Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFR6_LEIDO

TriTrypDb:

LdBPK_301340.1 , LdCL_300018600 , LDHU3_30.1720

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFR6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.694
CLV_C14_Caspase3-7	596	600	PF00656	0.741
CLV_NRD_NRD_1	15	17	PF00675	0.515
CLV_NRD_NRD_1	229	231	PF00675	0.526
CLV_NRD_NRD_1	268	270	PF00675	0.475
CLV_NRD_NRD_1	343	345	PF00675	0.528
CLV_NRD_NRD_1	385	387	PF00675	0.421
CLV_NRD_NRD_1	401	403	PF00675	0.468
CLV_NRD_NRD_1	658	660	PF00675	0.641
CLV_NRD_NRD_1	680	682	PF00675	0.575
CLV_NRD_NRD_1	81	83	PF00675	0.399
CLV_PCSK_KEX2_1	15	17	PF00082	0.515
CLV_PCSK_KEX2_1	229	231	PF00082	0.643
CLV_PCSK_KEX2_1	268	270	PF00082	0.475
CLV_PCSK_KEX2_1	343	345	PF00082	0.573
CLV_PCSK_KEX2_1	384	386	PF00082	0.422
CLV_PCSK_KEX2_1	401	403	PF00082	0.411
CLV_PCSK_KEX2_1	657	659	PF00082	0.618
CLV_PCSK_KEX2_1	680	682	PF00082	0.575
CLV_PCSK_SKI1_1	15	19	PF00082	0.405
CLV_PCSK_SKI1_1	230	234	PF00082	0.620
CLV_PCSK_SKI1_1	261	265	PF00082	0.620
CLV_PCSK_SKI1_1	269	273	PF00082	0.394
CLV_PCSK_SKI1_1	300	304	PF00082	0.467
CLV_PCSK_SKI1_1	370	374	PF00082	0.419
CLV_PCSK_SKI1_1	385	389	PF00082	0.582
CLV_PCSK_SKI1_1	402	406	PF00082	0.456
CLV_PCSK_SKI1_1	635	639	PF00082	0.472
CLV_Separin_Metazoa	180	184	PF03568	0.425
CLV_Separin_Metazoa	666	670	PF03568	0.608
DEG_APCC_DBOX_1	136	144	PF00400	0.398
DEG_APCC_DBOX_1	14	22	PF00400	0.331
DEG_APCC_DBOX_1	267	275	PF00400	0.562
DEG_APCC_DBOX_1	401	409	PF00400	0.412
DEG_APCC_DBOX_1	515	523	PF00400	0.561
DOC_CYCLIN_RxL_1	13	24	PF00134	0.403
DOC_CYCLIN_RxL_1	297	305	PF00134	0.456
DOC_CYCLIN_RxL_1	432	442	PF00134	0.415
DOC_MIT_MIM_1	430	439	PF04212	0.399
DOC_PP2B_LxvP_1	48	51	PF13499	0.446
DOC_USP7_MATH_1	199	203	PF00917	0.675
DOC_USP7_MATH_1	216	220	PF00917	0.734
DOC_USP7_MATH_1	314	318	PF00917	0.576
DOC_USP7_MATH_1	331	335	PF00917	0.447
DOC_USP7_MATH_1	506	510	PF00917	0.533
DOC_USP7_MATH_1	576	580	PF00917	0.769
DOC_USP7_MATH_1	66	70	PF00917	0.602
DOC_WW_Pin1_4	104	109	PF00397	0.564
DOC_WW_Pin1_4	210	215	PF00397	0.778
DOC_WW_Pin1_4	222	227	PF00397	0.655
DOC_WW_Pin1_4	233	238	PF00397	0.540
DOC_WW_Pin1_4	26	31	PF00397	0.560
DOC_WW_Pin1_4	307	312	PF00397	0.514
DOC_WW_Pin1_4	597	602	PF00397	0.623
DOC_WW_Pin1_4	606	611	PF00397	0.587
DOC_WW_Pin1_4	668	673	PF00397	0.672
LIG_14-3-3_CanoR_1	137	146	PF00244	0.327
LIG_14-3-3_CanoR_1	190	199	PF00244	0.525
LIG_14-3-3_CanoR_1	209	213	PF00244	0.588
LIG_14-3-3_CanoR_1	261	266	PF00244	0.503
LIG_14-3-3_CanoR_1	385	395	PF00244	0.534
LIG_14-3-3_CanoR_1	530	540	PF00244	0.456
LIG_Actin_WH2_2	33	49	PF00022	0.466
LIG_BIR_III_4	558	562	PF00653	0.563
LIG_BRCT_BRCA1_1	217	221	PF00533	0.757
LIG_CaM_IQ_9	278	294	PF13499	0.515
LIG_Clathr_ClatBox_1	436	440	PF01394	0.404
LIG_EH1_1	42	50	PF00400	0.417
LIG_EH1_1	83	91	PF00400	0.345
LIG_eIF4E_1	632	638	PF01652	0.534
LIG_FHA_1	108	114	PF00498	0.453
LIG_FHA_1	139	145	PF00498	0.424
LIG_FHA_1	262	268	PF00498	0.551
LIG_FHA_1	354	360	PF00498	0.476
LIG_FHA_1	532	538	PF00498	0.544
LIG_FHA_1	671	677	PF00498	0.493
LIG_FHA_1	688	694	PF00498	0.413
LIG_FHA_2	387	393	PF00498	0.396
LIG_FHA_2	425	431	PF00498	0.471
LIG_FHA_2	508	514	PF00498	0.560
LIG_FHA_2	533	539	PF00498	0.544
LIG_FHA_2	55	61	PF00498	0.579
LIG_LIR_Gen_1	31	41	PF02991	0.352
LIG_LIR_Nem_3	296	302	PF02991	0.425
LIG_LIR_Nem_3	31	36	PF02991	0.370
LIG_LIR_Nem_3	633	637	PF02991	0.529
LIG_NRBOX	624	630	PF00104	0.526
LIG_PCNA_yPIPBox_3	164	178	PF02747	0.504
LIG_PCNA_yPIPBox_3	489	502	PF02747	0.462
LIG_PCNA_yPIPBox_3	6	14	PF02747	0.361
LIG_PCNA_yPIPBox_3	615	629	PF02747	0.562
LIG_PCNA_yPIPBox_3	678	692	PF02747	0.560
LIG_PTB_Apo_2	259	266	PF02174	0.552
LIG_PTB_Phospho_1	259	265	PF10480	0.554
LIG_SH2_CRK	299	303	PF00017	0.468
LIG_SH2_CRK	634	638	PF00017	0.437
LIG_SH2_STAP1	96	100	PF00017	0.459
LIG_SH2_STAT3	185	188	PF00017	0.352
LIG_SH3_3	193	199	PF00018	0.712
LIG_SH3_3	20	26	PF00018	0.492
LIG_SUMO_SIM_anti_2	434	440	PF11976	0.424
LIG_SUMO_SIM_par_1	149	154	PF11976	0.332
LIG_SUMO_SIM_par_1	434	440	PF11976	0.515
LIG_SUMO_SIM_par_1	468	474	PF11976	0.559
LIG_SUMO_SIM_par_1	66	71	PF11976	0.513
LIG_TRAF2_1	167	170	PF00917	0.492
LIG_TRAF2_1	2	5	PF00917	0.508
LIG_TRAF2_1	252	255	PF00917	0.629
LIG_TRAF2_1	389	392	PF00917	0.522
LIG_TRAF2_1	582	585	PF00917	0.600
LIG_TRAF2_1	61	64	PF00917	0.547
LIG_TRFH_1	185	189	PF08558	0.477
MOD_CDK_SPxxK_3	222	229	PF00069	0.522
MOD_CDK_SPxxK_3	597	604	PF00069	0.609
MOD_CDK_SPxxK_3	606	613	PF00069	0.537
MOD_CK1_1	202	208	PF00069	0.634
MOD_CK1_1	238	244	PF00069	0.664
MOD_CK1_1	460	466	PF00069	0.524
MOD_CK1_1	53	59	PF00069	0.552
MOD_CK1_1	579	585	PF00069	0.753
MOD_CK1_1	674	680	PF00069	0.523
MOD_CK2_1	386	392	PF00069	0.420
MOD_CK2_1	424	430	PF00069	0.475
MOD_CK2_1	532	538	PF00069	0.520
MOD_CK2_1	54	60	PF00069	0.572
MOD_CK2_1	579	585	PF00069	0.750
MOD_GlcNHglycan	153	156	PF01048	0.378
MOD_GlcNHglycan	201	204	PF01048	0.581
MOD_GlcNHglycan	218	221	PF01048	0.783
MOD_GlcNHglycan	316	319	PF01048	0.643
MOD_GlcNHglycan	549	552	PF01048	0.544
MOD_GlcNHglycan	558	562	PF01048	0.578
MOD_GlcNHglycan	570	573	PF01048	0.553
MOD_GSK3_1	100	107	PF00069	0.572
MOD_GSK3_1	158	165	PF00069	0.554
MOD_GSK3_1	309	316	PF00069	0.694
MOD_GSK3_1	332	339	PF00069	0.613
MOD_GSK3_1	360	367	PF00069	0.527
MOD_GSK3_1	456	463	PF00069	0.655
MOD_GSK3_1	50	57	PF00069	0.580
MOD_GSK3_1	507	514	PF00069	0.565
MOD_GSK3_1	670	677	PF00069	0.552
MOD_N-GLC_1	261	266	PF02516	0.503
MOD_N-GLC_1	457	462	PF02516	0.523
MOD_N-GLC_1	463	468	PF02516	0.491
MOD_N-GLC_1	511	516	PF02516	0.558
MOD_N-GLC_2	85	87	PF02516	0.399
MOD_NEK2_1	101	106	PF00069	0.603
MOD_NEK2_1	208	213	PF00069	0.705
MOD_NEK2_1	313	318	PF00069	0.633
MOD_NEK2_1	457	462	PF00069	0.553
MOD_NEK2_1	547	552	PF00069	0.576
MOD_NEK2_1	630	635	PF00069	0.414
MOD_NEK2_1	687	692	PF00069	0.498
MOD_PIKK_1	107	113	PF00454	0.526
MOD_PIKK_1	138	144	PF00454	0.376
MOD_PIKK_1	31	37	PF00454	0.501
MOD_PIKK_1	361	367	PF00454	0.490
MOD_PIKK_1	424	430	PF00454	0.472
MOD_PKA_2	208	214	PF00069	0.653
MOD_PKA_2	483	489	PF00069	0.573
MOD_PKA_2	603	609	PF00069	0.683
MOD_PKB_1	384	392	PF00069	0.534
MOD_Plk_1	261	267	PF00069	0.547
MOD_Plk_1	348	354	PF00069	0.463
MOD_Plk_1	457	463	PF00069	0.506
MOD_Plk_1	511	517	PF00069	0.558
MOD_Plk_1	576	582	PF00069	0.664
MOD_Plk_2-3	584	590	PF00069	0.786
MOD_Plk_4	336	342	PF00069	0.505
MOD_Plk_4	576	582	PF00069	0.782
MOD_Plk_4	624	630	PF00069	0.456
MOD_Plk_4	641	647	PF00069	0.464
MOD_Plk_4	671	677	PF00069	0.564
MOD_Plk_4	687	693	PF00069	0.362
MOD_ProDKin_1	104	110	PF00069	0.553
MOD_ProDKin_1	210	216	PF00069	0.776
MOD_ProDKin_1	222	228	PF00069	0.656
MOD_ProDKin_1	233	239	PF00069	0.539
MOD_ProDKin_1	26	32	PF00069	0.557
MOD_ProDKin_1	307	313	PF00069	0.520
MOD_ProDKin_1	597	603	PF00069	0.626
MOD_ProDKin_1	606	612	PF00069	0.581
MOD_ProDKin_1	668	674	PF00069	0.666
MOD_SUMO_for_1	396	399	PF00179	0.537
MOD_SUMO_rev_2	161	166	PF00179	0.427
MOD_SUMO_rev_2	270	276	PF00179	0.412
MOD_SUMO_rev_2	288	294	PF00179	0.424
TRG_DiLeu_BaEn_3	662	668	PF01217	0.546
TRG_DiLeu_BaEn_4	584	590	PF01217	0.603
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.477
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.549
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.338
TRG_ENDOCYTIC_2	299	302	PF00928	0.443
TRG_ENDOCYTIC_2	634	637	PF00928	0.438
TRG_ER_diArg_1	14	16	PF00400	0.514
TRG_ER_diArg_1	228	230	PF00400	0.527
TRG_ER_diArg_1	267	269	PF00400	0.483
TRG_ER_diArg_1	383	386	PF00400	0.482
TRG_ER_diArg_1	657	659	PF00400	0.626
TRG_NES_CRM1_1	413	426	PF08389	0.574
TRG_NES_CRM1_1	430	442	PF08389	0.295
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	300	305	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	435	440	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	469	474	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	635	640	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P981	Leptomonas seymouri	57%	95%
A0A1X0P283	Trypanosomatidae	29%	100%
A0A3R7NW91	Trypanosoma rangeli	31%	100%
A4HI80	Leishmania braziliensis	79%	100%
A4I5F9	Leishmania infantum	99%	100%
E9B0Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q7H6	Leishmania major	93%	100%
V5DQP9	Trypanosoma cruzi	33%	100%