Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFV3_LEIDO

TriTrypDb:

LdBPK_303380.1 , LdCL_300039400 , LDHU3_30.4480

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFV3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.685
CLV_NRD_NRD_1	282	284	PF00675	0.488
CLV_NRD_NRD_1	382	384	PF00675	0.553
CLV_NRD_NRD_1	385	387	PF00675	0.523
CLV_NRD_NRD_1	8	10	PF00675	0.651
CLV_PCSK_FUR_1	380	384	PF00082	0.567
CLV_PCSK_KEX2_1	128	130	PF00082	0.737
CLV_PCSK_KEX2_1	179	181	PF00082	0.787
CLV_PCSK_KEX2_1	202	204	PF00082	0.621
CLV_PCSK_KEX2_1	220	222	PF00082	0.466
CLV_PCSK_KEX2_1	245	247	PF00082	0.633
CLV_PCSK_KEX2_1	282	284	PF00082	0.464
CLV_PCSK_KEX2_1	382	384	PF00082	0.553
CLV_PCSK_KEX2_1	385	387	PF00082	0.523
CLV_PCSK_KEX2_1	8	10	PF00082	0.605
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.609
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.629
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.466
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.633
CLV_PCSK_SKI1_1	3	7	PF00082	0.565
CLV_PCSK_SKI1_1	302	306	PF00082	0.594
DEG_Nend_UBRbox_3	1	3	PF02207	0.579
DOC_CKS1_1	197	202	PF01111	0.675
DOC_PP1_RVXF_1	249	256	PF00149	0.594
DOC_PP2B_LxvP_1	305	308	PF13499	0.586
DOC_PP2B_PxIxI_1	17	23	PF00149	0.539
DOC_PP4_FxxP_1	357	360	PF00568	0.544
DOC_PP4_FxxP_1	65	68	PF00568	0.564
DOC_USP7_MATH_1	141	145	PF00917	0.666
DOC_USP7_MATH_1	219	223	PF00917	0.655
DOC_USP7_MATH_1	230	234	PF00917	0.631
DOC_USP7_MATH_1	257	261	PF00917	0.661
DOC_USP7_MATH_1	66	70	PF00917	0.588
DOC_USP7_MATH_1	92	96	PF00917	0.615
DOC_USP7_UBL2_3	302	306	PF12436	0.717
DOC_WW_Pin1_4	131	136	PF00397	0.611
DOC_WW_Pin1_4	14	19	PF00397	0.454
DOC_WW_Pin1_4	196	201	PF00397	0.543
DOC_WW_Pin1_4	267	272	PF00397	0.494
DOC_WW_Pin1_4	338	343	PF00397	0.633
DOC_WW_Pin1_4	70	75	PF00397	0.695
LIG_14-3-3_CanoR_1	203	208	PF00244	0.763
LIG_14-3-3_CanoR_1	276	285	PF00244	0.483
LIG_14-3-3_CanoR_1	324	328	PF00244	0.644
LIG_BRCT_BRCA1_1	259	263	PF00533	0.537
LIG_BRCT_BRCA1_1	353	357	PF00533	0.576
LIG_FHA_1	15	21	PF00498	0.603
LIG_FHA_1	341	347	PF00498	0.637
LIG_FHA_1	43	49	PF00498	0.533
LIG_FHA_2	100	106	PF00498	0.514
LIG_FHA_2	164	170	PF00498	0.592
LIG_FHA_2	360	366	PF00498	0.451
LIG_LIR_Apic_2	354	360	PF02991	0.496
LIG_LIR_Apic_2	63	68	PF02991	0.555
LIG_LIR_Gen_1	53	64	PF02991	0.521
LIG_LIR_Nem_3	53	59	PF02991	0.499
LIG_PCNA_yPIPBox_3	35	48	PF02747	0.475
LIG_PTB_Apo_2	372	379	PF02174	0.577
LIG_PTB_Phospho_1	372	378	PF10480	0.578
LIG_SH2_CRK	56	60	PF00017	0.519
LIG_SH2_STAT5	26	29	PF00017	0.473
LIG_SH2_STAT5	267	270	PF00017	0.476
LIG_SH2_STAT5	363	366	PF00017	0.507
LIG_SH3_3	132	138	PF00018	0.777
LIG_SH3_3	167	173	PF00018	0.739
LIG_SH3_3	265	271	PF00018	0.528
LIG_SH3_3	341	347	PF00018	0.526
LIG_SH3_3	71	77	PF00018	0.666
LIG_SH3_5	374	378	PF00018	0.582
LIG_TYR_ITIM	54	59	PF00017	0.499
MOD_CDC14_SPxK_1	270	273	PF00782	0.490
MOD_CDK_SPxK_1	196	202	PF00069	0.566
MOD_CDK_SPxK_1	267	273	PF00069	0.493
MOD_CDK_SPxxK_3	196	203	PF00069	0.639
MOD_CK1_1	144	150	PF00069	0.737
MOD_CK1_1	288	294	PF00069	0.584
MOD_CK1_1	84	90	PF00069	0.641
MOD_CK2_1	163	169	PF00069	0.771
MOD_CK2_1	219	225	PF00069	0.683
MOD_CK2_1	266	272	PF00069	0.592
MOD_CK2_1	99	105	PF00069	0.552
MOD_Cter_Amidation	200	203	PF01082	0.703
MOD_GlcNHglycan	113	116	PF01048	0.593
MOD_GlcNHglycan	129	132	PF01048	0.809
MOD_GlcNHglycan	143	146	PF01048	0.642
MOD_GlcNHglycan	287	290	PF01048	0.651
MOD_GlcNHglycan	302	305	PF01048	0.653
MOD_GlcNHglycan	62	65	PF01048	0.652
MOD_GSK3_1	127	134	PF00069	0.621
MOD_GSK3_1	144	151	PF00069	0.764
MOD_GSK3_1	206	213	PF00069	0.696
MOD_GSK3_1	219	226	PF00069	0.561
MOD_GSK3_1	66	73	PF00069	0.614
MOD_GSK3_1	78	85	PF00069	0.529
MOD_GSK3_1	99	106	PF00069	0.627
MOD_N-GLC_1	285	290	PF02516	0.463
MOD_N-GLC_1	81	86	PF02516	0.762
MOD_NEK2_1	111	116	PF00069	0.657
MOD_NEK2_1	277	282	PF00069	0.434
MOD_NEK2_1	300	305	PF00069	0.478
MOD_NEK2_1	376	381	PF00069	0.595
MOD_NEK2_1	4	9	PF00069	0.678
MOD_NEK2_2	230	235	PF00069	0.523
MOD_NEK2_2	351	356	PF00069	0.574
MOD_PIKK_1	277	283	PF00454	0.481
MOD_PIKK_1	42	48	PF00454	0.555
MOD_PKA_1	211	217	PF00069	0.627
MOD_PKA_2	323	329	PF00069	0.756
MOD_PKA_2	351	357	PF00069	0.594
MOD_Plk_2-3	359	365	PF00069	0.449
MOD_Plk_4	106	112	PF00069	0.605
MOD_ProDKin_1	131	137	PF00069	0.605
MOD_ProDKin_1	14	20	PF00069	0.454
MOD_ProDKin_1	196	202	PF00069	0.545
MOD_ProDKin_1	267	273	PF00069	0.493
MOD_ProDKin_1	338	344	PF00069	0.626
MOD_ProDKin_1	70	76	PF00069	0.691
MOD_SUMO_for_1	117	120	PF00179	0.502
MOD_SUMO_for_1	34	37	PF00179	0.573
MOD_SUMO_for_1	50	53	PF00179	0.405
MOD_SUMO_rev_2	120	130	PF00179	0.770
MOD_SUMO_rev_2	209	214	PF00179	0.751
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.558
TRG_ENDOCYTIC_2	56	59	PF00928	0.511
TRG_ER_diArg_1	178	181	PF00400	0.589
TRG_ER_diArg_1	282	284	PF00400	0.590
TRG_ER_diArg_1	380	383	PF00400	0.544
TRG_ER_diArg_1	385	387	PF00400	0.523
TRG_NLS_Bipartite_1	202	224	PF00514	0.729
TRG_NLS_MonoCore_2	201	206	PF00514	0.658
TRG_NLS_MonoExtC_3	219	225	PF00514	0.650
TRG_NLS_MonoExtN_4	200	206	PF00514	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU67	Leptomonas seymouri	46%	86%
A0A0S4JF36	Bodo saltans	26%	95%
A0A422P3G4	Trypanosoma rangeli	32%	74%
A4HIS1	Leishmania braziliensis	67%	98%
A4I617	Leishmania infantum	99%	100%
C9ZQY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	79%
E9B1A8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q6V6	Leishmania major	87%	100%
V5BPG9	Trypanosoma cruzi	32%	71%