Homologous to eukaryotic mitochondrial carriers responsible for FAD and/or folate uptake. In some organisms, homologs also transport thiamine.. Localization: Mitochondrial (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 26 |
| NetGPI | no | yes: 0, no: 26 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 27 |
| GO:0110165 | cellular anatomical entity | 1 | 27 |
| GO:0005739 | mitochondrion | 5 | 2 |
| GO:0043226 | organelle | 2 | 2 |
| GO:0043227 | membrane-bounded organelle | 3 | 2 |
| GO:0043229 | intracellular organelle | 3 | 2 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 2 |
Related structures:
AlphaFold database: A0A3Q8IFU6
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006810 | transport | 3 | 27 |
| GO:0006862 | nucleotide transport | 6 | 24 |
| GO:0009987 | cellular process | 1 | 27 |
| GO:0015748 | organophosphate ester transport | 5 | 24 |
| GO:0015931 | nucleobase-containing compound transport | 5 | 24 |
| GO:0051179 | localization | 1 | 27 |
| GO:0051234 | establishment of localization | 2 | 27 |
| GO:0055085 | transmembrane transport | 2 | 27 |
| GO:0071702 | organic substance transport | 4 | 27 |
| GO:0071705 | nitrogen compound transport | 4 | 27 |
| GO:0006811 | monoatomic ion transport | 4 | 3 |
| GO:0006820 | monoatomic anion transport | 5 | 3 |
| GO:0006835 | dicarboxylic acid transport | 7 | 3 |
| GO:0015711 | organic anion transport | 5 | 3 |
| GO:0015849 | organic acid transport | 5 | 3 |
| GO:0015884 | folic acid transport | 5 | 3 |
| GO:0034220 | monoatomic ion transmembrane transport | 3 | 3 |
| GO:0035461 | vitamin transmembrane transport | 3 | 3 |
| GO:0042886 | amide transport | 5 | 3 |
| GO:0046942 | carboxylic acid transport | 6 | 3 |
| GO:0051180 | vitamin transport | 4 | 3 |
| GO:0072337 | modified amino acid transport | 5 | 3 |
| GO:0098656 | monoatomic anion transmembrane transport | 4 | 3 |
| GO:0098838 | folate transmembrane transport | 4 | 3 |
| GO:1903825 | organic acid transmembrane transport | 3 | 3 |
| GO:1904947 | folate import into mitochondrion | 4 | 3 |
| GO:1905039 | carboxylic acid transmembrane transport | 4 | 3 |
| GO:1990542 | mitochondrial transmembrane transport | 3 | 3 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005215 | transporter activity | 1 | 3 |
| GO:0005342 | organic acid transmembrane transporter activity | 3 | 3 |
| GO:0008509 | monoatomic anion transmembrane transporter activity | 4 | 3 |
| GO:0008514 | organic anion transmembrane transporter activity | 5 | 3 |
| GO:0008517 | folic acid transmembrane transporter activity | 4 | 3 |
| GO:0015075 | monoatomic ion transmembrane transporter activity | 3 | 3 |
| GO:0015215 | nucleotide transmembrane transporter activity | 4 | 3 |
| GO:0015230 | FAD transmembrane transporter activity | 5 | 3 |
| GO:0015605 | organophosphate ester transmembrane transporter activity | 3 | 3 |
| GO:0015932 | nucleobase-containing compound transmembrane transporter activity | 3 | 3 |
| GO:0022857 | transmembrane transporter activity | 2 | 3 |
| GO:0042887 | amide transmembrane transporter activity | 3 | 3 |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 4 | 3 |
| GO:0072349 | modified amino acid transmembrane transporter activity | 3 | 3 |
| GO:0090482 | vitamin transmembrane transporter activity | 3 | 3 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 42 | 46 | PF00656 | 0.186 |
| CLV_MEL_PAP_1 | 143 | 149 | PF00089 | 0.233 |
| CLV_NRD_NRD_1 | 113 | 115 | PF00675 | 0.410 |
| CLV_NRD_NRD_1 | 237 | 239 | PF00675 | 0.541 |
| CLV_PCSK_KEX2_1 | 112 | 114 | PF00082 | 0.401 |
| CLV_PCSK_KEX2_1 | 296 | 298 | PF00082 | 0.176 |
| CLV_PCSK_PC1ET2_1 | 112 | 114 | PF00082 | 0.438 |
| CLV_PCSK_PC1ET2_1 | 296 | 298 | PF00082 | 0.191 |
| CLV_PCSK_PC7_1 | 292 | 298 | PF00082 | 0.151 |
| CLV_PCSK_SKI1_1 | 255 | 259 | PF00082 | 0.294 |
| CLV_PCSK_SKI1_1 | 285 | 289 | PF00082 | 0.277 |
| CLV_PCSK_SKI1_1 | 317 | 321 | PF00082 | 0.327 |
| CLV_PCSK_SKI1_1 | 58 | 62 | PF00082 | 0.445 |
| CLV_Separin_Metazoa | 182 | 186 | PF03568 | 0.151 |
| DEG_APCC_DBOX_1 | 284 | 292 | PF00400 | 0.440 |
| DEG_APCC_DBOX_1 | 316 | 324 | PF00400 | 0.243 |
| DOC_CYCLIN_yCln2_LP_2 | 30 | 36 | PF00134 | 0.332 |
| DOC_MAPK_gen_1 | 238 | 244 | PF00069 | 0.444 |
| DOC_MAPK_HePTP_8 | 235 | 249 | PF00069 | 0.186 |
| DOC_MAPK_HePTP_8 | 66 | 78 | PF00069 | 0.151 |
| DOC_MAPK_MEF2A_6 | 69 | 78 | PF00069 | 0.151 |
| DOC_PP1_RVXF_1 | 36 | 42 | PF00149 | 0.299 |
| DOC_PP1_SILK_1 | 58 | 63 | PF00149 | 0.151 |
| DOC_PP2B_LxvP_1 | 216 | 219 | PF13499 | 0.235 |
| DOC_PP2B_PxIxI_1 | 263 | 269 | PF00149 | 0.163 |
| DOC_PP4_FxxP_1 | 222 | 225 | PF00568 | 0.301 |
| DOC_USP7_MATH_1 | 116 | 120 | PF00917 | 0.630 |
| LIG_14-3-3_CanoR_1 | 100 | 106 | PF00244 | 0.335 |
| LIG_14-3-3_CanoR_1 | 125 | 132 | PF00244 | 0.638 |
| LIG_14-3-3_CanoR_1 | 185 | 191 | PF00244 | 0.312 |
| LIG_14-3-3_CanoR_1 | 208 | 216 | PF00244 | 0.222 |
| LIG_Actin_WH2_2 | 316 | 332 | PF00022 | 0.363 |
| LIG_APCC_ABBA_1 | 321 | 326 | PF00400 | 0.410 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.668 |
| LIG_FHA_1 | 127 | 133 | PF00498 | 0.482 |
| LIG_FHA_1 | 154 | 160 | PF00498 | 0.352 |
| LIG_FHA_1 | 178 | 184 | PF00498 | 0.326 |
| LIG_FHA_1 | 221 | 227 | PF00498 | 0.253 |
| LIG_FHA_1 | 252 | 258 | PF00498 | 0.275 |
| LIG_FHA_1 | 26 | 32 | PF00498 | 0.272 |
| LIG_FHA_1 | 277 | 283 | PF00498 | 0.566 |
| LIG_FHA_2 | 102 | 108 | PF00498 | 0.555 |
| LIG_FHA_2 | 40 | 46 | PF00498 | 0.325 |
| LIG_LIR_Gen_1 | 139 | 147 | PF02991 | 0.523 |
| LIG_LIR_Nem_3 | 139 | 143 | PF02991 | 0.494 |
| LIG_LIR_Nem_3 | 205 | 210 | PF02991 | 0.250 |
| LIG_LIR_Nem_3 | 281 | 287 | PF02991 | 0.425 |
| LIG_LIR_Nem_3 | 56 | 60 | PF02991 | 0.197 |
| LIG_Pex14_2 | 324 | 328 | PF04695 | 0.368 |
| LIG_REV1ctd_RIR_1 | 75 | 83 | PF16727 | 0.326 |
| LIG_SH2_CRK | 227 | 231 | PF00017 | 0.291 |
| LIG_SH2_CRK | 57 | 61 | PF00017 | 0.236 |
| LIG_SH2_CRK | 95 | 99 | PF00017 | 0.308 |
| LIG_SH2_STAP1 | 325 | 329 | PF00017 | 0.246 |
| LIG_SH2_STAT3 | 99 | 102 | PF00017 | 0.392 |
| LIG_SH2_STAT5 | 97 | 100 | PF00017 | 0.310 |
| LIG_SUMO_SIM_anti_2 | 241 | 246 | PF11976 | 0.278 |
| LIG_SUMO_SIM_par_1 | 264 | 270 | PF11976 | 0.338 |
| LIG_WRC_WIRS_1 | 187 | 192 | PF05994 | 0.256 |
| LIG_WRC_WIRS_1 | 284 | 289 | PF05994 | 0.448 |
| MOD_CK1_1 | 121 | 127 | PF00069 | 0.649 |
| MOD_CK1_1 | 154 | 160 | PF00069 | 0.297 |
| MOD_CK1_1 | 177 | 183 | PF00069 | 0.283 |
| MOD_CK1_1 | 251 | 257 | PF00069 | 0.320 |
| MOD_CK1_1 | 290 | 296 | PF00069 | 0.526 |
| MOD_CK1_1 | 307 | 313 | PF00069 | 0.202 |
| MOD_CK2_1 | 101 | 107 | PF00069 | 0.509 |
| MOD_CK2_1 | 124 | 130 | PF00069 | 0.682 |
| MOD_GlcNHglycan | 118 | 121 | PF01048 | 0.438 |
| MOD_GlcNHglycan | 156 | 159 | PF01048 | 0.347 |
| MOD_GlcNHglycan | 174 | 179 | PF01048 | 0.520 |
| MOD_GlcNHglycan | 210 | 213 | PF01048 | 0.423 |
| MOD_GlcNHglycan | 5 | 8 | PF01048 | 0.481 |
| MOD_GSK3_1 | 124 | 131 | PF00069 | 0.639 |
| MOD_GSK3_1 | 147 | 154 | PF00069 | 0.326 |
| MOD_GSK3_1 | 194 | 201 | PF00069 | 0.245 |
| MOD_GSK3_1 | 283 | 290 | PF00069 | 0.470 |
| MOD_GSK3_1 | 307 | 314 | PF00069 | 0.285 |
| MOD_GSK3_1 | 40 | 47 | PF00069 | 0.256 |
| MOD_GSK3_1 | 81 | 88 | PF00069 | 0.407 |
| MOD_NEK2_1 | 14 | 19 | PF00069 | 0.262 |
| MOD_NEK2_1 | 147 | 152 | PF00069 | 0.297 |
| MOD_NEK2_1 | 166 | 171 | PF00069 | 0.226 |
| MOD_NEK2_1 | 194 | 199 | PF00069 | 0.224 |
| MOD_NEK2_1 | 226 | 231 | PF00069 | 0.244 |
| MOD_NEK2_1 | 287 | 292 | PF00069 | 0.462 |
| MOD_NEK2_1 | 311 | 316 | PF00069 | 0.307 |
| MOD_PIKK_1 | 17 | 23 | PF00454 | 0.291 |
| MOD_PIKK_1 | 40 | 46 | PF00454 | 0.222 |
| MOD_PKA_2 | 124 | 130 | PF00069 | 0.659 |
| MOD_PKA_2 | 304 | 310 | PF00069 | 0.509 |
| MOD_PKA_2 | 39 | 45 | PF00069 | 0.186 |
| MOD_PKB_1 | 38 | 46 | PF00069 | 0.241 |
| MOD_Plk_1 | 240 | 246 | PF00069 | 0.267 |
| MOD_Plk_4 | 101 | 107 | PF00069 | 0.413 |
| MOD_Plk_4 | 240 | 246 | PF00069 | 0.245 |
| MOD_Plk_4 | 25 | 31 | PF00069 | 0.242 |
| TRG_ENDOCYTIC_2 | 227 | 230 | PF00928 | 0.246 |
| TRG_ENDOCYTIC_2 | 284 | 287 | PF00928 | 0.442 |
| TRG_ENDOCYTIC_2 | 325 | 328 | PF00928 | 0.231 |
| TRG_ENDOCYTIC_2 | 57 | 60 | PF00928 | 0.244 |
| TRG_ENDOCYTIC_2 | 95 | 98 | PF00928 | 0.299 |
| TRG_ER_diArg_1 | 37 | 40 | PF00400 | 0.290 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P2Z6 | Leptomonas seymouri | 25% | 94% |
| A0A0N0P4V4 | Leptomonas seymouri | 27% | 95% |
| A0A0N0P7T5 | Leptomonas seymouri | 24% | 100% |
| A0A0N0P7X0 | Leptomonas seymouri | 22% | 100% |
| A0A0N1IMP5 | Leptomonas seymouri | 67% | 100% |
| A0A0N1PFJ3 | Leptomonas seymouri | 40% | 93% |
| A0A0S4IZG7 | Bodo saltans | 21% | 97% |
| A0A0S4J045 | Bodo saltans | 25% | 95% |
| A0A0S4J9F4 | Bodo saltans | 42% | 100% |
| A0A0S4JHC1 | Bodo saltans | 29% | 97% |
| A0A1D6N272 | Zea mays | 25% | 100% |
| A0A1X0NUM8 | Trypanosomatidae | 42% | 100% |
| A0A1X0NUU7 | Trypanosomatidae | 49% | 100% |
| A0A1X0P6S2 | Trypanosomatidae | 31% | 100% |
| A0A1X0PA63 | Trypanosomatidae | 24% | 87% |
| A0A3Q8IIC0 | Leishmania donovani | 25% | 100% |
| A0A3Q8IKX9 | Leishmania donovani | 42% | 100% |
| A0A3R7LCB2 | Trypanosoma rangeli | 46% | 100% |
| A0A3R7P246 | Trypanosoma rangeli | 42% | 100% |
| A0A3S5H800 | Leishmania donovani | 28% | 93% |
| A0A3S7WVJ8 | Leishmania donovani | 26% | 98% |
| A0A422N763 | Trypanosoma rangeli | 30% | 99% |
| A0A422NF39 | Trypanosoma rangeli | 22% | 100% |
| A3KPP4 | Danio rerio | 24% | 100% |
| A4H7Y2 | Leishmania braziliensis | 22% | 100% |
| A4HA67 | Leishmania braziliensis | 26% | 100% |
| A4HDW8 | Leishmania braziliensis | 23% | 94% |
| A4HK93 | Leishmania braziliensis | 40% | 100% |
| A4HK94 | Leishmania braziliensis | 78% | 100% |
| A4HN00 | Leishmania braziliensis | 27% | 100% |
| A4HN69 | Leishmania braziliensis | 27% | 100% |
| A4HYC8 | Leishmania infantum | 26% | 100% |
| A4I7S8 | Leishmania infantum | 42% | 100% |
| A4I7S9 | Leishmania infantum | 100% | 100% |
| A4IBM3 | Leishmania infantum | 27% | 100% |
| A4IBT7 | Leishmania infantum | 25% | 100% |
| A4RF23 | Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) | 27% | 100% |
| B0G159 | Dictyostelium discoideum | 22% | 71% |
| B4FIJ0 | Zea mays | 25% | 100% |
| C9ZM27 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 23% | 88% |
| C9ZNU5 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 24% | 100% |
| C9ZYS8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 25% | 100% |
| C9ZZ11 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 26% | 100% |
| D0A9Y8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 40% | 97% |
| D0A9Z0 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 44% | 99% |
| E8NHL5 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 28% | 100% |
| E9AFF7 | Leishmania major | 28% | 100% |
| E9AFM4 | Leishmania major | 25% | 100% |
| E9AQ09 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 22% | 100% |
| E9AS62 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 26% | 100% |
| E9AX97 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 23% | 93% |
| E9B2N6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 41% | 99% |
| E9B2N7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 88% | 100% |
| E9B6S7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 24% | 100% |
| F1RFX9 | Sus scrofa | 23% | 100% |
| O04200 | Arabidopsis thaliana | 25% | 100% |
| O13660 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 22% | 100% |
| O22261 | Arabidopsis thaliana | 24% | 100% |
| O43808 | Homo sapiens | 23% | 100% |
| O70579 | Mus musculus | 22% | 100% |
| P0CAT2 | Danio rerio | 21% | 100% |
| P22292 | Bos taurus | 24% | 100% |
| P39953 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 25% | 100% |
| P40464 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 25% | 100% |
| P40556 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 24% | 90% |
| P55851 | Homo sapiens | 24% | 100% |
| P90992 | Caenorhabditis elegans | 22% | 100% |
| P97700 | Rattus norvegicus | 23% | 100% |
| Q02978 | Homo sapiens | 23% | 100% |
| Q08DK7 | Bos taurus | 23% | 100% |
| Q29RM1 | Bos taurus | 23% | 100% |
| Q3TZX3 | Mus musculus | 24% | 100% |
| Q4Q5H0 | Leishmania major | 89% | 100% |
| Q4Q5H1 | Leishmania major | 43% | 100% |
| Q4QA75 | Leishmania major | 22% | 94% |
| Q4QDA4 | Leishmania major | 25% | 100% |
| Q505J6 | Rattus norvegicus | 22% | 100% |
| Q54FU9 | Dictyostelium discoideum | 22% | 100% |
| Q54QN2 | Dictyostelium discoideum | 25% | 100% |
| Q5NVC1 | Pongo abelii | 22% | 100% |
| Q5PQM9 | Rattus norvegicus | 26% | 100% |
| Q5R5A8 | Pongo abelii | 24% | 100% |
| Q5XGI1 | Xenopus tropicalis | 25% | 100% |
| Q5ZKP7 | Gallus gallus | 22% | 100% |
| Q6DG32 | Danio rerio | 23% | 100% |
| Q6GQ22 | Xenopus laevis | 25% | 100% |
| Q6IZB5 | Cricetulus griseus | 23% | 100% |
| Q6P036 | Danio rerio | 24% | 100% |
| Q75A82 | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) | 23% | 99% |
| Q76P23 | Dictyostelium discoideum | 20% | 100% |
| Q7K566 | Drosophila melanogaster | 25% | 100% |
| Q7S2H8 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 25% | 100% |
| Q7XA87 | Arabidopsis thaliana | 28% | 100% |
| Q86AV5 | Dictyostelium discoideum | 20% | 100% |
| Q8BMG8 | Mus musculus | 23% | 100% |
| Q8HXE3 | Macaca fascicularis | 26% | 100% |
| Q8RWA5 | Arabidopsis thaliana | 22% | 93% |
| Q8RXZ9 | Arabidopsis thaliana | 25% | 100% |
| Q922G0 | Mus musculus | 22% | 100% |
| Q944H5 | Arabidopsis thaliana | 23% | 82% |
| Q95J75 | Macaca fascicularis | 25% | 100% |
| Q96CQ1 | Homo sapiens | 23% | 100% |
| Q9BV35 | Homo sapiens | 23% | 72% |
| Q9CR58 | Mus musculus | 26% | 100% |
| Q9CR62 | Mus musculus | 23% | 100% |
| Q9FI43 | Arabidopsis thaliana | 24% | 69% |
| Q9FI73 | Arabidopsis thaliana | 25% | 99% |
| Q9GMZ1 | Canis lupus familiaris | 23% | 100% |
| Q9H2D1 | Homo sapiens | 25% | 100% |
| Q9HC21 | Homo sapiens | 23% | 100% |
| Q9P6L7 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 24% | 93% |
| Q9SUV1 | Arabidopsis thaliana | 21% | 86% |
| Q9Z2B2 | Mus musculus | 25% | 100% |
| V5B150 | Trypanosoma cruzi | 45% | 100% |
| V5BDR1 | Trypanosoma cruzi | 24% | 100% |
| V5BGM6 | Trypanosoma cruzi | 43% | 100% |
| V5BKU8 | Trypanosoma cruzi | 24% | 88% |
| V5BTA6 | Trypanosoma cruzi | 26% | 100% |
| V5BTE8 | Trypanosoma cruzi | 29% | 99% |