Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFS9_LEIDO

TriTrypDb:

LdBPK_302700.1 , LdCL_300032600 , LDHU3_30.3620

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

A0A3Q8IFS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFS9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.392
CLV_NRD_NRD_1	177	179	PF00675	0.403
CLV_NRD_NRD_1	199	201	PF00675	0.633
CLV_NRD_NRD_1	252	254	PF00675	0.642
CLV_NRD_NRD_1	261	263	PF00675	0.529
CLV_NRD_NRD_1	307	309	PF00675	0.731
CLV_PCSK_KEX2_1	12	14	PF00082	0.392
CLV_PCSK_KEX2_1	177	179	PF00082	0.403
CLV_PCSK_KEX2_1	199	201	PF00082	0.596
CLV_PCSK_KEX2_1	252	254	PF00082	0.615
CLV_PCSK_KEX2_1	307	309	PF00082	0.731
CLV_PCSK_KEX2_1	385	387	PF00082	0.538
CLV_PCSK_KEX2_1	65	67	PF00082	0.398
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.538
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.398
CLV_PCSK_PC7_1	195	201	PF00082	0.602
CLV_PCSK_SKI1_1	183	187	PF00082	0.548
CLV_PCSK_SKI1_1	263	267	PF00082	0.662
CLV_PCSK_SKI1_1	33	37	PF00082	0.368
CLV_PCSK_SKI1_1	369	373	PF00082	0.712
CLV_PCSK_SKI1_1	5	9	PF00082	0.512
CLV_PCSK_SKI1_1	97	101	PF00082	0.326
DEG_COP1_1	276	284	PF00400	0.597
DEG_ODPH_VHL_1	345	356	PF01847	0.532
DEG_SPOP_SBC_1	150	154	PF00917	0.376
DEG_SPOP_SBC_1	328	332	PF00917	0.570
DOC_CYCLIN_RxL_1	94	105	PF00134	0.333
DOC_CYCLIN_yCln2_LP_2	272	275	PF00134	0.704
DOC_MAPK_gen_1	65	73	PF00069	0.344
DOC_PP1_RVXF_1	95	102	PF00149	0.336
DOC_PP2B_LxvP_1	272	275	PF13499	0.704
DOC_PP2B_PxIxI_1	236	242	PF00149	0.636
DOC_SPAK_OSR1_1	86	90	PF12202	0.478
DOC_USP7_MATH_1	291	295	PF00917	0.617
DOC_USP7_MATH_1	327	331	PF00917	0.479
DOC_WW_Pin1_4	233	238	PF00397	0.649
DOC_WW_Pin1_4	309	314	PF00397	0.593
LIG_14-3-3_CanoR_1	21	29	PF00244	0.578
LIG_14-3-3_CanoR_1	349	354	PF00244	0.656
LIG_14-3-3_CanoR_1	97	102	PF00244	0.382
LIG_Clathr_ClatBox_1	223	227	PF01394	0.548
LIG_Clathr_ClatBox_1	70	74	PF01394	0.325
LIG_CtBP_PxDLS_1	274	278	PF00389	0.569
LIG_EVH1_1	203	207	PF00568	0.561
LIG_FHA_1	127	133	PF00498	0.474
LIG_FHA_1	150	156	PF00498	0.381
LIG_FHA_1	23	29	PF00498	0.379
LIG_FHA_1	267	273	PF00498	0.757
LIG_FHA_1	373	379	PF00498	0.595
LIG_FHA_2	123	129	PF00498	0.382
LIG_FHA_2	246	252	PF00498	0.585
LIG_FHA_2	318	324	PF00498	0.566
LIG_FHA_2	98	104	PF00498	0.464
LIG_LIR_Apic_2	323	327	PF02991	0.536
LIG_LIR_Gen_1	190	198	PF02991	0.458
LIG_LIR_Gen_1	40	47	PF02991	0.361
LIG_LIR_Nem_3	100	104	PF02991	0.351
LIG_LIR_Nem_3	190	196	PF02991	0.451
LIG_LIR_Nem_3	34	38	PF02991	0.416
LIG_LIR_Nem_3	40	45	PF02991	0.345
LIG_LIR_Nem_3	82	88	PF02991	0.377
LIG_RPA_C_Fungi	173	185	PF08784	0.520
LIG_SH2_CRK	193	197	PF00017	0.461
LIG_SH2_PTP2	42	45	PF00017	0.332
LIG_SH2_PTP2	88	91	PF00017	0.469
LIG_SH2_STAT5	193	196	PF00017	0.595
LIG_SH2_STAT5	247	250	PF00017	0.575
LIG_SH2_STAT5	337	340	PF00017	0.561
LIG_SH2_STAT5	380	383	PF00017	0.563
LIG_SH2_STAT5	42	45	PF00017	0.342
LIG_SH2_STAT5	88	91	PF00017	0.363
LIG_SH3_2	230	235	PF14604	0.536
LIG_SH3_3	201	207	PF00018	0.550
LIG_SH3_3	227	233	PF00018	0.640
LIG_SH3_3	351	357	PF00018	0.681
LIG_SH3_3	373	379	PF00018	0.662
LIG_SH3_3	4	10	PF00018	0.520
LIG_SH3_CIN85_PxpxPR_1	230	235	PF14604	0.672
LIG_SUMO_SIM_par_1	216	222	PF11976	0.626
LIG_SUMO_SIM_par_1	69	74	PF11976	0.329
LIG_TYR_ITIM	378	383	PF00017	0.558
LIG_UBA3_1	223	229	PF00899	0.548
LIG_WRC_WIRS_1	32	37	PF05994	0.362
LIG_WW_3	232	236	PF00397	0.539
MOD_CK1_1	114	120	PF00069	0.478
MOD_CK1_1	225	231	PF00069	0.588
MOD_CK1_1	276	282	PF00069	0.603
MOD_CK1_1	31	37	PF00069	0.377
MOD_CK2_1	122	128	PF00069	0.380
MOD_CK2_1	133	139	PF00069	0.493
MOD_CK2_1	312	318	PF00069	0.679
MOD_Cter_Amidation	260	263	PF01082	0.539
MOD_Cter_Amidation	383	386	PF01082	0.545
MOD_GlcNHglycan	112	116	PF01048	0.377
MOD_GlcNHglycan	165	168	PF01048	0.450
MOD_GlcNHglycan	189	192	PF01048	0.457
MOD_GlcNHglycan	282	285	PF01048	0.582
MOD_GlcNHglycan	53	56	PF01048	0.456
MOD_GSK3_1	122	129	PF00069	0.379
MOD_GSK3_1	150	157	PF00069	0.488
MOD_GSK3_1	187	194	PF00069	0.447
MOD_GSK3_1	273	280	PF00069	0.674
MOD_GSK3_1	291	298	PF00069	0.641
MOD_GSK3_1	299	306	PF00069	0.516
MOD_GSK3_1	365	372	PF00069	0.593
MOD_N-GLC_1	150	155	PF02516	0.382
MOD_N-GLC_1	187	192	PF02516	0.510
MOD_NEK2_1	132	137	PF00069	0.378
MOD_NEK2_1	277	282	PF00069	0.681
MOD_NEK2_1	329	334	PF00069	0.570
MOD_NEK2_1	362	367	PF00069	0.709
MOD_NEK2_2	92	97	PF00069	0.333
MOD_PK_1	349	355	PF00069	0.543
MOD_PKA_1	369	375	PF00069	0.624
MOD_PKA_2	198	204	PF00069	0.569
MOD_Plk_1	150	156	PF00069	0.367
MOD_Plk_1	317	323	PF00069	0.665
MOD_Plk_2-3	222	228	PF00069	0.643
MOD_Plk_2-3	317	323	PF00069	0.545
MOD_Plk_4	151	157	PF00069	0.367
MOD_Plk_4	268	274	PF00069	0.654
MOD_Plk_4	317	323	PF00069	0.559
MOD_Plk_4	349	355	PF00069	0.582
MOD_Plk_4	97	103	PF00069	0.496
MOD_ProDKin_1	233	239	PF00069	0.650
MOD_ProDKin_1	309	315	PF00069	0.585
MOD_SUMO_rev_2	221	230	PF00179	0.641
TRG_ENDOCYTIC_2	193	196	PF00928	0.458
TRG_ENDOCYTIC_2	380	383	PF00928	0.563
TRG_ENDOCYTIC_2	42	45	PF00928	0.346
TRG_ER_diArg_1	177	180	PF00400	0.413
TRG_ER_diArg_1	198	200	PF00400	0.624
TRG_ER_diArg_1	252	254	PF00400	0.463
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB83	Leptomonas seymouri	45%	88%
A4I5U7	Leishmania infantum	100%	100%
E9B142	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q724	Leishmania major	93%	100%