Protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IFR1_LEIDO

TriTrypDb:

LdBPK_342850.1 , LdCL_340036600 , LDHU3_34.4860

Length:

941

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFR1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	614	618	PF00656	0.531
CLV_NRD_NRD_1	264	266	PF00675	0.633
CLV_NRD_NRD_1	306	308	PF00675	0.417
CLV_NRD_NRD_1	417	419	PF00675	0.356
CLV_NRD_NRD_1	480	482	PF00675	0.310
CLV_NRD_NRD_1	483	485	PF00675	0.310
CLV_NRD_NRD_1	538	540	PF00675	0.310
CLV_NRD_NRD_1	598	600	PF00675	0.438
CLV_NRD_NRD_1	60	62	PF00675	0.619
CLV_NRD_NRD_1	672	674	PF00675	0.681
CLV_NRD_NRD_1	85	87	PF00675	0.614
CLV_NRD_NRD_1	873	875	PF00675	0.659
CLV_PCSK_FUR_1	304	308	PF00082	0.483
CLV_PCSK_FUR_1	481	485	PF00082	0.310
CLV_PCSK_FUR_1	82	86	PF00082	0.609
CLV_PCSK_KEX2_1	264	266	PF00082	0.633
CLV_PCSK_KEX2_1	306	308	PF00082	0.417
CLV_PCSK_KEX2_1	416	418	PF00082	0.349
CLV_PCSK_KEX2_1	480	482	PF00082	0.310
CLV_PCSK_KEX2_1	483	485	PF00082	0.310
CLV_PCSK_KEX2_1	598	600	PF00082	0.438
CLV_PCSK_KEX2_1	60	62	PF00082	0.619
CLV_PCSK_KEX2_1	672	674	PF00082	0.681
CLV_PCSK_KEX2_1	84	86	PF00082	0.623
CLV_PCSK_KEX2_1	872	874	PF00082	0.653
CLV_PCSK_KEX2_1	891	893	PF00082	0.656
CLV_PCSK_PC1ET2_1	872	874	PF00082	0.649
CLV_PCSK_PC1ET2_1	891	893	PF00082	0.656
CLV_PCSK_PC7_1	594	600	PF00082	0.417
CLV_PCSK_PC7_1	868	874	PF00082	0.649
CLV_PCSK_SKI1_1	252	256	PF00082	0.592
CLV_PCSK_SKI1_1	369	373	PF00082	0.310
CLV_PCSK_SKI1_1	451	455	PF00082	0.310
CLV_PCSK_SKI1_1	686	690	PF00082	0.593
DEG_Nend_UBRbox_3	1	3	PF02207	0.609
DEG_SCF_FBW7_1	147	153	PF00400	0.561
DEG_SCF_FBW7_1	462	469	PF00400	0.294
DEG_SPOP_SBC_1	151	155	PF00917	0.632
DOC_CKS1_1	147	152	PF01111	0.562
DOC_CKS1_1	193	198	PF01111	0.595
DOC_CKS1_1	463	468	PF01111	0.294
DOC_CYCLIN_yCln2_LP_2	689	695	PF00134	0.569
DOC_MAPK_gen_1	304	311	PF00069	0.464
DOC_MAPK_gen_1	82	91	PF00069	0.581
DOC_MAPK_MEF2A_6	357	364	PF00069	0.425
DOC_PIKK_1	343	351	PF02985	0.543
DOC_PP1_RVXF_1	603	610	PF00149	0.441
DOC_PP2B_LxvP_1	188	191	PF13499	0.642
DOC_PP2B_LxvP_1	667	670	PF13499	0.649
DOC_PP2B_LxvP_1	689	692	PF13499	0.571
DOC_USP7_MATH_1	150	154	PF00917	0.649
DOC_USP7_MATH_1	432	436	PF00917	0.396
DOC_USP7_MATH_1	718	722	PF00917	0.654
DOC_USP7_MATH_1	730	734	PF00917	0.561
DOC_USP7_MATH_1	78	82	PF00917	0.597
DOC_USP7_MATH_1	788	792	PF00917	0.612
DOC_USP7_MATH_1	796	800	PF00917	0.647
DOC_USP7_MATH_1	831	835	PF00917	0.659
DOC_USP7_MATH_1	844	848	PF00917	0.671
DOC_USP7_UBL2_3	540	544	PF12436	0.310
DOC_USP7_UBL2_3	927	931	PF12436	0.595
DOC_WW_Pin1_4	110	115	PF00397	0.663
DOC_WW_Pin1_4	120	125	PF00397	0.635
DOC_WW_Pin1_4	146	151	PF00397	0.676
DOC_WW_Pin1_4	192	197	PF00397	0.677
DOC_WW_Pin1_4	202	207	PF00397	0.578
DOC_WW_Pin1_4	212	217	PF00397	0.559
DOC_WW_Pin1_4	231	236	PF00397	0.497
DOC_WW_Pin1_4	288	293	PF00397	0.606
DOC_WW_Pin1_4	462	467	PF00397	0.294
DOC_WW_Pin1_4	553	558	PF00397	0.421
DOC_WW_Pin1_4	790	795	PF00397	0.607
DOC_WW_Pin1_4	816	821	PF00397	0.662
DOC_WW_Pin1_4	839	844	PF00397	0.630
LIG_14-3-3_CanoR_1	117	127	PF00244	0.559
LIG_14-3-3_CanoR_1	146	150	PF00244	0.648
LIG_14-3-3_CanoR_1	173	183	PF00244	0.584
LIG_14-3-3_CanoR_1	416	424	PF00244	0.383
LIG_14-3-3_CanoR_1	503	508	PF00244	0.318
LIG_14-3-3_CanoR_1	737	743	PF00244	0.699
LIG_14-3-3_CanoR_1	795	803	PF00244	0.691
LIG_14-3-3_CanoR_1	84	90	PF00244	0.632
LIG_14-3-3_CanoR_1	99	103	PF00244	0.620
LIG_Actin_WH2_2	367	382	PF00022	0.331
LIG_APCC_ABBA_1	691	696	PF00400	0.565
LIG_BIR_III_4	621	625	PF00653	0.641
LIG_BIR_III_4	650	654	PF00653	0.672
LIG_BRCT_BRCA1_1	522	526	PF00533	0.310
LIG_deltaCOP1_diTrp_1	519	526	PF00928	0.310
LIG_FHA_1	133	139	PF00498	0.615
LIG_FHA_1	421	427	PF00498	0.310
LIG_FHA_1	468	474	PF00498	0.310
LIG_FHA_1	531	537	PF00498	0.310
LIG_FHA_1	733	739	PF00498	0.639
LIG_FHA_1	781	787	PF00498	0.674
LIG_FHA_1	903	909	PF00498	0.644
LIG_FHA_2	322	328	PF00498	0.387
LIG_FHA_2	862	868	PF00498	0.681
LIG_LIR_Apic_2	815	821	PF02991	0.592
LIG_LIR_Gen_1	321	331	PF02991	0.445
LIG_LIR_Gen_1	501	508	PF02991	0.326
LIG_LIR_Gen_1	519	529	PF02991	0.310
LIG_LIR_Gen_1	582	592	PF02991	0.378
LIG_LIR_Nem_3	101	105	PF02991	0.581
LIG_LIR_Nem_3	423	427	PF02991	0.310
LIG_LIR_Nem_3	501	507	PF02991	0.326
LIG_LIR_Nem_3	519	525	PF02991	0.310
LIG_LIR_Nem_3	535	541	PF02991	0.310
LIG_LIR_Nem_3	566	570	PF02991	0.367
LIG_LIR_Nem_3	582	588	PF02991	0.383
LIG_MYND_1	127	131	PF01753	0.658
LIG_NRBOX	184	190	PF00104	0.579
LIG_NRBOX	520	526	PF00104	0.310
LIG_Pex14_1	522	526	PF04695	0.310
LIG_Pex14_2	319	323	PF04695	0.399
LIG_SH2_CRK	427	431	PF00017	0.310
LIG_SH2_CRK	504	508	PF00017	0.310
LIG_SH2_CRK	585	589	PF00017	0.375
LIG_SH2_CRK	818	822	PF00017	0.646
LIG_SH2_GRB2like	63	66	PF00017	0.617
LIG_SH2_GRB2like	827	830	PF00017	0.557
LIG_SH2_NCK_1	504	508	PF00017	0.310
LIG_SH2_STAP1	504	508	PF00017	0.310
LIG_SH2_STAP1	585	589	PF00017	0.448
LIG_SH2_STAT5	391	394	PF00017	0.310
LIG_SH2_STAT5	402	405	PF00017	0.310
LIG_SH2_STAT5	427	430	PF00017	0.310
LIG_SH2_STAT5	472	475	PF00017	0.310
LIG_SH2_STAT5	827	830	PF00017	0.557
LIG_SH3_1	818	824	PF00018	0.573
LIG_SH3_3	121	127	PF00018	0.655
LIG_SH3_3	176	182	PF00018	0.606
LIG_SH3_3	325	331	PF00018	0.460
LIG_SH3_3	460	466	PF00018	0.340
LIG_SH3_3	600	606	PF00018	0.442
LIG_SH3_3	663	669	PF00018	0.670
LIG_SH3_3	689	695	PF00018	0.663
LIG_SH3_3	774	780	PF00018	0.576
LIG_SH3_3	818	824	PF00018	0.611
LIG_SxIP_EBH_1	164	173	PF03271	0.570
LIG_TRAF2_1	331	334	PF00917	0.630
LIG_TRAF2_1	353	356	PF00917	0.520
LIG_WW_3	490	494	PF00397	0.310
LIG_WW_3	669	673	PF00397	0.646
MOD_CAAXbox	938	941	PF01239	0.556
MOD_CDK_SPK_2	110	115	PF00069	0.646
MOD_CDK_SPK_2	288	293	PF00069	0.606
MOD_CDK_SPK_2	790	795	PF00069	0.666
MOD_CDK_SPxK_1	212	218	PF00069	0.649
MOD_CDK_SPxxK_3	110	117	PF00069	0.606
MOD_CK1_1	118	124	PF00069	0.682
MOD_CK1_1	16	22	PF00069	0.543
MOD_CK1_1	161	167	PF00069	0.642
MOD_CK1_1	394	400	PF00069	0.310
MOD_CK1_1	435	441	PF00069	0.428
MOD_CK1_1	506	512	PF00069	0.314
MOD_CK1_1	702	708	PF00069	0.675
MOD_CK1_1	92	98	PF00069	0.619
MOD_CK2_1	16	22	PF00069	0.543
MOD_CK2_1	315	321	PF00069	0.419
MOD_CK2_1	482	488	PF00069	0.310
MOD_CK2_1	796	802	PF00069	0.746
MOD_CK2_1	806	812	PF00069	0.557
MOD_CK2_1	848	854	PF00069	0.613
MOD_CK2_1	861	867	PF00069	0.634
MOD_GlcNHglycan	117	120	PF01048	0.662
MOD_GlcNHglycan	168	171	PF01048	0.594
MOD_GlcNHglycan	19	22	PF01048	0.495
MOD_GlcNHglycan	266	271	PF01048	0.729
MOD_GlcNHglycan	393	396	PF01048	0.310
MOD_GlcNHglycan	637	640	PF01048	0.587
MOD_GlcNHglycan	662	665	PF01048	0.717
MOD_GlcNHglycan	701	704	PF01048	0.636
MOD_GlcNHglycan	708	711	PF01048	0.711
MOD_GlcNHglycan	720	723	PF01048	0.578
MOD_GlcNHglycan	732	735	PF01048	0.616
MOD_GlcNHglycan	745	748	PF01048	0.636
MOD_GlcNHglycan	799	802	PF01048	0.701
MOD_GlcNHglycan	814	817	PF01048	0.505
MOD_GlcNHglycan	833	836	PF01048	0.525
MOD_GlcNHglycan	850	853	PF01048	0.607
MOD_GlcNHglycan	874	877	PF01048	0.612
MOD_GlcNHglycan	94	97	PF01048	0.602
MOD_GSK3_1	109	116	PF00069	0.699
MOD_GSK3_1	12	19	PF00069	0.576
MOD_GSK3_1	132	139	PF00069	0.617
MOD_GSK3_1	142	149	PF00069	0.557
MOD_GSK3_1	208	215	PF00069	0.675
MOD_GSK3_1	315	322	PF00069	0.418
MOD_GSK3_1	416	423	PF00069	0.310
MOD_GSK3_1	453	460	PF00069	0.319
MOD_GSK3_1	462	469	PF00069	0.310
MOD_GSK3_1	499	506	PF00069	0.324
MOD_GSK3_1	611	618	PF00069	0.519
MOD_GSK3_1	702	709	PF00069	0.686
MOD_GSK3_1	732	739	PF00069	0.702
MOD_GSK3_1	812	819	PF00069	0.656
MOD_GSK3_1	844	851	PF00069	0.607
MOD_GSK3_1	85	92	PF00069	0.623
MOD_N-GLC_1	12	17	PF02516	0.559
MOD_N-GLC_1	151	156	PF02516	0.682
MOD_N-GLC_1	158	163	PF02516	0.630
MOD_N-GLC_1	166	171	PF02516	0.533
MOD_N-GLC_1	248	253	PF02516	0.643
MOD_N-GLC_1	6	11	PF02516	0.614
MOD_N-GLC_1	660	665	PF02516	0.673
MOD_N-GLC_1	78	83	PF02516	0.675
MOD_N-GLC_1	812	817	PF02516	0.656
MOD_N-GLC_1	856	861	PF02516	0.632
MOD_N-GLC_1	89	94	PF02516	0.559
MOD_N-GLC_2	882	884	PF02516	0.676
MOD_NEK2_1	136	141	PF00069	0.641
MOD_NEK2_1	294	299	PF00069	0.478
MOD_NEK2_1	319	324	PF00069	0.398
MOD_NEK2_1	482	487	PF00069	0.310
MOD_NEK2_1	498	503	PF00069	0.310
MOD_NEK2_1	587	592	PF00069	0.371
MOD_NEK2_1	615	620	PF00069	0.572
MOD_NEK2_1	848	853	PF00069	0.616
MOD_NEK2_1	89	94	PF00069	0.610
MOD_NEK2_1	908	913	PF00069	0.638
MOD_NEK2_2	749	754	PF00069	0.642
MOD_PIKK_1	118	124	PF00454	0.675
MOD_PIKK_1	416	422	PF00454	0.335
MOD_PIKK_1	55	61	PF00454	0.617
MOD_PK_1	503	509	PF00069	0.314
MOD_PK_1	551	557	PF00069	0.411
MOD_PKA_1	416	422	PF00069	0.310
MOD_PKA_1	84	90	PF00069	0.616
MOD_PKA_1	872	878	PF00069	0.585
MOD_PKA_2	145	151	PF00069	0.649
MOD_PKA_2	416	422	PF00069	0.328
MOD_PKA_2	482	488	PF00069	0.310
MOD_PKA_2	498	504	PF00069	0.327
MOD_PKA_2	736	742	PF00069	0.700
MOD_PKA_2	84	90	PF00069	0.629
MOD_PKA_2	861	867	PF00069	0.637
MOD_PKA_2	872	878	PF00069	0.590
MOD_PKA_2	92	98	PF00069	0.621
MOD_PKB_1	82	90	PF00069	0.603
MOD_Plk_1	158	164	PF00069	0.646
MOD_Plk_1	334	340	PF00069	0.520
MOD_Plk_1	551	557	PF00069	0.411
MOD_Plk_1	6	12	PF00069	0.616
MOD_Plk_1	611	617	PF00069	0.550
MOD_Plk_1	761	767	PF00069	0.644
MOD_Plk_1	78	84	PF00069	0.663
MOD_Plk_1	806	812	PF00069	0.659
MOD_Plk_1	856	862	PF00069	0.608
MOD_Plk_1	908	914	PF00069	0.636
MOD_Plk_4	13	19	PF00069	0.550
MOD_Plk_4	52	58	PF00069	0.573
MOD_Plk_4	587	593	PF00069	0.377
MOD_Plk_4	6	12	PF00069	0.592
MOD_Plk_4	823	829	PF00069	0.549
MOD_ProDKin_1	110	116	PF00069	0.662
MOD_ProDKin_1	120	126	PF00069	0.636
MOD_ProDKin_1	146	152	PF00069	0.677
MOD_ProDKin_1	192	198	PF00069	0.677
MOD_ProDKin_1	202	208	PF00069	0.574
MOD_ProDKin_1	212	218	PF00069	0.598
MOD_ProDKin_1	231	237	PF00069	0.496
MOD_ProDKin_1	288	294	PF00069	0.597
MOD_ProDKin_1	462	468	PF00069	0.294
MOD_ProDKin_1	553	559	PF00069	0.414
MOD_ProDKin_1	790	796	PF00069	0.609
MOD_ProDKin_1	816	822	PF00069	0.662
MOD_ProDKin_1	839	845	PF00069	0.633
MOD_SUMO_for_1	362	365	PF00179	0.310
MOD_SUMO_rev_2	365	371	PF00179	0.310
TRG_DiLeu_BaEn_1	343	348	PF01217	0.567
TRG_DiLeu_BaEn_2	565	571	PF01217	0.374
TRG_DiLeu_BaEn_4	333	339	PF01217	0.629
TRG_ENDOCYTIC_2	402	405	PF00928	0.322
TRG_ENDOCYTIC_2	427	430	PF00928	0.310
TRG_ENDOCYTIC_2	504	507	PF00928	0.310
TRG_ENDOCYTIC_2	585	588	PF00928	0.377
TRG_ER_diArg_1	114	117	PF00400	0.630
TRG_ER_diArg_1	303	306	PF00400	0.416
TRG_ER_diArg_1	415	418	PF00400	0.324
TRG_ER_diArg_1	480	482	PF00400	0.310
TRG_ER_diArg_1	60	62	PF00400	0.603
TRG_ER_diArg_1	671	673	PF00400	0.661
TRG_ER_diArg_1	82	85	PF00400	0.609
TRG_NES_CRM1_1	519	530	PF08389	0.310
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	561	566	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK71	Leptomonas seymouri	50%	100%
A4HB21	Leishmania braziliensis	62%	96%
A4IA78	Leishmania infantum	100%	100%
E9B591	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4Q2P2	Leishmania major	90%	100%