Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFW2_LEIDO

TriTrypDb:

LdBPK_343900.1 , LdCL_340048400 , LDHU3_34.6200

Length:

689

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFW2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0048487	beta-tubulin binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.519
CLV_C14_Caspase3-7	637	641	PF00656	0.530
CLV_NRD_NRD_1	167	169	PF00675	0.283
CLV_NRD_NRD_1	325	327	PF00675	0.549
CLV_NRD_NRD_1	436	438	PF00675	0.390
CLV_NRD_NRD_1	523	525	PF00675	0.478
CLV_NRD_NRD_1	673	675	PF00675	0.369
CLV_PCSK_KEX2_1	166	168	PF00082	0.304
CLV_PCSK_KEX2_1	325	327	PF00082	0.549
CLV_PCSK_KEX2_1	436	438	PF00082	0.405
CLV_PCSK_KEX2_1	591	593	PF00082	0.605
CLV_PCSK_KEX2_1	673	675	PF00082	0.369
CLV_PCSK_KEX2_1	72	74	PF00082	0.393
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.358
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.626
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.325
CLV_PCSK_SKI1_1	15	19	PF00082	0.646
CLV_PCSK_SKI1_1	152	156	PF00082	0.351
CLV_PCSK_SKI1_1	167	171	PF00082	0.243
CLV_PCSK_SKI1_1	268	272	PF00082	0.585
CLV_PCSK_SKI1_1	436	440	PF00082	0.403
CLV_PCSK_SKI1_1	491	495	PF00082	0.438
CLV_PCSK_SKI1_1	524	528	PF00082	0.480
CLV_PCSK_SKI1_1	674	678	PF00082	0.370
CLV_PCSK_SKI1_1	684	688	PF00082	0.323
DEG_APCC_DBOX_1	673	681	PF00400	0.503
DEG_APCC_KENBOX_2	303	307	PF00400	0.444
DOC_CKS1_1	357	362	PF01111	0.529
DOC_CKS1_1	651	656	PF01111	0.531
DOC_CYCLIN_RxL_1	295	305	PF00134	0.475
DOC_MAPK_gen_1	11	20	PF00069	0.611
DOC_MAPK_gen_1	50	58	PF00069	0.562
DOC_MAPK_gen_1	673	679	PF00069	0.516
DOC_MAPK_MEF2A_6	378	386	PF00069	0.543
DOC_PP1_RVXF_1	150	156	PF00149	0.539
DOC_PP1_RVXF_1	383	389	PF00149	0.390
DOC_PP1_RVXF_1	682	689	PF00149	0.371
DOC_PP2B_PxIxI_1	279	285	PF00149	0.448
DOC_PP4_FxxP_1	204	207	PF00568	0.428
DOC_PP4_FxxP_1	388	391	PF00568	0.388
DOC_PP4_FxxP_1	603	606	PF00568	0.551
DOC_USP7_MATH_1	209	213	PF00917	0.555
DOC_USP7_MATH_1	606	610	PF00917	0.601
DOC_USP7_UBL2_3	11	15	PF12436	0.656
DOC_USP7_UBL2_3	29	33	PF12436	0.491
DOC_USP7_UBL2_3	68	72	PF12436	0.568
DOC_WW_Pin1_4	356	361	PF00397	0.615
DOC_WW_Pin1_4	500	505	PF00397	0.490
DOC_WW_Pin1_4	515	520	PF00397	0.476
DOC_WW_Pin1_4	650	655	PF00397	0.526
LIG_14-3-3_CanoR_1	143	153	PF00244	0.468
LIG_14-3-3_CanoR_1	222	226	PF00244	0.547
LIG_14-3-3_CanoR_1	250	259	PF00244	0.544
LIG_14-3-3_CanoR_1	272	278	PF00244	0.442
LIG_14-3-3_CanoR_1	325	332	PF00244	0.539
LIG_14-3-3_CanoR_1	385	389	PF00244	0.396
LIG_14-3-3_CanoR_1	436	441	PF00244	0.447
LIG_14-3-3_CanoR_1	472	478	PF00244	0.536
LIG_14-3-3_CanoR_1	513	521	PF00244	0.486
LIG_14-3-3_CanoR_1	616	624	PF00244	0.416
LIG_14-3-3_CanoR_1	684	689	PF00244	0.362
LIG_Actin_WH2_2	582	597	PF00022	0.505
LIG_BRCT_BRCA1_1	275	279	PF00533	0.431
LIG_BRCT_BRCA1_1	564	568	PF00533	0.530
LIG_Clathr_ClatBox_1	354	358	PF01394	0.549
LIG_Clathr_ClatBox_1	474	478	PF01394	0.407
LIG_deltaCOP1_diTrp_1	461	468	PF00928	0.406
LIG_eIF4E_1	646	652	PF01652	0.505
LIG_FHA_1	135	141	PF00498	0.520
LIG_FHA_1	228	234	PF00498	0.546
LIG_FHA_1	247	253	PF00498	0.383
LIG_FHA_1	265	271	PF00498	0.553
LIG_FHA_1	333	339	PF00498	0.488
LIG_FHA_1	426	432	PF00498	0.633
LIG_FHA_1	548	554	PF00498	0.450
LIG_FHA_1	606	612	PF00498	0.598
LIG_FHA_1	666	672	PF00498	0.501
LIG_FHA_2	340	346	PF00498	0.553
LIG_FHA_2	41	47	PF00498	0.569
LIG_FHA_2	452	458	PF00498	0.494
LIG_FHA_2	484	490	PF00498	0.623
LIG_FHA_2	605	611	PF00498	0.598
LIG_FHA_2	626	632	PF00498	0.548
LIG_FHA_2	651	657	PF00498	0.533
LIG_Integrin_RGD_1	482	484	PF01839	0.657
LIG_IRF3_LxIS_1	382	387	PF10401	0.482
LIG_LIR_Apic_2	201	207	PF02991	0.428
LIG_LIR_Apic_2	387	391	PF02991	0.406
LIG_LIR_Apic_2	590	596	PF02991	0.562
LIG_LIR_Apic_2	600	606	PF02991	0.554
LIG_LIR_Gen_1	193	203	PF02991	0.525
LIG_LIR_Gen_1	224	233	PF02991	0.483
LIG_LIR_Gen_1	271	282	PF02991	0.438
LIG_LIR_Gen_1	453	460	PF02991	0.405
LIG_LIR_Gen_1	529	535	PF02991	0.445
LIG_LIR_Gen_1	54	63	PF02991	0.584
LIG_LIR_Gen_1	555	564	PF02991	0.415
LIG_LIR_Gen_1	609	617	PF02991	0.398
LIG_LIR_Gen_1	678	686	PF02991	0.476
LIG_LIR_Gen_1	96	104	PF02991	0.539
LIG_LIR_Nem_3	193	198	PF02991	0.525
LIG_LIR_Nem_3	224	228	PF02991	0.466
LIG_LIR_Nem_3	271	277	PF02991	0.449
LIG_LIR_Nem_3	317	322	PF02991	0.426
LIG_LIR_Nem_3	327	332	PF02991	0.317
LIG_LIR_Nem_3	453	459	PF02991	0.413
LIG_LIR_Nem_3	487	493	PF02991	0.455
LIG_LIR_Nem_3	529	534	PF02991	0.445
LIG_LIR_Nem_3	54	58	PF02991	0.584
LIG_LIR_Nem_3	565	570	PF02991	0.445
LIG_LIR_Nem_3	609	615	PF02991	0.384
LIG_LIR_Nem_3	643	649	PF02991	0.471
LIG_LIR_Nem_3	678	682	PF02991	0.484
LIG_LIR_Nem_3	96	101	PF02991	0.539
LIG_MLH1_MIPbox_1	564	568	PF16413	0.433
LIG_NRBOX	647	653	PF00104	0.405
LIG_PDZ_Wminus1_1	687	689	PF00595	0.362
LIG_Pex14_2	119	123	PF04695	0.476
LIG_Pex14_2	402	406	PF04695	0.503
LIG_Pex14_2	564	568	PF04695	0.394
LIG_PTB_Apo_2	664	671	PF02174	0.522
LIG_PTB_Phospho_1	664	670	PF10480	0.525
LIG_SH2_CRK	195	199	PF00017	0.525
LIG_SH2_CRK	236	240	PF00017	0.449
LIG_SH2_CRK	649	653	PF00017	0.402
LIG_SH2_NCK_1	182	186	PF00017	0.537
LIG_SH2_NCK_1	195	199	PF00017	0.537
LIG_SH2_STAP1	236	240	PF00017	0.498
LIG_SH2_STAP1	319	323	PF00017	0.518
LIG_SH2_STAP1	558	562	PF00017	0.386
LIG_SH2_STAT5	218	221	PF00017	0.528
LIG_SH2_STAT5	322	325	PF00017	0.503
LIG_SH2_STAT5	55	58	PF00017	0.563
LIG_SH2_STAT5	567	570	PF00017	0.422
LIG_SH2_STAT5	670	673	PF00017	0.482
LIG_SH2_STAT5	92	95	PF00017	0.589
LIG_SH3_3	291	297	PF00018	0.507
LIG_SH3_3	376	382	PF00018	0.571
LIG_SH3_4	11	18	PF00018	0.664
LIG_SUMO_SIM_par_1	136	142	PF11976	0.581
LIG_SUMO_SIM_par_1	473	478	PF11976	0.391
LIG_TRAF2_1	596	599	PF00917	0.623
LIG_UBA3_1	299	304	PF00899	0.622
LIG_UBA3_1	522	527	PF00899	0.479
LIG_WRC_WIRS_1	340	345	PF05994	0.462
LIG_WW_3	370	374	PF00397	0.607
MOD_CK1_1	102	108	PF00069	0.499
MOD_CK1_1	122	128	PF00069	0.345
MOD_CK1_1	197	203	PF00069	0.581
MOD_CK1_1	229	235	PF00069	0.525
MOD_CK1_1	273	279	PF00069	0.426
MOD_CK1_1	324	330	PF00069	0.542
MOD_CK1_1	417	423	PF00069	0.469
MOD_CK1_1	515	521	PF00069	0.533
MOD_CK1_1	650	656	PF00069	0.566
MOD_CK2_1	24	30	PF00069	0.569
MOD_CK2_1	339	345	PF00069	0.483
MOD_CK2_1	48	54	PF00069	0.570
MOD_CK2_1	483	489	PF00069	0.515
MOD_CK2_1	650	656	PF00069	0.566
MOD_GlcNHglycan	241	244	PF01048	0.379
MOD_GlcNHglycan	252	255	PF01048	0.334
MOD_GlcNHglycan	416	419	PF01048	0.510
MOD_GlcNHglycan	528	531	PF01048	0.508
MOD_GSK3_1	118	125	PF00069	0.473
MOD_GSK3_1	194	201	PF00069	0.544
MOD_GSK3_1	244	251	PF00069	0.512
MOD_GSK3_1	264	271	PF00069	0.345
MOD_GSK3_1	317	324	PF00069	0.493
MOD_GSK3_1	417	424	PF00069	0.488
MOD_GSK3_1	436	443	PF00069	0.393
MOD_GSK3_1	511	518	PF00069	0.559
MOD_GSK3_1	562	569	PF00069	0.506
MOD_GSK3_1	630	637	PF00069	0.564
MOD_N-GLC_1	145	150	PF02516	0.338
MOD_N-GLC_1	634	639	PF02516	0.503
MOD_NEK2_1	119	124	PF00069	0.581
MOD_NEK2_1	227	232	PF00069	0.591
MOD_NEK2_1	332	337	PF00069	0.457
MOD_NEK2_1	421	426	PF00069	0.603
MOD_NEK2_1	451	456	PF00069	0.479
MOD_NEK2_1	468	473	PF00069	0.526
MOD_NEK2_1	512	517	PF00069	0.549
MOD_NEK2_1	526	531	PF00069	0.353
MOD_NEK2_1	58	63	PF00069	0.528
MOD_NEK2_1	587	592	PF00069	0.428
MOD_NEK2_1	611	616	PF00069	0.531
MOD_NEK2_1	630	635	PF00069	0.286
MOD_NEK2_1	665	670	PF00069	0.484
MOD_NEK2_2	657	662	PF00069	0.516
MOD_PIKK_1	227	233	PF00454	0.578
MOD_PIKK_1	324	330	PF00454	0.556
MOD_PIKK_1	48	54	PF00454	0.525
MOD_PIKK_1	562	568	PF00454	0.500
MOD_PKA_1	436	442	PF00069	0.475
MOD_PKA_2	191	197	PF00069	0.525
MOD_PKA_2	221	227	PF00069	0.522
MOD_PKA_2	324	330	PF00069	0.540
MOD_PKA_2	384	390	PF00069	0.408
MOD_PKA_2	436	442	PF00069	0.510
MOD_PKA_2	512	518	PF00069	0.555
MOD_PKA_2	587	593	PF00069	0.411
MOD_Plk_1	102	108	PF00069	0.494
MOD_Plk_1	332	338	PF00069	0.432
MOD_Plk_1	58	64	PF00069	0.520
MOD_Plk_1	599	605	PF00069	0.569
MOD_Plk_1	634	640	PF00069	0.382
MOD_Plk_1	657	663	PF00069	0.514
MOD_Plk_2-3	339	345	PF00069	0.457
MOD_Plk_2-3	599	605	PF00069	0.627
MOD_Plk_2-3	80	86	PF00069	0.520
MOD_Plk_4	134	140	PF00069	0.586
MOD_Plk_4	209	215	PF00069	0.516
MOD_Plk_4	390	396	PF00069	0.407
MOD_Plk_4	397	403	PF00069	0.416
MOD_Plk_4	436	442	PF00069	0.462
MOD_Plk_4	451	457	PF00069	0.484
MOD_Plk_4	634	640	PF00069	0.506
MOD_Plk_4	647	653	PF00069	0.382
MOD_Plk_4	88	94	PF00069	0.566
MOD_ProDKin_1	356	362	PF00069	0.609
MOD_ProDKin_1	500	506	PF00069	0.493
MOD_ProDKin_1	515	521	PF00069	0.472
MOD_ProDKin_1	650	656	PF00069	0.527
MOD_SUMO_for_1	67	70	PF00179	0.562
MOD_SUMO_rev_2	147	154	PF00179	0.558
TRG_DiLeu_BaEn_1	149	154	PF01217	0.553
TRG_DiLeu_BaEn_1	489	494	PF01217	0.374
TRG_DiLeu_BaEn_1	678	683	PF01217	0.502
TRG_DiLeu_BaEn_2	537	543	PF01217	0.427
TRG_DiLeu_BaEn_4	538	544	PF01217	0.526
TRG_DiLeu_BaLyEn_6	497	502	PF01217	0.529
TRG_ENDOCYTIC_2	195	198	PF00928	0.579
TRG_ENDOCYTIC_2	218	221	PF00928	0.512
TRG_ENDOCYTIC_2	236	239	PF00928	0.383
TRG_ENDOCYTIC_2	329	332	PF00928	0.371
TRG_ENDOCYTIC_2	55	58	PF00928	0.589
TRG_ENDOCYTIC_2	558	561	PF00928	0.373
TRG_ENDOCYTIC_2	567	570	PF00928	0.388
TRG_ENDOCYTIC_2	649	652	PF00928	0.408
TRG_ER_diArg_1	346	349	PF00400	0.489
TRG_ER_diArg_1	435	437	PF00400	0.546
TRG_ER_diArg_1	672	674	PF00400	0.370
TRG_NLS_MonoExtN_4	163	170	PF00514	0.549
TRG_NLS_MonoExtN_4	71	76	PF00514	0.498
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	500	505	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	524	528	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	551	555	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P710	Leptomonas seymouri	70%	98%
A0A0S4KLU8	Bodo saltans	40%	100%
A0A1X0PA51	Trypanosomatidae	47%	100%
A0A3R7MX42	Trypanosoma rangeli	45%	98%
A4HBD0	Leishmania braziliensis	83%	100%
A4IAH8	Leishmania infantum	100%	100%
C9ZLR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B5K2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q2D4	Leishmania major	96%	100%
V5BLS6	Trypanosoma cruzi	46%	98%