Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFS6_LEIDO

TriTrypDb:

LdBPK_260880.1 , LdCL_260014400 , LDHU3_26.1130

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3Q8IFS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFS6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0001653	peptide receptor activity	3	11
GO:0038023	signaling receptor activity	2	11
GO:0060089	molecular transducer activity	1	11
GO:0140625	opioid growth factor receptor activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.644
CLV_C14_Caspase3-7	27	31	PF00656	0.557
CLV_C14_Caspase3-7	291	295	PF00656	0.780
CLV_C14_Caspase3-7	396	400	PF00656	0.558
CLV_C14_Caspase3-7	60	64	PF00656	0.766
CLV_NRD_NRD_1	209	211	PF00675	0.596
CLV_NRD_NRD_1	307	309	PF00675	0.686
CLV_PCSK_KEX2_1	209	211	PF00082	0.596
CLV_PCSK_KEX2_1	307	309	PF00082	0.686
CLV_PCSK_KEX2_1	390	392	PF00082	0.521
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.589
CLV_PCSK_SKI1_1	210	214	PF00082	0.537
CLV_PCSK_SKI1_1	249	253	PF00082	0.601
CLV_PCSK_SKI1_1	261	265	PF00082	0.474
CLV_PCSK_SKI1_1	332	336	PF00082	0.416
CLV_PCSK_SKI1_1	358	362	PF00082	0.416
DEG_APCC_DBOX_1	260	268	PF00400	0.612
DEG_Nend_UBRbox_2	1	3	PF02207	0.779
DEG_SPOP_SBC_1	58	62	PF00917	0.726
DOC_ANK_TNKS_1	289	296	PF00023	0.554
DOC_CYCLIN_RxL_1	207	216	PF00134	0.501
DOC_CYCLIN_RxL_1	329	336	PF00134	0.409
DOC_CYCLIN_yCln2_LP_2	105	108	PF00134	0.497
DOC_MAPK_gen_1	329	339	PF00069	0.446
DOC_MAPK_MEF2A_6	136	145	PF00069	0.421
DOC_MAPK_MEF2A_6	332	339	PF00069	0.386
DOC_PP1_RVXF_1	134	140	PF00149	0.439
DOC_PP1_RVXF_1	343	350	PF00149	0.452
DOC_PP1_RVXF_1	356	362	PF00149	0.382
DOC_PP2B_LxvP_1	105	108	PF13499	0.497
DOC_PP4_FxxP_1	361	364	PF00568	0.510
DOC_USP7_MATH_1	193	197	PF00917	0.637
DOC_USP7_UBL2_3	385	389	PF12436	0.536
DOC_WW_Pin1_4	75	80	PF00397	0.774
DOC_WW_Pin1_4	83	88	PF00397	0.676
DOC_WW_Pin1_4	91	96	PF00397	0.596
LIG_14-3-3_CanoR_1	228	234	PF00244	0.435
LIG_14-3-3_CanoR_1	329	335	PF00244	0.431
LIG_14-3-3_CanoR_1	42	48	PF00244	0.511
LIG_Actin_WH2_2	327	343	PF00022	0.489
LIG_BRCT_BRCA1_1	190	194	PF00533	0.523
LIG_BRCT_BRCA1_1	318	322	PF00533	0.557
LIG_BRCT_BRCA1_1	36	40	PF00533	0.447
LIG_eIF4E_1	231	237	PF01652	0.502
LIG_FHA_1	275	281	PF00498	0.738
LIG_FHA_1	49	55	PF00498	0.603
LIG_FHA_2	14	20	PF00498	0.746
LIG_FHA_2	394	400	PF00498	0.597
LIG_FHA_2	76	82	PF00498	0.703
LIG_GBD_Chelix_1	342	350	PF00786	0.424
LIG_LIR_Apic_2	266	271	PF02991	0.439
LIG_LIR_Gen_1	133	142	PF02991	0.479
LIG_LIR_Gen_1	201	212	PF02991	0.564
LIG_LIR_Gen_1	232	240	PF02991	0.405
LIG_LIR_Gen_1	260	270	PF02991	0.587
LIG_LIR_Gen_1	316	323	PF02991	0.561
LIG_LIR_Gen_1	336	347	PF02991	0.400
LIG_LIR_Gen_1	52	59	PF02991	0.701
LIG_LIR_Nem_3	133	137	PF02991	0.498
LIG_LIR_Nem_3	201	207	PF02991	0.518
LIG_LIR_Nem_3	227	233	PF02991	0.463
LIG_LIR_Nem_3	260	265	PF02991	0.463
LIG_LIR_Nem_3	316	320	PF02991	0.609
LIG_LIR_Nem_3	336	342	PF02991	0.346
LIG_LIR_Nem_3	353	359	PF02991	0.447
LIG_LIR_Nem_3	52	58	PF02991	0.732
LIG_MYND_1	144	148	PF01753	0.480
LIG_NRBOX	202	208	PF00104	0.548
LIG_NRBOX	330	336	PF00104	0.366
LIG_Pex14_1	258	262	PF04695	0.453
LIG_REV1ctd_RIR_1	237	247	PF16727	0.558
LIG_SH2_CRK	231	235	PF00017	0.458
LIG_SH2_CRK	268	272	PF00017	0.474
LIG_SH2_CRK	356	360	PF00017	0.484
LIG_SH2_PTP2	233	236	PF00017	0.495
LIG_SH2_STAP1	122	126	PF00017	0.570
LIG_SH2_STAP1	204	208	PF00017	0.570
LIG_SH2_STAP1	231	235	PF00017	0.392
LIG_SH2_STAT3	122	125	PF00017	0.578
LIG_SH2_STAT5	233	236	PF00017	0.380
LIG_SH3_1	308	314	PF00018	0.539
LIG_SH3_3	138	144	PF00018	0.435
LIG_SH3_3	217	223	PF00018	0.494
LIG_SH3_3	308	314	PF00018	0.659
LIG_SH3_3	372	378	PF00018	0.550
LIG_SH3_3	68	74	PF00018	0.777
LIG_SUMO_SIM_anti_2	214	222	PF11976	0.581
LIG_SUMO_SIM_anti_2	232	238	PF11976	0.345
LIG_SUMO_SIM_anti_2	94	100	PF11976	0.601
LIG_SUMO_SIM_par_1	94	100	PF11976	0.338
LIG_TRAF2_1	257	260	PF00917	0.615
LIG_TYR_ITIM	229	234	PF00017	0.395
LIG_WRC_WIRS_1	317	322	PF05994	0.644
LIG_WW_1	314	317	PF00397	0.632
MOD_CK1_1	173	179	PF00069	0.563
MOD_CK1_1	196	202	PF00069	0.517
MOD_CK1_1	383	389	PF00069	0.582
MOD_CK1_1	88	94	PF00069	0.602
MOD_CK2_1	13	19	PF00069	0.740
MOD_CK2_1	181	187	PF00069	0.727
MOD_CK2_1	196	202	PF00069	0.484
MOD_CK2_1	75	81	PF00069	0.776
MOD_GlcNHglycan	165	168	PF01048	0.702
MOD_GlcNHglycan	182	186	PF01048	0.693
MOD_GlcNHglycan	190	193	PF01048	0.745
MOD_GlcNHglycan	198	201	PF01048	0.549
MOD_GlcNHglycan	324	327	PF01048	0.528
MOD_GlcNHglycan	71	74	PF01048	0.756
MOD_GlcNHglycan	75	78	PF01048	0.742
MOD_GSK3_1	169	176	PF00069	0.725
MOD_GSK3_1	194	201	PF00069	0.528
MOD_GSK3_1	270	277	PF00069	0.669
MOD_GSK3_1	282	289	PF00069	0.724
MOD_GSK3_1	379	386	PF00069	0.570
MOD_GSK3_1	393	400	PF00069	0.437
MOD_GSK3_1	58	65	PF00069	0.724
MOD_GSK3_1	69	76	PF00069	0.641
MOD_GSK3_1	81	88	PF00069	0.693
MOD_N-GLC_1	169	174	PF02516	0.677
MOD_NEK2_1	194	199	PF00069	0.617
MOD_NEK2_1	322	327	PF00069	0.540
MOD_PIKK_1	275	281	PF00454	0.628
MOD_PIKK_1	45	51	PF00454	0.606
MOD_PK_1	299	305	PF00069	0.543
MOD_PKA_2	393	399	PF00069	0.559
MOD_Plk_1	366	372	PF00069	0.416
MOD_Plk_4	229	235	PF00069	0.390
MOD_Plk_4	299	305	PF00069	0.543
MOD_Plk_4	366	372	PF00069	0.466
MOD_Plk_4	85	91	PF00069	0.635
MOD_Plk_4	94	100	PF00069	0.521
MOD_ProDKin_1	75	81	PF00069	0.776
MOD_ProDKin_1	83	89	PF00069	0.665
MOD_ProDKin_1	91	97	PF00069	0.582
TRG_DiLeu_BaEn_1	202	207	PF01217	0.577
TRG_DiLeu_BaEn_1	247	252	PF01217	0.642
TRG_DiLeu_BaEn_1	260	265	PF01217	0.578
TRG_DiLeu_BaEn_4	247	253	PF01217	0.530
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.425
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.508
TRG_DiLeu_BaLyEn_6	355	360	PF01217	0.421
TRG_ENDOCYTIC_2	204	207	PF00928	0.520
TRG_ENDOCYTIC_2	231	234	PF00928	0.461
TRG_ENDOCYTIC_2	262	265	PF00928	0.450
TRG_ENDOCYTIC_2	317	320	PF00928	0.582
TRG_ENDOCYTIC_2	356	359	PF00928	0.480
TRG_ENDOCYTIC_2	41	44	PF00928	0.518
TRG_ER_diArg_1	208	210	PF00400	0.587
TRG_NES_CRM1_1	336	348	PF08389	0.529
TRG_NLS_MonoExtN_4	387	393	PF00514	0.511
TRG_Pf-PMV_PEXEL_1	210	214	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ78	Leptomonas seymouri	51%	100%
A0A1X0NT07	Trypanosomatidae	35%	100%
A0A422MXD1	Trypanosoma rangeli	38%	100%
A4HEU6	Leishmania braziliensis	73%	98%
A4I220	Leishmania infantum	99%	100%
C9ZRY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AY69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q9A3	Leishmania major	91%	100%
V5BUN4	Trypanosoma cruzi	33%	100%