LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

EGF-like domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
EGF-like domain-containing protein
Gene product:
hypothetical protein, conserved (fragment)
Species:
Leishmania donovani
UniProt:
A0A3Q8IFR8_LEIDO
TriTrypDb:
LdBPK_013340.1 * , LdBPK_013350.1 * , LdCL_310034000 , LDHU3_31.4640
Length:
823

Annotations

LeishMANIAdb annotations

The last domain of this multidomain protein is related to animal Stabilins, known lipoprotein receptors. related to the T. cruzi protein “Enriched in surface-labeled proteome protein 10”. Family has expanded on multiple Kinetoplastid branches, also in free-living species. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 4
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0016020 membrane 2 15
GO:0110165 cellular anatomical entity 1 15

Expansion

Sequence features

A0A3Q8IFR8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFR8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 174 178 PF00656 0.524
CLV_C14_Caspase3-7 447 451 PF00656 0.349
CLV_C14_Caspase3-7 641 645 PF00656 0.457
CLV_NRD_NRD_1 6 8 PF00675 0.650
CLV_NRD_NRD_1 752 754 PF00675 0.458
CLV_NRD_NRD_1 787 789 PF00675 0.538
CLV_NRD_NRD_1 807 809 PF00675 0.543
CLV_NRD_NRD_1 812 814 PF00675 0.512
CLV_PCSK_KEX2_1 6 8 PF00082 0.650
CLV_PCSK_KEX2_1 752 754 PF00082 0.460
CLV_PCSK_KEX2_1 789 791 PF00082 0.551
CLV_PCSK_KEX2_1 807 809 PF00082 0.554
CLV_PCSK_KEX2_1 811 813 PF00082 0.547
CLV_PCSK_PC1ET2_1 789 791 PF00082 0.522
CLV_PCSK_PC1ET2_1 811 813 PF00082 0.548
CLV_PCSK_PC7_1 807 813 PF00082 0.550
CLV_PCSK_SKI1_1 7 11 PF00082 0.647
CLV_PCSK_SKI1_1 76 80 PF00082 0.629
CLV_PCSK_SKI1_1 807 811 PF00082 0.528
DEG_APCC_DBOX_1 41 49 PF00400 0.384
DEG_MDM2_SWIB_1 10 17 PF02201 0.399
DEG_Nend_Nbox_1 1 3 PF02207 0.408
DEG_SCF_FBW7_1 449 456 PF00400 0.338
DEG_SPOP_SBC_1 245 249 PF00917 0.429
DEG_SPOP_SBC_1 334 338 PF00917 0.503
DOC_CDC14_PxL_1 209 217 PF14671 0.450
DOC_CKS1_1 269 274 PF01111 0.474
DOC_CKS1_1 331 336 PF01111 0.459
DOC_CKS1_1 700 705 PF01111 0.402
DOC_CYCLIN_yCln2_LP_2 736 742 PF00134 0.270
DOC_MAPK_FxFP_2 77 80 PF00069 0.412
DOC_MAPK_gen_1 788 799 PF00069 0.646
DOC_MAPK_MEF2A_6 345 353 PF00069 0.445
DOC_MAPK_MEF2A_6 539 546 PF00069 0.429
DOC_MAPK_MEF2A_6 792 801 PF00069 0.694
DOC_MAPK_RevD_3 739 753 PF00069 0.412
DOC_MAPK_RevD_3 799 813 PF00069 0.747
DOC_PP1_RVXF_1 4 11 PF00149 0.378
DOC_PP2B_LxvP_1 736 739 PF13499 0.284
DOC_PP4_FxxP_1 106 109 PF00568 0.373
DOC_PP4_FxxP_1 77 80 PF00568 0.475
DOC_USP7_MATH_1 245 249 PF00917 0.466
DOC_USP7_MATH_1 334 338 PF00917 0.500
DOC_USP7_MATH_1 548 552 PF00917 0.471
DOC_USP7_MATH_1 649 653 PF00917 0.441
DOC_USP7_MATH_1 85 89 PF00917 0.493
DOC_WW_Pin1_4 105 110 PF00397 0.421
DOC_WW_Pin1_4 185 190 PF00397 0.528
DOC_WW_Pin1_4 268 273 PF00397 0.396
DOC_WW_Pin1_4 330 335 PF00397 0.394
DOC_WW_Pin1_4 449 454 PF00397 0.469
DOC_WW_Pin1_4 505 510 PF00397 0.376
DOC_WW_Pin1_4 59 64 PF00397 0.442
DOC_WW_Pin1_4 699 704 PF00397 0.482
LIG_14-3-3_CanoR_1 240 245 PF00244 0.418
LIG_14-3-3_CanoR_1 328 334 PF00244 0.422
LIG_14-3-3_CanoR_1 395 404 PF00244 0.248
LIG_14-3-3_CanoR_1 660 665 PF00244 0.418
LIG_14-3-3_CanoR_1 84 94 PF00244 0.487
LIG_Actin_WH2_2 524 541 PF00022 0.280
LIG_APCC_ABBA_1 485 490 PF00400 0.425
LIG_BIR_III_4 629 633 PF00653 0.484
LIG_BRCT_BRCA1_1 159 163 PF00533 0.530
LIG_BRCT_BRCA1_1 479 483 PF00533 0.306
LIG_BRCT_BRCA1_1 681 685 PF00533 0.458
LIG_BRCT_BRCA1_1 87 91 PF00533 0.360
LIG_deltaCOP1_diTrp_1 146 152 PF00928 0.430
LIG_FHA_1 224 230 PF00498 0.366
LIG_FHA_1 245 251 PF00498 0.485
LIG_FHA_1 255 261 PF00498 0.397
LIG_FHA_1 420 426 PF00498 0.427
LIG_FHA_1 473 479 PF00498 0.351
LIG_FHA_1 480 486 PF00498 0.258
LIG_FHA_1 506 512 PF00498 0.368
LIG_FHA_2 172 178 PF00498 0.495
LIG_FHA_2 203 209 PF00498 0.442
LIG_FHA_2 247 253 PF00498 0.343
LIG_FHA_2 301 307 PF00498 0.432
LIG_FHA_2 361 367 PF00498 0.283
LIG_FHA_2 375 381 PF00498 0.483
LIG_FHA_2 443 449 PF00498 0.360
LIG_FHA_2 66 72 PF00498 0.460
LIG_LIR_Apic_2 103 109 PF02991 0.367
LIG_LIR_Apic_2 151 156 PF02991 0.378
LIG_LIR_Apic_2 697 703 PF02991 0.436
LIG_LIR_Gen_1 122 132 PF02991 0.333
LIG_LIR_Gen_1 13 20 PF02991 0.608
LIG_LIR_Gen_1 201 212 PF02991 0.448
LIG_LIR_Gen_1 371 380 PF02991 0.305
LIG_LIR_Gen_1 727 736 PF02991 0.346
LIG_LIR_Gen_1 762 772 PF02991 0.625
LIG_LIR_Nem_3 122 127 PF02991 0.367
LIG_LIR_Nem_3 13 17 PF02991 0.616
LIG_LIR_Nem_3 146 150 PF02991 0.403
LIG_LIR_Nem_3 201 207 PF02991 0.400
LIG_LIR_Nem_3 208 212 PF02991 0.340
LIG_LIR_Nem_3 350 356 PF02991 0.304
LIG_LIR_Nem_3 362 367 PF02991 0.371
LIG_LIR_Nem_3 371 376 PF02991 0.425
LIG_LIR_Nem_3 377 382 PF02991 0.335
LIG_LIR_Nem_3 51 56 PF02991 0.356
LIG_LIR_Nem_3 727 731 PF02991 0.298
LIG_LIR_Nem_3 762 767 PF02991 0.777
LIG_LIR_Nem_3 771 775 PF02991 0.747
LIG_LYPXL_yS_3 513 516 PF13949 0.429
LIG_PCNA_PIPBox_1 803 812 PF02747 0.667
LIG_PCNA_yPIPBox_3 802 810 PF02747 0.666
LIG_Pex14_2 10 14 PF04695 0.619
LIG_Pex14_2 283 287 PF04695 0.373
LIG_Pex14_2 353 357 PF04695 0.466
LIG_Rb_pABgroove_1 135 143 PF01858 0.379
LIG_SH2_CRK 124 128 PF00017 0.462
LIG_SH2_CRK 153 157 PF00017 0.457
LIG_SH2_CRK 209 213 PF00017 0.454
LIG_SH2_CRK 241 245 PF00017 0.439
LIG_SH2_CRK 56 60 PF00017 0.426
LIG_SH2_CRK 700 704 PF00017 0.433
LIG_SH2_GRB2like 232 235 PF00017 0.452
LIG_SH2_NCK_1 153 157 PF00017 0.457
LIG_SH2_NCK_1 700 704 PF00017 0.397
LIG_SH2_SRC 232 235 PF00017 0.452
LIG_SH2_STAP1 261 265 PF00017 0.519
LIG_SH2_STAP1 347 351 PF00017 0.367
LIG_SH2_STAP1 421 425 PF00017 0.338
LIG_SH2_STAP1 696 700 PF00017 0.469
LIG_SH2_STAT5 100 103 PF00017 0.410
LIG_SH2_STAT5 204 207 PF00017 0.437
LIG_SH2_STAT5 209 212 PF00017 0.395
LIG_SH2_STAT5 35 38 PF00017 0.386
LIG_SH2_STAT5 421 424 PF00017 0.413
LIG_SH2_STAT5 696 699 PF00017 0.465
LIG_SH3_3 266 272 PF00018 0.473
LIG_SH3_3 528 534 PF00018 0.380
LIG_SH3_3 577 583 PF00018 0.410
LIG_SH3_3 75 81 PF00018 0.327
LIG_SUMO_SIM_anti_2 134 142 PF11976 0.463
LIG_SUMO_SIM_anti_2 422 427 PF11976 0.388
LIG_SUMO_SIM_anti_2 727 733 PF11976 0.384
LIG_TYR_ITIM 207 212 PF00017 0.455
LIG_UBA3_1 796 802 PF00899 0.667
LIG_WRC_WIRS_1 149 154 PF05994 0.553
LIG_WW_1 720 723 PF00397 0.615
LIG_WW_3 620 624 PF00397 0.571
MOD_CK1_1 165 171 PF00069 0.531
MOD_CK1_1 220 226 PF00069 0.553
MOD_CK1_1 28 34 PF00069 0.625
MOD_CK1_1 297 303 PF00069 0.573
MOD_CK1_1 311 317 PF00069 0.440
MOD_CK1_1 386 392 PF00069 0.406
MOD_CK1_1 442 448 PF00069 0.444
MOD_CK1_1 477 483 PF00069 0.534
MOD_CK1_1 616 622 PF00069 0.685
MOD_CK1_1 699 705 PF00069 0.647
MOD_CK1_1 715 721 PF00069 0.454
MOD_CK2_1 202 208 PF00069 0.573
MOD_CK2_1 246 252 PF00069 0.529
MOD_CK2_1 442 448 PF00069 0.476
MOD_CMANNOS 11 14 PF00535 0.532
MOD_DYRK1A_RPxSP_1 505 509 PF00069 0.356
MOD_GlcNHglycan 159 162 PF01048 0.594
MOD_GlcNHglycan 181 184 PF01048 0.792
MOD_GlcNHglycan 219 222 PF01048 0.653
MOD_GlcNHglycan 23 26 PF01048 0.609
MOD_GlcNHglycan 313 316 PF01048 0.534
MOD_GlcNHglycan 322 325 PF01048 0.530
MOD_GlcNHglycan 366 370 PF01048 0.461
MOD_GlcNHglycan 490 494 PF01048 0.341
MOD_GlcNHglycan 539 542 PF01048 0.499
MOD_GlcNHglycan 564 567 PF01048 0.579
MOD_GlcNHglycan 597 600 PF01048 0.452
MOD_GlcNHglycan 616 619 PF01048 0.636
MOD_GlcNHglycan 646 649 PF01048 0.490
MOD_GlcNHglycan 689 692 PF01048 0.599
MOD_GlcNHglycan 736 739 PF01048 0.390
MOD_GlcNHglycan 818 821 PF01048 0.678
MOD_GlcNHglycan 87 90 PF01048 0.601
MOD_GSK3_1 131 138 PF00069 0.683
MOD_GSK3_1 21 28 PF00069 0.624
MOD_GSK3_1 240 247 PF00069 0.570
MOD_GSK3_1 264 271 PF00069 0.560
MOD_GSK3_1 316 323 PF00069 0.436
MOD_GSK3_1 329 336 PF00069 0.488
MOD_GSK3_1 383 390 PF00069 0.488
MOD_GSK3_1 439 446 PF00069 0.440
MOD_GSK3_1 449 456 PF00069 0.458
MOD_GSK3_1 468 475 PF00069 0.452
MOD_GSK3_1 477 484 PF00069 0.491
MOD_GSK3_1 55 62 PF00069 0.452
MOD_GSK3_1 65 72 PF00069 0.503
MOD_GSK3_1 694 701 PF00069 0.578
MOD_GSK3_1 95 102 PF00069 0.437
MOD_N-GLC_1 135 140 PF02516 0.684
MOD_N-GLC_1 233 238 PF02516 0.470
MOD_N-GLC_1 33 38 PF02516 0.415
MOD_N-GLC_1 387 392 PF02516 0.383
MOD_N-GLC_1 419 424 PF02516 0.460
MOD_N-GLC_1 595 600 PF02516 0.444
MOD_N-GLC_1 613 618 PF02516 0.660
MOD_N-GLC_1 63 68 PF02516 0.529
MOD_N-GLC_1 69 74 PF02516 0.527
MOD_N-GLC_2 407 409 PF02516 0.437
MOD_NEK2_1 10 15 PF00069 0.530
MOD_NEK2_1 157 162 PF00069 0.609
MOD_NEK2_1 20 25 PF00069 0.607
MOD_NEK2_1 215 220 PF00069 0.627
MOD_NEK2_1 259 264 PF00069 0.556
MOD_NEK2_1 360 365 PF00069 0.447
MOD_NEK2_1 383 388 PF00069 0.345
MOD_NEK2_1 398 403 PF00069 0.428
MOD_NEK2_1 466 471 PF00069 0.407
MOD_NEK2_1 488 493 PF00069 0.326
MOD_NEK2_1 537 542 PF00069 0.461
MOD_NEK2_1 734 739 PF00069 0.295
MOD_NEK2_2 148 153 PF00069 0.448
MOD_NEK2_2 261 266 PF00069 0.648
MOD_NEK2_2 548 553 PF00069 0.584
MOD_OFUCOSY 394 400 PF10250 0.538
MOD_OFUCOSY 409 416 PF10250 0.387
MOD_OFUCOSY 561 568 PF10250 0.575
MOD_OFUCOSY 679 684 PF10250 0.594
MOD_PIKK_1 162 168 PF00454 0.537
MOD_PIKK_1 220 226 PF00454 0.617
MOD_PIKK_1 63 69 PF00454 0.511
MOD_PIKK_1 704 710 PF00454 0.659
MOD_PKA_2 28 34 PF00069 0.483
MOD_PKA_2 715 721 PF00069 0.466
MOD_Plk_1 135 141 PF00069 0.713
MOD_Plk_1 245 251 PF00069 0.567
MOD_Plk_1 294 300 PF00069 0.578
MOD_Plk_1 33 39 PF00069 0.580
MOD_Plk_1 347 353 PF00069 0.518
MOD_Plk_1 365 371 PF00069 0.272
MOD_Plk_1 387 393 PF00069 0.415
MOD_Plk_1 419 425 PF00069 0.431
MOD_Plk_1 526 532 PF00069 0.553
MOD_Plk_1 680 686 PF00069 0.589
MOD_Plk_1 69 75 PF00069 0.527
MOD_Plk_2-3 246 252 PF00069 0.411
MOD_Plk_4 10 16 PF00069 0.456
MOD_Plk_4 135 141 PF00069 0.669
MOD_Plk_4 233 239 PF00069 0.449
MOD_Plk_4 28 34 PF00069 0.590
MOD_Plk_4 387 393 PF00069 0.532
MOD_Plk_4 421 427 PF00069 0.454
MOD_Plk_4 474 480 PF00069 0.492
MOD_Plk_4 527 533 PF00069 0.451
MOD_Plk_4 70 76 PF00069 0.545
MOD_ProDKin_1 105 111 PF00069 0.531
MOD_ProDKin_1 185 191 PF00069 0.672
MOD_ProDKin_1 268 274 PF00069 0.494
MOD_ProDKin_1 330 336 PF00069 0.494
MOD_ProDKin_1 449 455 PF00069 0.589
MOD_ProDKin_1 505 511 PF00069 0.455
MOD_ProDKin_1 59 65 PF00069 0.548
MOD_ProDKin_1 699 705 PF00069 0.612
TRG_DiLeu_BaLyEn_6 506 511 PF01217 0.359
TRG_ENDOCYTIC_2 124 127 PF00928 0.537
TRG_ENDOCYTIC_2 204 207 PF00928 0.450
TRG_ENDOCYTIC_2 209 212 PF00928 0.426
TRG_ENDOCYTIC_2 241 244 PF00928 0.477
TRG_ENDOCYTIC_2 364 367 PF00928 0.338
TRG_ENDOCYTIC_2 513 516 PF00928 0.572
TRG_ENDOCYTIC_2 56 59 PF00928 0.581
TRG_ENDOCYTIC_2 723 726 PF00928 0.612
TRG_ER_diArg_1 5 7 PF00400 0.568
TRG_ER_diArg_1 713 716 PF00400 0.512
TRG_ER_diArg_1 751 753 PF00400 0.536
TRG_ER_diArg_1 788 791 PF00400 0.735
TRG_ER_diArg_1 806 808 PF00400 0.676
TRG_NLS_MonoExtC_3 787 792 PF00514 0.664
TRG_Pf-PMV_PEXEL_1 773 778 PF00026 0.709

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4JPQ5 Bodo saltans 27% 98%
A0A1X0NFL6 Trypanosomatidae 33% 100%
A0A3S7X4W3 Leishmania donovani 70% 100%
A4HJP2 Leishmania braziliensis 57% 100%
A4I711 Leishmania infantum 99% 100%
A4I759 Leishmania infantum 70% 97%
C9ZIV1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZIW8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9B252 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
E9B253 Leishmania mexicana (strain MHOM/GT/2001/U1103) 65% 100%
Q4Q607 Leishmania major 78% 100%
Q4Q608 Leishmania major 78% 100%
Q4Q609 Leishmania major 78% 100%
V5BQ27 Trypanosoma cruzi 32% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS