Zinc-finger_protein_conserved/GeneDB:LmjF.30.2250

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFW9_LEIDO

TriTrypDb:

LdBPK_302260.1 , LdCL_300028100 , LDHU3_30.3060

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8IFW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFW9

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0022613	ribonucleoprotein complex biogenesis	4	1
GO:0042273	ribosomal large subunit biogenesis	5	1
GO:0044085	cellular component biogenesis	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.513
CLV_NRD_NRD_1	200	202	PF00675	0.209
CLV_NRD_NRD_1	280	282	PF00675	0.448
CLV_NRD_NRD_1	32	34	PF00675	0.516
CLV_NRD_NRD_1	91	93	PF00675	0.489
CLV_PCSK_KEX2_1	122	124	PF00082	0.513
CLV_PCSK_KEX2_1	279	281	PF00082	0.507
CLV_PCSK_KEX2_1	285	287	PF00082	0.472
CLV_PCSK_KEX2_1	304	306	PF00082	0.344
CLV_PCSK_KEX2_1	31	33	PF00082	0.432
CLV_PCSK_KEX2_1	339	341	PF00082	0.549
CLV_PCSK_KEX2_1	95	97	PF00082	0.440
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.570
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.523
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.329
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.552
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.440
CLV_PCSK_PC7_1	281	287	PF00082	0.498
CLV_PCSK_SKI1_1	157	161	PF00082	0.258
CLV_PCSK_SKI1_1	235	239	PF00082	0.219
CLV_PCSK_SKI1_1	281	285	PF00082	0.576
CLV_Separin_Metazoa	15	19	PF03568	0.503
DOC_ANK_TNKS_1	30	37	PF00023	0.406
DOC_MAPK_gen_1	201	209	PF00069	0.426
DOC_MAPK_MEF2A_6	345	354	PF00069	0.483
DOC_MAPK_NFAT4_5	345	353	PF00069	0.482
DOC_PP4_FxxP_1	181	184	PF00568	0.443
DOC_USP7_MATH_1	126	130	PF00917	0.645
DOC_USP7_MATH_1	338	342	PF00917	0.554
DOC_USP7_MATH_1	99	103	PF00917	0.475
DOC_USP7_UBL2_3	139	143	PF12436	0.575
DOC_USP7_UBL2_3	275	279	PF12436	0.547
DOC_WW_Pin1_4	236	241	PF00397	0.512
DOC_WW_Pin1_4	59	64	PF00397	0.581
LIG_14-3-3_CanoR_1	214	219	PF00244	0.477
LIG_14-3-3_CanoR_1	38	47	PF00244	0.472
LIG_14-3-3_CanoR_1	85	91	PF00244	0.437
LIG_BIR_II_1	1	5	PF00653	0.421
LIG_BIR_III_2	135	139	PF00653	0.563
LIG_DLG_GKlike_1	214	221	PF00625	0.499
LIG_FHA_1	180	186	PF00498	0.409
LIG_FHA_1	313	319	PF00498	0.452
LIG_FHA_1	354	360	PF00498	0.597
LIG_FHA_1	4	10	PF00498	0.446
LIG_FHA_1	85	91	PF00498	0.409
LIG_FHA_2	229	235	PF00498	0.416
LIG_GBD_Chelix_1	199	207	PF00786	0.299
LIG_Integrin_RGD_1	133	135	PF01839	0.612
LIG_Integrin_RGD_1	265	267	PF01839	0.629
LIG_LIR_Apic_2	180	184	PF02991	0.445
LIG_LIR_Gen_1	215	224	PF02991	0.404
LIG_LIR_Gen_1	239	250	PF02991	0.415
LIG_LIR_Gen_1	73	80	PF02991	0.434
LIG_LIR_Nem_3	215	221	PF02991	0.419
LIG_LIR_Nem_3	239	245	PF02991	0.416
LIG_LIR_Nem_3	73	77	PF02991	0.419
LIG_PCNA_PIPBox_1	192	201	PF02747	0.424
LIG_PCNA_yPIPBox_3	192	202	PF02747	0.424
LIG_SH2_CRK	246	250	PF00017	0.474
LIG_SH2_STAP1	246	250	PF00017	0.434
LIG_SH2_STAP1	65	69	PF00017	0.476
LIG_SH2_STAT5	198	201	PF00017	0.409
LIG_SH3_CIN85_PxpxPR_1	291	296	PF14604	0.637
LIG_TRAF2_1	319	322	PF00917	0.508
LIG_UBA3_1	195	202	PF00899	0.419
LIG_WRC_WIRS_1	178	183	PF05994	0.424
MOD_CK1_1	106	112	PF00069	0.530
MOD_CK1_1	217	223	PF00069	0.451
MOD_CK1_1	353	359	PF00069	0.478
MOD_CK1_1	76	82	PF00069	0.419
MOD_CK2_1	216	222	PF00069	0.499
MOD_CK2_1	228	234	PF00069	0.495
MOD_CK2_1	45	51	PF00069	0.476
MOD_Cter_Amidation	277	280	PF01082	0.551
MOD_GlcNHglycan	114	117	PF01048	0.530
MOD_GlcNHglycan	128	131	PF01048	0.546
MOD_GlcNHglycan	164	167	PF01048	0.279
MOD_GlcNHglycan	340	343	PF01048	0.536
MOD_GSK3_1	108	115	PF00069	0.491
MOD_GSK3_1	179	186	PF00069	0.485
MOD_GSK3_1	212	219	PF00069	0.459
MOD_GSK3_1	59	66	PF00069	0.620
MOD_GSK3_1	79	86	PF00069	0.492
MOD_GSK3_1	99	106	PF00069	0.435
MOD_NEK2_1	107	112	PF00069	0.557
MOD_NEK2_1	228	233	PF00069	0.492
MOD_NEK2_1	25	30	PF00069	0.454
MOD_NEK2_1	350	355	PF00069	0.433
MOD_NEK2_2	70	75	PF00069	0.428
MOD_PIKK_1	38	44	PF00454	0.482
MOD_PKA_2	228	234	PF00069	0.495
MOD_PKA_2	295	301	PF00069	0.609
MOD_PKA_2	45	51	PF00069	0.521
MOD_PKA_2	84	90	PF00069	0.441
MOD_PKA_2	99	105	PF00069	0.435
MOD_PKB_1	214	222	PF00069	0.499
MOD_Plk_1	350	356	PF00069	0.550
MOD_Plk_4	103	109	PF00069	0.582
MOD_ProDKin_1	236	242	PF00069	0.512
MOD_ProDKin_1	59	65	PF00069	0.570
MOD_SUMO_for_1	284	287	PF00179	0.630
MOD_SUMO_rev_2	129	138	PF00179	0.547
TRG_DiLeu_BaEn_1	322	327	PF01217	0.470
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.512
TRG_ENDOCYTIC_2	242	245	PF00928	0.412
TRG_ENDOCYTIC_2	246	249	PF00928	0.421
TRG_ER_diArg_1	280	282	PF00400	0.501
TRG_ER_diArg_1	291	294	PF00400	0.523
TRG_ER_diArg_1	30	33	PF00400	0.392
TRG_Pf-PMV_PEXEL_1	316	321	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3A3	Leptomonas seymouri	76%	99%
A0A0S4ILF0	Bodo saltans	47%	100%
A0A1X0P2R4	Trypanosomatidae	53%	100%
A0A422NW52	Trypanosoma rangeli	52%	100%
A4HIF7	Leishmania braziliensis	82%	100%
A4I5Q3	Leishmania infantum	100%	100%
C9ZR22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B0Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
G0S920	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	25%	69%
O59811	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	80%
P38344	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	94%
Q06709	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	86%
Q4Q768	Leishmania major	94%	100%
Q8H1G5	Arabidopsis thaliana	23%	92%
Q9ZQ18	Arabidopsis thaliana	24%	94%
V5BC84	Trypanosoma cruzi	53%	100%