Hypothetical_protein_conserved

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFS5_LEIDO

TriTrypDb:

LdBPK_320890.1 , LdCL_320014400 , LDHU3_32.1130

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	yes	yes: 10

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IFS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFS5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	25	31	PF00089	0.351
CLV_NRD_NRD_1	336	338	PF00675	0.365
CLV_NRD_NRD_1	42	44	PF00675	0.393
CLV_PCSK_KEX2_1	336	338	PF00082	0.396
CLV_PCSK_KEX2_1	42	44	PF00082	0.354
CLV_PCSK_SKI1_1	342	346	PF00082	0.373
CLV_PCSK_SKI1_1	42	46	PF00082	0.389
CLV_PCSK_SKI1_1	420	424	PF00082	0.420
CLV_PCSK_SKI1_1	469	473	PF00082	0.422
CLV_PCSK_SKI1_1	88	92	PF00082	0.284
DEG_Nend_UBRbox_1	1	4	PF02207	0.628
DEG_SCF_FBW7_1	110	115	PF00400	0.593
DOC_CKS1_1	167	172	PF01111	0.527
DOC_CKS1_1	56	61	PF01111	0.351
DOC_MAPK_gen_1	341	347	PF00069	0.359
DOC_MAPK_gen_1	42	50	PF00069	0.354
DOC_PP4_FxxP_1	205	208	PF00568	0.663
DOC_PP4_FxxP_1	300	303	PF00568	0.474
DOC_PP4_MxPP_1	212	215	PF00568	0.537
DOC_USP7_MATH_1	112	116	PF00917	0.743
DOC_USP7_MATH_1	200	204	PF00917	0.585
DOC_USP7_MATH_1	416	420	PF00917	0.446
DOC_WW_Pin1_4	106	111	PF00397	0.647
DOC_WW_Pin1_4	166	171	PF00397	0.562
DOC_WW_Pin1_4	348	353	PF00397	0.439
DOC_WW_Pin1_4	406	411	PF00397	0.414
DOC_WW_Pin1_4	55	60	PF00397	0.351
LIG_14-3-3_CanoR_1	28	36	PF00244	0.261
LIG_14-3-3_CanoR_1	383	393	PF00244	0.422
LIG_14-3-3_CanoR_1	43	49	PF00244	0.295
LIG_14-3-3_CanoR_1	448	457	PF00244	0.503
LIG_14-3-3_CanoR_1	80	86	PF00244	0.351
LIG_AP2alpha_1	72	76	PF02296	0.351
LIG_AP2alpha_2	219	221	PF02296	0.565
LIG_EVH1_2	303	307	PF00568	0.387
LIG_FHA_1	100	106	PF00498	0.509
LIG_FHA_1	167	173	PF00498	0.567
LIG_FHA_1	20	26	PF00498	0.273
LIG_FHA_1	263	269	PF00498	0.570
LIG_FHA_1	303	309	PF00498	0.399
LIG_FHA_1	314	320	PF00498	0.390
LIG_FHA_1	35	41	PF00498	0.373
LIG_FHA_1	64	70	PF00498	0.345
LIG_FHA_2	322	328	PF00498	0.289
LIG_FHA_2	448	454	PF00498	0.524
LIG_LIR_Apic_2	203	208	PF02991	0.666
LIG_LIR_Gen_1	305	315	PF02991	0.356
LIG_LIR_Gen_1	321	329	PF02991	0.427
LIG_LIR_Nem_3	13	17	PF02991	0.586
LIG_LIR_Nem_3	270	275	PF02991	0.614
LIG_LIR_Nem_3	305	310	PF02991	0.345
LIG_LIR_Nem_3	327	332	PF02991	0.358
LIG_Pex14_2	72	76	PF04695	0.351
LIG_SH2_GRB2like	101	104	PF00017	0.468
LIG_SH2_GRB2like	438	441	PF00017	0.452
LIG_SH2_SRC	438	441	PF00017	0.452
LIG_SH2_STAP1	101	105	PF00017	0.484
LIG_SH2_STAP1	400	404	PF00017	0.471
LIG_SH2_STAT5	101	104	PF00017	0.533
LIG_SH2_STAT5	294	297	PF00017	0.541
LIG_SH2_STAT5	367	370	PF00017	0.561
LIG_SH2_STAT5	380	383	PF00017	0.472
LIG_SH2_STAT5	438	441	PF00017	0.371
LIG_SH3_3	135	141	PF00018	0.706
LIG_SH3_3	148	154	PF00018	0.790
LIG_SH3_3	157	163	PF00018	0.678
LIG_SH3_3	180	186	PF00018	0.596
LIG_SH3_3	232	238	PF00018	0.576
LIG_SH3_3	389	395	PF00018	0.478
LIG_SH3_3	486	492	PF00018	0.514
LIG_SUMO_SIM_anti_2	309	314	PF11976	0.332
LIG_SUMO_SIM_anti_2	353	360	PF11976	0.379
LIG_TRAF2_1	503	506	PF00917	0.472
LIG_TRAF2_2	214	219	PF00917	0.549
LIG_WRC_WIRS_1	358	363	PF05994	0.384
MOD_CDK_SPxxK_3	406	413	PF00069	0.400
MOD_CK1_1	51	57	PF00069	0.366
MOD_CK2_1	321	327	PF00069	0.294
MOD_CK2_1	425	431	PF00069	0.430
MOD_CK2_1	447	453	PF00069	0.505
MOD_GlcNHglycan	106	109	PF01048	0.553
MOD_GlcNHglycan	123	126	PF01048	0.567
MOD_GlcNHglycan	372	375	PF01048	0.352
MOD_GlcNHglycan	427	430	PF01048	0.405
MOD_GSK3_1	104	111	PF00069	0.568
MOD_GSK3_1	15	22	PF00069	0.512
MOD_GSK3_1	23	30	PF00069	0.202
MOD_GSK3_1	302	309	PF00069	0.423
MOD_GSK3_1	402	409	PF00069	0.525
MOD_GSK3_1	430	437	PF00069	0.387
MOD_GSK3_1	44	51	PF00069	0.377
MOD_GSK3_1	449	456	PF00069	0.339
MOD_GSK3_1	95	102	PF00069	0.383
MOD_NEK2_1	121	126	PF00069	0.606
MOD_NEK2_1	231	236	PF00069	0.577
MOD_NEK2_1	402	407	PF00069	0.530
MOD_NEK2_1	99	104	PF00069	0.292
MOD_NEK2_2	200	205	PF00069	0.614
MOD_NEK2_2	318	323	PF00069	0.306
MOD_PIKK_1	15	21	PF00454	0.582
MOD_PIKK_1	173	179	PF00454	0.766
MOD_PKA_2	27	33	PF00069	0.261
MOD_PKA_2	447	453	PF00069	0.519
MOD_Plk_1	64	70	PF00069	0.286
MOD_Plk_2-3	453	459	PF00069	0.458
MOD_Plk_4	200	206	PF00069	0.688
MOD_Plk_4	302	308	PF00069	0.391
MOD_Plk_4	318	324	PF00069	0.359
MOD_Plk_4	357	363	PF00069	0.441
MOD_Plk_4	434	440	PF00069	0.389
MOD_Plk_4	64	70	PF00069	0.264
MOD_ProDKin_1	106	112	PF00069	0.653
MOD_ProDKin_1	166	172	PF00069	0.562
MOD_ProDKin_1	348	354	PF00069	0.434
MOD_ProDKin_1	406	412	PF00069	0.412
MOD_ProDKin_1	55	61	PF00069	0.351
MOD_SUMO_rev_2	477	484	PF00179	0.466
MOD_SUMO_rev_2	494	504	PF00179	0.602
TRG_ENDOCYTIC_2	272	275	PF00928	0.539
TRG_ENDOCYTIC_2	297	300	PF00928	0.626
TRG_ER_diArg_1	1	4	PF00400	0.818
TRG_ER_diArg_1	335	337	PF00400	0.344
TRG_ER_diArg_1	41	43	PF00400	0.357
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7M5	Leptomonas seymouri	64%	100%
A0A422N8U4	Trypanosoma rangeli	42%	100%
A4HK65	Leishmania braziliensis	82%	100%
A4I7Q0	Leishmania infantum	100%	100%
E9B2K9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	67%
Q4Q5J8	Leishmania major	92%	97%
V5B118	Trypanosoma cruzi	43%	100%