Calpain family cysteine protease, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calpain-like cysteine peptidase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IFT5_LEIDO

TriTrypDb:

LdBPK_321020.1 , LdCL_320015900 , LDHU3_32.1360

Length:

1888

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0019538	protein metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004175	endopeptidase activity	4	9
GO:0004197	cysteine-type endopeptidase activity	5	9
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	9
GO:0008233	peptidase activity	3	9
GO:0008234	cysteine-type peptidase activity	4	9
GO:0016787	hydrolase activity	2	9
GO:0140096	catalytic activity, acting on a protein	2	9

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1028	1032	PF00656	0.788
CLV_C14_Caspase3-7	516	520	PF00656	0.644
CLV_C14_Caspase3-7	611	615	PF00656	0.564
CLV_C14_Caspase3-7	961	965	PF00656	0.573
CLV_NRD_NRD_1	1214	1216	PF00675	0.569
CLV_NRD_NRD_1	1362	1364	PF00675	0.486
CLV_NRD_NRD_1	1400	1402	PF00675	0.636
CLV_NRD_NRD_1	1409	1411	PF00675	0.676
CLV_NRD_NRD_1	1428	1430	PF00675	0.659
CLV_NRD_NRD_1	1436	1438	PF00675	0.565

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9A0	Leptomonas seymouri	43%	97%
A0A3S5IQR2	Trypanosoma rangeli	28%	100%
A4HK78	Leishmania braziliensis	68%	100%
A4I7R3	Leishmania infantum	99%	100%
D0A9W8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B2M1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q5I5	Leishmania major	91%	100%

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