Papain-like cysteine peptidase (DUF1796), putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative papain-like cysteine peptidase (DUF1796), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IFT0_LEIDO

TriTrypDb:

LdBPK_301590.1 , LdCL_300021200 , LDHU3_30.2070

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFT0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	254	258	PF00656	0.504
CLV_C14_Caspase3-7	320	324	PF00656	0.553
CLV_NRD_NRD_1	146	148	PF00675	0.330
CLV_NRD_NRD_1	242	244	PF00675	0.454
CLV_NRD_NRD_1	308	310	PF00675	0.596
CLV_NRD_NRD_1	396	398	PF00675	0.594
CLV_PCSK_FUR_1	397	401	PF00082	0.376
CLV_PCSK_KEX2_1	145	147	PF00082	0.378
CLV_PCSK_KEX2_1	242	244	PF00082	0.578
CLV_PCSK_KEX2_1	396	398	PF00082	0.505
CLV_PCSK_KEX2_1	399	401	PF00082	0.473
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.431
CLV_PCSK_SKI1_1	169	173	PF00082	0.458
CLV_PCSK_SKI1_1	207	211	PF00082	0.433
CLV_PCSK_SKI1_1	288	292	PF00082	0.355
CLV_PCSK_SKI1_1	410	414	PF00082	0.414
DEG_Nend_Nbox_1	1	3	PF02207	0.281
DEG_SCF_FBW7_1	53	60	PF00400	0.194
DEG_SCF_FBW7_2	312	318	PF00400	0.402
DEG_SPOP_SBC_1	247	251	PF00917	0.515
DOC_CKS1_1	312	317	PF01111	0.399
DOC_CYCLIN_RxL_1	407	415	PF00134	0.546
DOC_MAPK_gen_1	197	206	PF00069	0.368
DOC_PIKK_1	369	376	PF02985	0.343
DOC_PP1_RVXF_1	167	174	PF00149	0.388
DOC_PP2B_LxvP_1	154	157	PF13499	0.222
DOC_USP7_MATH_1	226	230	PF00917	0.463
DOC_USP7_MATH_1	247	251	PF00917	0.757
DOC_USP7_MATH_1	25	29	PF00917	0.362
DOC_USP7_MATH_1	255	259	PF00917	0.662
DOC_USP7_MATH_1	64	68	PF00917	0.246
DOC_USP7_MATH_1	89	93	PF00917	0.276
DOC_USP7_MATH_1	98	102	PF00917	0.219
DOC_WW_Pin1_4	231	236	PF00397	0.457
DOC_WW_Pin1_4	311	316	PF00397	0.552
DOC_WW_Pin1_4	53	58	PF00397	0.248
DOC_WW_Pin1_4	68	73	PF00397	0.197
DOC_WW_Pin1_4	77	82	PF00397	0.234
DOC_WW_Pin1_4	96	101	PF00397	0.281
LIG_14-3-3_CanoR_1	169	174	PF00244	0.329
LIG_14-3-3_CanoR_1	248	256	PF00244	0.485
LIG_14-3-3_CanoR_1	3	8	PF00244	0.317
LIG_14-3-3_CanoR_1	35	39	PF00244	0.305
LIG_14-3-3_CterR_2	410	415	PF00244	0.533
LIG_APCC_ABBA_1	313	318	PF00400	0.398
LIG_BIR_III_4	102	106	PF00653	0.194
LIG_BRCT_BRCA1_1	27	31	PF00533	0.276
LIG_FHA_1	206	212	PF00498	0.315
LIG_FHA_1	217	223	PF00498	0.427
LIG_FHA_1	54	60	PF00498	0.276
LIG_FHA_1	69	75	PF00498	0.174
LIG_FHA_2	129	135	PF00498	0.341
LIG_LIR_Gen_1	277	286	PF02991	0.418
LIG_LIR_Gen_1	28	38	PF02991	0.461
LIG_LIR_Gen_1	314	322	PF02991	0.535
LIG_LIR_Gen_1	404	413	PF02991	0.523
LIG_LIR_LC3C_4	208	212	PF02991	0.433
LIG_LIR_Nem_3	277	282	PF02991	0.428
LIG_LIR_Nem_3	28	34	PF02991	0.389
LIG_LIR_Nem_3	314	319	PF02991	0.539
LIG_LIR_Nem_3	37	41	PF02991	0.323
LIG_LIR_Nem_3	404	409	PF02991	0.490
LIG_NRBOX	408	414	PF00104	0.532
LIG_Pex14_2	335	339	PF04695	0.405
LIG_PTAP_UEV_1	94	99	PF05743	0.194
LIG_SH2_CRK	279	283	PF00017	0.446
LIG_SH2_SRC	305	308	PF00017	0.534
LIG_SH2_STAP1	302	306	PF00017	0.516
LIG_SH2_STAT3	87	90	PF00017	0.224
LIG_SH2_STAT5	305	308	PF00017	0.608
LIG_SH2_STAT5	316	319	PF00017	0.543
LIG_SH2_STAT5	87	90	PF00017	0.276
LIG_SH3_1	309	315	PF00018	0.407
LIG_SH3_3	309	315	PF00018	0.559
LIG_SH3_3	52	58	PF00018	0.294
LIG_SH3_3	92	98	PF00018	0.199
LIG_SUMO_SIM_anti_2	208	214	PF11976	0.315
LIG_SUMO_SIM_par_1	208	214	PF11976	0.375
LIG_SUMO_SIM_par_1	39	45	PF11976	0.276
LIG_TRAF2_1	163	166	PF00917	0.239
LIG_TRAF2_1	182	185	PF00917	0.341
LIG_TRAF2_1	24	27	PF00917	0.341
LIG_TRAF2_1	81	84	PF00917	0.276
LIG_UBA3_1	282	291	PF00899	0.367
MOD_CK1_1	250	256	PF00069	0.601
MOD_CK1_1	263	269	PF00069	0.440
MOD_CK1_1	337	343	PF00069	0.554
MOD_CK1_1	96	102	PF00069	0.267
MOD_GlcNHglycan	253	256	PF01048	0.612
MOD_GlcNHglycan	262	265	PF01048	0.566
MOD_GlcNHglycan	339	342	PF01048	0.584
MOD_GlcNHglycan	357	360	PF01048	0.560
MOD_GlcNHglycan	68	71	PF01048	0.488
MOD_GlcNHglycan	95	98	PF01048	0.259
MOD_GSK3_1	11	18	PF00069	0.276
MOD_GSK3_1	169	176	PF00069	0.337
MOD_GSK3_1	246	253	PF00069	0.725
MOD_GSK3_1	255	262	PF00069	0.563
MOD_GSK3_1	263	270	PF00069	0.461
MOD_GSK3_1	278	285	PF00069	0.566
MOD_GSK3_1	291	298	PF00069	0.483
MOD_GSK3_1	301	308	PF00069	0.443
MOD_GSK3_1	330	337	PF00069	0.466
MOD_GSK3_1	49	56	PF00069	0.276
MOD_GSK3_1	64	71	PF00069	0.174
MOD_GSK3_1	89	96	PF00069	0.298
MOD_N-GLC_1	135	140	PF02516	0.465
MOD_N-GLC_1	77	82	PF02516	0.231
MOD_NEK2_1	122	127	PF00069	0.375
MOD_NEK2_1	15	20	PF00069	0.311
MOD_NEK2_1	173	178	PF00069	0.297
MOD_NEK2_1	295	300	PF00069	0.479
MOD_NEK2_1	335	340	PF00069	0.510
MOD_NEK2_1	49	54	PF00069	0.395
MOD_PIKK_1	122	128	PF00454	0.375
MOD_PKA_2	247	253	PF00069	0.503
MOD_PKA_2	328	334	PF00069	0.476
MOD_PKA_2	34	40	PF00069	0.288
MOD_PKB_1	167	175	PF00069	0.231
MOD_Plk_1	25	31	PF00069	0.457
MOD_Plk_1	295	301	PF00069	0.483
MOD_Plk_1	317	323	PF00069	0.504
MOD_Plk_2-3	267	273	PF00069	0.503
MOD_Plk_4	11	17	PF00069	0.306
MOD_Plk_4	169	175	PF00069	0.305
MOD_Plk_4	267	273	PF00069	0.537
MOD_Plk_4	278	284	PF00069	0.450
MOD_Plk_4	301	307	PF00069	0.531
MOD_ProDKin_1	231	237	PF00069	0.450
MOD_ProDKin_1	311	317	PF00069	0.401
MOD_ProDKin_1	53	59	PF00069	0.248
MOD_ProDKin_1	68	74	PF00069	0.197
MOD_ProDKin_1	77	83	PF00069	0.234
MOD_ProDKin_1	96	102	PF00069	0.281
TRG_DiLeu_BaEn_1	267	272	PF01217	0.442
TRG_DiLeu_BaEn_4	184	190	PF01217	0.424
TRG_ENDOCYTIC_2	279	282	PF00928	0.383
TRG_ENDOCYTIC_2	316	319	PF00928	0.460
TRG_ER_diArg_1	144	147	PF00400	0.394
TRG_ER_diArg_1	167	170	PF00400	0.294
TRG_ER_diArg_1	201	204	PF00400	0.246
TRG_ER_diArg_1	241	243	PF00400	0.399
TRG_Pf-PMV_PEXEL_1	410	415	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L5	Leptomonas seymouri	29%	100%
A0A0S4JE30	Bodo saltans	37%	100%
A0A0S4JK16	Bodo saltans	28%	95%
A0A1X0NVQ6	Trypanosomatidae	30%	100%
A0A1X0P1X9	Trypanosomatidae	42%	100%
A0A3R7KWZ0	Trypanosoma rangeli	29%	100%
A0A3R7KYN0	Trypanosoma rangeli	43%	100%
A0A3S7WTN3	Leishmania donovani	29%	100%
A4H8A5	Leishmania braziliensis	28%	84%
A4HIA2	Leishmania braziliensis	82%	100%
A4HWM5	Leishmania infantum	29%	89%
A4I5I6	Leishmania infantum	100%	100%
C9ZXR2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AQD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	89%
E9B0T1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q7E7	Leishmania major	93%	100%
Q4QF43	Leishmania major	29%	89%
V5BPI9	Trypanosoma cruzi	41%	100%
V5BUE5	Trypanosoma cruzi	29%	100%