Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFR9_LEIDO

TriTrypDb:

LdBPK_342960.1 , LdCL_340038400 , LDHU3_34.5080

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	339	343	PF00656	0.688
CLV_NRD_NRD_1	216	218	PF00675	0.656
CLV_NRD_NRD_1	258	260	PF00675	0.675
CLV_NRD_NRD_1	326	328	PF00675	0.643
CLV_NRD_NRD_1	334	336	PF00675	0.619
CLV_NRD_NRD_1	344	346	PF00675	0.682
CLV_NRD_NRD_1	384	386	PF00675	0.742
CLV_NRD_NRD_1	68	70	PF00675	0.589
CLV_NRD_NRD_1	87	89	PF00675	0.639
CLV_PCSK_FUR_1	324	328	PF00082	0.605
CLV_PCSK_KEX2_1	216	218	PF00082	0.656
CLV_PCSK_KEX2_1	258	260	PF00082	0.672
CLV_PCSK_KEX2_1	311	313	PF00082	0.660
CLV_PCSK_KEX2_1	316	318	PF00082	0.611
CLV_PCSK_KEX2_1	326	328	PF00082	0.615
CLV_PCSK_KEX2_1	334	336	PF00082	0.625
CLV_PCSK_KEX2_1	344	346	PF00082	0.700
CLV_PCSK_KEX2_1	383	385	PF00082	0.636
CLV_PCSK_KEX2_1	87	89	PF00082	0.779
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.738
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.690
CLV_PCSK_PC7_1	312	318	PF00082	0.632
CLV_PCSK_PC7_1	330	336	PF00082	0.692
CLV_PCSK_PC7_1	379	385	PF00082	0.625
CLV_PCSK_SKI1_1	21	25	PF00082	0.629
CLV_PCSK_SKI1_1	261	265	PF00082	0.677
CLV_PCSK_SKI1_1	334	338	PF00082	0.693
DOC_ANK_TNKS_1	337	344	PF00023	0.689
DOC_MAPK_gen_1	258	267	PF00069	0.678
DOC_MAPK_gen_1	69	79	PF00069	0.656
DOC_PP4_FxxP_1	10	13	PF00568	0.487
DOC_USP7_MATH_1	100	104	PF00917	0.608
DOC_USP7_MATH_1	178	182	PF00917	0.741
DOC_USP7_MATH_1	285	289	PF00917	0.697
DOC_USP7_MATH_2	158	164	PF00917	0.662
DOC_WW_Pin1_4	119	124	PF00397	0.638
DOC_WW_Pin1_4	140	145	PF00397	0.709
DOC_WW_Pin1_4	161	166	PF00397	0.650
DOC_WW_Pin1_4	304	309	PF00397	0.765
DOC_WW_Pin1_4	77	82	PF00397	0.566
DOC_WW_Pin1_4	96	101	PF00397	0.553
LIG_14-3-3_CanoR_1	210	214	PF00244	0.712
LIG_14-3-3_CanoR_1	276	284	PF00244	0.631
LIG_14-3-3_CanoR_1	312	316	PF00244	0.694
LIG_14-3-3_CanoR_1	87	95	PF00244	0.761
LIG_Actin_WH2_2	31	49	PF00022	0.459
LIG_BIR_III_2	198	202	PF00653	0.637
LIG_Clathr_ClatBox_1	241	245	PF01394	0.573
LIG_deltaCOP1_diTrp_1	15	22	PF00928	0.492
LIG_FHA_1	51	57	PF00498	0.597
LIG_FHA_2	226	232	PF00498	0.580
LIG_FHA_2	266	272	PF00498	0.648
LIG_FHA_2	289	295	PF00498	0.677
LIG_FHA_2	376	382	PF00498	0.617
LIG_FHA_2	87	93	PF00498	0.683
LIG_LIR_Gen_1	15	23	PF02991	0.481
LIG_LIR_Gen_1	262	272	PF02991	0.602
LIG_LIR_Nem_3	15	19	PF02991	0.471
LIG_LIR_Nem_3	262	267	PF02991	0.549
LIG_PTAP_UEV_1	202	207	PF05743	0.712
LIG_SH2_STAP1	14	18	PF00017	0.593
LIG_SH3_3	177	183	PF00018	0.662
LIG_SH3_3	200	206	PF00018	0.656
LIG_TRAF2_1	112	115	PF00917	0.746
LIG_TRAF2_1	279	282	PF00917	0.599
LIG_TRAF2_1	390	393	PF00917	0.629
MOD_CDK_SPxxK_3	119	126	PF00069	0.721
MOD_CDK_SPxxK_3	304	311	PF00069	0.695
MOD_CK1_1	142	148	PF00069	0.698
MOD_CK1_1	163	169	PF00069	0.685
MOD_CK1_1	225	231	PF00069	0.587
MOD_CK1_1	288	294	PF00069	0.630
MOD_CK2_1	225	231	PF00069	0.587
MOD_CK2_1	275	281	PF00069	0.613
MOD_CK2_1	52	58	PF00069	0.567
MOD_CK2_1	86	92	PF00069	0.733
MOD_Cter_Amidation	324	327	PF01082	0.621
MOD_Cter_Amidation	342	345	PF01082	0.706
MOD_GlcNHglycan	109	112	PF01048	0.733
MOD_GlcNHglycan	15	19	PF01048	0.600
MOD_GlcNHglycan	167	170	PF01048	0.707
MOD_GlcNHglycan	269	275	PF01048	0.613
MOD_GlcNHglycan	278	281	PF01048	0.656
MOD_GlcNHglycan	285	288	PF01048	0.657
MOD_GlcNHglycan	330	333	PF01048	0.732
MOD_GSK3_1	161	168	PF00069	0.667
MOD_GSK3_1	218	225	PF00069	0.632
MOD_GSK3_1	272	279	PF00069	0.612
MOD_GSK3_1	307	314	PF00069	0.744
MOD_GSK3_1	50	57	PF00069	0.597
MOD_GSK3_1	82	89	PF00069	0.690
MOD_GSK3_1	96	103	PF00069	0.521
MOD_LATS_1	182	188	PF00433	0.616
MOD_NEK2_1	139	144	PF00069	0.566
MOD_NEK2_1	209	214	PF00069	0.768
MOD_NEK2_1	22	27	PF00069	0.612
MOD_NEK2_1	272	277	PF00069	0.606
MOD_NEK2_1	283	288	PF00069	0.640
MOD_NEK2_1	360	365	PF00069	0.664
MOD_NEK2_1	95	100	PF00069	0.644
MOD_NEK2_2	219	224	PF00069	0.630
MOD_PIKK_1	124	130	PF00454	0.662
MOD_PIKK_1	184	190	PF00454	0.733
MOD_PIKK_1	285	291	PF00454	0.759
MOD_PIKK_1	392	398	PF00454	0.667
MOD_PKA_1	311	317	PF00069	0.654
MOD_PKA_1	326	332	PF00069	0.615
MOD_PKA_1	344	350	PF00069	0.734
MOD_PKA_1	384	390	PF00069	0.606
MOD_PKA_1	69	75	PF00069	0.534
MOD_PKA_2	107	113	PF00069	0.692
MOD_PKA_2	172	178	PF00069	0.607
MOD_PKA_2	201	207	PF00069	0.744
MOD_PKA_2	209	215	PF00069	0.692
MOD_PKA_2	275	281	PF00069	0.740
MOD_PKA_2	311	317	PF00069	0.633
MOD_PKA_2	326	332	PF00069	0.661
MOD_PKA_2	344	350	PF00069	0.734
MOD_PKA_2	384	390	PF00069	0.637
MOD_PKA_2	86	92	PF00069	0.767
MOD_PKB_1	324	332	PF00069	0.604
MOD_Plk_1	14	20	PF00069	0.476
MOD_Plk_1	392	398	PF00069	0.627
MOD_Plk_2-3	52	58	PF00069	0.567
MOD_Plk_4	134	140	PF00069	0.671
MOD_Plk_4	172	178	PF00069	0.694
MOD_Plk_4	219	225	PF00069	0.691
MOD_Plk_4	32	38	PF00069	0.611
MOD_ProDKin_1	119	125	PF00069	0.640
MOD_ProDKin_1	140	146	PF00069	0.711
MOD_ProDKin_1	161	167	PF00069	0.650
MOD_ProDKin_1	304	310	PF00069	0.765
MOD_ProDKin_1	77	83	PF00069	0.565
MOD_ProDKin_1	96	102	PF00069	0.554
MOD_SUMO_rev_2	230	237	PF00179	0.550
TRG_DiLeu_BaEn_2	259	265	PF01217	0.537
TRG_ENDOCYTIC_2	64	67	PF00928	0.560
TRG_ER_diArg_1	324	327	PF00400	0.653
TRG_ER_diArg_1	344	346	PF00400	0.728
TRG_ER_diArg_1	382	385	PF00400	0.641
TRG_ER_diArg_1	61	64	PF00400	0.596
TRG_NLS_MonoExtC_3	315	321	PF00514	0.513
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB80	Leptomonas seymouri	35%	74%
A4HB37	Leishmania braziliensis	55%	99%
A4IAN2	Leishmania infantum	99%	100%
E9B5A7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q2M6	Leishmania major	85%	100%