Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFY1_LEIDO

TriTrypDb:

LdBPK_350090.1 , LdCL_350005900 , LDHU3_35.0150

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFY1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.519
CLV_NRD_NRD_1	13	15	PF00675	0.507
CLV_NRD_NRD_1	143	145	PF00675	0.516
CLV_NRD_NRD_1	202	204	PF00675	0.572
CLV_NRD_NRD_1	252	254	PF00675	0.590
CLV_NRD_NRD_1	69	71	PF00675	0.571
CLV_NRD_NRD_1	91	93	PF00675	0.561
CLV_PCSK_FUR_1	11	15	PF00082	0.556
CLV_PCSK_KEX2_1	13	15	PF00082	0.516
CLV_PCSK_KEX2_1	141	143	PF00082	0.509
CLV_PCSK_KEX2_1	178	180	PF00082	0.549
CLV_PCSK_KEX2_1	202	204	PF00082	0.609
CLV_PCSK_KEX2_1	252	254	PF00082	0.590
CLV_PCSK_KEX2_1	69	71	PF00082	0.553
CLV_PCSK_KEX2_1	76	78	PF00082	0.361
CLV_PCSK_KEX2_1	9	11	PF00082	0.559
CLV_PCSK_KEX2_1	90	92	PF00082	0.454
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.566
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.549
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.483
CLV_PCSK_PC7_1	9	15	PF00082	0.523
CLV_PCSK_SKI1_1	118	122	PF00082	0.608
CLV_PCSK_SKI1_1	151	155	PF00082	0.630
DEG_APCC_DBOX_1	76	84	PF00400	0.436
DOC_MAPK_gen_1	178	184	PF00069	0.537
DOC_MAPK_MEF2A_6	108	116	PF00069	0.565
DOC_USP7_MATH_1	218	222	PF00917	0.430
DOC_USP7_MATH_1	4	8	PF00917	0.635
DOC_WW_Pin1_4	276	281	PF00397	0.728
LIG_14-3-3_CanoR_1	100	109	PF00244	0.533
LIG_14-3-3_CanoR_1	275	280	PF00244	0.760
LIG_14-3-3_CanoR_1	69	78	PF00244	0.512
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_deltaCOP1_diTrp_1	129	136	PF00928	0.560
LIG_DLG_GKlike_1	260	267	PF00625	0.700
LIG_FHA_1	104	110	PF00498	0.612
LIG_FHA_1	179	185	PF00498	0.497
LIG_FHA_2	246	252	PF00498	0.724
LIG_LIR_Apic_2	257	262	PF02991	0.612
LIG_LIR_Nem_3	266	271	PF02991	0.600
LIG_NRBOX	79	85	PF00104	0.439
LIG_Pex14_1	132	136	PF04695	0.653
LIG_RPA_C_Fungi	198	210	PF08784	0.450
LIG_RPA_C_Fungi	65	77	PF08784	0.552
LIG_SH2_CRK	259	263	PF00017	0.600
LIG_SH2_CRK	268	272	PF00017	0.610
LIG_SH2_NCK_1	21	25	PF00017	0.553
LIG_SH2_STAT3	64	67	PF00017	0.416
LIG_SH2_STAT5	157	160	PF00017	0.614
LIG_SH2_STAT5	226	229	PF00017	0.448
LIG_SH2_STAT5	64	67	PF00017	0.499
LIG_SH3_CIN85_PxpxPR_1	113	118	PF14604	0.479
LIG_SUMO_SIM_anti_2	119	124	PF11976	0.507
LIG_SUMO_SIM_par_1	180	185	PF11976	0.493
LIG_TRAF2_1	72	75	PF00917	0.535
LIG_TRAF2_1	93	96	PF00917	0.630
MOD_CK1_1	160	166	PF00069	0.604
MOD_CK2_1	132	138	PF00069	0.478
MOD_CK2_1	160	166	PF00069	0.581
MOD_CK2_1	245	251	PF00069	0.715
MOD_CK2_1	260	266	PF00069	0.447
MOD_CK2_1	267	273	PF00069	0.612
MOD_CK2_1	83	89	PF00069	0.577
MOD_GlcNHglycan	237	240	PF01048	0.581
MOD_GlcNHglycan	39	42	PF01048	0.509
MOD_GlcNHglycan	5	9	PF01048	0.616
MOD_GSK3_1	235	242	PF00069	0.656
MOD_NEK2_1	227	232	PF00069	0.603
MOD_NEK2_1	237	242	PF00069	0.736
MOD_NEK2_1	267	272	PF00069	0.632
MOD_NEK2_1	83	88	PF00069	0.504
MOD_NEK2_2	103	108	PF00069	0.536
MOD_PIKK_1	241	247	PF00454	0.635
MOD_PIKK_1	70	76	PF00454	0.619
MOD_PIKK_1	83	89	PF00454	0.565
MOD_PKA_1	178	184	PF00069	0.498
MOD_PKA_2	160	166	PF00069	0.527
MOD_PKA_2	167	173	PF00069	0.428
MOD_PKA_2	178	184	PF00069	0.539
MOD_PKA_2	245	251	PF00069	0.656
MOD_PKA_2	274	280	PF00069	0.769
MOD_Plk_1	187	193	PF00069	0.625
MOD_Plk_4	160	166	PF00069	0.604
MOD_Plk_4	267	273	PF00069	0.636
MOD_ProDKin_1	276	282	PF00069	0.736
MOD_SUMO_for_1	177	180	PF00179	0.547
TRG_DiLeu_BaEn_1	61	66	PF01217	0.546
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.515
TRG_ENDOCYTIC_2	268	271	PF00928	0.603
TRG_ER_diArg_1	12	14	PF00400	0.542
TRG_ER_diArg_1	142	144	PF00400	0.543
TRG_ER_diArg_1	252	254	PF00400	0.582
TRG_ER_diArg_1	9	11	PF00400	0.582
TRG_ER_diArg_1	90	92	PF00400	0.552
TRG_Pf-PMV_PEXEL_1	210	214	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Q7	Leptomonas seymouri	42%	100%
A4HM48	Leishmania braziliensis	72%	100%
A4IAR0	Leishmania infantum	100%	100%
E9AEI6	Leishmania major	91%	100%
E9B5P7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%