LeishMANIAdb
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Acyltransferase family protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Acyltransferase family protein
Gene product:
1-acyl-sn-glycerol-3-phosphateacyltransferase-l ik eprotein, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IFY7_LEIDO
TriTrypDb:
LdBPK_322070.1 , LdCL_320026100 , LDHU3_32.2570
Length:
277

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Annotations by Jardim et al.

Phospholipid biosynthesis, 1-acyl-sn-glycerol-3-phosphateacyltransferase-lik e

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0016020 membrane 2 14
GO:0110165 cellular anatomical entity 1 14

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IFY7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFY7

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 1
GO:0006644 phospholipid metabolic process 4 1
GO:0006650 glycerophospholipid metabolic process 5 1
GO:0006654 phosphatidic acid biosynthetic process 6 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0008152 metabolic process 1 1
GO:0008610 lipid biosynthetic process 4 1
GO:0008654 phospholipid biosynthetic process 5 1
GO:0009058 biosynthetic process 2 1
GO:0009987 cellular process 1 1
GO:0019637 organophosphate metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0045017 glycerolipid biosynthetic process 4 1
GO:0046473 phosphatidic acid metabolic process 6 1
GO:0046474 glycerophospholipid biosynthetic process 5 1
GO:0046486 glycerolipid metabolic process 4 1
GO:0071704 organic substance metabolic process 2 1
GO:0090407 organophosphate biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 16
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 7 8
GO:0008374 O-acyltransferase activity 5 8
GO:0016411 acylglycerol O-acyltransferase activity 6 8
GO:0016740 transferase activity 2 16
GO:0016746 acyltransferase activity 3 16
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 8
GO:0042171 lysophosphatidic acid acyltransferase activity 6 8
GO:0071617 lysophospholipid acyltransferase activity 5 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 226 230 PF00656 0.314
CLV_NRD_NRD_1 164 166 PF00675 0.408
CLV_NRD_NRD_1 167 169 PF00675 0.396
CLV_NRD_NRD_1 4 6 PF00675 0.331
CLV_NRD_NRD_1 58 60 PF00675 0.476
CLV_PCSK_FUR_1 165 169 PF00082 0.425
CLV_PCSK_KEX2_1 163 165 PF00082 0.424
CLV_PCSK_KEX2_1 167 169 PF00082 0.388
CLV_PCSK_KEX2_1 4 6 PF00082 0.331
CLV_PCSK_PC7_1 163 169 PF00082 0.421
CLV_PCSK_SKI1_1 241 245 PF00082 0.477
CLV_PCSK_SKI1_1 273 277 PF00082 0.625
CLV_PCSK_SKI1_1 88 92 PF00082 0.368
DEG_SPOP_SBC_1 43 47 PF00917 0.348
DOC_CYCLIN_yClb1_LxF_4 190 195 PF00134 0.221
DOC_MAPK_gen_1 163 174 PF00069 0.202
DOC_MAPK_gen_1 261 270 PF00069 0.357
DOC_MAPK_gen_1 85 93 PF00069 0.238
DOC_MAPK_MEF2A_6 12 21 PF00069 0.427
DOC_MAPK_MEF2A_6 85 93 PF00069 0.204
DOC_PP1_RVXF_1 190 196 PF00149 0.207
DOC_PP1_RVXF_1 57 64 PF00149 0.283
DOC_PP4_FxxP_1 122 125 PF00568 0.196
DOC_PP4_FxxP_1 234 237 PF00568 0.260
DOC_USP7_MATH_1 104 108 PF00917 0.282
DOC_USP7_MATH_1 219 223 PF00917 0.308
LIG_14-3-3_CanoR_1 12 18 PF00244 0.406
LIG_14-3-3_CanoR_1 241 249 PF00244 0.265
LIG_14-3-3_CanoR_1 59 64 PF00244 0.263
LIG_Actin_WH2_2 46 61 PF00022 0.201
LIG_AP2alpha_2 100 102 PF02296 0.209
LIG_APCC_ABBA_1 172 177 PF00400 0.199
LIG_BIR_II_1 1 5 PF00653 0.624
LIG_BRCT_BRCA1_1 40 44 PF00533 0.340
LIG_deltaCOP1_diTrp_1 112 122 PF00928 0.196
LIG_EH_1 188 192 PF12763 0.292
LIG_EH_1 69 73 PF12763 0.241
LIG_EH1_1 17 25 PF00400 0.246
LIG_eIF4E_1 18 24 PF01652 0.375
LIG_FHA_1 14 20 PF00498 0.227
LIG_FHA_1 212 218 PF00498 0.305
LIG_FHA_2 43 49 PF00498 0.315
LIG_LIR_Apic_2 233 237 PF02991 0.256
LIG_LIR_Gen_1 100 110 PF02991 0.219
LIG_LIR_Gen_1 146 155 PF02991 0.292
LIG_LIR_Gen_1 16 25 PF02991 0.284
LIG_LIR_Nem_3 100 105 PF02991 0.226
LIG_LIR_Nem_3 146 151 PF02991 0.292
LIG_LIR_Nem_3 16 21 PF02991 0.286
LIG_LIR_Nem_3 229 234 PF02991 0.285
LIG_Pex14_2 122 126 PF04695 0.218
LIG_Pex14_2 191 195 PF04695 0.189
LIG_SH2_STAT5 18 21 PF00017 0.272
LIG_SH2_STAT5 231 234 PF00017 0.232
LIG_SH3_2 187 192 PF14604 0.292
LIG_SH3_3 181 187 PF00018 0.246
LIG_SH3_3 37 43 PF00018 0.340
LIG_SUMO_SIM_par_1 207 212 PF11976 0.233
LIG_TRAF2_1 245 248 PF00917 0.267
LIG_WRC_WIRS_1 231 236 PF05994 0.325
MOD_CK1_1 147 153 PF00069 0.299
MOD_CK1_1 242 248 PF00069 0.350
MOD_CK2_1 209 215 PF00069 0.243
MOD_CK2_1 242 248 PF00069 0.282
MOD_CK2_1 42 48 PF00069 0.347
MOD_GlcNHglycan 211 214 PF01048 0.423
MOD_GlcNHglycan 221 224 PF01048 0.473
MOD_GlcNHglycan 244 247 PF01048 0.562
MOD_GlcNHglycan 96 99 PF01048 0.407
MOD_GSK3_1 143 150 PF00069 0.195
MOD_GSK3_1 38 45 PF00069 0.444
MOD_NEK2_1 13 18 PF00069 0.289
MOD_NEK2_1 19 24 PF00069 0.302
MOD_NEK2_1 209 214 PF00069 0.284
MOD_NEK2_2 71 76 PF00069 0.237
MOD_PIKK_1 247 253 PF00454 0.251
MOD_PKA_1 144 150 PF00069 0.266
MOD_PKA_1 59 65 PF00069 0.273
MOD_PKA_2 219 225 PF00069 0.331
MOD_Plk_4 111 117 PF00069 0.226
MOD_Plk_4 13 19 PF00069 0.303
MOD_Plk_4 202 208 PF00069 0.226
MOD_Plk_4 59 65 PF00069 0.313
TRG_DiLeu_BaLyEn_6 9 14 PF01217 0.488
TRG_ENDOCYTIC_2 18 21 PF00928 0.283
TRG_ENDOCYTIC_2 231 234 PF00928 0.298
TRG_ER_diArg_1 163 165 PF00400 0.204
TRG_ER_diArg_1 166 168 PF00400 0.193

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P455 Leptomonas seymouri 29% 81%
A0A0N0P6B0 Leptomonas seymouri 80% 96%
A0A0S4IQ05 Bodo saltans 29% 82%
A0A0S4JRP7 Bodo saltans 50% 100%
A0A1X0NUQ7 Trypanosomatidae 58% 100%
A0A3S5IQW0 Trypanosoma rangeli 59% 100%
A4H420 Leishmania braziliensis 30% 78%
A4HKI5 Leishmania braziliensis 88% 100%
A4HSA1 Leishmania infantum 24% 100%
A4I4U1 Leishmania infantum 24% 100%
A4I816 Leishmania infantum 100% 100%
D0AA81 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
E9AE89 Leishmania major 24% 100%
E9AK86 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 90%
E9ALJ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B2X4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q42670 Cocos nucifera 23% 90%
Q4Q582 Leishmania major 94% 100%
Q59188 Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) 26% 100%
Q9LLY4 Brassica napus 27% 81%
V5ALB6 Trypanosoma cruzi 58% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS