PPPDE putative peptidase domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PPPDE putative peptidase domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IFV8_LEIDO

TriTrypDb:

LdBPK_321390.1 , LdCL_320019600 , LDHU3_32.1760

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3Q8IFV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFV8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070646	protein modification by small protein removal	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008233	peptidase activity	3	12
GO:0016787	hydrolase activity	2	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.307
CLV_C14_Caspase3-7	395	399	PF00656	0.390
CLV_NRD_NRD_1	374	376	PF00675	0.611
CLV_NRD_NRD_1	43	45	PF00675	0.754
CLV_PCSK_KEX2_1	174	176	PF00082	0.507
CLV_PCSK_KEX2_1	359	361	PF00082	0.552
CLV_PCSK_KEX2_1	374	376	PF00082	0.640
CLV_PCSK_KEX2_1	537	539	PF00082	0.421
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.507
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.593
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.586
CLV_PCSK_PC1ET2_1	537	539	PF00082	0.297
CLV_PCSK_SKI1_1	268	272	PF00082	0.556
CLV_PCSK_SKI1_1	279	283	PF00082	0.548
CLV_PCSK_SKI1_1	360	364	PF00082	0.510
CLV_PCSK_SKI1_1	37	41	PF00082	0.640
CLV_PCSK_SKI1_1	376	380	PF00082	0.555
CLV_PCSK_SKI1_1	403	407	PF00082	0.556
CLV_PCSK_SKI1_1	459	463	PF00082	0.298
CLV_PCSK_SKI1_1	469	473	PF00082	0.272
CLV_PCSK_SKI1_1	538	542	PF00082	0.413
CLV_PCSK_SKI1_1	551	555	PF00082	0.316
CLV_PCSK_SKI1_1	75	79	PF00082	0.802
DEG_APCC_DBOX_1	458	466	PF00400	0.594
DEG_APCC_KENBOX_2	60	64	PF00400	0.596
DEG_ODPH_VHL_1	400	411	PF01847	0.279
DEG_SCF_FBW7_1	87	93	PF00400	0.493
DOC_ANK_TNKS_1	462	469	PF00023	0.597
DOC_CKS1_1	39	44	PF01111	0.556
DOC_CKS1_1	87	92	PF01111	0.495
DOC_CYCLIN_RxL_1	264	274	PF00134	0.314
DOC_CYCLIN_RxL_1	276	286	PF00134	0.220
DOC_CYCLIN_RxL_1	356	366	PF00134	0.372
DOC_CYCLIN_RxL_1	400	410	PF00134	0.281
DOC_CYCLIN_yClb5_NLxxxL_5	445	454	PF00134	0.250
DOC_MAPK_gen_1	219	227	PF00069	0.272
DOC_MAPK_gen_1	359	365	PF00069	0.358
DOC_MAPK_gen_1	374	385	PF00069	0.362
DOC_MAPK_gen_1	44	55	PF00069	0.548
DOC_MAPK_gen_1	493	501	PF00069	0.350
DOC_MAPK_JIP1_4	351	357	PF00069	0.390
DOC_MAPK_JIP1_4	379	385	PF00069	0.393
DOC_MAPK_MEF2A_6	157	165	PF00069	0.301
DOC_MAPK_MEF2A_6	48	55	PF00069	0.548
DOC_MAPK_MEF2A_6	69	76	PF00069	0.469
DOC_MAPK_NFAT4_5	48	56	PF00069	0.486
DOC_MAPK_RevD_3	361	376	PF00069	0.348
DOC_MAPK_RevD_3	524	538	PF00069	0.434
DOC_PP1_RVXF_1	467	473	PF00149	0.537
DOC_PP2B_LxvP_1	128	131	PF13499	0.541
DOC_PP2B_LxvP_1	183	186	PF13499	0.307
DOC_USP7_MATH_1	497	501	PF00917	0.320
DOC_USP7_MATH_1	569	573	PF00917	0.582
DOC_USP7_MATH_1	90	94	PF00917	0.549
DOC_USP7_UBL2_3	370	374	PF12436	0.354
DOC_USP7_UBL2_3	57	61	PF12436	0.508
DOC_WW_Pin1_4	363	368	PF00397	0.361
DOC_WW_Pin1_4	38	43	PF00397	0.556
DOC_WW_Pin1_4	416	421	PF00397	0.339
DOC_WW_Pin1_4	6	11	PF00397	0.550
DOC_WW_Pin1_4	86	91	PF00397	0.554
LIG_14-3-3_CanoR_1	317	322	PF00244	0.375
LIG_14-3-3_CanoR_1	44	52	PF00244	0.537
LIG_14-3-3_CanoR_1	551	556	PF00244	0.592
LIG_14-3-3_CanoR_1	561	569	PF00244	0.576
LIG_14-3-3_CanoR_1	582	591	PF00244	0.547
LIG_14-3-3_CanoR_1	75	82	PF00244	0.542
LIG_14-3-3_CanoR_1	94	99	PF00244	0.348
LIG_Actin_WH2_2	458	476	PF00022	0.584
LIG_APCC_ABBA_1	198	203	PF00400	0.354
LIG_BRCT_BRCA1_1	232	236	PF00533	0.307
LIG_BRCT_BRCA1_1	595	599	PF00533	0.624
LIG_Clathr_ClatBox_1	180	184	PF01394	0.354
LIG_FHA_1	2	8	PF00498	0.533
LIG_FHA_1	21	27	PF00498	0.493
LIG_FHA_1	220	226	PF00498	0.290
LIG_FHA_1	343	349	PF00498	0.393
LIG_FHA_1	395	401	PF00498	0.398
LIG_FHA_1	411	417	PF00498	0.338
LIG_FHA_1	529	535	PF00498	0.451
LIG_FHA_1	552	558	PF00498	0.502
LIG_FHA_1	586	592	PF00498	0.598
LIG_FHA_1	76	82	PF00498	0.565
LIG_FHA_2	153	159	PF00498	0.423
LIG_FHA_2	622	628	PF00498	0.587
LIG_GBD_Chelix_1	357	365	PF00786	0.585
LIG_GBD_Chelix_1	552	560	PF00786	0.341
LIG_LIR_Gen_1	460	466	PF02991	0.477
LIG_LIR_Gen_1	496	506	PF02991	0.312
LIG_LIR_Gen_1	570	581	PF02991	0.570
LIG_LIR_Nem_3	233	239	PF02991	0.348
LIG_LIR_Nem_3	251	255	PF02991	0.184
LIG_LIR_Nem_3	423	427	PF02991	0.332
LIG_LIR_Nem_3	460	464	PF02991	0.566
LIG_LIR_Nem_3	496	501	PF02991	0.330
LIG_LIR_Nem_3	570	576	PF02991	0.607
LIG_MLH1_MIPbox_1	232	236	PF16413	0.307
LIG_MYND_1	10	14	PF01753	0.484
LIG_NRBOX	551	557	PF00104	0.575
LIG_NRBOX	617	623	PF00104	0.582
LIG_PCNA_yPIPBox_3	574	582	PF02747	0.537
LIG_PDZ_Class_2	625	630	PF00595	0.524
LIG_Pex14_1	424	428	PF04695	0.367
LIG_PTB_Apo_2	440	447	PF02174	0.442
LIG_REV1ctd_RIR_1	233	241	PF16727	0.357
LIG_SH2_CRK	252	256	PF00017	0.324
LIG_SH2_CRK	484	488	PF00017	0.337
LIG_SH2_PTP2	408	411	PF00017	0.319
LIG_SH2_SRC	408	411	PF00017	0.301
LIG_SH2_STAP1	548	552	PF00017	0.576
LIG_SH2_STAP1	603	607	PF00017	0.558
LIG_SH2_STAT5	201	204	PF00017	0.347
LIG_SH2_STAT5	280	283	PF00017	0.298
LIG_SH2_STAT5	368	371	PF00017	0.324
LIG_SH2_STAT5	408	411	PF00017	0.325
LIG_SH2_STAT5	515	518	PF00017	0.321
LIG_SH2_STAT5	593	596	PF00017	0.578
LIG_SH3_3	272	278	PF00018	0.382
LIG_SH3_3	29	35	PF00018	0.531
LIG_SH3_3	36	42	PF00018	0.499
LIG_SH3_3	4	10	PF00018	0.502
LIG_SH3_3	592	598	PF00018	0.553
LIG_SH3_3	84	90	PF00018	0.540
LIG_Sin3_3	382	389	PF02671	0.276
LIG_SUMO_SIM_par_1	361	366	PF11976	0.380
LIG_TYR_ITIM	406	411	PF00017	0.312
MOD_CDK_SPK_2	6	11	PF00069	0.500
MOD_CDK_SPxK_1	38	44	PF00069	0.498
MOD_CDK_SPxxK_3	363	370	PF00069	0.376
MOD_CDK_SPxxK_3	38	45	PF00069	0.498
MOD_CK1_1	332	338	PF00069	0.394
MOD_CK1_1	46	52	PF00069	0.544
MOD_CK1_1	585	591	PF00069	0.560
MOD_CK1_1	612	618	PF00069	0.600
MOD_CK2_1	293	299	PF00069	0.342
MOD_GlcNHglycan	190	193	PF01048	0.478
MOD_GlcNHglycan	331	334	PF01048	0.543
MOD_GlcNHglycan	563	566	PF01048	0.402
MOD_GSK3_1	1	8	PF00069	0.581
MOD_GSK3_1	211	218	PF00069	0.286
MOD_GSK3_1	338	345	PF00069	0.385
MOD_GSK3_1	412	419	PF00069	0.375
MOD_GSK3_1	445	452	PF00069	0.438
MOD_GSK3_1	76	83	PF00069	0.538
MOD_GSK3_1	86	93	PF00069	0.516
MOD_N-GLC_1	131	136	PF02516	0.631
MOD_N-GLC_1	612	617	PF02516	0.327
MOD_NEK2_1	1	6	PF00069	0.449
MOD_NEK2_1	225	230	PF00069	0.272
MOD_NEK2_1	271	276	PF00069	0.286
MOD_NEK2_1	301	306	PF00069	0.425
MOD_NEK2_1	308	313	PF00069	0.437
MOD_NEK2_1	329	334	PF00069	0.391
MOD_NEK2_1	506	511	PF00069	0.371
MOD_NEK2_1	583	588	PF00069	0.470
MOD_NEK2_1	96	101	PF00069	0.547
MOD_PIKK_1	538	544	PF00454	0.615
MOD_PK_1	323	329	PF00069	0.426
MOD_PK_1	94	100	PF00069	0.513
MOD_PKA_2	350	356	PF00069	0.394
MOD_PKA_2	43	49	PF00069	0.562
MOD_PKB_1	213	221	PF00069	0.245
MOD_Plk_1	131	137	PF00069	0.459
MOD_Plk_1	46	52	PF00069	0.492
MOD_Plk_1	507	513	PF00069	0.395
MOD_Plk_4	143	149	PF00069	0.373
MOD_Plk_4	2	8	PF00069	0.446
MOD_Plk_4	28	34	PF00069	0.582
MOD_Plk_4	35	41	PF00069	0.573
MOD_Plk_4	412	418	PF00069	0.317
MOD_Plk_4	449	455	PF00069	0.402
MOD_Plk_4	497	503	PF00069	0.306
MOD_Plk_4	508	514	PF00069	0.179
MOD_Plk_4	551	557	PF00069	0.497
MOD_ProDKin_1	363	369	PF00069	0.358
MOD_ProDKin_1	38	44	PF00069	0.557
MOD_ProDKin_1	416	422	PF00069	0.341
MOD_ProDKin_1	6	12	PF00069	0.550
MOD_ProDKin_1	86	92	PF00069	0.553
MOD_SUMO_for_1	289	292	PF00179	0.357
MOD_SUMO_rev_2	62	70	PF00179	0.469
TRG_DiLeu_BaEn_1	614	619	PF01217	0.520
TRG_DiLeu_BaEn_2	264	270	PF01217	0.357
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.581
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.443
TRG_ENDOCYTIC_2	17	20	PF00928	0.574
TRG_ENDOCYTIC_2	252	255	PF00928	0.302
TRG_ENDOCYTIC_2	408	411	PF00928	0.304
TRG_ENDOCYTIC_2	484	487	PF00928	0.449
TRG_ENDOCYTIC_2	603	606	PF00928	0.528
TRG_ER_diArg_1	213	216	PF00400	0.302
TRG_ER_diArg_1	316	319	PF00400	0.444
TRG_ER_diArg_1	560	563	PF00400	0.597
TRG_NLS_Bipartite_1	359	378	PF00514	0.322
TRG_Pf-PMV_PEXEL_1	268	273	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	319	324	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICK7	Leptomonas seymouri	63%	100%
A0A0S4J986	Bodo saltans	28%	100%
A0A1X0NUY4	Trypanosomatidae	40%	100%
A0A3R7KQA7	Trypanosoma rangeli	34%	100%
A4HKC1	Leishmania braziliensis	75%	100%
A4I7V0	Leishmania infantum	100%	100%
D0AA08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B2Q8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q5E9	Leishmania major	91%	100%
V5BQT4	Trypanosoma cruzi	38%	100%