Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IFW4_LEIDO

TriTrypDb:

LdBPK_231380.1 , LdCL_230020900 , LDHU3_23.1830

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFW4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	358	362	PF00656	0.403
CLV_NRD_NRD_1	203	205	PF00675	0.496
CLV_NRD_NRD_1	263	265	PF00675	0.475
CLV_NRD_NRD_1	324	326	PF00675	0.478
CLV_NRD_NRD_1	84	86	PF00675	0.388
CLV_PCSK_FUR_1	458	462	PF00082	0.466
CLV_PCSK_FUR_1	82	86	PF00082	0.382
CLV_PCSK_KEX2_1	162	164	PF00082	0.718
CLV_PCSK_KEX2_1	205	207	PF00082	0.501
CLV_PCSK_KEX2_1	30	32	PF00082	0.546
CLV_PCSK_KEX2_1	460	462	PF00082	0.479
CLV_PCSK_KEX2_1	84	86	PF00082	0.459
CLV_PCSK_KEX2_1	91	93	PF00082	0.481
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.584
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.479
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.546
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.479
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.506
CLV_PCSK_SKI1_1	198	202	PF00082	0.535
CLV_PCSK_SKI1_1	208	212	PF00082	0.477
CLV_PCSK_SKI1_1	428	432	PF00082	0.525
CLV_PCSK_SKI1_1	442	446	PF00082	0.644
CLV_PCSK_SKI1_1	64	68	PF00082	0.492
CLV_PCSK_SKI1_1	92	96	PF00082	0.439
CLV_Separin_Metazoa	61	65	PF03568	0.475
DEG_APCC_DBOX_1	17	25	PF00400	0.399
DEG_APCC_KENBOX_2	356	360	PF00400	0.399
DOC_CYCLIN_yClb1_LxF_4	448	454	PF00134	0.505
DOC_MAPK_gen_1	144	152	PF00069	0.491
DOC_MAPK_gen_1	262	270	PF00069	0.492
DOC_MAPK_MEF2A_6	385	393	PF00069	0.492
DOC_PP4_FxxP_1	165	168	PF00568	0.503
DOC_USP7_MATH_1	184	188	PF00917	0.575
DOC_USP7_MATH_1	29	33	PF00917	0.513
DOC_USP7_MATH_1	371	375	PF00917	0.460
DOC_USP7_MATH_1	65	69	PF00917	0.507
DOC_USP7_UBL2_3	456	460	PF12436	0.448
DOC_WW_Pin1_4	222	227	PF00397	0.536
LIG_14-3-3_CanoR_1	144	150	PF00244	0.511
LIG_14-3-3_CanoR_1	18	22	PF00244	0.421
LIG_14-3-3_CanoR_1	190	194	PF00244	0.500
LIG_14-3-3_CanoR_1	208	217	PF00244	0.357
LIG_14-3-3_CanoR_1	218	226	PF00244	0.518
LIG_14-3-3_CanoR_1	292	296	PF00244	0.462
LIG_14-3-3_CanoR_1	31	39	PF00244	0.494
LIG_14-3-3_CanoR_1	433	440	PF00244	0.524
LIG_14-3-3_CanoR_1	92	98	PF00244	0.532
LIG_CaM_IQ_9	77	93	PF13499	0.413
LIG_FHA_1	223	229	PF00498	0.518
LIG_FHA_1	232	238	PF00498	0.513
LIG_FHA_2	120	126	PF00498	0.653
LIG_FHA_2	190	196	PF00498	0.500
LIG_FHA_2	379	385	PF00498	0.390
LIG_FHA_2	56	62	PF00498	0.517
LIG_FHA_2	93	99	PF00498	0.491
LIG_GBD_Chelix_1	245	253	PF00786	0.526
LIG_LIR_Gen_1	12	21	PF02991	0.408
LIG_LIR_Gen_1	369	376	PF02991	0.508
LIG_LIR_Nem_3	12	17	PF02991	0.404
LIG_LIR_Nem_3	343	347	PF02991	0.415
LIG_LIR_Nem_3	369	375	PF02991	0.510
LIG_NRBOX	346	352	PF00104	0.493
LIG_SH2_CRK	344	348	PF00017	0.459
LIG_SH2_CRK	372	376	PF00017	0.506
LIG_SH2_STAT5	416	419	PF00017	0.476
LIG_SH2_STAT5	450	453	PF00017	0.545
LIG_SH3_3	115	121	PF00018	0.684
LIG_SH3_3	418	424	PF00018	0.489
LIG_TRAF2_1	177	180	PF00917	0.516
LIG_TRAF2_1	319	322	PF00917	0.522
LIG_TRAF2_1	32	35	PF00917	0.513
LIG_TRAF2_1	381	384	PF00917	0.401
LIG_TRAF2_1	434	437	PF00917	0.560
LIG_TRAF2_1	69	72	PF00917	0.544
LIG_UBA3_1	199	205	PF00899	0.444
MOD_CK1_1	283	289	PF00069	0.440
MOD_CK1_1	299	305	PF00069	0.443
MOD_CK1_1	311	317	PF00069	0.454
MOD_CK1_1	374	380	PF00069	0.561
MOD_CK1_1	41	47	PF00069	0.538
MOD_CK1_1	422	428	PF00069	0.548
MOD_CK2_1	173	179	PF00069	0.624
MOD_CK2_1	29	35	PF00069	0.371
MOD_CK2_1	357	363	PF00069	0.475
MOD_CK2_1	378	384	PF00069	0.391
MOD_CK2_1	460	466	PF00069	0.531
MOD_CK2_1	55	61	PF00069	0.522
MOD_CK2_1	65	71	PF00069	0.455
MOD_CK2_1	9	15	PF00069	0.466
MOD_CK2_1	92	98	PF00069	0.493
MOD_GlcNHglycan	108	111	PF01048	0.514
MOD_GlcNHglycan	122	125	PF01048	0.650
MOD_GlcNHglycan	175	178	PF01048	0.683
MOD_GlcNHglycan	186	189	PF01048	0.447
MOD_GlcNHglycan	26	30	PF01048	0.524
MOD_GlcNHglycan	313	316	PF01048	0.499
MOD_GlcNHglycan	43	46	PF01048	0.404
MOD_GlcNHglycan	52	55	PF01048	0.477
MOD_GlcNHglycan	67	70	PF01048	0.473
MOD_GSK3_1	102	109	PF00069	0.589
MOD_GSK3_1	189	196	PF00069	0.516
MOD_GSK3_1	227	234	PF00069	0.674
MOD_GSK3_1	25	32	PF00069	0.409
MOD_GSK3_1	37	44	PF00069	0.462
MOD_GSK3_1	374	381	PF00069	0.405
MOD_GSK3_1	415	422	PF00069	0.542
MOD_GSK3_1	9	16	PF00069	0.485
MOD_N-GLC_2	133	135	PF02516	0.582
MOD_NEK2_1	145	150	PF00069	0.505
MOD_NEK2_1	189	194	PF00069	0.505
MOD_NEK2_1	245	250	PF00069	0.498
MOD_NEK2_1	38	43	PF00069	0.539
MOD_PIKK_1	247	253	PF00454	0.515
MOD_PIKK_1	283	289	PF00454	0.454
MOD_PIKK_1	296	302	PF00454	0.452
MOD_PIKK_1	30	36	PF00454	0.514
MOD_PIKK_1	378	384	PF00454	0.410
MOD_PIKK_1	395	401	PF00454	0.354
MOD_PKA_1	30	36	PF00069	0.514
MOD_PKA_1	460	466	PF00069	0.505
MOD_PKA_2	17	23	PF00069	0.416
MOD_PKA_2	184	190	PF00069	0.480
MOD_PKA_2	217	223	PF00069	0.510
MOD_PKA_2	291	297	PF00069	0.477
MOD_PKA_2	30	36	PF00069	0.468
MOD_PKA_2	432	438	PF00069	0.500
MOD_PKA_2	460	466	PF00069	0.544
MOD_PKB_1	206	214	PF00069	0.497
MOD_Plk_1	179	185	PF00069	0.582
MOD_Plk_1	231	237	PF00069	0.549
MOD_Plk_1	442	448	PF00069	0.508
MOD_Plk_2-3	9	15	PF00069	0.466
MOD_Plk_4	156	162	PF00069	0.482
MOD_Plk_4	308	314	PF00069	0.531
MOD_Plk_4	371	377	PF00069	0.505
MOD_Plk_4	422	428	PF00069	0.548
MOD_Plk_4	9	15	PF00069	0.531
MOD_ProDKin_1	222	228	PF00069	0.540
MOD_SUMO_for_1	6	9	PF00179	0.506
TRG_DiLeu_BaEn_1	232	237	PF01217	0.546
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.426
TRG_ENDOCYTIC_2	14	17	PF00928	0.401
TRG_ENDOCYTIC_2	344	347	PF00928	0.440
TRG_ENDOCYTIC_2	372	375	PF00928	0.509
TRG_ENDOCYTIC_2	450	453	PF00928	0.545
TRG_ENDOCYTIC_2	83	86	PF00928	0.483
TRG_ER_diArg_1	203	206	PF00400	0.469
TRG_ER_diArg_1	83	85	PF00400	0.389
TRG_NLS_MonoCore_2	263	268	PF00514	0.486
TRG_NLS_MonoExtC_3	203	208	PF00514	0.444
TRG_NLS_MonoExtN_4	204	209	PF00514	0.399
TRG_NLS_MonoExtN_4	262	269	PF00514	0.521
TRG_Pf-PMV_PEXEL_1	208	213	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	282	287	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	318	322	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9S1	Leptomonas seymouri	25%	100%
A4HCY5	Leishmania braziliensis	69%	100%
A4I0H0	Leishmania infantum	98%	100%
E9AWD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QB40	Leishmania major	90%	100%