Component of IIS longevity pathway SMK-1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFV0_LEIDO

TriTrypDb:

LdBPK_313090.1 , LdCL_310039200 , LDHU3_31.5300

Length:

987

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0008287	protein serine/threonine phosphatase complex	4	1
GO:0030289	protein phosphatase 4 complex	5	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1903293	phosphatase complex	3	1

Expansion

Sequence features

A0A3Q8IFV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFV0

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0008047	enzyme activator activity	3	1
GO:0019208	phosphatase regulator activity	3	1
GO:0019211	phosphatase activator activity	4	1
GO:0019888	protein phosphatase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0072542	protein phosphatase activator activity	5	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.486
CLV_C14_Caspase3-7	39	43	PF00656	0.646
CLV_C14_Caspase3-7	490	494	PF00656	0.462
CLV_C14_Caspase3-7	508	512	PF00656	0.301
CLV_C14_Caspase3-7	599	603	PF00656	0.547
CLV_C14_Caspase3-7	649	653	PF00656	0.502
CLV_C14_Caspase3-7	679	683	PF00656	0.567
CLV_C14_Caspase3-7	867	871	PF00656	0.791
CLV_C14_Caspase3-7	890	894	PF00656	0.721
CLV_C14_Caspase3-7	961	965	PF00656	0.802
CLV_MEL_PAP_1	952	958	PF00089	0.728
CLV_NRD_NRD_1	146	148	PF00675	0.539
CLV_NRD_NRD_1	255	257	PF00675	0.359
CLV_NRD_NRD_1	268	270	PF00675	0.220
CLV_NRD_NRD_1	518	520	PF00675	0.450
CLV_NRD_NRD_1	631	633	PF00675	0.614
CLV_NRD_NRD_1	650	652	PF00675	0.283
CLV_NRD_NRD_1	954	956	PF00675	0.783
CLV_PCSK_FUR_1	144	148	PF00082	0.557
CLV_PCSK_KEX2_1	146	148	PF00082	0.561
CLV_PCSK_KEX2_1	179	181	PF00082	0.559
CLV_PCSK_KEX2_1	255	257	PF00082	0.359
CLV_PCSK_KEX2_1	268	270	PF00082	0.220
CLV_PCSK_KEX2_1	518	520	PF00082	0.412
CLV_PCSK_KEX2_1	60	62	PF00082	0.769
CLV_PCSK_KEX2_1	631	633	PF00082	0.614
CLV_PCSK_KEX2_1	650	652	PF00082	0.273
CLV_PCSK_KEX2_1	954	956	PF00082	0.783
CLV_PCSK_KEX2_1	959	961	PF00082	0.787
CLV_PCSK_KEX2_1	978	980	PF00082	0.712
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.559
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.769
CLV_PCSK_PC1ET2_1	959	961	PF00082	0.787
CLV_PCSK_PC1ET2_1	978	980	PF00082	0.700
CLV_PCSK_PC7_1	955	961	PF00082	0.783
CLV_PCSK_SKI1_1	134	138	PF00082	0.523
CLV_PCSK_SKI1_1	216	220	PF00082	0.398
CLV_PCSK_SKI1_1	268	272	PF00082	0.328
CLV_PCSK_SKI1_1	379	383	PF00082	0.445
CLV_PCSK_SKI1_1	469	473	PF00082	0.469
CLV_PCSK_SKI1_1	477	481	PF00082	0.489
CLV_PCSK_SKI1_1	654	658	PF00082	0.578
CLV_Separin_Metazoa	433	437	PF03568	0.372
CLV_Separin_Metazoa	521	525	PF03568	0.505
DEG_APCC_DBOX_1	468	476	PF00400	0.486
DEG_APCC_DBOX_1	533	541	PF00400	0.383
DEG_Nend_UBRbox_2	1	3	PF02207	0.605
DEG_SPOP_SBC_1	684	688	PF00917	0.517
DEG_SPOP_SBC_1	791	795	PF00917	0.560
DEG_SPOP_SBC_1	899	903	PF00917	0.766
DEG_SPOP_SBC_1	919	923	PF00917	0.658
DOC_CKS1_1	824	829	PF01111	0.716
DOC_CKS1_1	874	879	PF01111	0.600
DOC_CYCLIN_RxL_1	469	480	PF00134	0.523
DOC_CYCLIN_yClb5_NLxxxL_5	162	171	PF00134	0.444
DOC_MAPK_gen_1	179	185	PF00069	0.542
DOC_MAPK_gen_1	255	265	PF00069	0.379
DOC_MAPK_gen_1	379	388	PF00069	0.446
DOC_MAPK_gen_1	518	525	PF00069	0.433
DOC_MAPK_gen_1	650	658	PF00069	0.473
DOC_MAPK_MEF2A_6	296	303	PF00069	0.328
DOC_MAPK_MEF2A_6	382	390	PF00069	0.531
DOC_MAPK_MEF2A_6	469	476	PF00069	0.504
DOC_MAPK_NFAT4_5	296	304	PF00069	0.363
DOC_MAPK_NFAT4_5	469	477	PF00069	0.510
DOC_PP2B_LxvP_1	889	892	PF13499	0.586
DOC_PP2B_LxvP_1	935	938	PF13499	0.703
DOC_PP2B_PxIxI_1	283	289	PF00149	0.475
DOC_PP4_FxxP_1	222	225	PF00568	0.475
DOC_PP4_FxxP_1	272	275	PF00568	0.328
DOC_SPAK_OSR1_1	524	528	PF12202	0.440
DOC_USP7_MATH_1	37	41	PF00917	0.681
DOC_USP7_MATH_1	51	55	PF00917	0.734
DOC_USP7_MATH_1	663	667	PF00917	0.602
DOC_USP7_MATH_1	791	795	PF00917	0.572
DOC_USP7_MATH_1	845	849	PF00917	0.732
DOC_USP7_MATH_1	858	862	PF00917	0.790
DOC_USP7_MATH_1	882	886	PF00917	0.773
DOC_USP7_MATH_1	899	903	PF00917	0.781
DOC_USP7_MATH_1	920	924	PF00917	0.786
DOC_USP7_MATH_1	982	986	PF00917	0.712
DOC_WW_Pin1_4	221	226	PF00397	0.385
DOC_WW_Pin1_4	329	334	PF00397	0.363
DOC_WW_Pin1_4	348	353	PF00397	0.633
DOC_WW_Pin1_4	625	630	PF00397	0.599
DOC_WW_Pin1_4	717	722	PF00397	0.618
DOC_WW_Pin1_4	779	784	PF00397	0.501
DOC_WW_Pin1_4	819	824	PF00397	0.638
DOC_WW_Pin1_4	873	878	PF00397	0.737
DOC_WW_Pin1_4	891	896	PF00397	0.714
LIG_14-3-3_CanoR_1	134	140	PF00244	0.504
LIG_14-3-3_CanoR_1	216	222	PF00244	0.434
LIG_14-3-3_CanoR_1	268	273	PF00244	0.328
LIG_14-3-3_CanoR_1	320	324	PF00244	0.449
LIG_14-3-3_CanoR_1	341	345	PF00244	0.398
LIG_14-3-3_CanoR_1	477	482	PF00244	0.500
LIG_14-3-3_CanoR_1	553	557	PF00244	0.662
LIG_14-3-3_CanoR_1	654	659	PF00244	0.574
LIG_BRCT_BRCA1_1	290	294	PF00533	0.428
LIG_EH1_1	25	33	PF00400	0.378
LIG_eIF4E_1	539	545	PF01652	0.443
LIG_FHA_1	104	110	PF00498	0.482
LIG_FHA_1	314	320	PF00498	0.441
LIG_FHA_1	325	331	PF00498	0.394
LIG_FHA_1	406	412	PF00498	0.435
LIG_FHA_1	622	628	PF00498	0.553
LIG_FHA_1	639	645	PF00498	0.296
LIG_FHA_1	668	674	PF00498	0.387
LIG_FHA_1	752	758	PF00498	0.502
LIG_FHA_1	791	797	PF00498	0.561
LIG_FHA_1	910	916	PF00498	0.792
LIG_FHA_2	269	275	PF00498	0.449
LIG_FHA_2	340	346	PF00498	0.485
LIG_FHA_2	506	512	PF00498	0.424
LIG_FHA_2	63	69	PF00498	0.770
LIG_FHA_2	644	650	PF00498	0.464
LIG_FHA_2	845	851	PF00498	0.768
LIG_FHA_2	959	965	PF00498	0.596
LIG_FXI_DFP_1	808	812	PF00024	0.612
LIG_GBD_Chelix_1	540	548	PF00786	0.458
LIG_IRF3_LxIS_1	32	39	PF10401	0.555
LIG_LIR_Apic_2	220	225	PF02991	0.300
LIG_LIR_Apic_2	271	275	PF02991	0.328
LIG_LIR_Gen_1	18	29	PF02991	0.410
LIG_LIR_Gen_1	259	270	PF02991	0.325
LIG_LIR_Gen_1	310	319	PF02991	0.449
LIG_LIR_Gen_1	393	403	PF02991	0.369
LIG_LIR_Gen_1	720	726	PF02991	0.633
LIG_LIR_Gen_1	806	816	PF02991	0.516
LIG_LIR_Gen_1	91	100	PF02991	0.519
LIG_LIR_Nem_3	130	136	PF02991	0.444
LIG_LIR_Nem_3	18	24	PF02991	0.579
LIG_LIR_Nem_3	259	265	PF02991	0.322
LIG_LIR_Nem_3	310	314	PF02991	0.417
LIG_LIR_Nem_3	393	398	PF02991	0.363
LIG_LIR_Nem_3	720	725	PF02991	0.623
LIG_LIR_Nem_3	806	811	PF02991	0.559
LIG_LIR_Nem_3	91	96	PF02991	0.511
LIG_NRBOX	470	476	PF00104	0.349
LIG_PCNA_PIPBox_1	637	646	PF02747	0.530
LIG_PCNA_yPIPBox_3	631	644	PF02747	0.414
LIG_PDZ_Class_1	982	987	PF00595	0.728
LIG_Pex14_2	317	321	PF04695	0.449
LIG_SH2_CRK	133	137	PF00017	0.533
LIG_SH2_CRK	311	315	PF00017	0.449
LIG_SH2_NCK_1	446	450	PF00017	0.469
LIG_SH2_PTP2	93	96	PF00017	0.515
LIG_SH2_SRC	111	114	PF00017	0.565
LIG_SH2_STAP1	111	115	PF00017	0.567
LIG_SH2_STAP1	418	422	PF00017	0.448
LIG_SH2_STAT3	100	103	PF00017	0.400
LIG_SH2_STAT5	100	103	PF00017	0.378
LIG_SH2_STAT5	184	187	PF00017	0.433
LIG_SH2_STAT5	191	194	PF00017	0.307
LIG_SH2_STAT5	539	542	PF00017	0.479
LIG_SH2_STAT5	675	678	PF00017	0.466
LIG_SH2_STAT5	93	96	PF00017	0.429
LIG_SH3_3	327	333	PF00018	0.457
LIG_SH3_3	429	435	PF00018	0.523
LIG_SH3_3	497	503	PF00018	0.509
LIG_SH3_3	529	535	PF00018	0.528
LIG_SH3_3	551	557	PF00018	0.664
LIG_SH3_3	742	748	PF00018	0.655
LIG_SH3_3	871	877	PF00018	0.793
LIG_SH3_3	889	895	PF00018	0.584
LIG_SUMO_SIM_anti_2	243	250	PF11976	0.413
LIG_SUMO_SIM_anti_2	607	614	PF11976	0.503
LIG_SUMO_SIM_par_1	502	508	PF11976	0.296
LIG_SUMO_SIM_par_1	607	614	PF11976	0.467
LIG_SUMO_SIM_par_1	654	660	PF11976	0.547
LIG_SUMO_SIM_par_1	753	758	PF11976	0.504
LIG_TRAF2_1	264	267	PF00917	0.363
LIG_TRAF2_1	65	68	PF00917	0.770
LIG_TRAF2_1	778	781	PF00917	0.473
LIG_TYR_ITIM	770	775	PF00017	0.578
LIG_UBA3_1	609	617	PF00899	0.549
LIG_WRC_WIRS_1	262	267	PF05994	0.385
LIG_WRC_WIRS_1	314	319	PF05994	0.449
LIG_WRC_WIRS_1	506	511	PF05994	0.324
LIG_WRC_WIRS_1	640	645	PF05994	0.437
LIG_WW_3	433	437	PF00397	0.547
MOD_CDC14_SPxK_1	628	631	PF00782	0.646
MOD_CDK_SPxK_1	625	631	PF00069	0.612
MOD_CDK_SPxxK_3	625	632	PF00069	0.618
MOD_CK1_1	15	21	PF00069	0.579
MOD_CK1_1	312	318	PF00069	0.342
MOD_CK1_1	447	453	PF00069	0.460
MOD_CK1_1	638	644	PF00069	0.432
MOD_CK1_1	710	716	PF00069	0.667
MOD_CK1_1	795	801	PF00069	0.571
MOD_CK1_1	803	809	PF00069	0.544
MOD_CK1_1	861	867	PF00069	0.730
MOD_CK1_1	885	891	PF00069	0.669
MOD_CK1_1	909	915	PF00069	0.754
MOD_CK1_1	92	98	PF00069	0.562
MOD_CK1_1	923	929	PF00069	0.785
MOD_CK2_1	261	267	PF00069	0.344
MOD_CK2_1	339	345	PF00069	0.398
MOD_CK2_1	481	487	PF00069	0.507
MOD_CK2_1	605	611	PF00069	0.497
MOD_CK2_1	62	68	PF00069	0.778
MOD_CK2_1	730	736	PF00069	0.693
MOD_CK2_1	795	801	PF00069	0.581
MOD_CK2_1	844	850	PF00069	0.727
MOD_CK2_1	866	872	PF00069	0.731
MOD_CK2_1	940	946	PF00069	0.787
MOD_Cter_Amidation	253	256	PF01082	0.363
MOD_Cter_Amidation	58	61	PF01082	0.766
MOD_GlcNHglycan	2	5	PF01048	0.658
MOD_GlcNHglycan	259	262	PF01048	0.385
MOD_GlcNHglycan	352	355	PF01048	0.655
MOD_GlcNHglycan	39	42	PF01048	0.643
MOD_GlcNHglycan	483	486	PF01048	0.502
MOD_GlcNHglycan	53	56	PF01048	0.724
MOD_GlcNHglycan	560	563	PF01048	0.624
MOD_GlcNHglycan	712	715	PF01048	0.649
MOD_GlcNHglycan	801	805	PF01048	0.693
MOD_GlcNHglycan	880	883	PF01048	0.795
MOD_GlcNHglycan	889	892	PF01048	0.635
MOD_GlcNHglycan	902	905	PF01048	0.777
MOD_GlcNHglycan	908	911	PF01048	0.625
MOD_GlcNHglycan	926	929	PF01048	0.755
MOD_GlcNHglycan	938	941	PF01048	0.683
MOD_GlcNHglycan	983	987	PF01048	0.731
MOD_GSK3_1	135	142	PF00069	0.571
MOD_GSK3_1	15	22	PF00069	0.447
MOD_GSK3_1	217	224	PF00069	0.342
MOD_GSK3_1	257	264	PF00069	0.385
MOD_GSK3_1	309	316	PF00069	0.344
MOD_GSK3_1	355	362	PF00069	0.577
MOD_GSK3_1	37	44	PF00069	0.686
MOD_GSK3_1	477	484	PF00069	0.442
MOD_GSK3_1	601	608	PF00069	0.538
MOD_GSK3_1	62	69	PF00069	0.762
MOD_GSK3_1	621	628	PF00069	0.345
MOD_GSK3_1	635	642	PF00069	0.344
MOD_GSK3_1	663	670	PF00069	0.472
MOD_GSK3_1	705	712	PF00069	0.561
MOD_GSK3_1	713	720	PF00069	0.614
MOD_GSK3_1	751	758	PF00069	0.535
MOD_GSK3_1	791	798	PF00069	0.562
MOD_GSK3_1	819	826	PF00069	0.687
MOD_GSK3_1	840	847	PF00069	0.689
MOD_GSK3_1	878	885	PF00069	0.653
MOD_GSK3_1	88	95	PF00069	0.405
MOD_GSK3_1	887	894	PF00069	0.627
MOD_GSK3_1	909	916	PF00069	0.798
MOD_GSK3_1	919	926	PF00069	0.774
MOD_GSK3_1	936	943	PF00069	0.665
MOD_GSK3_1	954	961	PF00069	0.784
MOD_NEK2_1	313	318	PF00069	0.363
MOD_NEK2_1	319	324	PF00069	0.363
MOD_NEK2_1	577	582	PF00069	0.571
MOD_NEK2_1	613	618	PF00069	0.435
MOD_NEK2_1	622	627	PF00069	0.438
MOD_NEK2_1	636	641	PF00069	0.304
MOD_NEK2_1	643	648	PF00069	0.386
MOD_NEK2_1	667	672	PF00069	0.442
MOD_NEK2_1	676	681	PF00069	0.444
MOD_NEK2_1	685	690	PF00069	0.259
MOD_NEK2_1	705	710	PF00069	0.619
MOD_NEK2_1	840	845	PF00069	0.754
MOD_NEK2_1	88	93	PF00069	0.425
MOD_NEK2_1	918	923	PF00069	0.743
MOD_NEK2_1	924	929	PF00069	0.689
MOD_OFUCOSY	442	448	PF10250	0.411
MOD_PIKK_1	755	761	PF00454	0.574
MOD_PK_1	954	960	PF00069	0.771
MOD_PKA_1	268	274	PF00069	0.328
MOD_PKA_1	954	960	PF00069	0.783
MOD_PKA_2	268	274	PF00069	0.341
MOD_PKA_2	319	325	PF00069	0.449
MOD_PKA_2	340	346	PF00069	0.439
MOD_PKA_2	552	558	PF00069	0.651
MOD_PKA_2	762	768	PF00069	0.473
MOD_PKA_2	940	946	PF00069	0.787
MOD_PKA_2	954	960	PF00069	0.783
MOD_PKB_1	960	968	PF00069	0.630
MOD_Plk_1	418	424	PF00069	0.459
MOD_Plk_1	728	734	PF00069	0.664
MOD_Plk_1	791	797	PF00069	0.561
MOD_Plk_1	800	806	PF00069	0.569
MOD_Plk_2-3	207	213	PF00069	0.475
MOD_Plk_2-3	355	361	PF00069	0.578
MOD_Plk_2-3	487	493	PF00069	0.484
MOD_Plk_2-3	866	872	PF00069	0.796
MOD_Plk_4	103	109	PF00069	0.353
MOD_Plk_4	217	223	PF00069	0.358
MOD_Plk_4	27	33	PF00069	0.439
MOD_Plk_4	278	284	PF00069	0.346
MOD_Plk_4	309	315	PF00069	0.320
MOD_Plk_4	331	337	PF00069	0.462
MOD_Plk_4	394	400	PF00069	0.395
MOD_Plk_4	441	447	PF00069	0.417
MOD_Plk_4	487	493	PF00069	0.484
MOD_Plk_4	577	583	PF00069	0.556
MOD_Plk_4	605	611	PF00069	0.446
MOD_Plk_4	622	628	PF00069	0.371
MOD_Plk_4	639	645	PF00069	0.250
MOD_Plk_4	654	660	PF00069	0.460
MOD_Plk_4	663	669	PF00069	0.512
MOD_Plk_4	721	727	PF00069	0.681
MOD_Plk_4	751	757	PF00069	0.544
MOD_Plk_4	89	95	PF00069	0.461
MOD_Plk_4	940	946	PF00069	0.787
MOD_ProDKin_1	221	227	PF00069	0.385
MOD_ProDKin_1	329	335	PF00069	0.363
MOD_ProDKin_1	348	354	PF00069	0.629
MOD_ProDKin_1	625	631	PF00069	0.612
MOD_ProDKin_1	717	723	PF00069	0.618
MOD_ProDKin_1	779	785	PF00069	0.505
MOD_ProDKin_1	819	825	PF00069	0.647
MOD_ProDKin_1	873	879	PF00069	0.729
MOD_ProDKin_1	891	897	PF00069	0.718
MOD_SUMO_rev_2	224	233	PF00179	0.366
MOD_SUMO_rev_2	970	980	PF00179	0.718
TRG_AP2beta_CARGO_1	259	269	PF09066	0.437
TRG_DiLeu_BaEn_2	368	374	PF01217	0.391
TRG_DiLeu_BaLyEn_6	470	475	PF01217	0.378
TRG_ENDOCYTIC_2	133	136	PF00928	0.447
TRG_ENDOCYTIC_2	311	314	PF00928	0.449
TRG_ENDOCYTIC_2	772	775	PF00928	0.566
TRG_ENDOCYTIC_2	93	96	PF00928	0.515
TRG_ER_diArg_1	144	147	PF00400	0.551
TRG_ER_diArg_1	631	633	PF00400	0.616
TRG_ER_diArg_1	953	955	PF00400	0.782
TRG_NLS_MonoExtC_3	958	964	PF00514	0.783
TRG_NLS_MonoExtC_3	977	983	PF00514	0.705
TRG_Pf-PMV_PEXEL_1	777	781	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P1	Leptomonas seymouri	66%	100%
A0A1X0NIG3	Trypanosomatidae	36%	100%
A0A3S5IR35	Trypanosoma rangeli	36%	100%
A4HJT7	Leishmania braziliensis	82%	100%
A4I7A3	Leishmania infantum	99%	100%
C9ZMI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZWJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B298	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q5W0	Leishmania major	96%	100%
V5B7M8	Trypanosoma cruzi	36%	100%