ADF-H domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFZ1_LEIDO

TriTrypDb:

LdBPK_302560.1 , LdCL_300031200 , LDHU3_30.3440

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0030863	cortical cytoskeleton	6	1
GO:0030864	cortical actin cytoskeleton	7	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFZ1

Function

Biological processes
Term	Name	Level	Count
GO:0008064	regulation of actin polymerization or depolymerization	6	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030832	regulation of actin filament length	5	1
GO:0030833	regulation of actin filament polymerization	7	1
GO:0032271	regulation of protein polymerization	6	1
GO:0032535	regulation of cellular component size	4	1
GO:0032956	regulation of actin cytoskeleton organization	5	1
GO:0032970	regulation of actin filament-based process	4	1
GO:0033043	regulation of organelle organization	5	1
GO:0043254	regulation of protein-containing complex assembly	5	1
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051493	regulation of cytoskeleton organization	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090066	regulation of anatomical structure size	3	1
GO:0110053	regulation of actin filament organization	6	1
GO:1902903	regulation of supramolecular fiber organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0008092	cytoskeletal protein binding	3	10
GO:0044877	protein-containing complex binding	2	1
GO:0051015	actin filament binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.363
CLV_NRD_NRD_1	147	149	PF00675	0.651
CLV_NRD_NRD_1	245	247	PF00675	0.292
CLV_NRD_NRD_1	310	312	PF00675	0.550
CLV_PCSK_FUR_1	145	149	PF00082	0.639
CLV_PCSK_KEX2_1	144	146	PF00082	0.615
CLV_PCSK_KEX2_1	147	149	PF00082	0.654
CLV_PCSK_KEX2_1	245	247	PF00082	0.292
CLV_PCSK_KEX2_1	310	312	PF00082	0.529
CLV_PCSK_KEX2_1	41	43	PF00082	0.403
CLV_PCSK_KEX2_1	59	61	PF00082	0.350
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.592
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.433
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.332
CLV_PCSK_SKI1_1	182	186	PF00082	0.450
CLV_PCSK_SKI1_1	246	250	PF00082	0.309
CLV_PCSK_SKI1_1	301	305	PF00082	0.464
DEG_Kelch_Keap1_1	236	241	PF01344	0.507
DEG_SCF_TRCP1_1	105	110	PF00400	0.509
DOC_CKS1_1	304	309	PF01111	0.490
DOC_CYCLIN_yCln2_LP_2	354	360	PF00134	0.578
DOC_MAPK_gen_1	166	176	PF00069	0.567
DOC_MAPK_gen_1	349	358	PF00069	0.642
DOC_MAPK_gen_1	41	48	PF00069	0.345
DOC_MAPK_RevD_3	230	246	PF00069	0.484
DOC_PP1_RVXF_1	232	238	PF00149	0.489
DOC_PP1_RVXF_1	244	251	PF00149	0.419
DOC_PP2B_LxvP_1	354	357	PF13499	0.580
DOC_PP4_FxxP_1	304	307	PF00568	0.475
DOC_USP7_MATH_1	34	38	PF00917	0.513
DOC_USP7_MATH_1	380	384	PF00917	0.627
DOC_USP7_MATH_1	53	57	PF00917	0.304
DOC_WW_Pin1_4	169	174	PF00397	0.613
DOC_WW_Pin1_4	274	279	PF00397	0.549
DOC_WW_Pin1_4	303	308	PF00397	0.473
DOC_WW_Pin1_4	375	380	PF00397	0.686
LIG_14-3-3_CanoR_1	147	152	PF00244	0.656
LIG_14-3-3_CanoR_1	182	188	PF00244	0.336
LIG_14-3-3_CanoR_1	234	238	PF00244	0.440
LIG_14-3-3_CanoR_1	331	335	PF00244	0.442
LIG_14-3-3_CanoR_1	347	357	PF00244	0.625
LIG_APCC_ABBA_1	127	132	PF00400	0.488
LIG_BRCT_BRCA1_1	105	109	PF00533	0.526
LIG_BRCT_BRCA1_1	321	325	PF00533	0.516
LIG_BRCT_BRCA1_1	36	40	PF00533	0.522
LIG_BRCT_BRCA1_1	87	91	PF00533	0.448
LIG_deltaCOP1_diTrp_1	225	233	PF00928	0.482
LIG_FHA_1	178	184	PF00498	0.463
LIG_FHA_1	338	344	PF00498	0.657
LIG_FHA_1	349	355	PF00498	0.731
LIG_FHA_1	387	393	PF00498	0.419
LIG_FHA_1	70	76	PF00498	0.466
LIG_FHA_2	163	169	PF00498	0.669
LIG_FHA_2	304	310	PF00498	0.518
LIG_GBD_Chelix_1	400	408	PF00786	0.402
LIG_LIR_Apic_2	302	307	PF02991	0.446
LIG_LIR_Gen_1	193	200	PF02991	0.502
LIG_LIR_Gen_1	88	98	PF02991	0.503
LIG_LIR_Nem_3	193	199	PF02991	0.502
LIG_LIR_Nem_3	227	233	PF02991	0.491
LIG_LIR_Nem_3	88	94	PF02991	0.497
LIG_LYPXL_S_1	268	272	PF13949	0.323
LIG_LYPXL_yS_3	269	272	PF13949	0.523
LIG_PCNA_yPIPBox_3	209	220	PF02747	0.438
LIG_PDZ_Class_3	403	408	PF00595	0.337
LIG_Pex14_2	233	237	PF04695	0.523
LIG_SH2_PTP2	50	53	PF00017	0.449
LIG_SH2_STAP1	281	285	PF00017	0.459
LIG_SH2_STAT5	284	287	PF00017	0.471
LIG_SH2_STAT5	47	50	PF00017	0.362
LIG_SH3_3	157	163	PF00018	0.704
LIG_SH3_3	167	173	PF00018	0.643
LIG_SH3_3	354	360	PF00018	0.678
LIG_SUMO_SIM_anti_2	387	394	PF11976	0.480
LIG_SUMO_SIM_par_1	171	177	PF11976	0.555
LIG_TRAF2_1	165	168	PF00917	0.602
LIG_TRAF2_1	224	227	PF00917	0.544
LIG_TRAF2_1	385	388	PF00917	0.469
LIG_UBA3_1	216	221	PF00899	0.474
MOD_CDK_SPxxK_3	303	310	PF00069	0.484
MOD_CK1_1	153	159	PF00069	0.564
MOD_CK1_1	177	183	PF00069	0.602
MOD_CK1_1	366	372	PF00069	0.653
MOD_CK1_1	90	96	PF00069	0.363
MOD_CK2_1	162	168	PF00069	0.664
MOD_CK2_1	169	175	PF00069	0.675
MOD_CK2_1	198	204	PF00069	0.573
MOD_CK2_1	235	241	PF00069	0.507
MOD_CK2_1	330	336	PF00069	0.454
MOD_CK2_1	382	388	PF00069	0.455
MOD_Cter_Amidation	145	148	PF01082	0.611
MOD_DYRK1A_RPxSP_1	169	173	PF00069	0.633
MOD_GlcNHglycan	105	108	PF01048	0.530
MOD_GlcNHglycan	155	158	PF01048	0.510
MOD_GlcNHglycan	175	179	PF01048	0.389
MOD_GlcNHglycan	301	304	PF01048	0.429
MOD_GlcNHglycan	36	39	PF01048	0.564
MOD_GlcNHglycan	366	369	PF01048	0.698
MOD_GSK3_1	103	110	PF00069	0.506
MOD_GSK3_1	200	207	PF00069	0.520
MOD_GSK3_1	299	306	PF00069	0.441
MOD_GSK3_1	319	326	PF00069	0.521
MOD_GSK3_1	348	355	PF00069	0.738
MOD_GSK3_1	366	373	PF00069	0.655
MOD_GSK3_1	382	389	PF00069	0.483
MOD_GSK3_1	65	72	PF00069	0.469
MOD_GSK3_1	81	88	PF00069	0.366
MOD_N-GLC_1	107	112	PF02516	0.489
MOD_N-GLC_1	190	195	PF02516	0.268
MOD_N-GLC_1	68	73	PF02516	0.523
MOD_NEK2_1	233	238	PF00069	0.435
MOD_NEK2_1	28	33	PF00069	0.373
MOD_NEK2_1	319	324	PF00069	0.552
MOD_NEK2_1	98	103	PF00069	0.550
MOD_NEK2_2	36	41	PF00069	0.459
MOD_PKA_1	147	153	PF00069	0.673
MOD_PKA_2	147	153	PF00069	0.627
MOD_PKA_2	168	174	PF00069	0.576
MOD_PKA_2	233	239	PF00069	0.425
MOD_PKA_2	330	336	PF00069	0.438
MOD_PKA_2	352	358	PF00069	0.629
MOD_PKA_2	8	14	PF00069	0.411
MOD_PKA_2	98	104	PF00069	0.616
MOD_PKB_1	145	153	PF00069	0.660
MOD_Plk_1	107	113	PF00069	0.496
MOD_Plk_1	320	326	PF00069	0.522
MOD_Plk_1	386	392	PF00069	0.436
MOD_Plk_4	320	326	PF00069	0.432
MOD_Plk_4	330	336	PF00069	0.563
MOD_Plk_4	53	59	PF00069	0.585
MOD_Plk_4	90	96	PF00069	0.467
MOD_Plk_4	98	104	PF00069	0.533
MOD_ProDKin_1	169	175	PF00069	0.604
MOD_ProDKin_1	274	280	PF00069	0.549
MOD_ProDKin_1	303	309	PF00069	0.478
MOD_ProDKin_1	375	381	PF00069	0.683
MOD_SUMO_rev_2	19	26	PF00179	0.413
TRG_DiLeu_BaEn_1	388	393	PF01217	0.365
TRG_ENDOCYTIC_2	269	272	PF00928	0.509
TRG_ENDOCYTIC_2	30	33	PF00928	0.341
TRG_ER_diArg_1	145	148	PF00400	0.633
TRG_ER_diArg_1	245	247	PF00400	0.504
TRG_ER_diArg_1	310	312	PF00400	0.529
TRG_NES_CRM1_1	92	105	PF08389	0.581
TRG_NLS_MonoExtC_3	143	148	PF00514	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5G8	Leptomonas seymouri	66%	100%
A0A1X0P342	Trypanosomatidae	40%	100%
A4HII8	Leishmania braziliensis	84%	100%
A4I5T2	Leishmania infantum	100%	100%
C9ZR53	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	91%
E9B127	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q738	Leishmania major	94%	100%
V5BMX2	Trypanosoma cruzi	42%	100%