Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFT7_LEIDO

TriTrypDb:

LdBPK_360830.1 , LdCL_360013200 , LDHU3_36.1080

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFT7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.434
CLV_NRD_NRD_1	102	104	PF00675	0.581
CLV_NRD_NRD_1	255	257	PF00675	0.473
CLV_NRD_NRD_1	331	333	PF00675	0.653
CLV_NRD_NRD_1	411	413	PF00675	0.763
CLV_NRD_NRD_1	421	423	PF00675	0.633
CLV_PCSK_FUR_1	100	104	PF00082	0.511
CLV_PCSK_KEX2_1	100	102	PF00082	0.593
CLV_PCSK_KEX2_1	331	333	PF00082	0.638
CLV_PCSK_KEX2_1	421	423	PF00082	0.653
CLV_PCSK_SKI1_1	282	286	PF00082	0.440
DEG_SPOP_SBC_1	373	377	PF00917	0.623
DEG_SPOP_SBC_1	397	401	PF00917	0.596
DOC_CKS1_1	204	209	PF01111	0.558
DOC_CKS1_1	60	65	PF01111	0.568
DOC_CYCLIN_yCln2_LP_2	330	336	PF00134	0.668
DOC_MAPK_HePTP_8	19	31	PF00069	0.418
DOC_MAPK_MEF2A_6	22	31	PF00069	0.436
DOC_PP1_RVXF_1	183	190	PF00149	0.510
DOC_PP2B_LxvP_1	249	252	PF13499	0.674
DOC_PP4_FxxP_1	23	26	PF00568	0.342
DOC_USP7_MATH_1	114	118	PF00917	0.687
DOC_USP7_MATH_1	180	184	PF00917	0.683
DOC_USP7_MATH_1	188	192	PF00917	0.750
DOC_USP7_MATH_1	229	233	PF00917	0.480
DOC_USP7_MATH_1	268	272	PF00917	0.785
DOC_USP7_MATH_1	372	376	PF00917	0.722
DOC_USP7_MATH_1	378	382	PF00917	0.597
DOC_USP7_MATH_1	383	387	PF00917	0.551
DOC_USP7_MATH_1	396	400	PF00917	0.751
DOC_USP7_MATH_1	404	408	PF00917	0.706
DOC_WW_Pin1_4	203	208	PF00397	0.686
DOC_WW_Pin1_4	367	372	PF00397	0.744
DOC_WW_Pin1_4	376	381	PF00397	0.752
DOC_WW_Pin1_4	59	64	PF00397	0.562
LIG_14-3-3_CanoR_1	157	161	PF00244	0.449
LIG_14-3-3_CanoR_1	298	305	PF00244	0.562
LIG_14-3-3_CanoR_1	61	71	PF00244	0.535
LIG_Actin_WH2_2	321	337	PF00022	0.669
LIG_BIR_II_1	1	5	PF00653	0.568
LIG_BRCT_BRCA1_1	185	189	PF00533	0.510
LIG_FHA_1	179	185	PF00498	0.612
LIG_FHA_2	1	7	PF00498	0.499
LIG_FHA_2	165	171	PF00498	0.713
LIG_FHA_2	204	210	PF00498	0.496
LIG_FHA_2	63	69	PF00498	0.411
LIG_FHA_2	8	14	PF00498	0.366
LIG_IRF3_LxIS_1	358	364	PF10401	0.463
LIG_LIR_Gen_1	194	204	PF02991	0.682
LIG_LIR_Nem_3	151	156	PF02991	0.434
LIG_LIR_Nem_3	194	199	PF02991	0.677
LIG_LIR_Nem_3	232	238	PF02991	0.545
LIG_LIR_Nem_3	6	11	PF02991	0.438
LIG_NRBOX	14	20	PF00104	0.437
LIG_SH2_CRK	153	157	PF00017	0.419
LIG_SH2_GRB2like	305	308	PF00017	0.586
LIG_SH2_SRC	11	14	PF00017	0.468
LIG_SH2_STAT5	11	14	PF00017	0.327
LIG_SH2_STAT5	305	308	PF00017	0.820
LIG_SH3_3	245	251	PF00018	0.605
LIG_SH3_3	291	297	PF00018	0.673
LIG_SH3_3	330	336	PF00018	0.592
LIG_SH3_CIN85_PxpxPR_1	295	300	PF14604	0.569
LIG_SUMO_SIM_anti_2	13	19	PF11976	0.457
LIG_SUMO_SIM_par_1	25	30	PF11976	0.432
LIG_TRAF2_1	208	211	PF00917	0.487
LIG_TRAF2_1	30	33	PF00917	0.491
LIG_TRAF2_1	65	68	PF00917	0.484
LIG_ULM_U2AF65_1	421	426	PF00076	0.694
LIG_WRC_WIRS_1	5	10	PF05994	0.405
LIG_WW_3	295	299	PF00397	0.602
MOD_CK1_1	183	189	PF00069	0.721
MOD_CK1_1	191	197	PF00069	0.575
MOD_CK1_1	386	392	PF00069	0.629
MOD_CK1_1	399	405	PF00069	0.696
MOD_CK1_1	7	13	PF00069	0.363
MOD_CK2_1	191	197	PF00069	0.573
MOD_CK2_1	203	209	PF00069	0.406
MOD_CK2_1	27	33	PF00069	0.463
MOD_CK2_1	275	281	PF00069	0.629
MOD_CK2_1	62	68	PF00069	0.409
MOD_GlcNHglycan	111	114	PF01048	0.707
MOD_GlcNHglycan	116	119	PF01048	0.670
MOD_GlcNHglycan	192	196	PF01048	0.601
MOD_GlcNHglycan	231	234	PF01048	0.452
MOD_GlcNHglycan	270	273	PF01048	0.623
MOD_GlcNHglycan	308	311	PF01048	0.771
MOD_GlcNHglycan	336	339	PF01048	0.633
MOD_GlcNHglycan	364	367	PF01048	0.752
MOD_GlcNHglycan	376	379	PF01048	0.717
MOD_GlcNHglycan	385	388	PF01048	0.722
MOD_GlcNHglycan	41	44	PF01048	0.579
MOD_GlcNHglycan	80	83	PF01048	0.398
MOD_GSK3_1	114	121	PF00069	0.581
MOD_GSK3_1	156	163	PF00069	0.542
MOD_GSK3_1	35	42	PF00069	0.675
MOD_GSK3_1	362	369	PF00069	0.718
MOD_GSK3_1	372	379	PF00069	0.699
MOD_GSK3_1	398	405	PF00069	0.729
MOD_N-GLC_1	121	126	PF02516	0.769
MOD_N-GLC_1	303	308	PF02516	0.737
MOD_N-GLC_1	39	44	PF02516	0.646
MOD_N-GLC_2	360	362	PF02516	0.614
MOD_NEK2_1	109	114	PF00069	0.519
MOD_NEK2_1	361	366	PF00069	0.776
MOD_NEK2_1	80	85	PF00069	0.402
MOD_NEK2_2	180	185	PF00069	0.521
MOD_PIKK_1	222	228	PF00454	0.617
MOD_PIKK_1	298	304	PF00454	0.700
MOD_PIKK_1	399	405	PF00454	0.654
MOD_PKA_1	412	418	PF00069	0.644
MOD_PKA_2	156	162	PF00069	0.565
MOD_PKA_2	334	340	PF00069	0.578
MOD_PKB_1	349	357	PF00069	0.537
MOD_Plk_1	27	33	PF00069	0.487
MOD_Plk_4	148	154	PF00069	0.535
MOD_Plk_4	244	250	PF00069	0.448
MOD_Plk_4	320	326	PF00069	0.694
MOD_Plk_4	343	349	PF00069	0.619
MOD_Plk_4	7	13	PF00069	0.411
MOD_ProDKin_1	203	209	PF00069	0.679
MOD_ProDKin_1	367	373	PF00069	0.746
MOD_ProDKin_1	376	382	PF00069	0.753
MOD_ProDKin_1	59	65	PF00069	0.564
TRG_DiLeu_BaEn_1	105	110	PF01217	0.438
TRG_DiLeu_BaEn_1	211	216	PF01217	0.529
TRG_DiLeu_BaEn_1	281	286	PF01217	0.585
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.458
TRG_ENDOCYTIC_2	153	156	PF00928	0.413
TRG_ER_diArg_1	100	103	PF00400	0.589
TRG_ER_diArg_1	297	300	PF00400	0.619
TRG_ER_diArg_1	330	332	PF00400	0.667
TRG_ER_diArg_1	348	351	PF00400	0.446
TRG_ER_diArg_1	421	424	PF00400	0.686
TRG_ER_diArg_1	88	91	PF00400	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFS7	Leptomonas seymouri	44%	99%
A0A1X0P881	Trypanosomatidae	28%	94%
A0A422NK60	Trypanosoma rangeli	29%	100%
A4HNT7	Leishmania braziliensis	68%	100%
A4ICQ7	Leishmania infantum	99%	100%
D0A2Q4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ASJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q1Z9	Leishmania major	89%	100%
V5BZW6	Trypanosoma cruzi	28%	100%