Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IFX5_LEIDO

TriTrypDb:

LdBPK_231550.1 , LdCL_230022700 , LDHU3_23.2080

Length:

689

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3Q8IFX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.766
CLV_C14_Caspase3-7	296	300	PF00656	0.734
CLV_C14_Caspase3-7	361	365	PF00656	0.695
CLV_C14_Caspase3-7	551	555	PF00656	0.780
CLV_NRD_NRD_1	130	132	PF00675	0.629
CLV_NRD_NRD_1	20	22	PF00675	0.620
CLV_NRD_NRD_1	31	33	PF00675	0.568
CLV_NRD_NRD_1	322	324	PF00675	0.569
CLV_NRD_NRD_1	346	348	PF00675	0.647
CLV_NRD_NRD_1	48	50	PF00675	0.480
CLV_NRD_NRD_1	599	601	PF00675	0.568
CLV_NRD_NRD_1	655	657	PF00675	0.511
CLV_PCSK_FUR_1	320	324	PF00082	0.504
CLV_PCSK_FUR_1	653	657	PF00082	0.519
CLV_PCSK_KEX2_1	132	134	PF00082	0.622
CLV_PCSK_KEX2_1	20	22	PF00082	0.620
CLV_PCSK_KEX2_1	31	33	PF00082	0.568
CLV_PCSK_KEX2_1	322	324	PF00082	0.569
CLV_PCSK_KEX2_1	346	348	PF00082	0.647
CLV_PCSK_KEX2_1	48	50	PF00082	0.480
CLV_PCSK_KEX2_1	599	601	PF00082	0.568
CLV_PCSK_KEX2_1	655	657	PF00082	0.511
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.611
CLV_PCSK_SKI1_1	211	215	PF00082	0.498
CLV_PCSK_SKI1_1	341	345	PF00082	0.588
CLV_PCSK_SKI1_1	411	415	PF00082	0.528
CLV_PCSK_SKI1_1	447	451	PF00082	0.594
CLV_PCSK_SKI1_1	48	52	PF00082	0.646
CLV_PCSK_SKI1_1	537	541	PF00082	0.647
CLV_PCSK_SKI1_1	599	603	PF00082	0.619
CLV_PCSK_SKI1_1	629	633	PF00082	0.490
DEG_SCF_FBW7_2	238	243	PF00400	0.790
DEG_SPOP_SBC_1	384	388	PF00917	0.777
DEG_SPOP_SBC_1	404	408	PF00917	0.854
DEG_SPOP_SBC_1	438	442	PF00917	0.700
DOC_CKS1_1	101	106	PF01111	0.850
DOC_CKS1_1	270	275	PF01111	0.778
DOC_MAPK_gen_1	653	663	PF00069	0.698
DOC_MAPK_JIP1_4	229	235	PF00069	0.802
DOC_MAPK_MEF2A_6	655	663	PF00069	0.741
DOC_PP1_RVXF_1	344	351	PF00149	0.847
DOC_PP1_RVXF_1	566	573	PF00149	0.679
DOC_PP2B_LxvP_1	38	41	PF13499	0.799
DOC_PP4_FxxP_1	339	342	PF00568	0.787
DOC_USP7_MATH_1	106	110	PF00917	0.784
DOC_USP7_MATH_1	166	170	PF00917	0.802
DOC_USP7_MATH_1	203	207	PF00917	0.838
DOC_USP7_MATH_1	253	257	PF00917	0.765
DOC_USP7_MATH_1	318	322	PF00917	0.815
DOC_USP7_MATH_1	327	331	PF00917	0.705
DOC_USP7_MATH_1	384	388	PF00917	0.794
DOC_USP7_MATH_1	404	408	PF00917	0.745
DOC_USP7_MATH_1	438	442	PF00917	0.822
DOC_USP7_MATH_1	484	488	PF00917	0.766
DOC_USP7_MATH_1	552	556	PF00917	0.837
DOC_USP7_MATH_1	63	67	PF00917	0.823
DOC_USP7_MATH_1	675	679	PF00917	0.394
DOC_USP7_UBL2_3	537	541	PF12436	0.847
DOC_WW_Pin1_4	100	105	PF00397	0.854
DOC_WW_Pin1_4	186	191	PF00397	0.824
DOC_WW_Pin1_4	195	200	PF00397	0.770
DOC_WW_Pin1_4	236	241	PF00397	0.838
DOC_WW_Pin1_4	269	274	PF00397	0.825
DOC_WW_Pin1_4	281	286	PF00397	0.720
DOC_WW_Pin1_4	31	36	PF00397	0.847
DOC_WW_Pin1_4	417	422	PF00397	0.723
DOC_WW_Pin1_4	447	452	PF00397	0.769
DOC_WW_Pin1_4	472	477	PF00397	0.777
DOC_WW_Pin1_4	480	485	PF00397	0.734
DOC_WW_Pin1_4	50	55	PF00397	0.663
DOC_WW_Pin1_4	584	589	PF00397	0.785
DOC_WW_Pin1_4	637	642	PF00397	0.831
DOC_WW_Pin1_4	8	13	PF00397	0.780
LIG_14-3-3_CanoR_1	20	30	PF00244	0.820
LIG_14-3-3_CanoR_1	232	236	PF00244	0.806
LIG_14-3-3_CanoR_1	31	35	PF00244	0.767
LIG_14-3-3_CanoR_1	437	445	PF00244	0.828
LIG_14-3-3_CanoR_1	48	54	PF00244	0.670
LIG_14-3-3_CanoR_1	490	497	PF00244	0.762
LIG_14-3-3_CanoR_1	599	605	PF00244	0.819
LIG_BRCT_BRCA1_1	677	681	PF00533	0.316
LIG_deltaCOP1_diTrp_1	567	572	PF00928	0.776
LIG_DLG_GKlike_1	297	304	PF00625	0.676
LIG_eIF4E_1	604	610	PF01652	0.736
LIG_FHA_1	187	193	PF00498	0.821
LIG_FHA_1	199	205	PF00498	0.732
LIG_FHA_1	269	275	PF00498	0.750
LIG_FHA_1	307	313	PF00498	0.846
LIG_FHA_1	365	371	PF00498	0.837
LIG_FHA_1	384	390	PF00498	0.690
LIG_FHA_1	489	495	PF00498	0.695
LIG_FHA_1	575	581	PF00498	0.632
LIG_FHA_1	59	65	PF00498	0.777
LIG_FHA_1	592	598	PF00498	0.794
LIG_FHA_1	600	606	PF00498	0.744
LIG_FHA_1	96	102	PF00498	0.792
LIG_FHA_2	218	224	PF00498	0.768
LIG_GBD_Chelix_1	362	370	PF00786	0.494
LIG_LIR_Apic_2	337	342	PF02991	0.786
LIG_LIR_Gen_1	299	307	PF02991	0.694
LIG_LIR_Gen_1	678	688	PF02991	0.394
LIG_LIR_Gen_1	79	90	PF02991	0.712
LIG_LIR_Nem_3	142	148	PF02991	0.818
LIG_LIR_Nem_3	299	304	PF02991	0.695
LIG_LIR_Nem_3	678	684	PF02991	0.431
LIG_LIR_Nem_3	79	85	PF02991	0.786
LIG_MLH1_MIPbox_1	677	681	PF16413	0.316
LIG_PCNA_PIPBox_1	673	682	PF02747	0.413
LIG_SH2_CRK	301	305	PF00017	0.698
LIG_SH2_SRC	529	532	PF00017	0.853
LIG_SH2_STAT5	604	607	PF00017	0.818
LIG_SH3_1	74	80	PF00018	0.695
LIG_SH3_2	315	320	PF14604	0.735
LIG_SH3_2	40	45	PF14604	0.844
LIG_SH3_3	117	123	PF00018	0.785
LIG_SH3_3	177	183	PF00018	0.832
LIG_SH3_3	261	267	PF00018	0.828
LIG_SH3_3	309	315	PF00018	0.846
LIG_SH3_3	37	43	PF00018	0.853
LIG_SH3_3	378	384	PF00018	0.742
LIG_SH3_3	387	393	PF00018	0.763
LIG_SH3_3	528	534	PF00018	0.851
LIG_SH3_3	638	644	PF00018	0.778
LIG_SH3_3	74	80	PF00018	0.695
LIG_SH3_4	537	544	PF00018	0.844
LIG_SUMO_SIM_anti_2	271	278	PF11976	0.722
LIG_SUMO_SIM_par_1	189	194	PF11976	0.820
LIG_SUMO_SIM_par_1	200	206	PF11976	0.744
LIG_SUMO_SIM_par_1	3	11	PF11976	0.756
LIG_SUMO_SIM_par_1	308	314	PF11976	0.733
LIG_SUMO_SIM_par_1	59	66	PF11976	0.708
LIG_SUMO_SIM_par_1	672	678	PF11976	0.433
LIG_TRAF2_1	619	622	PF00917	0.761
LIG_UBA3_1	460	468	PF00899	0.679
LIG_UBA3_1	659	667	PF00899	0.580
LIG_WRC_WIRS_1	676	681	PF05994	0.394
MOD_CDC14_SPxK_1	640	643	PF00782	0.683
MOD_CDK_SPK_2	31	36	PF00069	0.714
MOD_CDK_SPxK_1	637	643	PF00069	0.685
MOD_CDK_SPxxK_3	100	107	PF00069	0.852
MOD_CK1_1	14	20	PF00069	0.766
MOD_CK1_1	141	147	PF00069	0.791
MOD_CK1_1	175	181	PF00069	0.861
MOD_CK1_1	198	204	PF00069	0.766
MOD_CK1_1	217	223	PF00069	0.627
MOD_CK1_1	256	262	PF00069	0.768
MOD_CK1_1	286	292	PF00069	0.806
MOD_CK1_1	293	299	PF00069	0.751
MOD_CK1_1	300	306	PF00069	0.681
MOD_CK1_1	308	314	PF00069	0.689
MOD_CK1_1	326	332	PF00069	0.690
MOD_CK1_1	385	391	PF00069	0.820
MOD_CK1_1	403	409	PF00069	0.642
MOD_CK1_1	412	418	PF00069	0.765
MOD_CK1_1	441	447	PF00069	0.840
MOD_CK1_1	459	465	PF00069	0.647
MOD_CK1_1	483	489	PF00069	0.802
MOD_CK1_1	501	507	PF00069	0.726
MOD_CK1_1	515	521	PF00069	0.709
MOD_CK1_1	53	59	PF00069	0.796
MOD_CK1_1	544	550	PF00069	0.838
MOD_CK1_1	574	580	PF00069	0.719
MOD_CK1_1	592	598	PF00069	0.726
MOD_CK1_1	624	630	PF00069	0.742
MOD_CK1_1	646	652	PF00069	0.824
MOD_CK1_1	7	13	PF00069	0.830
MOD_CK2_1	318	324	PF00069	0.800
MOD_CK2_1	7	13	PF00069	0.752
MOD_CMANNOS	569	572	PF00535	0.632
MOD_Cter_Amidation	597	600	PF01082	0.498
MOD_Cter_Amidation	653	656	PF01082	0.524
MOD_DYRK1A_RPxSP_1	447	451	PF00069	0.771
MOD_GlcNHglycan	133	136	PF01048	0.536
MOD_GlcNHglycan	16	19	PF01048	0.644
MOD_GlcNHglycan	164	167	PF01048	0.613
MOD_GlcNHglycan	177	180	PF01048	0.519
MOD_GlcNHglycan	205	208	PF01048	0.639
MOD_GlcNHglycan	217	220	PF01048	0.511
MOD_GlcNHglycan	247	250	PF01048	0.602
MOD_GlcNHglycan	285	288	PF01048	0.567
MOD_GlcNHglycan	292	295	PF01048	0.535
MOD_GlcNHglycan	324	328	PF01048	0.533
MOD_GlcNHglycan	336	339	PF01048	0.505
MOD_GlcNHglycan	402	405	PF01048	0.581
MOD_GlcNHglycan	411	414	PF01048	0.516
MOD_GlcNHglycan	446	450	PF01048	0.596
MOD_GlcNHglycan	454	457	PF01048	0.608
MOD_GlcNHglycan	500	503	PF01048	0.498
MOD_GlcNHglycan	508	511	PF01048	0.506
MOD_GlcNHglycan	520	523	PF01048	0.409
MOD_GlcNHglycan	550	553	PF01048	0.571
MOD_GlcNHglycan	621	626	PF01048	0.634
MOD_GlcNHglycan	65	68	PF01048	0.537
MOD_GSK3_1	108	115	PF00069	0.730
MOD_GSK3_1	137	144	PF00069	0.719
MOD_GSK3_1	162	169	PF00069	0.778
MOD_GSK3_1	182	189	PF00069	0.845
MOD_GSK3_1	194	201	PF00069	0.720
MOD_GSK3_1	209	216	PF00069	0.692
MOD_GSK3_1	217	224	PF00069	0.762
MOD_GSK3_1	22	29	PF00069	0.645
MOD_GSK3_1	247	254	PF00069	0.770
MOD_GSK3_1	255	262	PF00069	0.783
MOD_GSK3_1	268	275	PF00069	0.716
MOD_GSK3_1	286	293	PF00069	0.733
MOD_GSK3_1	302	309	PF00069	0.694
MOD_GSK3_1	318	325	PF00069	0.668
MOD_GSK3_1	327	334	PF00069	0.743
MOD_GSK3_1	366	373	PF00069	0.829
MOD_GSK3_1	4	11	PF00069	0.829
MOD_GSK3_1	400	407	PF00069	0.792
MOD_GSK3_1	433	440	PF00069	0.744
MOD_GSK3_1	441	448	PF00069	0.781
MOD_GSK3_1	452	459	PF00069	0.721
MOD_GSK3_1	480	487	PF00069	0.849
MOD_GSK3_1	49	56	PF00069	0.856
MOD_GSK3_1	504	511	PF00069	0.817
MOD_GSK3_1	512	519	PF00069	0.736
MOD_GSK3_1	544	551	PF00069	0.765
MOD_GSK3_1	552	559	PF00069	0.837
MOD_GSK3_1	580	587	PF00069	0.704
MOD_GSK3_1	639	646	PF00069	0.814
MOD_GSK3_1	96	103	PF00069	0.796
MOD_N-GLC_1	175	180	PF02516	0.582
MOD_N-GLC_1	186	191	PF02516	0.551
MOD_N-GLC_1	209	214	PF02516	0.591
MOD_N-GLC_1	251	256	PF02516	0.584
MOD_N-GLC_1	404	409	PF02516	0.654
MOD_N-GLC_1	574	579	PF02516	0.474
MOD_NEK2_1	112	117	PF00069	0.682
MOD_NEK2_1	233	238	PF00069	0.760
MOD_NEK2_1	251	256	PF00069	0.631
MOD_NEK2_1	366	371	PF00069	0.776
MOD_NEK2_1	445	450	PF00069	0.774
MOD_NEK2_1	503	508	PF00069	0.716
MOD_NEK2_1	96	101	PF00069	0.860
MOD_NEK2_2	209	214	PF00069	0.697
MOD_NEK2_2	4	9	PF00069	0.782
MOD_NEK2_2	456	461	PF00069	0.723
MOD_NEK2_2	675	680	PF00069	0.316
MOD_PIKK_1	112	118	PF00454	0.818
MOD_PIKK_1	251	257	PF00454	0.785
MOD_PIKK_1	89	95	PF00454	0.770
MOD_PK_1	643	649	PF00069	0.689
MOD_PKA_1	131	137	PF00069	0.752
MOD_PKA_1	322	328	PF00069	0.774
MOD_PKA_1	48	54	PF00069	0.824
MOD_PKA_1	599	605	PF00069	0.763
MOD_PKA_2	106	112	PF00069	0.865
MOD_PKA_2	126	132	PF00069	0.648
MOD_PKA_2	231	237	PF00069	0.804
MOD_PKA_2	30	36	PF00069	0.857
MOD_PKA_2	322	328	PF00069	0.818
MOD_PKA_2	370	376	PF00069	0.728
MOD_PKA_2	48	54	PF00069	0.667
MOD_PKA_2	489	495	PF00069	0.792
MOD_PKA_2	544	550	PF00069	0.828
MOD_PKA_2	599	605	PF00069	0.763
MOD_PKB_1	295	303	PF00069	0.768
MOD_PKB_1	320	328	PF00069	0.734
MOD_Plk_1	107	113	PF00069	0.871
MOD_Plk_1	141	147	PF00069	0.763
MOD_Plk_1	209	215	PF00069	0.731
MOD_Plk_1	26	32	PF00069	0.801
MOD_Plk_1	574	580	PF00069	0.676
MOD_Plk_2-3	108	114	PF00069	0.872
MOD_Plk_2-3	358	364	PF00069	0.695
MOD_Plk_4	11	17	PF00069	0.779
MOD_Plk_4	272	278	PF00069	0.770
MOD_Plk_4	385	391	PF00069	0.738
MOD_Plk_4	456	462	PF00069	0.790
MOD_Plk_4	592	598	PF00069	0.817
MOD_Plk_4	600	606	PF00069	0.734
MOD_Plk_4	643	649	PF00069	0.689
MOD_Plk_4	675	681	PF00069	0.407
MOD_ProDKin_1	100	106	PF00069	0.852
MOD_ProDKin_1	186	192	PF00069	0.824
MOD_ProDKin_1	195	201	PF00069	0.770
MOD_ProDKin_1	236	242	PF00069	0.837
MOD_ProDKin_1	269	275	PF00069	0.824
MOD_ProDKin_1	281	287	PF00069	0.722
MOD_ProDKin_1	31	37	PF00069	0.848
MOD_ProDKin_1	417	423	PF00069	0.723
MOD_ProDKin_1	447	453	PF00069	0.767
MOD_ProDKin_1	472	478	PF00069	0.780
MOD_ProDKin_1	480	486	PF00069	0.734
MOD_ProDKin_1	50	56	PF00069	0.661
MOD_ProDKin_1	584	590	PF00069	0.786
MOD_ProDKin_1	637	643	PF00069	0.832
MOD_ProDKin_1	8	14	PF00069	0.780
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.777
TRG_ENDOCYTIC_2	301	304	PF00928	0.699
TRG_ER_diArg_1	130	133	PF00400	0.822
TRG_ER_diArg_1	20	22	PF00400	0.795
TRG_ER_diArg_1	30	32	PF00400	0.718
TRG_ER_diArg_1	320	323	PF00400	0.735
TRG_ER_diArg_1	346	348	PF00400	0.847
TRG_ER_diArg_1	377	380	PF00400	0.777
TRG_ER_diArg_1	47	49	PF00400	0.667
TRG_ER_diArg_1	599	601	PF00400	0.768
TRG_ER_diArg_1	614	617	PF00400	0.645
TRG_ER_diArg_1	653	656	PF00400	0.724

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HD02	Leishmania braziliensis	52%	99%
A4I0I7	Leishmania infantum	99%	100%
E9AWE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	98%
Q4QB23	Leishmania major	86%	100%