Serine esterase (DUF676), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative serine esterase (DUF676), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IFT8_LEIDO

TriTrypDb:

LdBPK_230950.1 , LdCL_230016100 , LDHU3_23.1300

Length:

931

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFT8

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0051536	iron-sulfur cluster binding	3	1
GO:0051537	2 iron, 2 sulfur cluster binding	4	1
GO:0051540	metal cluster binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.674
CLV_C14_Caspase3-7	34	38	PF00656	0.772
CLV_C14_Caspase3-7	698	702	PF00656	0.648
CLV_C14_Caspase3-7	829	833	PF00656	0.570
CLV_NRD_NRD_1	254	256	PF00675	0.597
CLV_NRD_NRD_1	328	330	PF00675	0.527
CLV_NRD_NRD_1	461	463	PF00675	0.513
CLV_NRD_NRD_1	477	479	PF00675	0.411
CLV_NRD_NRD_1	734	736	PF00675	0.672
CLV_NRD_NRD_1	774	776	PF00675	0.712
CLV_NRD_NRD_1	883	885	PF00675	0.594
CLV_PCSK_KEX2_1	21	23	PF00082	0.674
CLV_PCSK_KEX2_1	254	256	PF00082	0.597
CLV_PCSK_KEX2_1	328	330	PF00082	0.527
CLV_PCSK_KEX2_1	461	463	PF00082	0.513
CLV_PCSK_KEX2_1	476	478	PF00082	0.411
CLV_PCSK_KEX2_1	733	735	PF00082	0.673
CLV_PCSK_KEX2_1	746	748	PF00082	0.665
CLV_PCSK_KEX2_1	774	776	PF00082	0.712
CLV_PCSK_KEX2_1	883	885	PF00082	0.594
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.674
CLV_PCSK_PC1ET2_1	746	748	PF00082	0.601
CLV_PCSK_PC7_1	457	463	PF00082	0.494
CLV_PCSK_SKI1_1	197	201	PF00082	0.714
CLV_PCSK_SKI1_1	328	332	PF00082	0.548
CLV_PCSK_SKI1_1	372	376	PF00082	0.513
CLV_PCSK_SKI1_1	461	465	PF00082	0.513
CLV_PCSK_SKI1_1	477	481	PF00082	0.369
CLV_PCSK_SKI1_1	486	490	PF00082	0.386
CLV_PCSK_SKI1_1	532	536	PF00082	0.602
DEG_APCC_DBOX_1	192	200	PF00400	0.624
DEG_APCC_DBOX_1	371	379	PF00400	0.411
DEG_APCC_DBOX_1	399	407	PF00400	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.644
DEG_SPOP_SBC_1	176	180	PF00917	0.737
DEG_SPOP_SBC_1	182	186	PF00917	0.770
DEG_SPOP_SBC_1	631	635	PF00917	0.807
DEG_SPOP_SBC_1	656	660	PF00917	0.788
DEG_SPOP_SBC_1	813	817	PF00917	0.630
DOC_CKS1_1	416	421	PF01111	0.411
DOC_CYCLIN_RxL_1	457	466	PF00134	0.512
DOC_CYCLIN_RxL_1	475	484	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	427	433	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	725	731	PF00134	0.711
DOC_MAPK_gen_1	400	408	PF00069	0.411
DOC_MAPK_gen_1	733	740	PF00069	0.703
DOC_MAPK_HePTP_8	459	471	PF00069	0.402
DOC_MAPK_MEF2A_6	372	379	PF00069	0.411
DOC_MAPK_MEF2A_6	402	410	PF00069	0.499
DOC_MAPK_MEF2A_6	462	471	PF00069	0.411
DOC_MAPK_NFAT4_5	372	380	PF00069	0.411
DOC_PP1_RVXF_1	475	482	PF00149	0.411
DOC_PP2B_LxvP_1	582	585	PF13499	0.561
DOC_PP2B_LxvP_1	738	741	PF13499	0.696
DOC_PP2B_LxvP_1	811	814	PF13499	0.621
DOC_USP7_MATH_1	105	109	PF00917	0.606
DOC_USP7_MATH_1	156	160	PF00917	0.730
DOC_USP7_MATH_1	182	186	PF00917	0.748
DOC_USP7_MATH_1	38	42	PF00917	0.705
DOC_USP7_MATH_1	598	602	PF00917	0.649
DOC_USP7_MATH_1	631	635	PF00917	0.827
DOC_USP7_MATH_1	756	760	PF00917	0.736
DOC_USP7_MATH_1	77	81	PF00917	0.404
DOC_USP7_MATH_1	836	840	PF00917	0.676
DOC_USP7_MATH_1	845	849	PF00917	0.542
DOC_USP7_MATH_1	853	857	PF00917	0.487
DOC_WW_Pin1_4	12	17	PF00397	0.627
DOC_WW_Pin1_4	124	129	PF00397	0.769
DOC_WW_Pin1_4	131	136	PF00397	0.676
DOC_WW_Pin1_4	178	183	PF00397	0.715
DOC_WW_Pin1_4	283	288	PF00397	0.485
DOC_WW_Pin1_4	415	420	PF00397	0.367
DOC_WW_Pin1_4	639	644	PF00397	0.786
DOC_WW_Pin1_4	650	655	PF00397	0.738
DOC_WW_Pin1_4	739	744	PF00397	0.686
DOC_WW_Pin1_4	814	819	PF00397	0.793
DOC_WW_Pin1_4	855	860	PF00397	0.688
DOC_WW_Pin1_4	913	918	PF00397	0.573
LIG_14-3-3_CanoR_1	116	121	PF00244	0.758
LIG_14-3-3_CanoR_1	138	146	PF00244	0.657
LIG_14-3-3_CanoR_1	162	166	PF00244	0.755
LIG_14-3-3_CanoR_1	346	355	PF00244	0.535
LIG_14-3-3_CanoR_1	386	393	PF00244	0.439
LIG_14-3-3_CanoR_1	405	411	PF00244	0.273
LIG_14-3-3_CanoR_1	564	573	PF00244	0.727
LIG_14-3-3_CanoR_1	663	669	PF00244	0.733
LIG_14-3-3_CanoR_1	727	732	PF00244	0.658
LIG_14-3-3_CanoR_1	775	785	PF00244	0.706
LIG_14-3-3_CanoR_1	790	799	PF00244	0.671
LIG_14-3-3_CanoR_1	812	818	PF00244	0.620
LIG_14-3-3_CanoR_1	825	831	PF00244	0.615
LIG_14-3-3_CanoR_1	854	858	PF00244	0.687
LIG_14-3-3_CanoR_1	883	889	PF00244	0.611
LIG_Actin_WH2_2	590	606	PF00022	0.595
LIG_APCC_ABBA_1	679	684	PF00400	0.635
LIG_BRCT_BRCA1_1	495	499	PF00533	0.533
LIG_BRCT_BRCA1_1	665	669	PF00533	0.727
LIG_BRCT_BRCA1_1	725	729	PF00533	0.675
LIG_Clathr_ClatBox_1	377	381	PF01394	0.396
LIG_CSL_BTD_1	427	430	PF09270	0.411
LIG_deltaCOP1_diTrp_1	425	433	PF00928	0.411
LIG_EH1_1	572	580	PF00400	0.570
LIG_eIF4E_1	573	579	PF01652	0.637
LIG_FHA_1	167	173	PF00498	0.689
LIG_FHA_1	178	184	PF00498	0.668
LIG_FHA_1	492	498	PF00498	0.411
LIG_FHA_1	505	511	PF00498	0.628
LIG_FHA_1	622	628	PF00498	0.751
LIG_FHA_1	642	648	PF00498	0.571
LIG_FHA_1	676	682	PF00498	0.717
LIG_FHA_1	684	690	PF00498	0.802
LIG_FHA_1	756	762	PF00498	0.686
LIG_FHA_1	781	787	PF00498	0.720
LIG_FHA_1	821	827	PF00498	0.824
LIG_FHA_1	845	851	PF00498	0.664
LIG_FHA_2	13	19	PF00498	0.598
LIG_FHA_2	444	450	PF00498	0.367
LIG_FHA_2	482	488	PF00498	0.411
LIG_FHA_2	572	578	PF00498	0.579
LIG_FHA_2	862	868	PF00498	0.728
LIG_GBD_Chelix_1	878	886	PF00786	0.522
LIG_Integrin_isoDGR_2	273	275	PF01839	0.556
LIG_LIR_Gen_1	373	383	PF02991	0.411
LIG_LIR_Gen_1	409	417	PF02991	0.416
LIG_LIR_Gen_1	446	455	PF02991	0.408
LIG_LIR_Gen_1	496	505	PF02991	0.573
LIG_LIR_Gen_1	52	58	PF02991	0.458
LIG_LIR_Gen_1	538	547	PF02991	0.639
LIG_LIR_Gen_1	69	78	PF02991	0.501
LIG_LIR_Gen_1	726	736	PF02991	0.744
LIG_LIR_Nem_3	18	23	PF02991	0.585
LIG_LIR_Nem_3	365	369	PF02991	0.355
LIG_LIR_Nem_3	373	379	PF02991	0.356
LIG_LIR_Nem_3	409	413	PF02991	0.416
LIG_LIR_Nem_3	425	431	PF02991	0.252
LIG_LIR_Nem_3	446	450	PF02991	0.408
LIG_LIR_Nem_3	496	502	PF02991	0.594
LIG_LIR_Nem_3	507	512	PF02991	0.528
LIG_LIR_Nem_3	52	57	PF02991	0.460
LIG_LIR_Nem_3	69	73	PF02991	0.503
LIG_LIR_Nem_3	726	732	PF02991	0.770
LIG_LIR_Nem_3	763	767	PF02991	0.596
LIG_LIR_Nem_3	865	871	PF02991	0.578
LIG_NRBOX	1	7	PF00104	0.635
LIG_NRBOX	374	380	PF00104	0.420
LIG_PDZ_Class_2	926	931	PF00595	0.608
LIG_Pex14_1	428	432	PF04695	0.411
LIG_Pex14_2	669	673	PF04695	0.681
LIG_PTAP_UEV_1	145	150	PF05743	0.559
LIG_PTB_Apo_2	906	913	PF02174	0.581
LIG_SH2_CRK	132	136	PF00017	0.694
LIG_SH2_CRK	54	58	PF00017	0.446
LIG_SH2_CRK	871	875	PF00017	0.502
LIG_SH2_STAP1	335	339	PF00017	0.531
LIG_SH2_STAP1	447	451	PF00017	0.411
LIG_SH2_STAT3	262	265	PF00017	0.601
LIG_SH2_STAT5	292	295	PF00017	0.603
LIG_SH2_STAT5	376	379	PF00017	0.369
LIG_SH2_STAT5	432	435	PF00017	0.411
LIG_SH2_STAT5	573	576	PF00017	0.526
LIG_SH3_3	143	149	PF00018	0.730
LIG_SH3_3	170	176	PF00018	0.739
LIG_SH3_3	413	419	PF00018	0.513
LIG_SH3_3	47	53	PF00018	0.594
LIG_SH3_3	527	533	PF00018	0.576
LIG_SH3_3	689	695	PF00018	0.712
LIG_SH3_3	856	862	PF00018	0.647
LIG_SUMO_SIM_anti_2	82	87	PF11976	0.524
LIG_SUMO_SIM_par_1	164	171	PF11976	0.633
LIG_SUMO_SIM_par_1	376	381	PF11976	0.455
LIG_SUMO_SIM_par_1	531	538	PF11976	0.567
LIG_TRAF2_1	538	541	PF00917	0.586
LIG_TRAF2_1	923	926	PF00917	0.513
LIG_UBA3_1	1	7	PF00899	0.650
LIG_ULM_U2AF65_1	328	333	PF00076	0.551
LIG_WRC_WIRS_1	536	541	PF05994	0.580
MOD_CDK_SPK_2	814	819	PF00069	0.739
MOD_CDK_SPxxK_3	131	138	PF00069	0.561
MOD_CDK_SPxxK_3	739	746	PF00069	0.682
MOD_CK1_1	11	17	PF00069	0.616
MOD_CK1_1	167	173	PF00069	0.710
MOD_CK1_1	178	184	PF00069	0.738
MOD_CK1_1	286	292	PF00069	0.530
MOD_CK1_1	552	558	PF00069	0.726
MOD_CK1_1	562	568	PF00069	0.667
MOD_CK1_1	617	623	PF00069	0.643
MOD_CK1_1	634	640	PF00069	0.638
MOD_CK1_1	642	648	PF00069	0.781
MOD_CK1_1	711	717	PF00069	0.727
MOD_CK1_1	723	729	PF00069	0.583
MOD_CK1_1	769	775	PF00069	0.692
MOD_CK1_1	776	782	PF00069	0.688
MOD_CK1_1	798	804	PF00069	0.522
MOD_CK1_1	817	823	PF00069	0.525
MOD_CK1_1	824	830	PF00069	0.628
MOD_CK1_1	844	850	PF00069	0.735
MOD_CK1_1	852	858	PF00069	0.644
MOD_CK2_1	105	111	PF00069	0.579
MOD_CK2_1	443	449	PF00069	0.367
MOD_CK2_1	535	541	PF00069	0.523
MOD_CK2_1	608	614	PF00069	0.744
MOD_CK2_1	81	87	PF00069	0.518
MOD_GlcNHglycan	107	110	PF01048	0.620
MOD_GlcNHglycan	123	127	PF01048	0.611
MOD_GlcNHglycan	146	149	PF01048	0.729
MOD_GlcNHglycan	158	161	PF01048	0.581
MOD_GlcNHglycan	231	234	PF01048	0.768
MOD_GlcNHglycan	278	281	PF01048	0.556
MOD_GlcNHglycan	39	43	PF01048	0.750
MOD_GlcNHglycan	551	554	PF01048	0.709
MOD_GlcNHglycan	564	567	PF01048	0.643
MOD_GlcNHglycan	579	582	PF01048	0.546
MOD_GlcNHglycan	600	603	PF01048	0.780
MOD_GlcNHglycan	634	637	PF01048	0.673
MOD_GlcNHglycan	65	68	PF01048	0.523
MOD_GlcNHglycan	713	716	PF01048	0.758
MOD_GlcNHglycan	843	846	PF01048	0.694
MOD_GlcNHglycan	847	850	PF01048	0.732
MOD_GlcNHglycan	851	854	PF01048	0.798
MOD_GSK3_1	140	147	PF00069	0.725
MOD_GSK3_1	164	171	PF00069	0.699
MOD_GSK3_1	177	184	PF00069	0.761
MOD_GSK3_1	292	299	PF00069	0.582
MOD_GSK3_1	33	40	PF00069	0.743
MOD_GSK3_1	335	342	PF00069	0.565
MOD_GSK3_1	549	556	PF00069	0.736
MOD_GSK3_1	617	624	PF00069	0.724
MOD_GSK3_1	630	637	PF00069	0.692
MOD_GSK3_1	639	646	PF00069	0.822
MOD_GSK3_1	655	662	PF00069	0.554
MOD_GSK3_1	671	678	PF00069	0.684
MOD_GSK3_1	713	720	PF00069	0.702
MOD_GSK3_1	723	730	PF00069	0.686
MOD_GSK3_1	766	773	PF00069	0.707
MOD_GSK3_1	77	84	PF00069	0.452
MOD_GSK3_1	776	783	PF00069	0.728
MOD_GSK3_1	795	802	PF00069	0.613
MOD_GSK3_1	8	15	PF00069	0.615
MOD_GSK3_1	813	820	PF00069	0.671
MOD_GSK3_1	841	848	PF00069	0.718
MOD_GSK3_1	849	856	PF00069	0.672
MOD_GSK3_1	878	885	PF00069	0.528
MOD_N-GLC_1	406	411	PF02516	0.397
MOD_N-GLC_1	708	713	PF02516	0.710
MOD_N-GLC_1	777	782	PF02516	0.735
MOD_NEK2_1	10	15	PF00069	0.665
MOD_NEK2_1	166	171	PF00069	0.711
MOD_NEK2_1	276	281	PF00069	0.515
MOD_NEK2_1	362	367	PF00069	0.411
MOD_NEK2_1	481	486	PF00069	0.411
MOD_NEK2_1	623	628	PF00069	0.692
MOD_NEK2_1	664	669	PF00069	0.762
MOD_NEK2_1	826	831	PF00069	0.714
MOD_NEK2_1	841	846	PF00069	0.573
MOD_NEK2_1	882	887	PF00069	0.497
MOD_PIKK_1	296	302	PF00454	0.647
MOD_PIKK_1	559	565	PF00454	0.671
MOD_PIKK_1	648	654	PF00454	0.834
MOD_PIKK_1	708	714	PF00454	0.769
MOD_PK_1	116	122	PF00069	0.662
MOD_PK_1	140	146	PF00069	0.567
MOD_PK_1	915	921	PF00069	0.641
MOD_PKA_1	734	740	PF00069	0.663
MOD_PKA_2	139	145	PF00069	0.779
MOD_PKA_2	161	167	PF00069	0.683
MOD_PKA_2	345	351	PF00069	0.541
MOD_PKA_2	385	391	PF00069	0.513
MOD_PKA_2	734	740	PF00069	0.718
MOD_PKA_2	750	756	PF00069	0.542
MOD_PKA_2	773	779	PF00069	0.713
MOD_PKA_2	824	830	PF00069	0.610
MOD_PKA_2	845	851	PF00069	0.701
MOD_PKA_2	853	859	PF00069	0.637
MOD_PKA_2	882	888	PF00069	0.492
MOD_PKB_1	138	146	PF00069	0.570
MOD_PKB_1	569	577	PF00069	0.623
MOD_PKB_1	775	783	PF00069	0.735
MOD_Plk_1	186	192	PF00069	0.621
MOD_Plk_1	406	412	PF00069	0.397
MOD_Plk_1	656	662	PF00069	0.611
MOD_Plk_1	683	689	PF00069	0.707
MOD_Plk_1	777	783	PF00069	0.734
MOD_Plk_1	81	87	PF00069	0.518
MOD_Plk_1	821	827	PF00069	0.797
MOD_Plk_2-3	614	620	PF00069	0.627
MOD_Plk_4	161	167	PF00069	0.719
MOD_Plk_4	186	192	PF00069	0.612
MOD_Plk_4	313	319	PF00069	0.589
MOD_Plk_4	493	499	PF00069	0.520
MOD_Plk_4	608	614	PF00069	0.802
MOD_Plk_4	664	670	PF00069	0.721
MOD_Plk_4	720	726	PF00069	0.724
MOD_Plk_4	734	740	PF00069	0.612
MOD_Plk_4	781	787	PF00069	0.696
MOD_Plk_4	81	87	PF00069	0.513
MOD_Plk_4	836	842	PF00069	0.658
MOD_Plk_4	915	921	PF00069	0.641
MOD_ProDKin_1	12	18	PF00069	0.623
MOD_ProDKin_1	124	130	PF00069	0.759
MOD_ProDKin_1	131	137	PF00069	0.674
MOD_ProDKin_1	178	184	PF00069	0.716
MOD_ProDKin_1	283	289	PF00069	0.492
MOD_ProDKin_1	415	421	PF00069	0.367
MOD_ProDKin_1	639	645	PF00069	0.785
MOD_ProDKin_1	650	656	PF00069	0.736
MOD_ProDKin_1	739	745	PF00069	0.687
MOD_ProDKin_1	814	820	PF00069	0.795
MOD_ProDKin_1	855	861	PF00069	0.687
MOD_ProDKin_1	913	919	PF00069	0.563
MOD_SUMO_for_1	95	98	PF00179	0.512
MOD_SUMO_rev_2	189	199	PF00179	0.593
TRG_DiLeu_BaEn_1	373	378	PF01217	0.411
TRG_DiLeu_BaEn_3	925	931	PF01217	0.510
TRG_DiLeu_BaLyEn_6	459	464	PF01217	0.411
TRG_DiLeu_BaLyEn_6	740	745	PF01217	0.677
TRG_ENDOCYTIC_2	376	379	PF00928	0.411
TRG_ENDOCYTIC_2	447	450	PF00928	0.411
TRG_ENDOCYTIC_2	54	57	PF00928	0.447
TRG_ENDOCYTIC_2	871	874	PF00928	0.515
TRG_ER_diArg_1	399	402	PF00400	0.411
TRG_ER_diArg_1	461	463	PF00400	0.499
TRG_ER_diArg_1	475	478	PF00400	0.411
TRG_ER_diArg_1	732	735	PF00400	0.668
TRG_ER_diArg_1	774	777	PF00400	0.739
TRG_ER_diArg_1	882	884	PF00400	0.542
TRG_ER_diArg_1	888	891	PF00400	0.447
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.747
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	461	465	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q8	Leptomonas seymouri	47%	99%
A4HCU8	Leishmania braziliensis	66%	98%
A4I0C9	Leishmania infantum	99%	100%
E9AW93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QB85	Leishmania major	87%	100%