Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFW1_LEIDO

TriTrypDb:

LdBPK_302070.1 , LdCL_300026000 , LDHU3_30.2810

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFW1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.584
CLV_NRD_NRD_1	125	127	PF00675	0.722
CLV_NRD_NRD_1	154	156	PF00675	0.723
CLV_NRD_NRD_1	207	209	PF00675	0.606
CLV_NRD_NRD_1	226	228	PF00675	0.470
CLV_NRD_NRD_1	255	257	PF00675	0.642
CLV_NRD_NRD_1	292	294	PF00675	0.636
CLV_NRD_NRD_1	300	302	PF00675	0.550
CLV_NRD_NRD_1	70	72	PF00675	0.642
CLV_NRD_NRD_1	95	97	PF00675	0.655
CLV_PCSK_FUR_1	123	127	PF00082	0.726
CLV_PCSK_FUR_1	152	156	PF00082	0.679
CLV_PCSK_FUR_1	68	72	PF00082	0.784
CLV_PCSK_KEX2_1	12	14	PF00082	0.574
CLV_PCSK_KEX2_1	125	127	PF00082	0.683
CLV_PCSK_KEX2_1	154	156	PF00082	0.720
CLV_PCSK_KEX2_1	207	209	PF00082	0.583
CLV_PCSK_KEX2_1	226	228	PF00082	0.472
CLV_PCSK_KEX2_1	255	257	PF00082	0.700
CLV_PCSK_KEX2_1	292	294	PF00082	0.626
CLV_PCSK_KEX2_1	300	302	PF00082	0.507
CLV_PCSK_KEX2_1	70	72	PF00082	0.642
CLV_PCSK_KEX2_1	95	97	PF00082	0.654
CLV_PCSK_SKI1_1	96	100	PF00082	0.665
DEG_Nend_UBRbox_1	1	4	PF02207	0.685
DEG_SCF_FBW7_1	111	116	PF00400	0.735
DEG_SPOP_SBC_1	132	136	PF00917	0.597
DOC_CKS1_1	281	286	PF01111	0.665
DOC_MAPK_DCC_7	196	204	PF00069	0.710
DOC_MAPK_MEF2A_6	196	204	PF00069	0.710
DOC_MAPK_MEF2A_6	244	253	PF00069	0.666
DOC_USP7_MATH_1	100	104	PF00917	0.772
DOC_USP7_MATH_1	113	117	PF00917	0.711
DOC_USP7_MATH_1	131	135	PF00917	0.720
DOC_USP7_MATH_1	15	19	PF00917	0.595
DOC_USP7_MATH_1	160	164	PF00917	0.646
DOC_USP7_MATH_1	30	34	PF00917	0.632
DOC_USP7_UBL2_3	192	196	PF12436	0.710
DOC_USP7_UBL2_3	205	209	PF12436	0.487
DOC_WW_Pin1_4	109	114	PF00397	0.706
DOC_WW_Pin1_4	255	260	PF00397	0.662
DOC_WW_Pin1_4	280	285	PF00397	0.720
DOC_WW_Pin1_4	294	299	PF00397	0.582
DOC_WW_Pin1_4	62	67	PF00397	0.715
LIG_14-3-3_CanoR_1	114	122	PF00244	0.710
LIG_14-3-3_CanoR_1	133	142	PF00244	0.626
LIG_14-3-3_CanoR_1	162	167	PF00244	0.667
LIG_14-3-3_CanoR_1	173	183	PF00244	0.544
LIG_14-3-3_CanoR_1	300	304	PF00244	0.674
LIG_14-3-3_CanoR_1	95	104	PF00244	0.572
LIG_BRCT_BRCA1_1	167	171	PF00533	0.657
LIG_deltaCOP1_diTrp_1	243	248	PF00928	0.647
LIG_FHA_1	300	306	PF00498	0.627
LIG_FHA_1	42	48	PF00498	0.674
LIG_FHA_2	2	8	PF00498	0.696
LIG_LIR_Gen_1	18	24	PF02991	0.702
LIG_LIR_Gen_1	243	253	PF02991	0.663
LIG_LIR_Gen_1	302	311	PF02991	0.537
LIG_LIR_Nem_3	18	23	PF02991	0.701
LIG_LIR_Nem_3	243	249	PF02991	0.650
LIG_LIR_Nem_3	302	306	PF02991	0.531
LIG_SH2_PTP2	127	130	PF00017	0.724
LIG_SH2_SRC	127	130	PF00017	0.673
LIG_SH2_STAP1	55	59	PF00017	0.739
LIG_SH2_STAT5	127	130	PF00017	0.682
LIG_SH3_1	278	284	PF00018	0.671
LIG_SH3_2	200	205	PF14604	0.640
LIG_SH3_3	116	122	PF00018	0.730
LIG_SH3_3	125	131	PF00018	0.703
LIG_SH3_3	184	190	PF00018	0.577
LIG_SH3_3	191	197	PF00018	0.541
LIG_SH3_3	200	206	PF00018	0.490
LIG_SH3_3	268	274	PF00018	0.714
LIG_SH3_3	278	284	PF00018	0.698
LIG_SH3_4	192	199	PF00018	0.680
LIG_SH3_4	205	212	PF00018	0.691
LIG_SUMO_SIM_par_1	273	279	PF11976	0.713
LIG_WW_2	200	203	PF00397	0.683
MOD_CDK_SPK_2	109	114	PF00069	0.713
MOD_CDK_SPxK_1	294	300	PF00069	0.621
MOD_CDK_SPxK_1	62	68	PF00069	0.781
MOD_CDK_SPxxK_3	280	287	PF00069	0.668
MOD_CDK_SPxxK_3	294	301	PF00069	0.573
MOD_CK1_1	165	171	PF00069	0.706
MOD_CK1_1	172	178	PF00069	0.636
MOD_CK1_1	28	34	PF00069	0.767
MOD_CK2_1	1	7	PF00069	0.675
MOD_Cter_Amidation	253	256	PF01082	0.554
MOD_Cter_Amidation	290	293	PF01082	0.681
MOD_Cter_Amidation	68	71	PF01082	0.657
MOD_GlcNHglycan	149	152	PF01048	0.699
MOD_GlcNHglycan	158	161	PF01048	0.682
MOD_GlcNHglycan	220	223	PF01048	0.607
MOD_GlcNHglycan	239	242	PF01048	0.417
MOD_GSK3_1	109	116	PF00069	0.636
MOD_GSK3_1	156	163	PF00069	0.762
MOD_GSK3_1	165	172	PF00069	0.657
MOD_GSK3_1	43	50	PF00069	0.604
MOD_GSK3_1	96	103	PF00069	0.666
MOD_N-GLC_1	100	105	PF02516	0.739
MOD_N-GLC_1	173	178	PF02516	0.654
MOD_N-GLC_1	264	269	PF02516	0.591
MOD_NEK2_1	1	6	PF00069	0.655
MOD_NEK2_2	15	20	PF00069	0.574
MOD_PIKK_1	165	171	PF00454	0.696
MOD_PK_1	162	168	PF00069	0.744
MOD_PKA_2	113	119	PF00069	0.677
MOD_PKA_2	132	138	PF00069	0.707
MOD_PKA_2	172	178	PF00069	0.660
MOD_PKA_2	25	31	PF00069	0.620
MOD_PKA_2	299	305	PF00069	0.645
MOD_PKA_2	88	94	PF00069	0.765
MOD_Plk_1	117	123	PF00069	0.721
MOD_Plk_1	264	270	PF00069	0.626
MOD_Plk_1	50	56	PF00069	0.582
MOD_Plk_4	15	21	PF00069	0.556
MOD_Plk_4	182	188	PF00069	0.693
MOD_Plk_4	50	56	PF00069	0.697
MOD_ProDKin_1	109	115	PF00069	0.704
MOD_ProDKin_1	255	261	PF00069	0.662
MOD_ProDKin_1	280	286	PF00069	0.719
MOD_ProDKin_1	294	300	PF00069	0.578
MOD_ProDKin_1	62	68	PF00069	0.766
TRG_ER_diArg_1	122	125	PF00400	0.735
TRG_ER_diArg_1	152	155	PF00400	0.691
TRG_ER_diArg_1	206	208	PF00400	0.626
TRG_ER_diArg_1	217	220	PF00400	0.521
TRG_ER_diArg_1	292	294	PF00400	0.650
TRG_ER_diArg_1	299	301	PF00400	0.551
TRG_ER_diArg_1	67	70	PF00400	0.755
TRG_ER_diArg_1	94	96	PF00400	0.699
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.671

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P913	Leptomonas seymouri	62%	100%
A0A1X0P1U3	Trypanosomatidae	31%	100%
A0A422P3E4	Trypanosoma rangeli	34%	100%
A4HID8	Leishmania braziliensis	77%	100%
A4I5N5	Leishmania infantum	100%	100%
C9ZR04	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B0X9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q787	Leishmania major	93%	100%
V5BYT6	Trypanosoma cruzi	32%	99%