Ankyrin_repeats_(3_copies)/Ankyrin_repeat/Ankyrin _repeats_(Many_copies)_putative/Pfam:PF12796/Pfam:PF13606/P fam:PF00023/Pfam:PF13637/Pfam:PF13857

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies)/Ankyrin repeats (many copies), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IFT3_LEIDO

TriTrypDb:

LdBPK_343340.1 , LdCL_340042800 , LDHU3_34.5520

Length:

341

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFT3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	235	237	PF00675	0.629
CLV_NRD_NRD_1	262	264	PF00675	0.589
CLV_NRD_NRD_1	90	92	PF00675	0.431
CLV_PCSK_KEX2_1	234	236	PF00082	0.618
CLV_PCSK_KEX2_1	262	264	PF00082	0.596
CLV_PCSK_SKI1_1	16	20	PF00082	0.457
CLV_PCSK_SKI1_1	196	200	PF00082	0.513
DEG_COP1_1	250	259	PF00400	0.674
DOC_CKS1_1	136	141	PF01111	0.404
DOC_MAPK_gen_1	132	142	PF00069	0.308
DOC_MAPK_gen_1	179	188	PF00069	0.272
DOC_MAPK_MEF2A_6	148	156	PF00069	0.404
DOC_MAPK_MEF2A_6	179	188	PF00069	0.272
DOC_MAPK_MEF2A_6	247	256	PF00069	0.547
DOC_USP7_MATH_1	212	216	PF00917	0.511
DOC_USP7_MATH_1	274	278	PF00917	0.523
DOC_WW_Pin1_4	135	140	PF00397	0.258
DOC_WW_Pin1_4	168	173	PF00397	0.339
DOC_WW_Pin1_4	282	287	PF00397	0.687
DOC_WW_Pin1_4	45	50	PF00397	0.346
DOC_WW_Pin1_4	68	73	PF00397	0.339
LIG_14-3-3_CanoR_1	234	239	PF00244	0.605
LIG_Actin_WH2_2	180	198	PF00022	0.385
LIG_BIR_II_1	1	5	PF00653	0.492
LIG_FHA_1	149	155	PF00498	0.405
LIG_FHA_1	305	311	PF00498	0.685
LIG_FHA_2	311	317	PF00498	0.602
LIG_FHA_2	65	71	PF00498	0.420
LIG_LIR_Apic_2	280	286	PF02991	0.517
LIG_LIR_Apic_2	334	339	PF02991	0.567
LIG_LIR_Gen_1	150	160	PF02991	0.350
LIG_LIR_Gen_1	2	8	PF02991	0.312
LIG_LIR_Gen_1	71	82	PF02991	0.404
LIG_LIR_Nem_3	150	156	PF02991	0.315
LIG_LIR_Nem_3	178	184	PF02991	0.423
LIG_LIR_Nem_3	2	6	PF02991	0.295
LIG_LIR_Nem_3	33	38	PF02991	0.324
LIG_LIR_Nem_3	71	77	PF02991	0.404
LIG_NRBOX	118	124	PF00104	0.354
LIG_SH2_CRK	283	287	PF00017	0.600
LIG_SH2_CRK	336	340	PF00017	0.668
LIG_SH2_NCK_1	283	287	PF00017	0.540
LIG_SH2_NCK_1	336	340	PF00017	0.543
LIG_SH2_PTP2	35	38	PF00017	0.340
LIG_SH2_PTP2	74	77	PF00017	0.404
LIG_SH2_SRC	336	339	PF00017	0.599
LIG_SH2_SRC	87	90	PF00017	0.306
LIG_SH2_STAT5	141	144	PF00017	0.321
LIG_SH2_STAT5	153	156	PF00017	0.306
LIG_SH2_STAT5	35	38	PF00017	0.318
LIG_SH2_STAT5	39	42	PF00017	0.308
LIG_SH2_STAT5	74	77	PF00017	0.266
LIG_SH2_STAT5	87	90	PF00017	0.238
LIG_SH3_3	253	259	PF00018	0.547
LIG_SH3_3	284	290	PF00018	0.570
LIG_SH3_3	95	101	PF00018	0.306
LIG_TRAF2_1	134	137	PF00917	0.403
LIG_TRAF2_1	277	280	PF00917	0.513
LIG_WRC_WIRS_1	118	123	PF05994	0.204
MOD_CK2_1	174	180	PF00069	0.469
MOD_CK2_1	274	280	PF00069	0.552
MOD_CK2_1	310	316	PF00069	0.716
MOD_CK2_1	64	70	PF00069	0.355
MOD_GlcNHglycan	123	126	PF01048	0.388
MOD_GlcNHglycan	32	35	PF01048	0.308
MOD_GSK3_1	117	124	PF00069	0.428
MOD_GSK3_1	197	204	PF00069	0.556
MOD_GSK3_1	64	71	PF00069	0.376
MOD_N-GLC_1	30	35	PF02516	0.387
MOD_NEK2_1	121	126	PF00069	0.381
MOD_NEK2_1	73	78	PF00069	0.398
MOD_PK_1	324	330	PF00069	0.570
MOD_PKA_1	234	240	PF00069	0.551
MOD_PKA_2	102	108	PF00069	0.462
MOD_PKA_2	234	240	PF00069	0.686
MOD_PKA_2	299	305	PF00069	0.741
MOD_PKA_2	64	70	PF00069	0.269
MOD_Plk_4	117	123	PF00069	0.378
MOD_Plk_4	148	154	PF00069	0.404
MOD_Plk_4	305	311	PF00069	0.634
MOD_ProDKin_1	135	141	PF00069	0.258
MOD_ProDKin_1	168	174	PF00069	0.339
MOD_ProDKin_1	282	288	PF00069	0.690
MOD_ProDKin_1	45	51	PF00069	0.346
MOD_ProDKin_1	68	74	PF00069	0.339
MOD_SUMO_rev_2	167	172	PF00179	0.273
MOD_SUMO_rev_2	177	184	PF00179	0.276
MOD_SUMO_rev_2	250	257	PF00179	0.624
TRG_ENDOCYTIC_2	153	156	PF00928	0.272
TRG_ENDOCYTIC_2	181	184	PF00928	0.306
TRG_ENDOCYTIC_2	35	38	PF00928	0.324
TRG_ENDOCYTIC_2	74	77	PF00928	0.404
TRG_ER_diArg_1	206	209	PF00400	0.542
TRG_ER_diArg_1	233	236	PF00400	0.586
TRG_ER_diArg_1	261	263	PF00400	0.626
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB55	Leptomonas seymouri	67%	100%
A0A0S4IZ37	Bodo saltans	25%	93%
A0A1X0PAB8	Trypanosomatidae	47%	100%
A0A3R7RA24	Trypanosoma rangeli	43%	100%
A4HB74	Leishmania braziliensis	86%	100%
A4IAC2	Leishmania infantum	100%	100%
C9ZLX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B1A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	83%
E9B5E5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q2I8	Leishmania major	93%	100%
V5B6C0	Trypanosoma cruzi	48%	93%