Zinc finger CCCH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger CCCH domain-containing protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IFW3_LEIDO

TriTrypDb:

LdBPK_303630.1 , LdCL_300041700 , LDHU3_30.4820

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFW3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3
GO:0003729	mRNA binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.414
CLV_C14_Caspase3-7	247	251	PF00656	0.558
CLV_MEL_PAP_1	50	56	PF00089	0.662
CLV_NRD_NRD_1	167	169	PF00675	0.512
CLV_NRD_NRD_1	201	203	PF00675	0.571
CLV_PCSK_KEX2_1	167	169	PF00082	0.565
CLV_PCSK_KEX2_1	52	54	PF00082	0.679
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.679
CLV_PCSK_SKI1_1	143	147	PF00082	0.516
CLV_PCSK_SKI1_1	192	196	PF00082	0.490
CLV_PCSK_SKI1_1	212	216	PF00082	0.295
CLV_Separin_Metazoa	262	266	PF03568	0.508
DEG_SPOP_SBC_1	241	245	PF00917	0.682
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.525
DOC_MAPK_MEF2A_6	149	156	PF00069	0.419
DOC_PP2B_LxvP_1	89	92	PF13499	0.446
DOC_USP7_MATH_1	204	208	PF00917	0.476
DOC_USP7_MATH_1	241	245	PF00917	0.675
DOC_WW_Pin1_4	105	110	PF00397	0.538
DOC_WW_Pin1_4	13	18	PF00397	0.565
DOC_WW_Pin1_4	205	210	PF00397	0.532
DOC_WW_Pin1_4	21	26	PF00397	0.601
DOC_WW_Pin1_4	96	101	PF00397	0.616
LIG_14-3-3_CanoR_1	116	120	PF00244	0.745
LIG_14-3-3_CanoR_1	78	83	PF00244	0.392
LIG_Actin_WH2_2	187	204	PF00022	0.538
LIG_APCC_ABBA_1	152	157	PF00400	0.417
LIG_deltaCOP1_diTrp_1	216	225	PF00928	0.553
LIG_eIF4E_1	132	138	PF01652	0.547
LIG_FAT_LD_1	134	142	PF03623	0.531
LIG_FHA_1	110	116	PF00498	0.552
LIG_FHA_1	151	157	PF00498	0.435
LIG_FHA_1	97	103	PF00498	0.664
LIG_FHA_2	158	164	PF00498	0.529
LIG_LIR_Nem_3	139	145	PF02991	0.456
LIG_LIR_Nem_3	44	50	PF02991	0.673
LIG_MYND_1	100	104	PF01753	0.668
LIG_MYND_1	25	29	PF01753	0.734
LIG_NRBOX	133	139	PF00104	0.538
LIG_PCNA_yPIPBox_3	159	168	PF02747	0.413
LIG_PROFILIN_1	120	126	PF00235	0.476
LIG_SH2_PTP2	22	25	PF00017	0.633
LIG_SH2_PTP2	47	50	PF00017	0.672
LIG_SH2_STAP1	237	241	PF00017	0.575
LIG_SH2_STAT5	132	135	PF00017	0.565
LIG_SH2_STAT5	22	25	PF00017	0.598
LIG_SH2_STAT5	237	240	PF00017	0.599
LIG_SH2_STAT5	47	50	PF00017	0.672
LIG_SH3_1	22	28	PF00018	0.524
LIG_SH3_3	117	123	PF00018	0.428
LIG_SH3_3	22	28	PF00018	0.651
LIG_SH3_3	45	51	PF00018	0.663
LIG_SH3_3	89	95	PF00018	0.614
LIG_SH3_3	98	104	PF00018	0.655
LIG_UBA3_1	137	143	PF00899	0.520
LIG_WRC_WIRS_1	222	227	PF05994	0.554
MOD_CDK_SPxxK_3	109	116	PF00069	0.705
MOD_CDK_SPxxK_3	205	212	PF00069	0.555
MOD_CDK_SPxxK_3	96	103	PF00069	0.680
MOD_CK1_1	108	114	PF00069	0.587
MOD_CK1_1	9	15	PF00069	0.602
MOD_CK2_1	157	163	PF00069	0.533
MOD_CK2_1	204	210	PF00069	0.470
MOD_CK2_1	221	227	PF00069	0.383
MOD_CK2_1	248	254	PF00069	0.542
MOD_GlcNHglycan	128	131	PF01048	0.600
MOD_GlcNHglycan	250	253	PF01048	0.570
MOD_GlcNHglycan	256	259	PF01048	0.649
MOD_GSK3_1	105	112	PF00069	0.615
MOD_GSK3_1	126	133	PF00069	0.697
MOD_GSK3_1	217	224	PF00069	0.442
MOD_GSK3_1	235	242	PF00069	0.624
MOD_GSK3_1	56	63	PF00069	0.453
MOD_GSK3_1	6	13	PF00069	0.631
MOD_GSK3_1	69	76	PF00069	0.353
MOD_N-GLC_1	158	163	PF02516	0.423
MOD_NEK2_1	1	6	PF00069	0.535
MOD_NEK2_1	115	120	PF00069	0.707
MOD_NEK2_2	73	78	PF00069	0.284
MOD_PIKK_1	115	121	PF00454	0.737
MOD_PIKK_1	181	187	PF00454	0.534
MOD_PIKK_1	217	223	PF00454	0.525
MOD_PKA_2	115	121	PF00069	0.733
MOD_Plk_1	158	164	PF00069	0.427
MOD_ProDKin_1	105	111	PF00069	0.539
MOD_ProDKin_1	13	19	PF00069	0.566
MOD_ProDKin_1	205	211	PF00069	0.533
MOD_ProDKin_1	21	27	PF00069	0.604
MOD_ProDKin_1	96	102	PF00069	0.616
MOD_SUMO_rev_2	176	184	PF00179	0.480
MOD_SUMO_rev_2	206	214	PF00179	0.525
TRG_DiLeu_BaEn_1	210	215	PF01217	0.466
TRG_ENDOCYTIC_2	142	145	PF00928	0.380
TRG_ENDOCYTIC_2	47	50	PF00928	0.672
TRG_ER_diArg_1	166	168	PF00400	0.557
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I028	Leptomonas seymouri	83%	100%
A0A1X0P164	Trypanosomatidae	39%	94%
A0A3R7M044	Trypanosoma rangeli	42%	100%
A4HIU3	Leishmania braziliensis	90%	99%
A4I648	Leishmania infantum	99%	100%
C9ZRG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	86%
E9B1D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	99%
Q4Q6T1	Leishmania major	96%	99%
V5DNR8	Trypanosoma cruzi	39%	100%