Ribosomal protein l7/l12-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal protein l7/l12-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IFU2_LEIDO

TriTrypDb:

LdBPK_312950.1 , LdCL_310037800 , LDHU3_31.5120

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

A0A3Q8IFU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFU2

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	14	18	PF00082	0.581
CLV_PCSK_SKI1_1	141	145	PF00082	0.555
CLV_PCSK_SKI1_1	158	162	PF00082	0.203
CLV_PCSK_SKI1_1	38	42	PF00082	0.697
CLV_Separin_Metazoa	77	81	PF03568	0.672
DEG_Nend_UBRbox_1	1	4	PF02207	0.545
DOC_MAPK_gen_1	161	171	PF00069	0.274
DOC_MAPK_gen_1	196	204	PF00069	0.417
DOC_MAPK_gen_1	35	45	PF00069	0.682
DOC_MAPK_MEF2A_6	141	150	PF00069	0.367
DOC_PP1_RVXF_1	2	9	PF00149	0.361
DOC_PP2B_LxvP_1	43	46	PF13499	0.562
DOC_USP7_MATH_1	127	131	PF00917	0.586
DOC_USP7_UBL2_3	137	141	PF12436	0.543
DOC_WW_Pin1_4	38	43	PF00397	0.687
LIG_14-3-3_CanoR_1	14	21	PF00244	0.587
LIG_Actin_WH2_2	182	200	PF00022	0.368
LIG_FHA_1	145	151	PF00498	0.348
LIG_FHA_1	15	21	PF00498	0.547
LIG_FHA_2	140	146	PF00498	0.602
LIG_FHA_2	174	180	PF00498	0.358
LIG_LIR_Gen_1	57	67	PF02991	0.495
LIG_SH2_GRB2like	59	62	PF00017	0.457
LIG_SH2_SRC	94	97	PF00017	0.540
LIG_SH2_STAP1	94	98	PF00017	0.519
LIG_SH2_STAT5	59	62	PF00017	0.515
LIG_SH3_3	112	118	PF00018	0.645
LIG_TRAF2_1	170	173	PF00917	0.310
MOD_CK2_1	167	173	PF00069	0.364
MOD_GlcNHglycan	101	104	PF01048	0.590
MOD_GlcNHglycan	105	108	PF01048	0.571
MOD_GlcNHglycan	112	115	PF01048	0.548
MOD_GlcNHglycan	129	132	PF01048	0.570
MOD_GSK3_1	99	106	PF00069	0.656
MOD_NEK2_1	144	149	PF00069	0.352
MOD_NEK2_1	20	25	PF00069	0.636
MOD_NEK2_1	99	104	PF00069	0.603
MOD_PKA_2	99	105	PF00069	0.671
MOD_PKB_1	12	20	PF00069	0.484
MOD_Plk_1	139	145	PF00069	0.590
MOD_ProDKin_1	38	44	PF00069	0.686
MOD_SUMO_rev_2	170	177	PF00179	0.348
TRG_ENDOCYTIC_2	59	62	PF00928	0.475
TRG_ER_diArg_1	1	4	PF00400	0.644
TRG_ER_diArg_1	12	15	PF00400	0.595
TRG_Pf-PMV_PEXEL_1	4	9	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2G0	Leptomonas seymouri	62%	100%
A0A0S4JKH3	Bodo saltans	39%	88%
A0A1X0NIA7	Trypanosomatidae	46%	100%
A0A422NF54	Trypanosoma rangeli	45%	100%
A4HJS3	Leishmania braziliensis	76%	99%
A4I789	Leishmania infantum	99%	100%
C9ZMG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	99%
E9B284	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q5X4	Leishmania major	90%	100%
V5BGN2	Trypanosoma cruzi	43%	72%