 0.854
LIG_SH2_CRK 684 688 PF00017 0.760
LIG_SH2_CRK 722 726 PF00017 0.529
LIG_SH2_CRK 922 926 PF00017 0.684
LIG_SH2_GRB2like 684 687 PF00017 0.761
LIG_SH2_PTP2 699 702 PF00017 0.716
LIG_SH2_STAP1 262 266 PF00017 0.529
LIG_SH2_STAP1 372 376 PF00017 0.411
LIG_SH2_STAP1 54 58 PF00017 0.817
LIG_SH2_STAP1 777 781 PF00017 0.684
LIG_SH2_STAP1 878 882 PF00017 0.494
LIG_SH2_STAP1 922 926 PF00017 0.684
LIG_SH2_STAT3 362 365 PF00017 0.635
LIG_SH2_STAT5 195 198 PF00017 0.529
LIG_SH2_STAT5 331 334 PF00017 0.400
LIG_SH2_STAT5 337 340 PF00017 0.499
LIG_SH2_STAT5 356 359 PF00017 0.521
LIG_SH2_STAT5 385 388 PF00017 0.383
LIG_SH2_STAT5 395 398 PF00017 0.428
LIG_SH2_STAT5 699 702 PF00017 0.716
LIG_SH2_STAT5 714 717 PF00017 0.495
LIG_SH2_STAT5 722 725 PF00017 0.413
LIG_SH2_STAT5 756 759 PF00017 0.529
LIG_SH2_STAT5 825 828 PF00017 0.496
LIG_SH2_STAT5 841 844 PF00017 0.298
LIG_SH2_STAT5 859 862 PF00017 0.232
LIG_SH2_STAT5 889 892 PF00017 0.395
LIG_SH2_STAT5 904 907 PF00017 0.282
LIG_SH2_STAT5 916 919 PF00017 0.384
LIG_SH3_3 18 24 PF00018 0.823
LIG_SH3_3 500 506 PF00018 0.746
LIG_SH3_3 547 553 PF00018 0.860
LIG_SH3_3 559 565 PF00018 0.731
LIG_SH3_3 72 78 PF00018 0.828
LIG_SH3_3 788 794 PF00018 0.635
LIG_SH3_3 932 938 PF00018 0.764
LIG_SUMO_SIM_anti_2 416 422 PF11976 0.426
LIG_SUMO_SIM_anti_2 818 824 PF11976 0.391
LIG_SUMO_SIM_par_1 160 168 PF11976 0.529
LIG_SUMO_SIM_par_1 219 225 PF11976 0.529
LIG_SUMO_SIM_par_1 789 795 PF11976 0.631
LIG_TRAF2_1 445 448 PF00917 0.753
LIG_TRAF2_1 475 478 PF00917 0.720
LIG_TRAF2_1 497 500 PF00917 0.823
LIG_TYR_ITIM 712 717 PF00017 0.678
LIG_TYR_ITIM 720 725 PF00017 0.397
LIG_WRC_WIRS_1 287 292 PF05994 0.529
MOD_CDK_SPK_2 345 350 PF00069 0.591
MOD_CDK_SPxK_1 398 404 PF00069 0.435
MOD_CDK_SPxxK_3 661 668 PF00069 0.822
MOD_CK1_1 100 106 PF00069 0.832
MOD_CK1_1 163 169 PF00069 0.529
MOD_CK1_1 197 203 PF00069 0.529
MOD_CK1_1 57 63 PF00069 0.740
MOD_CK1_1 608 614 PF00069 0.765
MOD_CK1_1 622 628 PF00069 0.753
MOD_CK1_1 637 643 PF00069 0.674
MOD_CK1_1 666 672 PF00069 0.855
MOD_CK1_1 682 688 PF00069 0.580
MOD_CK1_1 883 889 PF00069 0.537
MOD_CK1_1 911 917 PF00069 0.529
MOD_CK1_1 959 965 PF00069 0.771
MOD_CK2_1 184 190 PF00069 0.391
MOD_CK2_1 33 39 PF00069 0.817
MOD_CK2_1 345 351 PF00069 0.635
MOD_CK2_1 472 478 PF00069 0.715
MOD_CK2_1 537 543 PF00069 0.754
MOD_CK2_1 581 587 PF00069 0.778
MOD_CK2_1 637 643 PF00069 0.831
MOD_CK2_1 704 710 PF00069 0.657
MOD_CK2_1 92 98 PF00069 0.857
MOD_CK2_1 99 105 PF00069 0.803
MOD_CMANNOS 871 874 PF00535 0.529
MOD_GlcNHglycan 102 105 PF01048 0.609
MOD_GlcNHglycan 196 199 PF01048 0.400
MOD_GlcNHglycan 290 293 PF01048 0.351
MOD_GlcNHglycan 494 498 PF01048 0.588
MOD_GlcNHglycan 512 515 PF01048 0.477
MOD_GlcNHglycan 557 560 PF01048 0.645
MOD_GlcNHglycan 665 668 PF01048 0.606
MOD_GlcNHglycan 836 839 PF01048 0.501
MOD_GlcNHglycan 958 961 PF01048 0.583
MOD_GSK3_1 107 114 PF00069 0.801
MOD_GSK3_1 160 167 PF00069 0.529
MOD_GSK3_1 25 32 PF00069 0.772
MOD_GSK3_1 5 12 PF00069 0.728
MOD_GSK3_1 533 540 PF00069 0.811
MOD_GSK3_1 54 61 PF00069 0.822
MOD_GSK3_1 619 626 PF00069 0.800
MOD_GSK3_1 634 641 PF00069 0.664
MOD_GSK3_1 657 664 PF00069 0.834
MOD_GSK3_1 676 683 PF00069 0.714
MOD_GSK3_1 704 711 PF00069 0.610
MOD_GSK3_1 832 839 PF00069 0.529
MOD_GSK3_1 907 914 PF00069 0.529
MOD_N-GLC_1 46 51 PF02516 0.604
MOD_N-GLC_1 622 627 PF02516 0.624
MOD_N-GLC_2 961 963 PF02516 0.476
MOD_NEK2_1 162 167 PF00069 0.529
MOD_NEK2_1 235 240 PF00069 0.529
MOD_NEK2_1 286 291 PF00069 0.529
MOD_NEK2_1 29 34 PF00069 0.869
MOD_NEK2_1 293 298 PF00069 0.364
MOD_NEK2_1 318 323 PF00069 0.529
MOD_NEK2_1 384 389 PF00069 0.426
MOD_NEK2_1 572 577 PF00069 0.763
MOD_NEK2_1 642 647 PF00069 0.725
MOD_NEK2_1 676 681 PF00069 0.742
MOD_NEK2_1 708 713 PF00069 0.572
MOD_NEK2_1 721 726 PF00069 0.383
MOD_NEK2_1 732 737 PF00069 0.361
MOD_NEK2_1 834 839 PF00069 0.467
MOD_NEK2_1 907 912 PF00069 0.529
MOD_NEK2_2 170 175 PF00069 0.529
MOD_NEK2_2 184 189 PF00069 0.223
MOD_NEK2_2 25 30 PF00069 0.839
MOD_NEK2_2 589 594 PF00069 0.855
MOD_PIKK_1 165 171 PF00454 0.529
MOD_PIKK_1 361 367 PF00454 0.635
MOD_PIKK_1 48 54 PF00454 0.828
MOD_PIKK_1 634 640 PF00454 0.796
MOD_PKA_1 128 134 PF00069 0.751
MOD_PKA_1 920 926 PF00069 0.689
MOD_PKA_2 29 35 PF00069 0.867
MOD_PKA_2 510 516 PF00069 0.764
MOD_PKA_2 632 638 PF00069 0.719
MOD_PKA_2 676 682 PF00069 0.803
MOD_PKA_2 89 95 PF00069 0.820
MOD_PKA_2 920 926 PF00069 0.689
MOD_PKB_1 359 367 PF00069 0.635
MOD_PKB_1 470 478 PF00069 0.715
MOD_PKB_1 785 793 PF00069 0.715
MOD_Plk_1 189 195 PF00069 0.391
MOD_Plk_1 54 60 PF00069 0.823
MOD_Plk_1 642 648 PF00069 0.851
MOD_Plk_2-3 430 436 PF00069 0.746
MOD_Plk_2-3 533 539 PF00069 0.790
MOD_Plk_2-3 710 716 PF00069 0.651
MOD_Plk_4 170 176 PF00069 0.529
MOD_Plk_4 189 195 PF00069 0.435
MOD_Plk_4 222 228 PF00069 0.529
MOD_Plk_4 243 249 PF00069 0.435
MOD_Plk_4 293 299 PF00069 0.529
MOD_Plk_4 54 60 PF00069 0.823
MOD_Plk_4 704 710 PF00069 0.571
MOD_Plk_4 787 793 PF00069 0.635
MOD_Plk_4 836 842 PF00069 0.529
MOD_Plk_4 912 918 PF00069 0.529
MOD_ProDKin_1 17 23 PF00069 0.797
MOD_ProDKin_1 345 351 PF00069 0.635
MOD_ProDKin_1 398 404 PF00069 0.435
MOD_ProDKin_1 543 549 PF00069 0.781
MOD_ProDKin_1 661 667 PF00069 0.866
MOD_ProDKin_1 74 80 PF00069 0.812
MOD_ProDKin_1 880 886 PF00069 0.527
MOD_SUMO_for_1 445 448 PF00179 0.753
MOD_SUMO_rev_2 36 44 PF00179 0.824
TRG_DiLeu_BaLyEn_6 525 530 PF01217 0.705
TRG_DiLeu_BaLyEn_6 586 591 PF01217 0.808
TRG_ENDOCYTIC_2 212 215 PF00928 0.637
TRG_ENDOCYTIC_2 254 257 PF00928 0.529
TRG_ENDOCYTIC_2 372 375 PF00928 0.529
TRG_ENDOCYTIC_2 385 388 PF00928 0.315
TRG_ENDOCYTIC_2 654 657 PF00928 0.772
TRG_ENDOCYTIC_2 714 717 PF00928 0.671
TRG_ENDOCYTIC_2 722 725 PF00928 0.397
TRG_ENDOCYTIC_2 748 751 PF00928 0.510
TRG_ENDOCYTIC_2 756 759 PF00928 0.397
TRG_ENDOCYTIC_2 777 780 PF00928 0.643
TRG_ENDOCYTIC_2 904 907 PF00928 0.529
TRG_ENDOCYTIC_2 922 925 PF00928 0.475
TRG_ER_diArg_1 150 152 PF00400 0.676
TRG_ER_diArg_1 342 345 PF00400 0.628
TRG_ER_diArg_1 358 361 PF00400 0.453
TRG_ER_diArg_1 370 372 PF00400 0.494
TRG_ER_diArg_1 458 461 PF00400 0.720
TRG_ER_diArg_1 676 678 PF00400 0.757
TRG_ER_diArg_1 920 922 PF00400 0.686
TRG_ER_diArg_1 933 935 PF00400 0.614
TRG_NES_CRM1_1 55 67 PF08389 0.711
TRG_NLS_MonoExtN_4 368 373 PF00514 0.635

Homologs

Protein Taxonomy Sequence identity Coverage
A4HJ52 Leishmania braziliensis 74% 100%
A4I6G6 Leishmania infantum 99% 100%
E9B1M3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 99%
Q4Q6J1 Leishmania major 92% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS