Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFU3_LEIDO

TriTrypDb:

LdBPK_343520.1 , LdCL_340044600 , LDHU3_34.5760

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFU3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	122	128	PF00089	0.620
CLV_NRD_NRD_1	107	109	PF00675	0.497
CLV_NRD_NRD_1	112	114	PF00675	0.508
CLV_NRD_NRD_1	140	142	PF00675	0.573
CLV_NRD_NRD_1	209	211	PF00675	0.529
CLV_NRD_NRD_1	267	269	PF00675	0.573
CLV_NRD_NRD_1	295	297	PF00675	0.673
CLV_NRD_NRD_1	300	302	PF00675	0.630
CLV_PCSK_FUR_1	293	297	PF00082	0.691
CLV_PCSK_KEX2_1	107	109	PF00082	0.497
CLV_PCSK_KEX2_1	112	114	PF00082	0.508
CLV_PCSK_KEX2_1	140	142	PF00082	0.534
CLV_PCSK_KEX2_1	209	211	PF00082	0.529
CLV_PCSK_KEX2_1	267	269	PF00082	0.573
CLV_PCSK_KEX2_1	295	297	PF00082	0.675
CLV_PCSK_KEX2_1	299	301	PF00082	0.614
CLV_PCSK_PC7_1	108	114	PF00082	0.562
CLV_PCSK_PC7_1	263	269	PF00082	0.667
CLV_PCSK_PC7_1	295	301	PF00082	0.601
CLV_PCSK_SKI1_1	108	112	PF00082	0.503
CLV_PCSK_SKI1_1	119	123	PF00082	0.550
CLV_PCSK_SKI1_1	144	148	PF00082	0.524
CLV_PCSK_SKI1_1	195	199	PF00082	0.601
CLV_PCSK_SKI1_1	267	271	PF00082	0.627
CLV_PCSK_SKI1_1	314	318	PF00082	0.621
DEG_APCC_DBOX_1	234	242	PF00400	0.671
DEG_APCC_DBOX_1	99	107	PF00400	0.533
DOC_CKS1_1	16	21	PF01111	0.597
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.611
DOC_MAPK_gen_1	193	201	PF00069	0.497
DOC_MAPK_gen_1	276	286	PF00069	0.580
DOC_PP1_RVXF_1	117	124	PF00149	0.519
DOC_PP1_RVXF_1	163	169	PF00149	0.512
DOC_PP1_RVXF_1	57	64	PF00149	0.640
DOC_PP4_FxxP_1	16	19	PF00568	0.594
DOC_USP7_MATH_1	224	228	PF00917	0.650
DOC_USP7_MATH_1	240	244	PF00917	0.414
DOC_USP7_MATH_1	4	8	PF00917	0.542
DOC_WW_Pin1_4	15	20	PF00397	0.639
DOC_WW_Pin1_4	35	40	PF00397	0.643
DOC_WW_Pin1_4	45	50	PF00397	0.630
LIG_14-3-3_CanoR_1	156	160	PF00244	0.574
LIG_14-3-3_CanoR_1	221	228	PF00244	0.518
LIG_14-3-3_CanoR_1	230	234	PF00244	0.480
LIG_14-3-3_CanoR_1	29	35	PF00244	0.699
LIG_14-3-3_CanoR_1	318	325	PF00244	0.683
LIG_14-3-3_CanoR_1	42	50	PF00244	0.617
LIG_14-3-3_CterR_2	345	348	PF00244	0.702
LIG_Actin_WH2_2	99	114	PF00022	0.584
LIG_APCC_ABBAyCdc20_2	144	150	PF00400	0.539
LIG_CaM_IQ_9	111	127	PF13499	0.515
LIG_deltaCOP1_diTrp_1	169	174	PF00928	0.589
LIG_deltaCOP1_diTrp_1	292	297	PF00928	0.647
LIG_deltaCOP1_diTrp_1	95	101	PF00928	0.568
LIG_FHA_1	16	22	PF00498	0.707
LIG_FHA_1	4	10	PF00498	0.543
LIG_FHA_1	77	83	PF00498	0.612
LIG_FHA_1	89	95	PF00498	0.403
LIG_FHA_2	156	162	PF00498	0.476
LIG_LIR_Gen_1	242	251	PF02991	0.638
LIG_LIR_Nem_3	242	247	PF02991	0.639
LIG_LIR_Nem_3	333	337	PF02991	0.598
LIG_SH2_STAP1	334	338	PF00017	0.657
LIG_SH2_STAT5	15	18	PF00017	0.552
LIG_SH2_STAT5	244	247	PF00017	0.704
LIG_SH2_STAT5	337	340	PF00017	0.656
LIG_SUMO_SIM_par_1	90	95	PF11976	0.451
MOD_CDK_SPxxK_3	35	42	PF00069	0.577
MOD_CK1_1	22	28	PF00069	0.747
MOD_CK1_1	74	80	PF00069	0.572
MOD_CK2_1	14	20	PF00069	0.743
MOD_CK2_1	155	161	PF00069	0.399
MOD_CK2_1	22	28	PF00069	0.677
MOD_CMANNOS	168	171	PF00535	0.520
MOD_CMANNOS	294	297	PF00535	0.547
MOD_GlcNHglycan	222	225	PF01048	0.563
MOD_GlcNHglycan	31	34	PF01048	0.742
MOD_GSK3_1	15	22	PF00069	0.751
MOD_GSK3_1	220	227	PF00069	0.567
MOD_GSK3_1	29	36	PF00069	0.556
MOD_GSK3_1	41	48	PF00069	0.661
MOD_NEK2_1	21	26	PF00069	0.746
MOD_NEK2_1	3	8	PF00069	0.728
MOD_PIKK_1	318	324	PF00454	0.590
MOD_PKA_2	155	161	PF00069	0.443
MOD_PKA_2	220	226	PF00069	0.543
MOD_PKA_2	229	235	PF00069	0.520
MOD_PKA_2	28	34	PF00069	0.821
MOD_PKA_2	41	47	PF00069	0.620
MOD_PKA_2	74	80	PF00069	0.594
MOD_PKB_1	200	208	PF00069	0.472
MOD_Plk_1	224	230	PF00069	0.583
MOD_Plk_2-3	155	161	PF00069	0.443
MOD_Plk_4	155	161	PF00069	0.566
MOD_Plk_4	240	246	PF00069	0.568
MOD_Plk_4	49	55	PF00069	0.613
MOD_Plk_4	88	94	PF00069	0.547
MOD_ProDKin_1	15	21	PF00069	0.640
MOD_ProDKin_1	35	41	PF00069	0.643
MOD_ProDKin_1	45	51	PF00069	0.628
TRG_DiLeu_BaEn_1	155	160	PF01217	0.510
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.618
TRG_ENDOCYTIC_2	244	247	PF00928	0.681
TRG_ER_diArg_1	106	108	PF00400	0.530
TRG_ER_diArg_1	111	113	PF00400	0.500
TRG_ER_diArg_1	117	120	PF00400	0.471
TRG_ER_diArg_1	140	142	PF00400	0.572
TRG_ER_diArg_1	177	180	PF00400	0.484
TRG_ER_diArg_1	208	210	PF00400	0.548
TRG_ER_diArg_1	294	296	PF00400	0.689
TRG_ER_diArg_1	298	301	PF00400	0.619
TRG_ER_diArg_1	9	12	PF00400	0.617
TRG_Pf-PMV_PEXEL_1	140	145	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILB8	Leptomonas seymouri	58%	100%
A0A1X0PA21	Trypanosomatidae	27%	100%
A4HB92	Leishmania braziliensis	67%	93%
A4IAE0	Leishmania infantum	99%	100%
E9B5G4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	98%
Q4Q2H1	Leishmania major	89%	100%