AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFS8_LEIDO

TriTrypDb:

LdBPK_323600.1 , LdCL_320041900 , LDHU3_32.4550

Length:

604

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8IFS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFS8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.411
CLV_NRD_NRD_1	291	293	PF00675	0.595
CLV_PCSK_KEX2_1	291	293	PF00082	0.671
CLV_PCSK_SKI1_1	104	108	PF00082	0.622
CLV_PCSK_SKI1_1	267	271	PF00082	0.598
CLV_PCSK_SKI1_1	303	307	PF00082	0.539
CLV_PCSK_SKI1_1	561	565	PF00082	0.441
CLV_PCSK_SKI1_1	86	90	PF00082	0.617
DEG_APCC_DBOX_1	302	310	PF00400	0.355
DEG_APCC_DBOX_1	560	568	PF00400	0.429
DEG_MDM2_SWIB_1	552	559	PF02201	0.493
DEG_SPOP_SBC_1	154	158	PF00917	0.384
DOC_ANK_TNKS_1	180	187	PF00023	0.432
DOC_CDC14_PxL_1	312	320	PF14671	0.439
DOC_CDC14_PxL_1	325	333	PF14671	0.379
DOC_CKS1_1	480	485	PF01111	0.401
DOC_CYCLIN_RxL_1	389	401	PF00134	0.420
DOC_CYCLIN_yClb1_LxF_4	69	74	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	310	316	PF00134	0.428
DOC_MAPK_DCC_7	8	18	PF00069	0.502
DOC_MAPK_gen_1	68	74	PF00069	0.446
DOC_MAPK_MEF2A_6	108	115	PF00069	0.406
DOC_MAPK_MEF2A_6	303	310	PF00069	0.389
DOC_MAPK_MEF2A_6	561	568	PF00069	0.393
DOC_MAPK_MEF2A_6	86	93	PF00069	0.406
DOC_MAPK_NFAT4_5	303	311	PF00069	0.388
DOC_MAPK_NFAT4_5	561	569	PF00069	0.419
DOC_PP1_RVXF_1	283	289	PF00149	0.385
DOC_PP1_RVXF_1	509	515	PF00149	0.370
DOC_PP1_RVXF_1	69	75	PF00149	0.395
DOC_PP2B_LxvP_1	397	400	PF13499	0.361
DOC_PP4_FxxP_1	531	534	PF00568	0.436
DOC_USP7_MATH_1	118	122	PF00917	0.380
DOC_USP7_MATH_1	131	135	PF00917	0.405
DOC_USP7_MATH_1	153	157	PF00917	0.427
DOC_USP7_MATH_1	261	265	PF00917	0.380
DOC_USP7_MATH_1	407	411	PF00917	0.424
DOC_USP7_MATH_1	41	45	PF00917	0.449
DOC_USP7_MATH_2	52	58	PF00917	0.430
DOC_WW_Pin1_4	479	484	PF00397	0.421
DOC_WW_Pin1_4	48	53	PF00397	0.436
LIG_14-3-3_CanoR_1	267	272	PF00244	0.394
LIG_14-3-3_CanoR_1	389	397	PF00244	0.432
LIG_14-3-3_CanoR_1	417	427	PF00244	0.423
LIG_14-3-3_CanoR_1	47	52	PF00244	0.480
LIG_14-3-3_CanoR_1	593	599	PF00244	0.688
LIG_14-3-3_CanoR_1	71	77	PF00244	0.432
LIG_Actin_WH2_2	458	473	PF00022	0.448
LIG_APCC_ABBA_1	489	494	PF00400	0.374
LIG_BIR_II_1	1	5	PF00653	0.702
LIG_BRCT_BRCA1_1	594	598	PF00533	0.653
LIG_deltaCOP1_diTrp_1	527	531	PF00928	0.377
LIG_EH1_1	73	81	PF00400	0.410
LIG_FHA_1	17	23	PF00498	0.480
LIG_FHA_1	430	436	PF00498	0.386
LIG_FHA_1	440	446	PF00498	0.369
LIG_FHA_1	480	486	PF00498	0.402
LIG_FHA_1	503	509	PF00498	0.427
LIG_FHA_1	56	62	PF00498	0.424
LIG_FHA_2	180	186	PF00498	0.372
LIG_IBAR_NPY_1	135	137	PF08397	0.394
LIG_LIR_Apic_2	219	223	PF02991	0.366
LIG_LIR_Apic_2	530	534	PF02991	0.408
LIG_LIR_Gen_1	227	237	PF02991	0.361
LIG_LIR_Gen_1	262	272	PF02991	0.319
LIG_LIR_Gen_1	401	408	PF02991	0.347
LIG_LIR_Gen_1	90	100	PF02991	0.409
LIG_LIR_Nem_3	227	232	PF02991	0.314
LIG_LIR_Nem_3	262	268	PF02991	0.318
LIG_LIR_Nem_3	596	602	PF02991	0.640
LIG_LIR_Nem_3	90	95	PF02991	0.262
LIG_LYPXL_S_1	314	318	PF13949	0.659
LIG_LYPXL_yS_3	315	318	PF13949	0.433
LIG_NRBOX	240	246	PF00104	0.354
LIG_PCNA_PIPBox_1	225	234	PF02747	0.372
LIG_PCNA_yPIPBox_3	321	334	PF02747	0.365
LIG_Pex14_2	552	556	PF04695	0.506
LIG_Pex14_3	372	377	PF04695	0.356
LIG_Rb_pABgroove_1	344	352	PF01858	0.342
LIG_SH2_CRK	350	354	PF00017	0.325
LIG_SH2_CRK	591	595	PF00017	0.664
LIG_SH2_GRB2like	599	602	PF00017	0.637
LIG_SH2_NCK_1	359	363	PF00017	0.464
LIG_SH2_NCK_1	591	595	PF00017	0.741
LIG_SH2_PTP2	220	223	PF00017	0.383
LIG_SH2_SRC	220	223	PF00017	0.392
LIG_SH2_STAT3	137	140	PF00017	0.466
LIG_SH2_STAT3	333	336	PF00017	0.299
LIG_SH2_STAT5	220	223	PF00017	0.318
LIG_SH2_STAT5	231	234	PF00017	0.325
LIG_SH2_STAT5	352	355	PF00017	0.363
LIG_SH2_STAT5	577	580	PF00017	0.370
LIG_SH2_STAT5	582	585	PF00017	0.592
LIG_SH3_3	310	316	PF00018	0.379
LIG_SH3_3	477	483	PF00018	0.426
LIG_SUMO_SIM_par_1	14	19	PF11976	0.437
LIG_SUMO_SIM_par_1	214	219	PF11976	0.405
LIG_TYR_ITIM	575	580	PF00017	0.266
LIG_UBA3_1	268	276	PF00899	0.400
LIG_WRC_WIRS_1	385	390	PF05994	0.456
LIG_WRC_WIRS_1	399	404	PF05994	0.278
MOD_CK1_1	121	127	PF00069	0.434
MOD_CK1_1	156	162	PF00069	0.441
MOD_CK1_1	165	171	PF00069	0.382
MOD_CK1_1	236	242	PF00069	0.436
MOD_CK1_1	281	287	PF00069	0.454
MOD_CK1_1	387	393	PF00069	0.424
MOD_CK1_1	4	10	PF00069	0.669
MOD_CK1_1	421	427	PF00069	0.470
MOD_CK1_1	536	542	PF00069	0.592
MOD_CK1_1	592	598	PF00069	0.737
MOD_CK2_1	48	54	PF00069	0.423
MOD_GlcNHglycan	167	170	PF01048	0.599
MOD_GlcNHglycan	27	30	PF01048	0.704
MOD_GlcNHglycan	353	356	PF01048	0.630
MOD_GlcNHglycan	390	393	PF01048	0.588
MOD_GlcNHglycan	405	408	PF01048	0.579
MOD_GlcNHglycan	409	412	PF01048	0.589
MOD_GlcNHglycan	420	423	PF01048	0.672
MOD_GlcNHglycan	477	480	PF01048	0.538
MOD_GSK3_1	126	133	PF00069	0.400
MOD_GSK3_1	154	161	PF00069	0.356
MOD_GSK3_1	25	32	PF00069	0.627
MOD_GSK3_1	384	391	PF00069	0.424
MOD_GSK3_1	403	410	PF00069	0.365
MOD_GSK3_1	41	48	PF00069	0.309
MOD_GSK3_1	475	482	PF00069	0.426
MOD_N-GLC_1	131	136	PF02516	0.657
MOD_N-GLC_1	162	167	PF02516	0.622
MOD_N-GLC_1	429	434	PF02516	0.623
MOD_NEK2_1	1	6	PF00069	0.695
MOD_NEK2_1	16	21	PF00069	0.259
MOD_NEK2_1	162	167	PF00069	0.375
MOD_NEK2_1	317	322	PF00069	0.418
MOD_NEK2_1	388	393	PF00069	0.390
MOD_NEK2_1	461	466	PF00069	0.389
MOD_NEK2_1	578	583	PF00069	0.445
MOD_NEK2_1	589	594	PF00069	0.747
MOD_PIKK_1	121	127	PF00454	0.321
MOD_PIKK_1	429	435	PF00454	0.409
MOD_PIKK_1	449	455	PF00454	0.234
MOD_PKA_2	118	124	PF00069	0.351
MOD_PKA_2	388	394	PF00069	0.421
MOD_PKA_2	416	422	PF00069	0.469
MOD_PKA_2	475	481	PF00069	0.384
MOD_PKA_2	592	598	PF00069	0.684
MOD_PKA_2	70	76	PF00069	0.436
MOD_Plk_1	162	168	PF00069	0.376
MOD_Plk_2-3	502	508	PF00069	0.420
MOD_Plk_4	123	129	PF00069	0.414
MOD_Plk_4	16	22	PF00069	0.414
MOD_Plk_4	195	201	PF00069	0.328
MOD_Plk_4	233	239	PF00069	0.383
MOD_Plk_4	267	273	PF00069	0.356
MOD_Plk_4	327	333	PF00069	0.312
MOD_Plk_4	578	584	PF00069	0.358
MOD_Plk_4	87	93	PF00069	0.336
MOD_ProDKin_1	479	485	PF00069	0.416
MOD_ProDKin_1	48	54	PF00069	0.434
MOD_SUMO_rev_2	419	427	PF00179	0.349
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.363
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.353
TRG_ENDOCYTIC_2	229	232	PF00928	0.337
TRG_ENDOCYTIC_2	315	318	PF00928	0.389
TRG_ENDOCYTIC_2	350	353	PF00928	0.318
TRG_ENDOCYTIC_2	577	580	PF00928	0.416
TRG_ENDOCYTIC_2	591	594	PF00928	0.620
TRG_ENDOCYTIC_2	599	602	PF00928	0.606
TRG_ER_diArg_1	290	292	PF00400	0.370
TRG_ER_diArg_1	5	8	PF00400	0.712
TRG_ER_FFAT_2	121	133	PF00635	0.462
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	459	463	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I361	Leptomonas seymouri	52%	100%
A0A0S4JGY4	Bodo saltans	25%	98%
A0A1X0NRX3	Trypanosomatidae	32%	100%
A0A422P343	Trypanosoma rangeli	36%	100%
A4HKY5	Leishmania braziliensis	76%	100%
A4I8G4	Leishmania infantum	100%	100%
E9B3C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q4T2	Leishmania major	91%	100%
V5DMC3	Trypanosoma cruzi	32%	100%