Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFV9_LEIDO

TriTrypDb:

LdBPK_261420.1 , LdCL_260019800 , LDHU3_26.1730

Length:

782

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	532	536	PF00656	0.597
CLV_C14_Caspase3-7	543	547	PF00656	0.597
CLV_C14_Caspase3-7	679	683	PF00656	0.682
CLV_NRD_NRD_1	134	136	PF00675	0.623
CLV_NRD_NRD_1	17	19	PF00675	0.588
CLV_NRD_NRD_1	483	485	PF00675	0.476
CLV_NRD_NRD_1	586	588	PF00675	0.445
CLV_NRD_NRD_1	691	693	PF00675	0.662
CLV_NRD_NRD_1	751	753	PF00675	0.408
CLV_NRD_NRD_1	92	94	PF00675	0.720
CLV_PCSK_FUR_1	131	135	PF00082	0.672
CLV_PCSK_KEX2_1	131	133	PF00082	0.605
CLV_PCSK_KEX2_1	134	136	PF00082	0.613
CLV_PCSK_KEX2_1	483	485	PF00082	0.476
CLV_PCSK_KEX2_1	691	693	PF00082	0.662
CLV_PCSK_KEX2_1	753	755	PF00082	0.403
CLV_PCSK_KEX2_1	92	94	PF00082	0.655
CLV_PCSK_PC1ET2_1	753	755	PF00082	0.403
CLV_PCSK_SKI1_1	34	38	PF00082	0.430
CLV_PCSK_SKI1_1	427	431	PF00082	0.354
CLV_PCSK_SKI1_1	450	454	PF00082	0.441
CLV_PCSK_SKI1_1	473	477	PF00082	0.390
CLV_PCSK_SKI1_1	489	493	PF00082	0.427
CLV_PCSK_SKI1_1	723	727	PF00082	0.501
CLV_PCSK_SKI1_1	736	740	PF00082	0.389
CLV_Separin_Metazoa	724	728	PF03568	0.412
DEG_MDM2_SWIB_1	230	238	PF02201	0.399
DEG_SPOP_SBC_1	347	351	PF00917	0.699
DEG_SPOP_SBC_1	393	397	PF00917	0.606
DOC_CKS1_1	418	423	PF01111	0.500
DOC_CYCLIN_RxL_1	30	38	PF00134	0.440
DOC_CYCLIN_RxL_1	483	496	PF00134	0.422
DOC_MAPK_gen_1	205	215	PF00069	0.373
DOC_MAPK_gen_1	273	282	PF00069	0.644
DOC_MAPK_gen_1	736	744	PF00069	0.403
DOC_MAPK_MEF2A_6	138	146	PF00069	0.631
DOC_MAPK_MEF2A_6	276	284	PF00069	0.587
DOC_MAPK_MEF2A_6	30	39	PF00069	0.601
DOC_MAPK_MEF2A_6	48	57	PF00069	0.276
DOC_MAPK_MEF2A_6	736	744	PF00069	0.440
DOC_PP1_RVXF_1	448	455	PF00149	0.426
DOC_PP2B_LxvP_1	170	173	PF13499	0.808
DOC_PP2B_LxvP_1	310	313	PF13499	0.539
DOC_PP2B_LxvP_1	453	456	PF13499	0.438
DOC_USP7_MATH_1	158	162	PF00917	0.676
DOC_USP7_MATH_1	187	191	PF00917	0.655
DOC_USP7_MATH_1	255	259	PF00917	0.670
DOC_USP7_MATH_1	347	351	PF00917	0.680
DOC_USP7_MATH_1	371	375	PF00917	0.687
DOC_USP7_MATH_1	392	396	PF00917	0.634
DOC_USP7_MATH_1	419	423	PF00917	0.524
DOC_USP7_MATH_1	456	460	PF00917	0.509
DOC_USP7_MATH_1	524	528	PF00917	0.558
DOC_USP7_MATH_1	545	549	PF00917	0.571
DOC_USP7_MATH_1	628	632	PF00917	0.573
DOC_USP7_MATH_1	674	678	PF00917	0.650
DOC_USP7_MATH_1	78	82	PF00917	0.693
DOC_USP7_UBL2_3	30	34	PF12436	0.522
DOC_WW_Pin1_4	161	166	PF00397	0.615
DOC_WW_Pin1_4	342	347	PF00397	0.610
DOC_WW_Pin1_4	407	412	PF00397	0.593
DOC_WW_Pin1_4	417	422	PF00397	0.545
DOC_WW_Pin1_4	473	478	PF00397	0.494
DOC_WW_Pin1_4	587	592	PF00397	0.479
DOC_WW_Pin1_4	610	615	PF00397	0.408
DOC_WW_Pin1_4	626	631	PF00397	0.426
DOC_WW_Pin1_4	672	677	PF00397	0.647
DOC_WW_Pin1_4	68	73	PF00397	0.637
DOC_WW_Pin1_4	92	97	PF00397	0.801
LIG_14-3-3_CanoR_1	103	112	PF00244	0.767
LIG_14-3-3_CanoR_1	223	227	PF00244	0.385
LIG_14-3-3_CanoR_1	359	366	PF00244	0.639
LIG_14-3-3_CanoR_1	427	432	PF00244	0.352
LIG_14-3-3_CanoR_1	52	56	PF00244	0.584
LIG_14-3-3_CanoR_1	587	591	PF00244	0.467
LIG_14-3-3_CanoR_1	727	731	PF00244	0.503
LIG_BIR_III_2	474	478	PF00653	0.451
LIG_BIR_III_2	673	677	PF00653	0.647
LIG_BIR_III_4	115	119	PF00653	0.638
LIG_BIR_III_4	157	161	PF00653	0.573
LIG_BIR_III_4	533	537	PF00653	0.598
LIG_BRCT_BRCA1_1	271	275	PF00533	0.748
LIG_BRCT_BRCA1_1	427	431	PF00533	0.352
LIG_Clathr_ClatBox_1	298	302	PF01394	0.484
LIG_Clathr_ClatBox_1	705	709	PF01394	0.589
LIG_CSL_BTD_1	453	456	PF09270	0.438
LIG_deltaCOP1_diTrp_1	463	470	PF00928	0.398
LIG_EVH1_2	740	744	PF00568	0.472
LIG_FHA_1	279	285	PF00498	0.539
LIG_FHA_1	336	342	PF00498	0.566
LIG_FHA_1	394	400	PF00498	0.748
LIG_FHA_1	412	418	PF00498	0.551
LIG_FHA_1	428	434	PF00498	0.309
LIG_FHA_1	436	442	PF00498	0.452
LIG_FHA_1	494	500	PF00498	0.675
LIG_FHA_1	52	58	PF00498	0.562
LIG_FHA_1	587	593	PF00498	0.364
LIG_FHA_1	667	673	PF00498	0.641
LIG_FHA_2	120	126	PF00498	0.579
LIG_FHA_2	474	480	PF00498	0.399
LIG_FHA_2	530	536	PF00498	0.591
LIG_FHA_2	677	683	PF00498	0.685
LIG_FXI_DFP_1	47	51	PF00024	0.389
LIG_LIR_Apic_2	161	165	PF02991	0.676
LIG_LIR_Apic_2	535	540	PF02991	0.615
LIG_LIR_Gen_1	231	239	PF02991	0.410
LIG_LIR_Gen_1	428	437	PF02991	0.347
LIG_LIR_LC3C_4	235	239	PF02991	0.432
LIG_LIR_Nem_3	231	237	PF02991	0.400
LIG_LIR_Nem_3	613	618	PF02991	0.436
LIG_LIR_Nem_3	68	73	PF02991	0.632
LIG_LIR_Nem_3	743	747	PF02991	0.598
LIG_LIR_Nem_3	95	100	PF02991	0.598
LIG_MYND_1	169	173	PF01753	0.653
LIG_Pex14_1	466	470	PF04695	0.409
LIG_Pex14_2	226	230	PF04695	0.373
LIG_SH2_CRK	70	74	PF00017	0.642
LIG_SH2_NCK_1	618	622	PF00017	0.506
LIG_SH2_NCK_1	70	74	PF00017	0.593
LIG_SH2_STAP1	593	597	PF00017	0.370
LIG_SH2_STAP1	618	622	PF00017	0.506
LIG_SH2_STAT3	766	769	PF00017	0.488
LIG_SH2_STAT5	110	113	PF00017	0.546
LIG_SH2_STAT5	424	427	PF00017	0.388
LIG_SH2_STAT5	581	584	PF00017	0.416
LIG_SH3_1	93	99	PF00018	0.639
LIG_SH3_2	633	638	PF14604	0.551
LIG_SH3_3	170	176	PF00018	0.626
LIG_SH3_3	323	329	PF00018	0.580
LIG_SH3_3	338	344	PF00018	0.671
LIG_SH3_3	627	633	PF00018	0.555
LIG_SH3_3	651	657	PF00018	0.614
LIG_SH3_3	687	693	PF00018	0.670
LIG_SH3_3	93	99	PF00018	0.661
LIG_SH3_4	84	91	PF00018	0.655
LIG_SUMO_SIM_anti_2	211	218	PF11976	0.373
LIG_SUMO_SIM_anti_2	42	49	PF11976	0.402
LIG_SUMO_SIM_anti_2	729	734	PF11976	0.403
LIG_SUMO_SIM_par_1	211	218	PF11976	0.373
LIG_SUMO_SIM_par_1	278	283	PF11976	0.644
LIG_SUMO_SIM_par_1	294	303	PF11976	0.348
LIG_SUMO_SIM_par_1	328	334	PF11976	0.531
LIG_SUMO_SIM_par_1	668	673	PF11976	0.619
LIG_SUMO_SIM_par_1	692	698	PF11976	0.588
LIG_SUMO_SIM_par_1	704	709	PF11976	0.536
LIG_TRAF2_1	317	320	PF00917	0.551
MOD_CDK_SPxK_1	417	423	PF00069	0.521
MOD_CK1_1	161	167	PF00069	0.644
MOD_CK1_1	229	235	PF00069	0.463
MOD_CK1_1	3	9	PF00069	0.567
MOD_CK1_1	331	337	PF00069	0.543
MOD_CK1_1	350	356	PF00069	0.777
MOD_CK1_1	361	367	PF00069	0.674
MOD_CK1_1	395	401	PF00069	0.615
MOD_CK1_1	410	416	PF00069	0.553
MOD_CK1_1	502	508	PF00069	0.540
MOD_CK1_1	520	526	PF00069	0.592
MOD_CK1_1	652	658	PF00069	0.593
MOD_CK1_1	677	683	PF00069	0.661
MOD_CK1_1	71	77	PF00069	0.665
MOD_CK2_1	119	125	PF00069	0.630
MOD_CK2_1	3	9	PF00069	0.645
MOD_CK2_1	71	77	PF00069	0.612
MOD_CMANNOS	454	457	PF00535	0.433
MOD_GlcNHglycan	139	142	PF01048	0.674
MOD_GlcNHglycan	147	151	PF01048	0.604
MOD_GlcNHglycan	189	192	PF01048	0.620
MOD_GlcNHglycan	2	5	PF01048	0.575
MOD_GlcNHglycan	231	234	PF01048	0.515
MOD_GlcNHglycan	257	260	PF01048	0.650
MOD_GlcNHglycan	294	297	PF01048	0.398
MOD_GlcNHglycan	305	308	PF01048	0.599
MOD_GlcNHglycan	333	336	PF01048	0.588
MOD_GlcNHglycan	350	353	PF01048	0.745
MOD_GlcNHglycan	390	393	PF01048	0.723
MOD_GlcNHglycan	427	430	PF01048	0.354
MOD_GlcNHglycan	496	499	PF01048	0.548
MOD_GlcNHglycan	501	504	PF01048	0.515
MOD_GlcNHglycan	542	545	PF01048	0.565
MOD_GlcNHglycan	546	550	PF01048	0.546
MOD_GSK3_1	101	108	PF00069	0.623
MOD_GSK3_1	119	126	PF00069	0.578
MOD_GSK3_1	161	168	PF00069	0.585
MOD_GSK3_1	222	229	PF00069	0.458
MOD_GSK3_1	331	338	PF00069	0.651
MOD_GSK3_1	342	349	PF00069	0.612
MOD_GSK3_1	371	378	PF00069	0.710
MOD_GSK3_1	388	395	PF00069	0.644
MOD_GSK3_1	407	414	PF00069	0.529
MOD_GSK3_1	487	494	PF00069	0.451
MOD_GSK3_1	520	527	PF00069	0.622
MOD_GSK3_1	582	589	PF00069	0.457
MOD_GSK3_1	634	641	PF00069	0.691
MOD_GSK3_1	668	675	PF00069	0.676
MOD_GSK3_1	678	685	PF00069	0.597
MOD_GSK3_1	88	95	PF00069	0.586
MOD_N-GLC_1	492	497	PF02516	0.436
MOD_N-GLC_1	682	687	PF02516	0.638
MOD_N-GLC_2	290	292	PF02516	0.369
MOD_N-GLC_2	554	556	PF02516	0.574
MOD_NEK2_1	491	496	PF00069	0.476
MOD_NEK2_1	56	61	PF00069	0.523
MOD_NEK2_1	746	751	PF00069	0.534
MOD_NEK2_2	51	56	PF00069	0.464
MOD_NEK2_2	597	602	PF00069	0.363
MOD_NEK2_2	697	702	PF00069	0.521
MOD_NMyristoyl	1	7	PF02799	0.574
MOD_PIKK_1	103	109	PF00454	0.671
MOD_PIKK_1	260	266	PF00454	0.601
MOD_PIKK_1	380	386	PF00454	0.655
MOD_PIKK_1	435	441	PF00454	0.385
MOD_PIKK_1	712	718	PF00454	0.380
MOD_PKA_2	222	228	PF00069	0.375
MOD_PKA_2	358	364	PF00069	0.530
MOD_PKA_2	388	394	PF00069	0.668
MOD_PKA_2	51	57	PF00069	0.575
MOD_PKA_2	517	523	PF00069	0.672
MOD_PKA_2	586	592	PF00069	0.469
MOD_PKA_2	726	732	PF00069	0.427
MOD_PKB_1	103	111	PF00069	0.598
MOD_Plk_1	644	650	PF00069	0.543
MOD_Plk_1	697	703	PF00069	0.519
MOD_Plk_2-3	668	674	PF00069	0.619
MOD_Plk_4	322	328	PF00069	0.541
MOD_Plk_4	51	57	PF00069	0.499
MOD_Plk_4	604	610	PF00069	0.515
MOD_Plk_4	638	644	PF00069	0.591
MOD_Plk_4	649	655	PF00069	0.523
MOD_ProDKin_1	161	167	PF00069	0.616
MOD_ProDKin_1	342	348	PF00069	0.611
MOD_ProDKin_1	407	413	PF00069	0.591
MOD_ProDKin_1	417	423	PF00069	0.532
MOD_ProDKin_1	473	479	PF00069	0.489
MOD_ProDKin_1	587	593	PF00069	0.473
MOD_ProDKin_1	610	616	PF00069	0.406
MOD_ProDKin_1	626	632	PF00069	0.433
MOD_ProDKin_1	672	678	PF00069	0.645
MOD_ProDKin_1	68	74	PF00069	0.640
MOD_ProDKin_1	92	98	PF00069	0.801
MOD_SUMO_rev_2	583	590	PF00179	0.462
TRG_DiLeu_BaEn_1	211	216	PF01217	0.316
TRG_DiLeu_BaEn_1	649	654	PF01217	0.591
TRG_DiLeu_BaEn_3	756	762	PF01217	0.344
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.667
TRG_DiLeu_BaLyEn_6	630	635	PF01217	0.508
TRG_ENDOCYTIC_2	70	73	PF00928	0.735
TRG_ER_diArg_1	102	105	PF00400	0.655
TRG_ER_diArg_1	131	134	PF00400	0.604
TRG_ER_diArg_1	690	692	PF00400	0.665
TRG_ER_diArg_1	751	754	PF00400	0.423
TRG_ER_diLys_1	778	782	PF00400	0.559
TRG_NLS_MonoExtN_4	15	22	PF00514	0.586
TRG_NLS_MonoExtN_4	270	277	PF00514	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P8	Leptomonas seymouri	41%	99%
A4HEZ9	Leishmania braziliensis	63%	99%
A4I278	Leishmania infantum	100%	100%
E9AYC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4Q950	Leishmania major	89%	100%