Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFS3_LEIDO

TriTrypDb:

LdBPK_360550.1 , LdCL_360010400 , LDHU3_36.0710

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFS3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	431	435	PF00656	0.474
CLV_NRD_NRD_1	162	164	PF00675	0.561
CLV_NRD_NRD_1	199	201	PF00675	0.572
CLV_NRD_NRD_1	229	231	PF00675	0.581
CLV_NRD_NRD_1	321	323	PF00675	0.554
CLV_NRD_NRD_1	402	404	PF00675	0.484
CLV_NRD_NRD_1	75	77	PF00675	0.627
CLV_NRD_NRD_1	93	95	PF00675	0.742
CLV_PCSK_KEX2_1	150	152	PF00082	0.600
CLV_PCSK_KEX2_1	229	231	PF00082	0.494
CLV_PCSK_KEX2_1	402	404	PF00082	0.484
CLV_PCSK_KEX2_1	423	425	PF00082	0.523
CLV_PCSK_KEX2_1	75	77	PF00082	0.627
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.483
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.554
CLV_PCSK_SKI1_1	164	168	PF00082	0.597
CLV_PCSK_SKI1_1	372	376	PF00082	0.650
CLV_PCSK_SKI1_1	85	89	PF00082	0.693
DEG_APCC_DBOX_1	410	418	PF00400	0.480
DEG_Nend_UBRbox_2	1	3	PF02207	0.553
DEG_ODPH_VHL_1	277	288	PF01847	0.578
DOC_MAPK_gen_1	200	207	PF00069	0.431
DOC_MAPK_gen_1	229	235	PF00069	0.540
DOC_MAPK_gen_1	75	83	PF00069	0.528
DOC_MAPK_MEF2A_6	108	117	PF00069	0.537
DOC_PP1_RVXF_1	161	168	PF00149	0.487
DOC_PP2B_PxIxI_1	328	334	PF00149	0.628
DOC_PP4_FxxP_1	167	170	PF00568	0.523
DOC_PP4_FxxP_1	268	271	PF00568	0.450
DOC_USP7_MATH_1	159	163	PF00917	0.571
DOC_USP7_MATH_1	21	25	PF00917	0.545
DOC_USP7_MATH_1	428	432	PF00917	0.475
DOC_WW_Pin1_4	55	60	PF00397	0.706
DOC_WW_Pin1_4	85	90	PF00397	0.604
LIG_14-3-3_CanoR_1	200	208	PF00244	0.391
LIG_14-3-3_CanoR_1	315	324	PF00244	0.563
LIG_14-3-3_CanoR_1	98	104	PF00244	0.598
LIG_Actin_WH2_2	125	143	PF00022	0.418
LIG_Actin_WH2_2	376	394	PF00022	0.522
LIG_APCC_ABBA_1	234	239	PF00400	0.440
LIG_APCC_ABBA_1	331	336	PF00400	0.511
LIG_BIR_III_4	66	70	PF00653	0.481
LIG_Clathr_ClatBox_1	380	384	PF01394	0.534
LIG_EH1_1	206	214	PF00400	0.418
LIG_FHA_1	134	140	PF00498	0.440
LIG_FHA_1	222	228	PF00498	0.431
LIG_FHA_1	271	277	PF00498	0.505
LIG_FHA_1	32	38	PF00498	0.453
LIG_FHA_2	265	271	PF00498	0.540
LIG_FHA_2	385	391	PF00498	0.572
LIG_FHA_2	399	405	PF00498	0.390
LIG_GBD_Chelix_1	10	18	PF00786	0.468
LIG_LIR_Apic_2	266	271	PF02991	0.513
LIG_LIR_Gen_1	128	134	PF02991	0.384
LIG_LIR_Gen_1	244	255	PF02991	0.428
LIG_LIR_Nem_3	128	133	PF02991	0.386
LIG_LIR_Nem_3	231	237	PF02991	0.484
LIG_LIR_Nem_3	240	246	PF02991	0.354
LIG_MYND_1	55	59	PF01753	0.533
LIG_NRBOX	128	134	PF00104	0.448
LIG_Pex14_2	247	251	PF04695	0.474
LIG_Pex14_2	264	268	PF04695	0.362
LIG_PTB_Apo_2	306	313	PF02174	0.544
LIG_PTB_Phospho_1	306	312	PF10480	0.548
LIG_Rb_LxCxE_1	249	267	PF01857	0.462
LIG_SH2_SRC	269	272	PF00017	0.497
LIG_SH2_STAP1	243	247	PF00017	0.403
LIG_SH2_STAP1	312	316	PF00017	0.610
LIG_SH2_STAP1	415	419	PF00017	0.464
LIG_SH2_STAT5	243	246	PF00017	0.431
LIG_SH2_STAT5	362	365	PF00017	0.490
LIG_SH3_3	215	221	PF00018	0.544
LIG_SH3_3	230	236	PF00018	0.599
LIG_SH3_3	276	282	PF00018	0.508
LIG_SH3_3	283	289	PF00018	0.505
LIG_SH3_3	342	348	PF00018	0.722
LIG_SH3_3	53	59	PF00018	0.568
LIG_SUMO_SIM_anti_2	376	382	PF11976	0.531
LIG_SUMO_SIM_par_1	379	384	PF11976	0.533
LIG_UBA3_1	356	360	PF00899	0.529
LIG_WRC_WIRS_1	265	270	PF05994	0.551
MOD_CDK_SPxxK_3	55	62	PF00069	0.641
MOD_CK1_1	119	125	PF00069	0.545
MOD_CK1_1	318	324	PF00069	0.569
MOD_CK1_1	337	343	PF00069	0.475
MOD_CK1_1	58	64	PF00069	0.629
MOD_CK2_1	352	358	PF00069	0.495
MOD_CK2_1	398	404	PF00069	0.451
MOD_Cter_Amidation	198	201	PF01082	0.578
MOD_Cter_Amidation	73	76	PF01082	0.540
MOD_GlcNHglycan	103	106	PF01048	0.667
MOD_GlcNHglycan	178	181	PF01048	0.426
MOD_GlcNHglycan	201	204	PF01048	0.478
MOD_GlcNHglycan	324	327	PF01048	0.704
MOD_GlcNHglycan	52	55	PF01048	0.582
MOD_GSK3_1	115	122	PF00069	0.412
MOD_GSK3_1	237	244	PF00069	0.505
MOD_GSK3_1	318	325	PF00069	0.658
MOD_GSK3_1	348	355	PF00069	0.528
MOD_GSK3_1	81	88	PF00069	0.578
MOD_GSK3_1	99	106	PF00069	0.672
MOD_N-GLC_1	159	164	PF02516	0.518
MOD_N-GLC_1	21	26	PF02516	0.544
MOD_NEK2_1	103	108	PF00069	0.560
MOD_NEK2_1	133	138	PF00069	0.463
MOD_NEK2_1	140	145	PF00069	0.513
MOD_NEK2_1	185	190	PF00069	0.514
MOD_NEK2_1	264	269	PF00069	0.620
MOD_NEK2_1	398	403	PF00069	0.489
MOD_NEK2_1	81	86	PF00069	0.715
MOD_NEK2_1	90	95	PF00069	0.750
MOD_NEK2_2	21	26	PF00069	0.544
MOD_NEK2_2	221	226	PF00069	0.403
MOD_NEK2_2	246	251	PF00069	0.492
MOD_OFUCOSY	100	107	PF10250	0.571
MOD_PIKK_1	119	125	PF00454	0.502
MOD_PIKK_1	270	276	PF00454	0.476
MOD_PIKK_1	315	321	PF00454	0.601
MOD_PIKK_1	384	390	PF00454	0.553
MOD_PIKK_1	48	54	PF00454	0.524
MOD_PKA_1	322	328	PF00069	0.658
MOD_PKA_2	140	146	PF00069	0.482
MOD_PKA_2	199	205	PF00069	0.453
MOD_PKA_2	334	340	PF00069	0.569
MOD_PKA_2	384	390	PF00069	0.604
MOD_Plk_1	241	247	PF00069	0.437
MOD_Plk_1	42	48	PF00069	0.524
MOD_Plk_4	125	131	PF00069	0.393
MOD_Plk_4	241	247	PF00069	0.470
MOD_Plk_4	264	270	PF00069	0.565
MOD_Plk_4	352	358	PF00069	0.579
MOD_ProDKin_1	55	61	PF00069	0.708
MOD_ProDKin_1	85	91	PF00069	0.603
MOD_SUMO_for_1	4	7	PF00179	0.460
MOD_SUMO_for_1	429	432	PF00179	0.425
MOD_SUMO_rev_2	355	361	PF00179	0.519
MOD_SUMO_rev_2	384	394	PF00179	0.422
TRG_DiLeu_BaEn_1	6	11	PF01217	0.502
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.439
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.467
TRG_ENDOCYTIC_2	130	133	PF00928	0.373
TRG_ENDOCYTIC_2	426	429	PF00928	0.508
TRG_ER_diArg_1	36	39	PF00400	0.454
TRG_ER_diArg_1	411	414	PF00400	0.504
TRG_NES_CRM1_1	28	43	PF08389	0.468
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JPJ4	Bodo saltans	35%	86%
A0A1X0P9M8	Trypanosomatidae	37%	100%
A0A422P297	Trypanosoma rangeli	35%	99%
A4HNR0	Leishmania braziliensis	73%	100%
A4ICT5	Leishmania infantum	99%	100%
D0A2L8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ASG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q226	Leishmania major	93%	100%