DUF1014-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFZ2_LEIDO

TriTrypDb:

LdBPK_350300.1 , LdCL_350008000 , LDHU3_35.0390

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFZ2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006260	DNA replication	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.425
CLV_C14_Caspase3-7	40	44	PF00656	0.484
CLV_NRD_NRD_1	283	285	PF00675	0.616
CLV_NRD_NRD_1	328	330	PF00675	0.475
CLV_NRD_NRD_1	52	54	PF00675	0.579
CLV_PCSK_KEX2_1	258	260	PF00082	0.545
CLV_PCSK_KEX2_1	282	284	PF00082	0.417
CLV_PCSK_KEX2_1	328	330	PF00082	0.476
CLV_PCSK_KEX2_1	54	56	PF00082	0.588
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.470
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.417
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.588
CLV_PCSK_SKI1_1	109	113	PF00082	0.411
CLV_PCSK_SKI1_1	127	131	PF00082	0.373
CLV_PCSK_SKI1_1	283	287	PF00082	0.436
CLV_Separin_Metazoa	325	329	PF03568	0.396
DOC_MAPK_gen_1	151	160	PF00069	0.510
DOC_MAPK_gen_1	258	265	PF00069	0.481
DOC_USP7_MATH_1	171	175	PF00917	0.764
DOC_USP7_MATH_1	190	194	PF00917	0.649
DOC_USP7_MATH_1	239	243	PF00917	0.715
DOC_USP7_MATH_1	38	42	PF00917	0.552
DOC_USP7_MATH_1	88	92	PF00917	0.577
DOC_USP7_UBL2_3	109	113	PF12436	0.408
DOC_USP7_UBL2_3	282	286	PF12436	0.405
DOC_WW_Pin1_4	160	165	PF00397	0.548
DOC_WW_Pin1_4	63	68	PF00397	0.480
LIG_14-3-3_CanoR_1	238	247	PF00244	0.711
LIG_14-3-3_CanoR_1	309	319	PF00244	0.519
LIG_BIR_III_4	128	132	PF00653	0.559
LIG_BRCT_BRCA1_1	107	111	PF00533	0.567
LIG_BRCT_BRCA1_1	30	34	PF00533	0.582
LIG_BRCT_BRCA1_1	65	69	PF00533	0.568
LIG_BRCT_BRCA1_2	107	113	PF00533	0.540
LIG_CaM_IQ_9	45	60	PF13499	0.454
LIG_FHA_1	2	8	PF00498	0.635
LIG_FHA_1	221	227	PF00498	0.575
LIG_FHA_1	25	31	PF00498	0.429
LIG_FHA_1	265	271	PF00498	0.596
LIG_FHA_2	123	129	PF00498	0.466
LIG_FHA_2	27	33	PF00498	0.540
LIG_LIR_Nem_3	145	150	PF02991	0.462
LIG_LIR_Nem_3	293	299	PF02991	0.527
LIG_LIR_Nem_3	31	37	PF02991	0.582
LIG_LIR_Nem_3	313	319	PF02991	0.396
LIG_MAD2	156	164	PF02301	0.500
LIG_Pex14_2	292	296	PF04695	0.379
LIG_SH2_CRK	299	303	PF00017	0.572
LIG_SH2_STAT3	136	139	PF00017	0.491
LIG_SH3_3	4	10	PF00018	0.477
LIG_SH3_3	91	97	PF00018	0.586
MOD_CK1_1	101	107	PF00069	0.595
MOD_CK1_1	142	148	PF00069	0.480
MOD_CK1_1	163	169	PF00069	0.640
MOD_CK1_1	205	211	PF00069	0.771
MOD_CK1_1	41	47	PF00069	0.446
MOD_CK2_1	142	148	PF00069	0.480
MOD_CK2_1	291	297	PF00069	0.405
MOD_DYRK1A_RPxSP_1	63	67	PF00069	0.562
MOD_GlcNHglycan	172	176	PF01048	0.626
MOD_GlcNHglycan	193	196	PF01048	0.675
MOD_GlcNHglycan	197	200	PF01048	0.543
MOD_GlcNHglycan	212	215	PF01048	0.638
MOD_GlcNHglycan	228	231	PF01048	0.579
MOD_GlcNHglycan	241	244	PF01048	0.574
MOD_GlcNHglycan	251	254	PF01048	0.550
MOD_GlcNHglycan	90	93	PF01048	0.567
MOD_GSK3_1	101	108	PF00069	0.564
MOD_GSK3_1	163	170	PF00069	0.662
MOD_GSK3_1	171	178	PF00069	0.626
MOD_GSK3_1	191	198	PF00069	0.718
MOD_GSK3_1	20	27	PF00069	0.372
MOD_GSK3_1	204	211	PF00069	0.677
MOD_GSK3_1	216	223	PF00069	0.593
MOD_GSK3_1	264	271	PF00069	0.551
MOD_GSK3_1	37	44	PF00069	0.435
MOD_GSK3_1	9	16	PF00069	0.462
MOD_NEK2_1	210	215	PF00069	0.746
MOD_NEK2_1	24	29	PF00069	0.444
MOD_NEK2_1	249	254	PF00069	0.528
MOD_NEK2_1	327	332	PF00069	0.451
MOD_NEK2_1	69	74	PF00069	0.432
MOD_NEK2_2	122	127	PF00069	0.499
MOD_PIKK_1	179	185	PF00454	0.617
MOD_PIKK_1	22	28	PF00454	0.368
MOD_PIKK_1	69	75	PF00454	0.508
MOD_PIKK_1	9	15	PF00454	0.483
MOD_PKA_2	101	107	PF00069	0.493
MOD_PKA_2	150	156	PF00069	0.448
MOD_PKA_2	208	214	PF00069	0.714
MOD_Plk_1	122	128	PF00069	0.518
MOD_Plk_1	20	26	PF00069	0.517
MOD_Plk_1	205	211	PF00069	0.649
MOD_Plk_1	56	62	PF00069	0.550
MOD_Plk_4	2	8	PF00069	0.719
MOD_ProDKin_1	160	166	PF00069	0.555
MOD_ProDKin_1	63	69	PF00069	0.477
MOD_SUMO_for_1	322	325	PF00179	0.398
MOD_SUMO_rev_2	134	142	PF00179	0.552
TRG_ENDOCYTIC_2	299	302	PF00928	0.587
TRG_ENDOCYTIC_2	319	322	PF00928	0.380
TRG_ER_diArg_1	283	285	PF00400	0.432
TRG_ER_diArg_1	327	329	PF00400	0.410
TRG_ER_diArg_1	53	56	PF00400	0.439
TRG_NES_CRM1_1	255	269	PF08389	0.600
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I316	Leptomonas seymouri	73%	100%
A0A0S4JRP8	Bodo saltans	35%	91%
A0A1X0NJS6	Trypanosomatidae	37%	82%
A0A3R7MJB6	Trypanosoma rangeli	37%	94%
A4HM69	Leishmania braziliensis	80%	92%
A4IAT1	Leishmania infantum	100%	100%
D0A2C8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AEK7	Leishmania major	94%	100%
E9B5R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BSV2	Trypanosoma cruzi	38%	95%