Proline dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Proline dehydrogenase, mitochondrial

Species:

Leishmania donovani

UniProt:

A0A3Q8IFX0_LEIDO

TriTrypDb:

LdBPK_261590.1 , LdCL_260021600 , LDHU3_26.2010

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFX0

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006520	amino acid metabolic process	3	12
GO:0006560	proline metabolic process	6	12
GO:0006562	proline catabolic process	5	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009063	amino acid catabolic process	4	12
GO:0009064	glutamine family amino acid metabolic process	5	12
GO:0009065	glutamine family amino acid catabolic process	6	12
GO:0009987	cellular process	1	12
GO:0016054	organic acid catabolic process	4	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044281	small molecule metabolic process	2	12
GO:0044282	small molecule catabolic process	3	12
GO:0046395	carboxylic acid catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12
GO:1901605	alpha-amino acid metabolic process	4	12
GO:1901606	alpha-amino acid catabolic process	5	12
GO:0006536	glutamate metabolic process	6	1
GO:0010133	proline catabolic process to glutamate	6	1
GO:0043648	dicarboxylic acid metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004657	proline dehydrogenase activity	5	12
GO:0016491	oxidoreductase activity	2	12
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	12
GO:0016649	oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor	4	12
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	5
GO:0005509	calcium ion binding	5	5
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	1
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0071949	FAD binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	390	394	PF00656	0.509
CLV_C14_Caspase3-7	542	546	PF00656	0.566
CLV_MEL_PAP_1	203	209	PF00089	0.270
CLV_MEL_PAP_1	487	493	PF00089	0.309
CLV_NRD_NRD_1	2	4	PF00675	0.593
CLV_NRD_NRD_1	240	242	PF00675	0.491
CLV_NRD_NRD_1	279	281	PF00675	0.291
CLV_NRD_NRD_1	532	534	PF00675	0.206
CLV_NRD_NRD_1	557	559	PF00675	0.341
CLV_PCSK_KEX2_1	2	4	PF00082	0.593
CLV_PCSK_KEX2_1	448	450	PF00082	0.248
CLV_PCSK_KEX2_1	532	534	PF00082	0.206
CLV_PCSK_KEX2_1	556	558	PF00082	0.335
CLV_PCSK_KEX2_1	73	75	PF00082	0.352
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.273
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.478
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.352
CLV_PCSK_SKI1_1	2	6	PF00082	0.618
CLV_PCSK_SKI1_1	220	224	PF00082	0.443
CLV_PCSK_SKI1_1	271	275	PF00082	0.348
CLV_PCSK_SKI1_1	291	295	PF00082	0.188
CLV_PCSK_SKI1_1	448	452	PF00082	0.248
CLV_PCSK_SKI1_1	553	557	PF00082	0.358
DEG_Nend_UBRbox_1	1	4	PF02207	0.642
DOC_CYCLIN_yClb5_NLxxxL_5	500	507	PF00134	0.509
DOC_MAPK_gen_1	241	247	PF00069	0.502
DOC_MAPK_gen_1	460	466	PF00069	0.509
DOC_MAPK_MEF2A_6	500	507	PF00069	0.519
DOC_MAPK_MEF2A_6	51	58	PF00069	0.369
DOC_PP1_RVXF_1	488	494	PF00149	0.509
DOC_PP2B_LxvP_1	503	506	PF13499	0.417
DOC_USP7_MATH_1	205	209	PF00917	0.270
DOC_USP7_MATH_1	315	319	PF00917	0.536
DOC_USP7_MATH_1	65	69	PF00917	0.470
DOC_USP7_UBL2_3	322	326	PF12436	0.509
DOC_USP7_UBL2_3	73	77	PF12436	0.412
DOC_WW_Pin1_4	180	185	PF00397	0.499
DOC_WW_Pin1_4	301	306	PF00397	0.430
DOC_WW_Pin1_4	427	432	PF00397	0.426
LIG_14-3-3_CanoR_1	19	24	PF00244	0.576
LIG_14-3-3_CanoR_1	206	214	PF00244	0.272
LIG_14-3-3_CanoR_1	331	335	PF00244	0.410
LIG_14-3-3_CanoR_1	42	50	PF00244	0.355
LIG_14-3-3_CanoR_1	420	428	PF00244	0.457
LIG_14-3-3_CanoR_1	490	494	PF00244	0.509
LIG_14-3-3_CanoR_1	57	62	PF00244	0.362
LIG_Clathr_ClatBox_1	298	302	PF01394	0.509
LIG_EH1_1	47	55	PF00400	0.368
LIG_eIF4E_1	48	54	PF01652	0.364
LIG_FHA_1	272	278	PF00498	0.528
LIG_FHA_1	293	299	PF00498	0.429
LIG_FHA_1	427	433	PF00498	0.509
LIG_FHA_1	476	482	PF00498	0.473
LIG_FHA_1	502	508	PF00498	0.410
LIG_FHA_1	82	88	PF00498	0.453
LIG_FHA_2	221	227	PF00498	0.532
LIG_FHA_2	384	390	PF00498	0.430
LIG_FHA_2	433	439	PF00498	0.407
LIG_FHA_2	540	546	PF00498	0.593
LIG_LIR_Gen_1	248	256	PF02991	0.415
LIG_LIR_Gen_1	60	71	PF02991	0.516
LIG_LIR_Gen_1	84	93	PF02991	0.394
LIG_LIR_Nem_3	248	252	PF02991	0.412
LIG_LIR_Nem_3	267	273	PF02991	0.482
LIG_LIR_Nem_3	323	328	PF02991	0.387
LIG_LIR_Nem_3	351	357	PF02991	0.417
LIG_LIR_Nem_3	380	384	PF02991	0.428
LIG_LIR_Nem_3	430	436	PF02991	0.417
LIG_LIR_Nem_3	45	50	PF02991	0.349
LIG_LIR_Nem_3	492	496	PF02991	0.509
LIG_LIR_Nem_3	84	88	PF02991	0.362
LIG_LIR_Nem_3	92	97	PF02991	0.327
LIG_Pex14_1	218	222	PF04695	0.318
LIG_Pex14_2	493	497	PF04695	0.509
LIG_Pex14_2	93	97	PF04695	0.394
LIG_SH2_CRK	249	253	PF00017	0.402
LIG_SH2_CRK	428	432	PF00017	0.406
LIG_SH2_CRK	515	519	PF00017	0.420
LIG_SH2_CRK	520	524	PF00017	0.392
LIG_SH2_CRK	85	89	PF00017	0.333
LIG_SH2_NCK_1	443	447	PF00017	0.496
LIG_SH2_STAP1	124	128	PF00017	0.360
LIG_SH2_STAP1	85	89	PF00017	0.406
LIG_SH2_STAT3	415	418	PF00017	0.428
LIG_SH2_STAT5	287	290	PF00017	0.473
LIG_SH2_STAT5	384	387	PF00017	0.415
LIG_SH2_STAT5	415	418	PF00017	0.542
LIG_SH2_STAT5	428	431	PF00017	0.451
LIG_SH2_STAT5	48	51	PF00017	0.403
LIG_SH2_STAT5	517	520	PF00017	0.406
LIG_SH2_STAT5	529	532	PF00017	0.406
LIG_SH2_STAT5	63	66	PF00017	0.274
LIG_SH2_STAT5	96	99	PF00017	0.400
LIG_SH3_1	3	9	PF00018	0.639
LIG_SH3_1	428	434	PF00018	0.373
LIG_SH3_1	516	522	PF00018	0.406
LIG_SH3_2	519	524	PF14604	0.406
LIG_SH3_3	148	154	PF00018	0.554
LIG_SH3_3	27	33	PF00018	0.503
LIG_SH3_3	3	9	PF00018	0.610
LIG_SH3_3	428	434	PF00018	0.373
LIG_SH3_3	516	522	PF00018	0.406
LIG_SH3_4	153	160	PF00018	0.379
LIG_SUMO_SIM_anti_2	472	478	PF11976	0.508
LIG_SUMO_SIM_par_1	297	302	PF11976	0.435
LIG_TRAF2_1	223	226	PF00917	0.435
LIG_TRAF2_1	435	438	PF00917	0.417
LIG_TYR_ITIM	247	252	PF00017	0.414
LIG_TYR_ITIM	518	523	PF00017	0.406
LIG_TYR_ITIM	83	88	PF00017	0.336
LIG_UBA3_1	334	340	PF00899	0.420
LIG_UBA3_1	551	556	PF00899	0.482
LIG_WRC_WIRS_1	451	456	PF05994	0.457
MOD_CDK_SPK_2	180	185	PF00069	0.427
MOD_CK1_1	146	152	PF00069	0.370
MOD_CK1_1	180	186	PF00069	0.512
MOD_CK1_1	489	495	PF00069	0.507
MOD_CK1_1	539	545	PF00069	0.558
MOD_CK1_1	81	87	PF00069	0.536
MOD_CK2_1	220	226	PF00069	0.532
MOD_CK2_1	315	321	PF00069	0.413
MOD_CK2_1	383	389	PF00069	0.430
MOD_CK2_1	432	438	PF00069	0.405
MOD_CK2_1	477	483	PF00069	0.488
MOD_Cter_Amidation	530	533	PF01082	0.206
MOD_GlcNHglycan	140	143	PF01048	0.621
MOD_GlcNHglycan	207	210	PF01048	0.277
MOD_GlcNHglycan	317	320	PF01048	0.257
MOD_GlcNHglycan	44	47	PF01048	0.456
MOD_GSK3_1	14	21	PF00069	0.526
MOD_GSK3_1	145	152	PF00069	0.340
MOD_GSK3_1	210	217	PF00069	0.358
MOD_GSK3_1	220	227	PF00069	0.397
MOD_GSK3_1	259	266	PF00069	0.427
MOD_GSK3_1	330	337	PF00069	0.416
MOD_GSK3_1	362	369	PF00069	0.536
MOD_GSK3_1	432	439	PF00069	0.439
MOD_GSK3_1	535	542	PF00069	0.456
MOD_N-GLC_1	501	506	PF02516	0.248
MOD_N-GLC_1	536	541	PF02516	0.248
MOD_N-GLC_1	545	550	PF02516	0.418
MOD_N-GLC_2	440	442	PF02516	0.273
MOD_NEK2_1	106	111	PF00069	0.361
MOD_NEK2_1	14	19	PF00069	0.575
MOD_NEK2_1	177	182	PF00069	0.341
MOD_NEK2_1	210	215	PF00069	0.420
MOD_NEK2_1	334	339	PF00069	0.457
MOD_NEK2_1	366	371	PF00069	0.457
MOD_NEK2_1	465	470	PF00069	0.416
MOD_NEK2_1	83	88	PF00069	0.447
MOD_NEK2_2	350	355	PF00069	0.417
MOD_PK_1	19	25	PF00069	0.596
MOD_PK_1	57	63	PF00069	0.526
MOD_PKA_2	106	112	PF00069	0.487
MOD_PKA_2	18	24	PF00069	0.580
MOD_PKA_2	205	211	PF00069	0.270
MOD_PKA_2	330	336	PF00069	0.409
MOD_PKA_2	419	425	PF00069	0.430
MOD_PKA_2	489	495	PF00069	0.506
MOD_Plk_1	143	149	PF00069	0.347
MOD_Plk_1	224	230	PF00069	0.499
MOD_Plk_1	350	356	PF00069	0.406
MOD_Plk_1	36	42	PF00069	0.365
MOD_Plk_1	501	507	PF00069	0.457
MOD_Plk_1	535	541	PF00069	0.422
MOD_Plk_1	545	551	PF00069	0.362
MOD_Plk_4	146	152	PF00069	0.373
MOD_Plk_4	172	178	PF00069	0.442
MOD_Plk_4	330	336	PF00069	0.402
MOD_Plk_4	350	356	PF00069	0.399
MOD_Plk_4	477	483	PF00069	0.509
MOD_Plk_4	536	542	PF00069	0.441
MOD_Plk_4	545	551	PF00069	0.426
MOD_Plk_4	83	89	PF00069	0.320
MOD_ProDKin_1	180	186	PF00069	0.509
MOD_ProDKin_1	301	307	PF00069	0.430
MOD_ProDKin_1	427	433	PF00069	0.426
MOD_SUMO_for_1	228	231	PF00179	0.472
TRG_DiLeu_BaEn_4	225	231	PF01217	0.424
TRG_ENDOCYTIC_2	249	252	PF00928	0.401
TRG_ENDOCYTIC_2	290	293	PF00928	0.412
TRG_ENDOCYTIC_2	515	518	PF00928	0.420
TRG_ENDOCYTIC_2	520	523	PF00928	0.392
TRG_ENDOCYTIC_2	63	66	PF00928	0.363
TRG_ENDOCYTIC_2	85	88	PF00928	0.348
TRG_ENDOCYTIC_2	94	97	PF00928	0.344
TRG_ER_diArg_1	1	3	PF00400	0.594
TRG_ER_diArg_1	397	400	PF00400	0.509
TRG_ER_diArg_1	41	44	PF00400	0.468
TRG_NLS_MonoExtN_4	553	560	PF00514	0.477
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.217

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUG0	Leptomonas seymouri	79%	99%
A0A0S4JS18	Bodo saltans	38%	99%
A0A1X0NS42	Trypanosomatidae	56%	100%
A0A3R7N3G7	Trypanosoma rangeli	54%	100%
A4HF16	Leishmania braziliensis	93%	100%
A4I294	Leishmania infantum	100%	100%
C9ZRP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AYE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O43272	Homo sapiens	30%	94%
O45228	Caenorhabditis elegans	30%	91%
Q04499	Drosophila melanogaster	30%	82%
Q148G5	Bos taurus	29%	95%
Q4Q933	Leishmania major	98%	100%
Q9WU79	Mus musculus	30%	94%
V5B5Q5	Trypanosoma cruzi	54%	99%