Methionyl-tRNA formyltransferase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methionyl-tRNA formyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IG07_LEIDO

TriTrypDb:

LdBPK_322390.1 , LdCL_320029200 , LDHU3_32.2960

Length:

986

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IG07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IG07

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0019988	charged-tRNA amino acid modification	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0071951	conversion of methionyl-tRNA to N-formyl-methionyl-tRNA	8	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:0009058	biosynthetic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004479	methionyl-tRNA formyltransferase activity	5	6
GO:0016740	transferase activity	2	7
GO:0016741	transferase activity, transferring one-carbon groups	3	6
GO:0016742	hydroxymethyl-, formyl- and related transferase activity	4	6
GO:0140098	catalytic activity, acting on RNA	3	6
GO:0140101	catalytic activity, acting on a tRNA	4	6
GO:0140640	catalytic activity, acting on a nucleic acid	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.554
CLV_C14_Caspase3-7	258	262	PF00656	0.529
CLV_C14_Caspase3-7	342	346	PF00656	0.647
CLV_C14_Caspase3-7	48	52	PF00656	0.671
CLV_C14_Caspase3-7	573	577	PF00656	0.535
CLV_C14_Caspase3-7	616	620	PF00656	0.518
CLV_NRD_NRD_1	116	118	PF00675	0.580
CLV_NRD_NRD_1	240	242	PF00675	0.237
CLV_NRD_NRD_1	38	40	PF00675	0.613
CLV_NRD_NRD_1	661	663	PF00675	0.450
CLV_NRD_NRD_1	786	788	PF00675	0.556
CLV_NRD_NRD_1	966	968	PF00675	0.557
CLV_PCSK_KEX2_1	209	211	PF00082	0.295
CLV_PCSK_KEX2_1	240	242	PF00082	0.258
CLV_PCSK_KEX2_1	38	40	PF00082	0.631
CLV_PCSK_KEX2_1	534	536	PF00082	0.549
CLV_PCSK_KEX2_1	661	663	PF00082	0.450
CLV_PCSK_KEX2_1	666	668	PF00082	0.474
CLV_PCSK_KEX2_1	786	788	PF00082	0.556
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.295
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.549
CLV_PCSK_PC1ET2_1	666	668	PF00082	0.512
CLV_PCSK_PC7_1	662	668	PF00082	0.523
CLV_PCSK_SKI1_1	106	110	PF00082	0.503
CLV_PCSK_SKI1_1	111	115	PF00082	0.481
CLV_PCSK_SKI1_1	204	208	PF00082	0.285
CLV_PCSK_SKI1_1	209	213	PF00082	0.303
CLV_PCSK_SKI1_1	371	375	PF00082	0.583
CLV_PCSK_SKI1_1	39	43	PF00082	0.592
CLV_PCSK_SKI1_1	488	492	PF00082	0.558
CLV_PCSK_SKI1_1	534	538	PF00082	0.531
CLV_PCSK_SKI1_1	661	665	PF00082	0.441
CLV_PCSK_SKI1_1	666	670	PF00082	0.498
CLV_PCSK_SKI1_1	67	71	PF00082	0.548
CLV_PCSK_SKI1_1	76	80	PF00082	0.470
CLV_PCSK_SKI1_1	799	803	PF00082	0.582
DEG_COP1_1	899	910	PF00400	0.635
DEG_Nend_UBRbox_1	1	4	PF02207	0.524
DEG_SPOP_SBC_1	121	125	PF00917	0.635
DEG_SPOP_SBC_1	31	35	PF00917	0.595
DEG_SPOP_SBC_1	855	859	PF00917	0.632
DOC_CKS1_1	510	515	PF01111	0.554
DOC_CYCLIN_RxL_1	796	806	PF00134	0.583
DOC_MAPK_gen_1	816	826	PF00069	0.622
DOC_MAPK_HePTP_8	964	981	PF00069	0.551
DOC_MAPK_MEF2A_6	959	966	PF00069	0.545
DOC_MAPK_MEF2A_6	973	981	PF00069	0.555
DOC_PP1_RVXF_1	278	284	PF00149	0.468
DOC_PP1_RVXF_1	486	493	PF00149	0.556
DOC_PP1_RVXF_1	784	791	PF00149	0.591
DOC_PP2B_LxvP_1	318	321	PF13499	0.621
DOC_PP2B_LxvP_1	736	739	PF13499	0.553
DOC_USP7_MATH_1	137	141	PF00917	0.742
DOC_USP7_MATH_1	14	18	PF00917	0.594
DOC_USP7_MATH_1	146	150	PF00917	0.733
DOC_USP7_MATH_1	259	263	PF00917	0.475
DOC_USP7_MATH_1	30	34	PF00917	0.548
DOC_USP7_MATH_1	321	325	PF00917	0.591
DOC_USP7_MATH_1	327	331	PF00917	0.588
DOC_USP7_MATH_1	415	419	PF00917	0.615
DOC_USP7_MATH_1	447	451	PF00917	0.623
DOC_USP7_MATH_1	513	517	PF00917	0.700
DOC_USP7_MATH_1	536	540	PF00917	0.619
DOC_USP7_UBL2_3	166	170	PF12436	0.699
DOC_USP7_UBL2_3	669	673	PF12436	0.535
DOC_USP7_UBL2_3	955	959	PF12436	0.556
DOC_WW_Pin1_4	157	162	PF00397	0.656
DOC_WW_Pin1_4	170	175	PF00397	0.807
DOC_WW_Pin1_4	178	183	PF00397	0.744
DOC_WW_Pin1_4	230	235	PF00397	0.486
DOC_WW_Pin1_4	24	29	PF00397	0.580
DOC_WW_Pin1_4	371	376	PF00397	0.623
DOC_WW_Pin1_4	445	450	PF00397	0.686
DOC_WW_Pin1_4	473	478	PF00397	0.587
DOC_WW_Pin1_4	494	499	PF00397	0.650
DOC_WW_Pin1_4	509	514	PF00397	0.609
DOC_WW_Pin1_4	646	651	PF00397	0.555
DOC_WW_Pin1_4	67	72	PF00397	0.529
DOC_WW_Pin1_4	719	724	PF00397	0.481
DOC_WW_Pin1_4	858	863	PF00397	0.640
LIG_14-3-3_CanoR_1	142	148	PF00244	0.680
LIG_14-3-3_CanoR_1	307	317	PF00244	0.591
LIG_14-3-3_CanoR_1	326	332	PF00244	0.631
LIG_14-3-3_CanoR_1	369	374	PF00244	0.560
LIG_14-3-3_CanoR_1	425	431	PF00244	0.544
LIG_14-3-3_CanoR_1	614	619	PF00244	0.512
LIG_14-3-3_CanoR_1	737	743	PF00244	0.547
LIG_14-3-3_CanoR_1	770	776	PF00244	0.535
LIG_14-3-3_CanoR_1	819	824	PF00244	0.599
LIG_14-3-3_CanoR_1	863	868	PF00244	0.697
LIG_Actin_WH2_2	648	663	PF00022	0.497
LIG_APCC_ABBA_1	979	984	PF00400	0.553
LIG_BRCT_BRCA1_1	232	236	PF00533	0.475
LIG_BRCT_BRCA1_1	580	584	PF00533	0.531
LIG_deltaCOP1_diTrp_1	573	578	PF00928	0.532
LIG_deltaCOP1_diTrp_1	944	949	PF00928	0.527
LIG_FHA_1	196	202	PF00498	0.529
LIG_FHA_1	310	316	PF00498	0.595
LIG_FHA_1	372	378	PF00498	0.680
LIG_FHA_1	397	403	PF00498	0.619
LIG_FHA_1	540	546	PF00498	0.597
LIG_FHA_1	694	700	PF00498	0.518
LIG_FHA_1	733	739	PF00498	0.559
LIG_FHA_1	741	747	PF00498	0.574
LIG_FHA_1	813	819	PF00498	0.543
LIG_FHA_1	972	978	PF00498	0.626
LIG_FHA_2	256	262	PF00498	0.529
LIG_FHA_2	309	315	PF00498	0.528
LIG_FHA_2	340	346	PF00498	0.639
LIG_FHA_2	389	395	PF00498	0.600
LIG_FHA_2	46	52	PF00498	0.477
LIG_FHA_2	68	74	PF00498	0.517
LIG_FHA_2	698	704	PF00498	0.515
LIG_FHA_2	728	734	PF00498	0.535
LIG_FHA_2	866	872	PF00498	0.646
LIG_LIR_Apic_2	202	208	PF02991	0.475
LIG_LIR_Apic_2	598	604	PF02991	0.504
LIG_LIR_Apic_2	634	638	PF02991	0.541
LIG_LIR_Gen_1	233	243	PF02991	0.475
LIG_LIR_Gen_1	581	591	PF02991	0.566
LIG_LIR_Gen_1	592	601	PF02991	0.572
LIG_LIR_Gen_1	741	750	PF02991	0.559
LIG_LIR_Nem_3	202	206	PF02991	0.489
LIG_LIR_Nem_3	23	29	PF02991	0.639
LIG_LIR_Nem_3	233	239	PF02991	0.475
LIG_LIR_Nem_3	364	368	PF02991	0.767
LIG_LIR_Nem_3	581	587	PF02991	0.571
LIG_LIR_Nem_3	592	596	PF02991	0.573
LIG_LIR_Nem_3	741	745	PF02991	0.564
LIG_LIR_Nem_3	934	940	PF02991	0.506
LIG_MAD2	662	670	PF02301	0.445
LIG_MYND_1	223	227	PF01753	0.475
LIG_MYND_1	748	752	PF01753	0.536
LIG_Pex14_1	574	578	PF04695	0.567
LIG_Pex14_2	578	582	PF04695	0.580
LIG_Rb_LxCxE_1	935	951	PF01857	0.512
LIG_SH2_CRK	601	605	PF00017	0.576
LIG_SH2_CRK	791	795	PF00017	0.578
LIG_SH2_CRK	937	941	PF00017	0.508
LIG_SH2_PTP2	978	981	PF00017	0.554
LIG_SH2_STAP1	195	199	PF00017	0.475
LIG_SH2_STAP1	580	584	PF00017	0.552
LIG_SH2_STAT3	929	932	PF00017	0.625
LIG_SH2_STAT5	205	208	PF00017	0.478
LIG_SH2_STAT5	282	285	PF00017	0.453
LIG_SH2_STAT5	635	638	PF00017	0.538
LIG_SH2_STAT5	87	90	PF00017	0.472
LIG_SH2_STAT5	906	909	PF00017	0.631
LIG_SH2_STAT5	929	932	PF00017	0.569
LIG_SH2_STAT5	978	981	PF00017	0.554
LIG_SH3_1	601	607	PF00018	0.580
LIG_SH3_3	155	161	PF00018	0.636
LIG_SH3_3	211	217	PF00018	0.460
LIG_SH3_3	268	274	PF00018	0.478
LIG_SH3_3	314	320	PF00018	0.702
LIG_SH3_3	374	380	PF00018	0.616
LIG_SH3_3	381	387	PF00018	0.700
LIG_SH3_3	453	459	PF00018	0.616
LIG_SH3_3	57	63	PF00018	0.465
LIG_SH3_3	601	607	PF00018	0.504
LIG_SH3_3	742	748	PF00018	0.549
LIG_SH3_3	91	97	PF00018	0.469
LIG_SH3_3	918	924	PF00018	0.616
LIG_SH3_4	669	676	PF00018	0.549
LIG_SUMO_SIM_anti_2	196	202	PF11976	0.475
LIG_SUMO_SIM_anti_2	311	319	PF11976	0.556
LIG_SUMO_SIM_anti_2	56	62	PF11976	0.469
LIG_SUMO_SIM_par_1	196	202	PF11976	0.529
LIG_SUMO_SIM_par_1	541	546	PF11976	0.596
LIG_SUMO_SIM_par_1	695	705	PF11976	0.658
LIG_SUMO_SIM_par_1	822	828	PF11976	0.619
LIG_TRAF2_1	687	690	PF00917	0.607
LIG_TRAF2_1	70	73	PF00917	0.517
LIG_TRAF2_1	810	813	PF00917	0.616
LIG_TRAF2_1	868	871	PF00917	0.583
LIG_TYR_ITIM	976	981	PF00017	0.551
LIG_UBA3_1	109	118	PF00899	0.582
LIG_WRC_WIRS_1	200	205	PF05994	0.475
MOD_CDK_SPK_2	858	863	PF00069	0.640
MOD_CDK_SPxK_1	646	652	PF00069	0.529
MOD_CK1_1	140	146	PF00069	0.598
MOD_CK1_1	173	179	PF00069	0.784
MOD_CK1_1	309	315	PF00069	0.593
MOD_CK1_1	389	395	PF00069	0.697
MOD_CK1_1	445	451	PF00069	0.718
MOD_CK1_1	524	530	PF00069	0.524
MOD_CK1_1	539	545	PF00069	0.599
MOD_CK1_1	566	572	PF00069	0.543
MOD_CK1_1	701	707	PF00069	0.590
MOD_CK1_1	857	863	PF00069	0.688
MOD_CK2_1	401	407	PF00069	0.643
MOD_CK2_1	67	73	PF00069	0.531
MOD_CK2_1	727	733	PF00069	0.535
MOD_CK2_1	865	871	PF00069	0.645
MOD_CMANNOS	946	949	PF00535	0.519
MOD_Cter_Amidation	36	39	PF01082	0.613
MOD_DYRK1A_RPxSP_1	371	375	PF00069	0.607
MOD_GlcNHglycan	106	109	PF01048	0.671
MOD_GlcNHglycan	149	152	PF01048	0.606
MOD_GlcNHglycan	161	164	PF01048	0.597
MOD_GlcNHglycan	17	20	PF01048	0.503
MOD_GlcNHglycan	175	178	PF01048	0.685
MOD_GlcNHglycan	261	264	PF01048	0.275
MOD_GlcNHglycan	323	326	PF01048	0.589
MOD_GlcNHglycan	327	330	PF01048	0.593
MOD_GlcNHglycan	335	338	PF01048	0.651
MOD_GlcNHglycan	403	406	PF01048	0.547
MOD_GlcNHglycan	449	452	PF01048	0.550
MOD_GlcNHglycan	515	518	PF01048	0.697
MOD_GlcNHglycan	523	526	PF01048	0.681
MOD_GlcNHglycan	545	548	PF01048	0.683
MOD_GlcNHglycan	6	9	PF01048	0.478
MOD_GlcNHglycan	763	767	PF01048	0.677
MOD_GlcNHglycan	808	811	PF01048	0.636
MOD_GSK3_1	100	107	PF00069	0.509
MOD_GSK3_1	120	127	PF00069	0.489
MOD_GSK3_1	137	144	PF00069	0.817
MOD_GSK3_1	166	173	PF00069	0.825
MOD_GSK3_1	195	202	PF00069	0.607
MOD_GSK3_1	230	237	PF00069	0.475
MOD_GSK3_1	255	262	PF00069	0.529
MOD_GSK3_1	306	313	PF00069	0.562
MOD_GSK3_1	321	328	PF00069	0.748
MOD_GSK3_1	329	336	PF00069	0.671
MOD_GSK3_1	348	355	PF00069	0.702
MOD_GSK3_1	388	395	PF00069	0.690
MOD_GSK3_1	410	417	PF00069	0.594
MOD_GSK3_1	441	448	PF00069	0.629
MOD_GSK3_1	509	516	PF00069	0.660
MOD_GSK3_1	523	530	PF00069	0.517
MOD_GSK3_1	539	546	PF00069	0.588
MOD_GSK3_1	563	570	PF00069	0.493
MOD_GSK3_1	574	581	PF00069	0.593
MOD_GSK3_1	636	643	PF00069	0.573
MOD_GSK3_1	671	678	PF00069	0.548
MOD_GSK3_1	693	700	PF00069	0.586
MOD_GSK3_1	824	831	PF00069	0.545
MOD_GSK3_1	850	857	PF00069	0.673
MOD_GSK3_1	886	893	PF00069	0.655
MOD_N-GLC_1	15	20	PF02516	0.556
MOD_N-GLC_1	241	246	PF02516	0.303
MOD_N-GLC_1	419	424	PF02516	0.598
MOD_N-GLC_1	640	645	PF02516	0.525
MOD_N-GLC_1	803	808	PF02516	0.576
MOD_NEK2_1	104	109	PF00069	0.496
MOD_NEK2_1	113	118	PF00069	0.520
MOD_NEK2_1	132	137	PF00069	0.660
MOD_NEK2_1	410	415	PF00069	0.735
MOD_NEK2_1	436	441	PF00069	0.638
MOD_NEK2_1	551	556	PF00069	0.593
MOD_NEK2_1	578	583	PF00069	0.545
MOD_NEK2_1	693	698	PF00069	0.542
MOD_NEK2_1	9	14	PF00069	0.521
MOD_NEK2_2	398	403	PF00069	0.568
MOD_NEK2_2	483	488	PF00069	0.599
MOD_NEK2_2	732	737	PF00069	0.562
MOD_PIKK_1	248	254	PF00454	0.495
MOD_PIKK_1	284	290	PF00454	0.438
MOD_PIKK_1	32	38	PF00454	0.623
MOD_PIKK_1	335	341	PF00454	0.693
MOD_PIKK_1	671	677	PF00454	0.576
MOD_PIKK_1	740	746	PF00454	0.553
MOD_PIKK_1	778	784	PF00454	0.618
MOD_PIKK_1	914	920	PF00454	0.697
MOD_PK_1	819	825	PF00069	0.622
MOD_PKA_1	76	82	PF00069	0.507
MOD_PKA_2	141	147	PF00069	0.705
MOD_PKA_2	306	312	PF00069	0.650
MOD_PKA_2	325	331	PF00069	0.729
MOD_PKA_2	349	355	PF00069	0.635
MOD_PKA_2	426	432	PF00069	0.539
MOD_PKA_2	613	619	PF00069	0.514
MOD_PKA_2	769	775	PF00069	0.601
MOD_PKA_2	804	810	PF00069	0.622
MOD_PKA_2	828	834	PF00069	0.608
MOD_PKA_2	9	15	PF00069	0.553
MOD_Plk_1	195	201	PF00069	0.529
MOD_Plk_1	241	247	PF00069	0.568
MOD_Plk_1	255	261	PF00069	0.499
MOD_Plk_1	313	319	PF00069	0.707
MOD_Plk_1	419	425	PF00069	0.601
MOD_Plk_1	640	646	PF00069	0.530
MOD_Plk_1	732	738	PF00069	0.568
MOD_Plk_1	933	939	PF00069	0.523
MOD_Plk_2-3	45	51	PF00069	0.530
MOD_Plk_4	181	187	PF00069	0.620
MOD_Plk_4	195	201	PF00069	0.585
MOD_Plk_4	221	227	PF00069	0.475
MOD_Plk_4	313	319	PF00069	0.648
MOD_Plk_4	361	367	PF00069	0.629
MOD_Plk_4	398	404	PF00069	0.646
MOD_Plk_4	419	425	PF00069	0.540
MOD_Plk_4	563	569	PF00069	0.549
MOD_ProDKin_1	157	163	PF00069	0.654
MOD_ProDKin_1	170	176	PF00069	0.806
MOD_ProDKin_1	178	184	PF00069	0.741
MOD_ProDKin_1	230	236	PF00069	0.486
MOD_ProDKin_1	24	30	PF00069	0.580
MOD_ProDKin_1	371	377	PF00069	0.625
MOD_ProDKin_1	445	451	PF00069	0.687
MOD_ProDKin_1	473	479	PF00069	0.586
MOD_ProDKin_1	494	500	PF00069	0.653
MOD_ProDKin_1	509	515	PF00069	0.611
MOD_ProDKin_1	646	652	PF00069	0.551
MOD_ProDKin_1	67	73	PF00069	0.531
MOD_ProDKin_1	719	725	PF00069	0.475
MOD_ProDKin_1	858	864	PF00069	0.640
MOD_SUMO_for_1	253	256	PF00179	0.460
MOD_SUMO_for_1	41	44	PF00179	0.581
MOD_SUMO_rev_2	99	104	PF00179	0.585
TRG_DiLeu_BaEn_2	48	54	PF01217	0.486
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.542
TRG_DiLeu_BaLyEn_6	601	606	PF01217	0.499
TRG_ENDOCYTIC_2	282	285	PF00928	0.452
TRG_ENDOCYTIC_2	593	596	PF00928	0.548
TRG_ENDOCYTIC_2	937	940	PF00928	0.492
TRG_ENDOCYTIC_2	978	981	PF00928	0.554
TRG_ER_diArg_1	133	136	PF00400	0.579
TRG_ER_diArg_1	239	241	PF00400	0.437
TRG_ER_diArg_1	368	371	PF00400	0.587
TRG_ER_diArg_1	424	427	PF00400	0.696
TRG_ER_diArg_1	660	662	PF00400	0.450
TRG_ER_diArg_1	786	789	PF00400	0.556
TRG_NLS_MonoExtC_3	665	670	PF00514	0.467
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	488	493	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCE1	Leptomonas seymouri	50%	84%
A4HKL4	Leishmania braziliensis	69%	98%
A4I847	Leishmania infantum	99%	100%
E9B305	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q551	Leishmania major	87%	98%