Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IFY0_LEIDO

TriTrypDb:

LdBPK_310140.1 , LdCL_310006300 , LDHU3_31.0170

Length:

825

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFY0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.632
CLV_C14_Caspase3-7	262	266	PF00656	0.605
CLV_C14_Caspase3-7	44	48	PF00656	0.623
CLV_NRD_NRD_1	283	285	PF00675	0.592
CLV_NRD_NRD_1	334	336	PF00675	0.483
CLV_NRD_NRD_1	379	381	PF00675	0.478
CLV_NRD_NRD_1	525	527	PF00675	0.542
CLV_NRD_NRD_1	545	547	PF00675	0.400
CLV_NRD_NRD_1	589	591	PF00675	0.448
CLV_NRD_NRD_1	609	611	PF00675	0.372
CLV_NRD_NRD_1	643	645	PF00675	0.477
CLV_PCSK_FUR_1	332	336	PF00082	0.670
CLV_PCSK_FUR_1	587	591	PF00082	0.450
CLV_PCSK_FUR_1	607	611	PF00082	0.379
CLV_PCSK_FUR_1	7	11	PF00082	0.635
CLV_PCSK_KEX2_1	100	102	PF00082	0.617
CLV_PCSK_KEX2_1	142	144	PF00082	0.617
CLV_PCSK_KEX2_1	282	284	PF00082	0.578
CLV_PCSK_KEX2_1	334	336	PF00082	0.525
CLV_PCSK_KEX2_1	486	488	PF00082	0.482
CLV_PCSK_KEX2_1	510	512	PF00082	0.472
CLV_PCSK_KEX2_1	525	527	PF00082	0.544
CLV_PCSK_KEX2_1	589	591	PF00082	0.461
CLV_PCSK_KEX2_1	600	602	PF00082	0.485
CLV_PCSK_KEX2_1	609	611	PF00082	0.347
CLV_PCSK_KEX2_1	9	11	PF00082	0.614
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.617
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.617
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.482
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.506
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.481
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.634
CLV_PCSK_PC7_1	278	284	PF00082	0.553
CLV_PCSK_SKI1_1	3	7	PF00082	0.576
CLV_PCSK_SKI1_1	38	42	PF00082	0.723
CLV_PCSK_SKI1_1	546	550	PF00082	0.550
CLV_PCSK_SKI1_1	600	604	PF00082	0.610
CLV_PCSK_SKI1_1	666	670	PF00082	0.465
DEG_APCC_DBOX_1	488	496	PF00400	0.430
DEG_APCC_DBOX_1	815	823	PF00400	0.587
DEG_ODPH_VHL_1	86	98	PF01847	0.524
DEG_SPOP_SBC_1	237	241	PF00917	0.623
DOC_CKS1_1	172	177	PF01111	0.619
DOC_MAPK_gen_1	472	481	PF00069	0.478
DOC_MAPK_gen_1	486	494	PF00069	0.378
DOC_MAPK_gen_1	552	560	PF00069	0.504
DOC_MAPK_gen_1	642	652	PF00069	0.386
DOC_MAPK_MEF2A_6	30	37	PF00069	0.622
DOC_MAPK_MEF2A_6	371	378	PF00069	0.477
DOC_PIKK_1	786	794	PF02985	0.495
DOC_PP1_RVXF_1	384	391	PF00149	0.480
DOC_PP1_RVXF_1	614	620	PF00149	0.348
DOC_PP2B_LxvP_1	152	155	PF13499	0.615
DOC_PP2B_LxvP_1	176	179	PF13499	0.554
DOC_PP2B_LxvP_1	224	227	PF13499	0.651
DOC_USP7_MATH_1	145	149	PF00917	0.646
DOC_USP7_MATH_1	155	159	PF00917	0.602
DOC_USP7_MATH_1	196	200	PF00917	0.699
DOC_USP7_MATH_1	254	258	PF00917	0.644
DOC_USP7_MATH_1	298	302	PF00917	0.599
DOC_USP7_MATH_1	316	320	PF00917	0.610
DOC_USP7_MATH_1	325	329	PF00917	0.504
DOC_USP7_MATH_1	33	37	PF00917	0.605
DOC_USP7_MATH_1	364	368	PF00917	0.491
DOC_USP7_MATH_1	818	822	PF00917	0.648
DOC_USP7_MATH_1	82	86	PF00917	0.672
DOC_USP7_MATH_2	160	166	PF00917	0.606
DOC_USP7_UBL2_3	434	438	PF12436	0.439
DOC_USP7_UBL2_3	596	600	PF12436	0.526
DOC_WW_Pin1_4	103	108	PF00397	0.680
DOC_WW_Pin1_4	156	161	PF00397	0.642
DOC_WW_Pin1_4	171	176	PF00397	0.550
DOC_WW_Pin1_4	183	188	PF00397	0.649
DOC_WW_Pin1_4	294	299	PF00397	0.592
DOC_WW_Pin1_4	321	326	PF00397	0.738
DOC_WW_Pin1_4	72	77	PF00397	0.699
LIG_14-3-3_CanoR_1	163	170	PF00244	0.537
LIG_14-3-3_CanoR_1	282	288	PF00244	0.602
LIG_14-3-3_CanoR_1	371	377	PF00244	0.477
LIG_14-3-3_CanoR_1	587	593	PF00244	0.485
LIG_14-3-3_CanoR_1	625	631	PF00244	0.530
LIG_14-3-3_CanoR_1	666	674	PF00244	0.499
LIG_14-3-3_CanoR_1	704	710	PF00244	0.464
LIG_14-3-3_CanoR_1	780	784	PF00244	0.567
LIG_14-3-3_CanoR_1	810	819	PF00244	0.643
LIG_Actin_WH2_2	343	360	PF00022	0.477
LIG_Actin_WH2_2	387	404	PF00022	0.441
LIG_Actin_WH2_2	531	548	PF00022	0.535
LIG_APCC_ABBA_1	204	209	PF00400	0.557
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_BIR_III_4	751	755	PF00653	0.516
LIG_BRCT_BRCA1_1	215	219	PF00533	0.665
LIG_BRCT_BRCA1_1	47	51	PF00533	0.614
LIG_EVH1_1	224	228	PF00568	0.659
LIG_FHA_1	240	246	PF00498	0.681
LIG_FHA_1	248	254	PF00498	0.590
LIG_FHA_1	266	272	PF00498	0.565
LIG_FHA_1	324	330	PF00498	0.612
LIG_FHA_1	630	636	PF00498	0.516
LIG_FHA_1	708	714	PF00498	0.511
LIG_FHA_1	81	87	PF00498	0.637
LIG_FHA_2	157	163	PF00498	0.599
LIG_FHA_2	395	401	PF00498	0.461
LIG_FHA_2	42	48	PF00498	0.733
LIG_FHA_2	667	673	PF00498	0.499
LIG_FHA_2	780	786	PF00498	0.508
LIG_Integrin_isoDGR_2	787	789	PF01839	0.488
LIG_LIR_Gen_1	395	404	PF02991	0.514
LIG_LIR_Gen_1	94	103	PF02991	0.531
LIG_LIR_Nem_3	395	401	PF02991	0.459
LIG_LIR_Nem_3	423	428	PF02991	0.481
LIG_LIR_Nem_3	94	98	PF02991	0.532
LIG_NRBOX	442	448	PF00104	0.483
LIG_SH2_CRK	425	429	PF00017	0.496
LIG_SH2_STAP1	448	452	PF00017	0.482
LIG_SH2_STAP1	464	468	PF00017	0.370
LIG_SH2_STAP1	531	535	PF00017	0.552
LIG_SH2_STAP1	631	635	PF00017	0.516
LIG_SH2_STAT3	680	683	PF00017	0.516
LIG_SH2_STAT5	631	634	PF00017	0.520
LIG_SH2_STAT5	804	807	PF00017	0.481
LIG_SH3_1	101	107	PF00018	0.598
LIG_SH3_3	101	107	PF00018	0.685
LIG_SH3_3	133	139	PF00018	0.602
LIG_SH3_3	167	173	PF00018	0.651
LIG_SH3_3	181	187	PF00018	0.594
LIG_SH3_3	222	228	PF00018	0.662
LIG_SH3_3	230	236	PF00018	0.711
LIG_SH3_3	61	67	PF00018	0.642
LIG_SH3_4	122	129	PF00018	0.539
LIG_TRAF2_1	267	270	PF00917	0.531
LIG_TRAF2_1	718	721	PF00917	0.518
LIG_WW_3	226	230	PF00397	0.676
MOD_CDC14_SPxK_1	297	300	PF00782	0.637
MOD_CDC14_SPxK_1	324	327	PF00782	0.598
MOD_CDK_SPxK_1	294	300	PF00069	0.619
MOD_CDK_SPxK_1	321	327	PF00069	0.738
MOD_CDK_SPxxK_3	156	163	PF00069	0.600
MOD_CK1_1	165	171	PF00069	0.665
MOD_CK1_1	183	189	PF00069	0.612
MOD_CK1_1	239	245	PF00069	0.636
MOD_CK1_1	286	292	PF00069	0.744
MOD_CK1_1	36	42	PF00069	0.593
MOD_CK1_1	459	465	PF00069	0.457
MOD_CK1_1	50	56	PF00069	0.679
MOD_CK1_1	626	632	PF00069	0.522
MOD_CK2_1	141	147	PF00069	0.601
MOD_CK2_1	15	21	PF00069	0.648
MOD_CK2_1	156	162	PF00069	0.598
MOD_CK2_1	394	400	PF00069	0.460
MOD_CK2_1	417	423	PF00069	0.406
MOD_CK2_1	467	473	PF00069	0.472
MOD_CK2_1	666	672	PF00069	0.499
MOD_GlcNHglycan	131	134	PF01048	0.660
MOD_GlcNHglycan	143	146	PF01048	0.579
MOD_GlcNHglycan	147	150	PF01048	0.646
MOD_GlcNHglycan	261	264	PF01048	0.622
MOD_GlcNHglycan	300	303	PF01048	0.712
MOD_GlcNHglycan	362	365	PF01048	0.456
MOD_GlcNHglycan	419	422	PF01048	0.448
MOD_GlcNHglycan	502	506	PF01048	0.464
MOD_GlcNHglycan	635	638	PF01048	0.510
MOD_GlcNHglycan	734	737	PF01048	0.517
MOD_GSK3_1	141	148	PF00069	0.666
MOD_GSK3_1	192	199	PF00069	0.685
MOD_GSK3_1	236	243	PF00069	0.657
MOD_GSK3_1	294	301	PF00069	0.573
MOD_GSK3_1	321	328	PF00069	0.682
MOD_GSK3_1	36	43	PF00069	0.692
MOD_GSK3_1	360	367	PF00069	0.502
MOD_GSK3_1	390	397	PF00069	0.462
MOD_GSK3_1	438	445	PF00069	0.486
MOD_GSK3_1	629	636	PF00069	0.515
MOD_GSK3_1	682	689	PF00069	0.466
MOD_GSK3_1	767	774	PF00069	0.509
MOD_GSK3_1	804	811	PF00069	0.501
MOD_GSK3_1	818	825	PF00069	0.523
MOD_LATS_1	808	814	PF00433	0.578
MOD_N-GLC_1	247	252	PF02516	0.667
MOD_N-GLC_1	265	270	PF02516	0.587
MOD_N-GLC_1	520	525	PF02516	0.500
MOD_NEK2_1	192	197	PF00069	0.599
MOD_NEK2_1	311	316	PF00069	0.607
MOD_NEK2_1	394	399	PF00069	0.458
MOD_NEK2_1	494	499	PF00069	0.562
MOD_NEK2_1	674	679	PF00069	0.535
MOD_NEK2_2	306	311	PF00069	0.565
MOD_NEK2_2	33	38	PF00069	0.621
MOD_PIKK_1	240	246	PF00454	0.675
MOD_PIKK_1	286	292	PF00454	0.641
MOD_PIKK_1	438	444	PF00454	0.473
MOD_PIKK_1	494	500	PF00454	0.527
MOD_PIKK_1	55	61	PF00454	0.658
MOD_PIKK_1	624	630	PF00454	0.446
MOD_PIKK_1	682	688	PF00454	0.465
MOD_PIKK_1	811	817	PF00454	0.548
MOD_PKA_1	283	289	PF00069	0.597
MOD_PKA_2	162	168	PF00069	0.655
MOD_PKA_2	283	289	PF00069	0.610
MOD_PKA_2	311	317	PF00069	0.628
MOD_PKA_2	588	594	PF00069	0.450
MOD_PKA_2	624	630	PF00069	0.487
MOD_PKA_2	674	680	PF00069	0.573
MOD_PKA_2	686	692	PF00069	0.412
MOD_PKA_2	767	773	PF00069	0.449
MOD_PKA_2	779	785	PF00069	0.444
MOD_Plk_1	24	30	PF00069	0.599
MOD_Plk_1	394	400	PF00069	0.470
MOD_Plk_1	408	414	PF00069	0.492
MOD_Plk_1	771	777	PF00069	0.501
MOD_Plk_2-3	13	19	PF00069	0.633
MOD_Plk_2-3	213	219	PF00069	0.606
MOD_Plk_2-3	265	271	PF00069	0.577
MOD_Plk_2-3	779	785	PF00069	0.577
MOD_Plk_4	185	191	PF00069	0.591
MOD_Plk_4	306	312	PF00069	0.688
MOD_Plk_4	442	448	PF00069	0.488
MOD_Plk_4	676	682	PF00069	0.465
MOD_Plk_4	779	785	PF00069	0.508
MOD_Plk_4	91	97	PF00069	0.569
MOD_ProDKin_1	103	109	PF00069	0.681
MOD_ProDKin_1	156	162	PF00069	0.642
MOD_ProDKin_1	171	177	PF00069	0.553
MOD_ProDKin_1	183	189	PF00069	0.650
MOD_ProDKin_1	294	300	PF00069	0.591
MOD_ProDKin_1	321	327	PF00069	0.738
MOD_ProDKin_1	72	78	PF00069	0.698
MOD_SUMO_rev_2	382	388	PF00179	0.479
MOD_SUMO_rev_2	395	404	PF00179	0.478
MOD_SUMO_rev_2	593	602	PF00179	0.521
TRG_DiLeu_BaEn_1	779	784	PF01217	0.443
TRG_ENDOCYTIC_2	425	428	PF00928	0.435
TRG_ER_diArg_1	282	284	PF00400	0.539
TRG_ER_diArg_1	331	334	PF00400	0.547
TRG_ER_diArg_1	587	590	PF00400	0.450
TRG_ER_diArg_1	607	610	PF00400	0.385
TRG_ER_diArg_1	616	619	PF00400	0.512
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	601	605	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	644	648	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	725	729	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE76	Leptomonas seymouri	55%	100%
A0A1X0NJ20	Trypanosomatidae	31%	92%
A4HIX7	Leishmania braziliensis	72%	98%
A4I6A6	Leishmania infantum	99%	100%
E9B1G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q6Q1	Leishmania major	88%	99%