Methyltransferase domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFZ7_LEIDO

TriTrypDb:

LdBPK_322220.1 , LdCL_320027600 , LDHU3_32.2760

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0034708	methyltransferase complex	4	1
GO:0035657	eRF1 methyltransferase complex	5	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A0A3Q8IFZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFZ7

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0032259	methylation	2	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0043414	macromolecule methylation	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.536
CLV_NRD_NRD_1	265	267	PF00675	0.490
CLV_PCSK_KEX2_1	265	267	PF00082	0.498
CLV_PCSK_SKI1_1	249	253	PF00082	0.419
CLV_PCSK_SKI1_1	71	75	PF00082	0.477
CLV_Separin_Metazoa	46	50	PF03568	0.423
DEG_APCC_KENBOX_2	274	278	PF00400	0.418
DOC_CYCLIN_RxL_1	68	77	PF00134	0.497
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.673
DOC_MAPK_gen_1	265	273	PF00069	0.468
DOC_PP2B_LxvP_1	155	158	PF13499	0.672
DOC_PP2B_LxvP_1	73	76	PF13499	0.501
DOC_PP4_FxxP_1	216	219	PF00568	0.331
DOC_PP4_FxxP_1	334	337	PF00568	0.575
DOC_USP7_MATH_1	5	9	PF00917	0.444
DOC_WW_Pin1_4	8	13	PF00397	0.423
LIG_14-3-3_CanoR_1	101	105	PF00244	0.591
LIG_14-3-3_CanoR_1	145	155	PF00244	0.698
LIG_14-3-3_CanoR_1	203	211	PF00244	0.491
LIG_14-3-3_CanoR_1	6	12	PF00244	0.416
LIG_Actin_WH2_2	34	51	PF00022	0.428
LIG_BIR_II_1	1	5	PF00653	0.621
LIG_BRCT_BRCA1_1	207	211	PF00533	0.476
LIG_CtBP_PxDLS_1	168	172	PF00389	0.524
LIG_FHA_1	125	131	PF00498	0.499
LIG_FHA_1	13	19	PF00498	0.489
LIG_FHA_1	185	191	PF00498	0.589
LIG_FHA_1	278	284	PF00498	0.437
LIG_FHA_1	297	303	PF00498	0.695
LIG_FHA_1	81	87	PF00498	0.677
LIG_FHA_2	123	129	PF00498	0.528
LIG_FHA_2	221	227	PF00498	0.379
LIG_FHA_2	287	293	PF00498	0.434
LIG_FHA_2	299	305	PF00498	0.610
LIG_LIR_Apic_2	8	12	PF02991	0.539
LIG_LIR_Gen_1	208	219	PF02991	0.376
LIG_LIR_Gen_1	33	41	PF02991	0.340
LIG_LIR_Nem_3	140	146	PF02991	0.611
LIG_LIR_Nem_3	208	214	PF02991	0.394
LIG_LIR_Nem_3	33	38	PF02991	0.342
LIG_NRBOX	69	75	PF00104	0.434
LIG_PCNA_TLS_4	249	256	PF02747	0.481
LIG_PTB_Apo_2	214	221	PF02174	0.333
LIG_PTB_Phospho_1	214	220	PF10480	0.329
LIG_SH2_CRK	143	147	PF00017	0.374
LIG_SH2_NCK_1	9	13	PF00017	0.535
LIG_SH2_STAP1	14	18	PF00017	0.505
LIG_SH2_STAT5	133	136	PF00017	0.494
LIG_SH2_STAT5	14	17	PF00017	0.384
LIG_SH2_STAT5	220	223	PF00017	0.357
LIG_SH2_STAT5	270	273	PF00017	0.327
LIG_SH2_STAT5	318	321	PF00017	0.454
LIG_SH2_STAT5	330	333	PF00017	0.392
LIG_SH3_3	101	107	PF00018	0.609
LIG_SH3_3	163	169	PF00018	0.747
LIG_SH3_3	216	222	PF00018	0.343
LIG_SH3_3	24	30	PF00018	0.382
LIG_SUMO_SIM_par_1	115	120	PF11976	0.344
LIG_SUMO_SIM_par_1	157	162	PF11976	0.677
LIG_SUMO_SIM_par_1	270	276	PF11976	0.367
LIG_TRAF2_1	224	227	PF00917	0.419
LIG_TRAF2_1	82	85	PF00917	0.699
LIG_TYR_ITIM	268	273	PF00017	0.457
MOD_CK1_1	181	187	PF00069	0.611
MOD_CK1_1	261	267	PF00069	0.443
MOD_CK1_1	312	318	PF00069	0.347
MOD_CK1_1	8	14	PF00069	0.517
MOD_CK2_1	122	128	PF00069	0.496
MOD_CK2_1	220	226	PF00069	0.380
MOD_CK2_1	286	292	PF00069	0.453
MOD_CK2_1	294	300	PF00069	0.567
MOD_CK2_1	7	13	PF00069	0.565
MOD_GlcNHglycan	148	151	PF01048	0.666
MOD_GlcNHglycan	161	164	PF01048	0.692
MOD_GlcNHglycan	180	183	PF01048	0.651
MOD_GlcNHglycan	205	208	PF01048	0.635
MOD_GlcNHglycan	296	299	PF01048	0.644
MOD_GlcNHglycan	62	65	PF01048	0.326
MOD_GlcNHglycan	97	100	PF01048	0.689
MOD_GSK3_1	122	129	PF00069	0.356
MOD_GSK3_1	146	153	PF00069	0.614
MOD_GSK3_1	177	184	PF00069	0.674
MOD_GSK3_1	294	301	PF00069	0.651
MOD_GSK3_1	312	319	PF00069	0.403
MOD_GSK3_1	8	15	PF00069	0.525
MOD_GSK3_1	95	102	PF00069	0.675
MOD_N-GLC_1	277	282	PF02516	0.522
MOD_NEK2_1	119	124	PF00069	0.400
MOD_NEK2_1	134	139	PF00069	0.599
MOD_NEK2_1	183	188	PF00069	0.586
MOD_NEK2_1	285	290	PF00069	0.424
MOD_NEK2_1	294	299	PF00069	0.570
MOD_NEK2_1	47	52	PF00069	0.458
MOD_NEK2_2	286	291	PF00069	0.405
MOD_NEK2_2	298	303	PF00069	0.501
MOD_PIKK_1	80	86	PF00454	0.670
MOD_PKA_2	134	140	PF00069	0.572
MOD_PKA_2	18	24	PF00069	0.453
MOD_PKA_2	294	300	PF00069	0.627
MOD_PKA_2	316	322	PF00069	0.431
MOD_PKA_2	5	11	PF00069	0.460
MOD_PKA_2	95	101	PF00069	0.641
MOD_Plk_1	119	125	PF00069	0.415
MOD_Plk_4	126	132	PF00069	0.486
MOD_Plk_4	134	140	PF00069	0.521
MOD_Plk_4	258	264	PF00069	0.436
MOD_Plk_4	31	37	PF00069	0.357
MOD_Plk_4	321	327	PF00069	0.451
MOD_Plk_4	62	68	PF00069	0.292
MOD_ProDKin_1	8	14	PF00069	0.417
MOD_SUMO_for_1	302	305	PF00179	0.620
TRG_DiLeu_BaEn_2	30	36	PF01217	0.359
TRG_ENDOCYTIC_2	143	146	PF00928	0.599
TRG_ENDOCYTIC_2	270	273	PF00928	0.453
TRG_ER_diArg_1	246	249	PF00400	0.360
TRG_ER_diArg_1	326	329	PF00400	0.386
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A8	Leptomonas seymouri	57%	94%
A0A0S4JAA0	Bodo saltans	37%	100%
A0A1X0NUU4	Trypanosomatidae	41%	100%
A0A3R7LIX6	Trypanosoma rangeli	42%	100%
A4HKJ9	Leishmania braziliensis	81%	100%
A4I831	Leishmania infantum	100%	100%
D0AA96	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B2Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q567	Leishmania major	91%	100%
V5BBL2	Trypanosoma cruzi	41%	100%