Leucine rich repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFU8_LEIDO

TriTrypDb:

LdBPK_261200.1 , LdCL_260017600 , LDHU3_26.1490

Length:

668

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3Q8IFU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFU8

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0036158	outer dynein arm assembly	7	10
GO:0036159	inner dynein arm assembly	7	10
GO:0043933	protein-containing complex organization	4	10
GO:0065003	protein-containing complex assembly	5	10
GO:0070286	axonemal dynein complex assembly	6	10
GO:0071840	cellular component organization or biogenesis	2	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0044877	protein-containing complex binding	2	10
GO:0070840	dynein complex binding	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.705
CLV_C14_Caspase3-7	525	529	PF00656	0.734
CLV_C14_Caspase3-7	552	556	PF00656	0.788
CLV_C14_Caspase3-7	593	597	PF00656	0.712
CLV_C14_Caspase3-7	600	604	PF00656	0.729
CLV_NRD_NRD_1	266	268	PF00675	0.653
CLV_NRD_NRD_1	338	340	PF00675	0.714
CLV_NRD_NRD_1	430	432	PF00675	0.404
CLV_NRD_NRD_1	454	456	PF00675	0.417
CLV_NRD_NRD_1	491	493	PF00675	0.515
CLV_PCSK_FUR_1	437	441	PF00082	0.568
CLV_PCSK_KEX2_1	266	268	PF00082	0.747
CLV_PCSK_KEX2_1	296	298	PF00082	0.561
CLV_PCSK_KEX2_1	338	340	PF00082	0.714
CLV_PCSK_KEX2_1	432	434	PF00082	0.512
CLV_PCSK_KEX2_1	439	441	PF00082	0.532
CLV_PCSK_KEX2_1	454	456	PF00082	0.308
CLV_PCSK_KEX2_1	491	493	PF00082	0.504
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.577
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.512
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.576
CLV_PCSK_SKI1_1	173	177	PF00082	0.426
CLV_PCSK_SKI1_1	432	436	PF00082	0.464
CLV_PCSK_SKI1_1	439	443	PF00082	0.456
CLV_PCSK_SKI1_1	447	451	PF00082	0.408
CLV_PCSK_SKI1_1	455	459	PF00082	0.355
DEG_COP1_1	655	667	PF00400	0.607
DEG_ODPH_VHL_1	72	85	PF01847	0.486
DEG_SIAH_1	106	114	PF03145	0.594
DEG_SPOP_SBC_1	624	628	PF00917	0.675
DOC_CDC14_PxL_1	407	415	PF14671	0.441
DOC_CYCLIN_RxL_1	433	446	PF00134	0.532
DOC_MAPK_gen_1	201	210	PF00069	0.528
DOC_MAPK_gen_1	296	303	PF00069	0.509
DOC_MAPK_gen_1	338	345	PF00069	0.751
DOC_MAPK_gen_1	409	418	PF00069	0.415
DOC_MAPK_gen_1	437	444	PF00069	0.493
DOC_PP1_RVXF_1	82	88	PF00149	0.397
DOC_USP7_MATH_1	113	117	PF00917	0.564
DOC_USP7_MATH_1	175	179	PF00917	0.505
DOC_USP7_MATH_1	246	250	PF00917	0.755
DOC_USP7_MATH_1	25	29	PF00917	0.734
DOC_USP7_MATH_1	358	362	PF00917	0.466
DOC_USP7_MATH_1	535	539	PF00917	0.767
DOC_USP7_MATH_1	599	603	PF00917	0.692
DOC_USP7_MATH_1	624	628	PF00917	0.759
DOC_USP7_MATH_1	645	649	PF00917	0.800
DOC_WW_Pin1_4	148	153	PF00397	0.739
DOC_WW_Pin1_4	239	244	PF00397	0.670
DOC_WW_Pin1_4	317	322	PF00397	0.616
LIG_14-3-3_CanoR_1	267	275	PF00244	0.756
LIG_14-3-3_CanoR_1	305	315	PF00244	0.480
LIG_14-3-3_CanoR_1	338	344	PF00244	0.791
LIG_14-3-3_CanoR_1	356	365	PF00244	0.440
LIG_14-3-3_CanoR_1	412	417	PF00244	0.424
LIG_14-3-3_CanoR_1	454	462	PF00244	0.579
LIG_14-3-3_CanoR_1	623	630	PF00244	0.819
LIG_14-3-3_CanoR_1	635	643	PF00244	0.641
LIG_Actin_WH2_2	403	419	PF00022	0.413
LIG_AP2alpha_2	112	114	PF02296	0.693
LIG_APCC_ABBA_1	77	82	PF00400	0.461
LIG_APCC_ABBAyCdc20_2	439	445	PF00400	0.493
LIG_BIR_II_1	1	5	PF00653	0.696
LIG_BRCT_BRCA1_1	210	214	PF00533	0.460
LIG_BRCT_BRCA1_2	210	216	PF00533	0.377
LIG_Clathr_ClatBox_1	404	408	PF01394	0.404
LIG_Clathr_ClatBox_1	441	445	PF01394	0.404
LIG_eIF4E_1	187	193	PF01652	0.546
LIG_FHA_1	205	211	PF00498	0.351
LIG_FHA_1	307	313	PF00498	0.445
LIG_FHA_1	38	44	PF00498	0.446
LIG_FHA_1	549	555	PF00498	0.561
LIG_FHA_1	7	13	PF00498	0.752
LIG_FHA_2	520	526	PF00498	0.655
LIG_FHA_2	557	563	PF00498	0.691
LIG_FHA_2	73	79	PF00498	0.542
LIG_LIR_Gen_1	174	183	PF02991	0.393
LIG_LIR_Gen_1	200	210	PF02991	0.438
LIG_LIR_Gen_1	310	321	PF02991	0.467
LIG_LIR_Gen_1	78	88	PF02991	0.406
LIG_LIR_Nem_3	174	179	PF02991	0.400
LIG_LIR_Nem_3	200	205	PF02991	0.455
LIG_LIR_Nem_3	310	316	PF02991	0.433
LIG_LIR_Nem_3	488	493	PF02991	0.528
LIG_LIR_Nem_3	75	80	PF02991	0.419
LIG_LYPXL_S_1	179	183	PF13949	0.400
LIG_LYPXL_yS_3	180	183	PF13949	0.401
LIG_PDZ_Class_1	663	668	PF00595	0.558
LIG_PTB_Apo_2	187	194	PF02174	0.522
LIG_PTB_Apo_2	63	70	PF02174	0.497
LIG_PTB_Phospho_1	63	69	PF10480	0.567
LIG_REV1ctd_RIR_1	212	219	PF16727	0.386
LIG_SH2_CRK	102	106	PF00017	0.605
LIG_SH2_CRK	384	388	PF00017	0.445
LIG_SH2_CRK	53	57	PF00017	0.441
LIG_SH2_CRK	69	73	PF00017	0.418
LIG_SH2_GRB2like	510	513	PF00017	0.607
LIG_SH2_NCK_1	69	73	PF00017	0.562
LIG_SH2_SRC	510	513	PF00017	0.685
LIG_SH2_STAP1	225	229	PF00017	0.577
LIG_SH2_STAP1	69	73	PF00017	0.562
LIG_SH2_STAT5	102	105	PF00017	0.588
LIG_SH2_STAT5	187	190	PF00017	0.474
LIG_SH2_STAT5	510	513	PF00017	0.647
LIG_SH2_STAT5	63	66	PF00017	0.418
LIG_SH2_STAT5	80	83	PF00017	0.410
LIG_SH3_3	102	108	PF00018	0.586
LIG_SH3_3	126	132	PF00018	0.737
LIG_SH3_3	286	292	PF00018	0.658
LIG_SH3_3	345	351	PF00018	0.744
LIG_SH3_5	506	510	PF00018	0.677
LIG_SUMO_SIM_anti_2	283	290	PF11976	0.698
LIG_SUMO_SIM_anti_2	386	391	PF11976	0.481
LIG_SUMO_SIM_anti_2	401	408	PF11976	0.292
LIG_SUMO_SIM_par_1	287	294	PF11976	0.494
LIG_SUMO_SIM_par_1	388	393	PF11976	0.375
LIG_SUMO_SIM_par_1	401	408	PF11976	0.386
LIG_TRAF2_1	474	477	PF00917	0.615
LIG_TYR_ITIM	382	387	PF00017	0.439
MOD_CK1_1	151	157	PF00069	0.737
MOD_CK1_1	23	29	PF00069	0.670
MOD_CK1_1	242	248	PF00069	0.673
MOD_CK1_1	249	255	PF00069	0.596
MOD_CK1_1	361	367	PF00069	0.376
MOD_CK1_1	539	545	PF00069	0.771
MOD_CK1_1	556	562	PF00069	0.733
MOD_CK1_1	648	654	PF00069	0.779
MOD_CK2_1	113	119	PF00069	0.501
MOD_CK2_1	151	157	PF00069	0.596
MOD_CK2_1	197	203	PF00069	0.580
MOD_CK2_1	535	541	PF00069	0.710
MOD_CK2_1	556	562	PF00069	0.716
MOD_CK2_1	609	615	PF00069	0.798
MOD_CK2_1	72	78	PF00069	0.457
MOD_GlcNHglycan	210	213	PF01048	0.470
MOD_GlcNHglycan	226	229	PF01048	0.390
MOD_GlcNHglycan	244	247	PF01048	0.652
MOD_GlcNHglycan	248	251	PF01048	0.739
MOD_GlcNHglycan	27	30	PF01048	0.660
MOD_GlcNHglycan	275	278	PF01048	0.708
MOD_GlcNHglycan	418	421	PF01048	0.401
MOD_GlcNHglycan	574	577	PF01048	0.807
MOD_GlcNHglycan	580	583	PF01048	0.776
MOD_GlcNHglycan	665	668	PF01048	0.629
MOD_GSK3_1	1	8	PF00069	0.732
MOD_GSK3_1	11	18	PF00069	0.686
MOD_GSK3_1	175	182	PF00069	0.472
MOD_GSK3_1	20	27	PF00069	0.624
MOD_GSK3_1	204	211	PF00069	0.319
MOD_GSK3_1	238	245	PF00069	0.749
MOD_GSK3_1	249	256	PF00069	0.717
MOD_GSK3_1	273	280	PF00069	0.724
MOD_GSK3_1	30	37	PF00069	0.537
MOD_GSK3_1	307	314	PF00069	0.436
MOD_GSK3_1	357	364	PF00069	0.413
MOD_GSK3_1	412	419	PF00069	0.430
MOD_GSK3_1	519	526	PF00069	0.619
MOD_GSK3_1	535	542	PF00069	0.745
MOD_GSK3_1	549	556	PF00069	0.704
MOD_GSK3_1	574	581	PF00069	0.694
MOD_GSK3_1	68	75	PF00069	0.537
MOD_LATS_1	336	342	PF00433	0.612
MOD_LATS_1	546	552	PF00433	0.699
MOD_N-GLC_1	20	25	PF02516	0.727
MOD_N-GLC_1	208	213	PF02516	0.395
MOD_N-GLC_1	31	36	PF02516	0.629
MOD_N-GLC_1	590	595	PF02516	0.797
MOD_NEK2_1	192	197	PF00069	0.545
MOD_NEK2_1	24	29	PF00069	0.674
MOD_NEK2_1	253	258	PF00069	0.657
MOD_NEK2_1	390	395	PF00069	0.362
MOD_NEK2_1	416	421	PF00069	0.407
MOD_NEK2_1	423	428	PF00069	0.441
MOD_NEK2_1	554	559	PF00069	0.567
MOD_NEK2_1	590	595	PF00069	0.573
MOD_NEK2_1	609	614	PF00069	0.802
MOD_NEK2_2	175	180	PF00069	0.475
MOD_NEK2_2	358	363	PF00069	0.469
MOD_PIKK_1	100	106	PF00454	0.541
MOD_PIKK_1	609	615	PF00454	0.801
MOD_PIKK_1	625	631	PF00454	0.815
MOD_PKA_1	338	344	PF00069	0.717
MOD_PKA_2	306	312	PF00069	0.486
MOD_PKA_2	338	344	PF00069	0.795
MOD_PKA_2	536	542	PF00069	0.793
MOD_PKA_2	6	12	PF00069	0.671
MOD_PKB_1	305	313	PF00069	0.279
MOD_PKB_1	431	439	PF00069	0.521
MOD_Plk_1	158	164	PF00069	0.677
MOD_Plk_1	197	203	PF00069	0.501
MOD_Plk_1	20	26	PF00069	0.750
MOD_Plk_1	284	290	PF00069	0.640
MOD_Plk_4	12	18	PF00069	0.552
MOD_Plk_4	175	181	PF00069	0.398
MOD_Plk_4	249	255	PF00069	0.589
MOD_Plk_4	284	290	PF00069	0.758
MOD_Plk_4	91	97	PF00069	0.571
MOD_ProDKin_1	148	154	PF00069	0.737
MOD_ProDKin_1	239	245	PF00069	0.664
MOD_ProDKin_1	317	323	PF00069	0.621
MOD_SUMO_rev_2	612	619	PF00179	0.721
MOD_SUMO_rev_2	78	86	PF00179	0.410
TRG_DiLeu_BaEn_1	401	406	PF01217	0.402
TRG_DiLeu_BaLyEn_6	437	442	PF01217	0.570
TRG_DiLeu_BaLyEn_6	489	494	PF01217	0.600
TRG_ENDOCYTIC_2	102	105	PF00928	0.588
TRG_ENDOCYTIC_2	180	183	PF00928	0.388
TRG_ENDOCYTIC_2	384	387	PF00928	0.413
TRG_ENDOCYTIC_2	69	72	PF00928	0.482
TRG_ENDOCYTIC_2	80	83	PF00928	0.342
TRG_ER_diArg_1	338	340	PF00400	0.761
TRG_ER_diArg_1	430	433	PF00400	0.512
TRG_ER_diArg_1	454	456	PF00400	0.417
TRG_ER_diArg_1	490	492	PF00400	0.519
TRG_NLS_MonoExtN_4	428	435	PF00514	0.525
TRG_Pf-PMV_PEXEL_1	440	445	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	617	621	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C5	Leptomonas seymouri	53%	100%
A0A0S4JQS0	Bodo saltans	37%	100%
A0A422N6Q2	Trypanosoma rangeli	41%	100%
A4HEX7	Leishmania braziliensis	71%	98%
A4I251	Leishmania infantum	99%	100%
C9ZRV3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AYA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q972	Leishmania major	90%	100%
V5DQX0	Trypanosoma cruzi	39%	90%