Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IFQ0_LEIDO

TriTrypDb:

LdBPK_312250.1 , LdCL_310030500 , LDHU3_31.3980

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFQ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	275	277	PF00675	0.682
CLV_NRD_NRD_1	300	302	PF00675	0.686
CLV_NRD_NRD_1	34	36	PF00675	0.617
CLV_NRD_NRD_1	341	343	PF00675	0.674
CLV_NRD_NRD_1	431	433	PF00675	0.624
CLV_NRD_NRD_1	584	586	PF00675	0.718
CLV_PCSK_KEX2_1	275	277	PF00082	0.721
CLV_PCSK_KEX2_1	300	302	PF00082	0.659
CLV_PCSK_KEX2_1	34	36	PF00082	0.617
CLV_PCSK_KEX2_1	340	342	PF00082	0.690
CLV_PCSK_KEX2_1	583	585	PF00082	0.689
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.689
CLV_PCSK_PC7_1	579	585	PF00082	0.632
CLV_PCSK_SKI1_1	304	308	PF00082	0.658
CLV_PCSK_SKI1_1	341	345	PF00082	0.668
CLV_PCSK_SKI1_1	37	41	PF00082	0.548
CLV_PCSK_SKI1_1	392	396	PF00082	0.729
CLV_PCSK_SKI1_1	426	430	PF00082	0.624
CLV_PCSK_SKI1_1	585	589	PF00082	0.632
DEG_SPOP_SBC_1	320	324	PF00917	0.608
DEG_SPOP_SBC_1	50	54	PF00917	0.554
DEG_SPOP_SBC_1	536	540	PF00917	0.609
DEG_SPOP_SBC_1	561	565	PF00917	0.683
DOC_ANK_TNKS_1	671	678	PF00023	0.597
DOC_CKS1_1	305	310	PF01111	0.636
DOC_CYCLIN_RxL_1	579	591	PF00134	0.582
DOC_MAPK_gen_1	583	589	PF00069	0.737
DOC_PP1_SILK_1	700	705	PF00149	0.649
DOC_PP2B_LxvP_1	126	129	PF13499	0.638
DOC_PP2B_LxvP_1	174	177	PF13499	0.548
DOC_PP2B_LxvP_1	194	197	PF13499	0.519
DOC_PP2B_LxvP_1	352	355	PF13499	0.687
DOC_PP2B_LxvP_1	450	453	PF13499	0.609
DOC_USP7_MATH_1	119	123	PF00917	0.649
DOC_USP7_MATH_1	293	297	PF00917	0.660
DOC_USP7_MATH_1	320	324	PF00917	0.651
DOC_USP7_MATH_1	419	423	PF00917	0.605
DOC_USP7_MATH_1	478	482	PF00917	0.611
DOC_USP7_MATH_1	536	540	PF00917	0.632
DOC_USP7_MATH_1	556	560	PF00917	0.545
DOC_USP7_MATH_1	561	565	PF00917	0.667
DOC_USP7_MATH_1	631	635	PF00917	0.625
DOC_USP7_MATH_1	723	727	PF00917	0.649
DOC_USP7_MATH_1	739	743	PF00917	0.485
DOC_USP7_MATH_2	85	91	PF00917	0.598
DOC_USP7_UBL2_3	366	370	PF12436	0.622
DOC_USP7_UBL2_3	755	759	PF12436	0.659
DOC_WW_Pin1_4	104	109	PF00397	0.621
DOC_WW_Pin1_4	188	193	PF00397	0.661
DOC_WW_Pin1_4	198	203	PF00397	0.623
DOC_WW_Pin1_4	210	215	PF00397	0.592
DOC_WW_Pin1_4	233	238	PF00397	0.642
DOC_WW_Pin1_4	241	246	PF00397	0.612
DOC_WW_Pin1_4	270	275	PF00397	0.663
DOC_WW_Pin1_4	286	291	PF00397	0.614
DOC_WW_Pin1_4	304	309	PF00397	0.575
DOC_WW_Pin1_4	421	426	PF00397	0.678
DOC_WW_Pin1_4	439	444	PF00397	0.681
DOC_WW_Pin1_4	51	56	PF00397	0.685
DOC_WW_Pin1_4	62	67	PF00397	0.650
DOC_WW_Pin1_4	640	645	PF00397	0.614
DOC_WW_Pin1_4	662	667	PF00397	0.703
DOC_WW_Pin1_4	712	717	PF00397	0.629
DOC_WW_Pin1_4	81	86	PF00397	0.459
LIG_14-3-3_CanoR_1	163	167	PF00244	0.620
LIG_14-3-3_CanoR_1	251	260	PF00244	0.645
LIG_14-3-3_CanoR_1	34	40	PF00244	0.579
LIG_14-3-3_CanoR_1	584	590	PF00244	0.688
LIG_14-3-3_CanoR_1	682	687	PF00244	0.629
LIG_APCC_ABBAyCdc20_2	40	46	PF00400	0.515
LIG_BIR_III_2	142	146	PF00653	0.627
LIG_BRCT_BRCA1_1	163	167	PF00533	0.631
LIG_BRCT_BRCA1_1	478	482	PF00533	0.556
LIG_BRCT_BRCA1_1	725	729	PF00533	0.652
LIG_CtBP_PxDLS_1	177	181	PF00389	0.604
LIG_CtBP_PxDLS_1	690	694	PF00389	0.604
LIG_CtBP_PxDLS_1	85	89	PF00389	0.555
LIG_EH1_1	696	704	PF00400	0.617
LIG_EVH1_1	450	454	PF00568	0.559
LIG_FHA_1	105	111	PF00498	0.626
LIG_FHA_1	236	242	PF00498	0.664
LIG_FHA_1	316	322	PF00498	0.657
LIG_FHA_1	561	567	PF00498	0.688
LIG_FHA_1	599	605	PF00498	0.661
LIG_FHA_2	586	592	PF00498	0.708
LIG_LIR_Apic_2	511	515	PF02991	0.564
LIG_LIR_Gen_1	133	143	PF02991	0.616
LIG_LIR_Gen_1	479	490	PF02991	0.564
LIG_LIR_Nem_3	133	139	PF02991	0.644
LIG_LIR_Nem_3	164	169	PF02991	0.554
LIG_LIR_Nem_3	244	249	PF02991	0.652
LIG_LIR_Nem_3	706	712	PF02991	0.620
LIG_LIR_Nem_3	78	83	PF02991	0.560
LIG_MLH1_MIPbox_1	163	167	PF16413	0.631
LIG_MYND_1	124	128	PF01753	0.643
LIG_MYND_1	387	391	PF01753	0.594
LIG_RPA_C_Fungi	738	750	PF08784	0.651
LIG_SH2_CRK	709	713	PF00017	0.628
LIG_SH2_SRC	44	47	PF00017	0.518
LIG_SH2_SRC	512	515	PF00017	0.586
LIG_SH2_STAP1	132	136	PF00017	0.666
LIG_SH2_STAT5	132	135	PF00017	0.613
LIG_SH2_STAT5	166	169	PF00017	0.643
LIG_SH2_STAT5	373	376	PF00017	0.632
LIG_SH3_3	118	124	PF00018	0.637
LIG_SH3_3	186	192	PF00018	0.645
LIG_SH3_3	201	207	PF00018	0.570
LIG_SH3_3	234	240	PF00018	0.682
LIG_SH3_3	242	248	PF00018	0.612
LIG_SH3_3	254	260	PF00018	0.518
LIG_SH3_3	287	293	PF00018	0.714
LIG_SH3_3	385	391	PF00018	0.677
LIG_SH3_3	445	451	PF00018	0.670
LIG_SH3_3	633	639	PF00018	0.623
LIG_SH3_4	755	762	PF00018	0.661
LIG_SUMO_SIM_anti_2	92	100	PF11976	0.582
LIG_SUMO_SIM_par_1	84	90	PF11976	0.548
LIG_TRAF2_2	756	761	PF00917	0.639
LIG_WRC_WIRS_1	77	82	PF05994	0.562
MOD_CDC14_SPxK_1	273	276	PF00782	0.592
MOD_CDK_SPK_2	270	275	PF00069	0.595
MOD_CDK_SPK_2	421	426	PF00069	0.678
MOD_CDK_SPxK_1	270	276	PF00069	0.595
MOD_CDK_SPxK_1	51	57	PF00069	0.622
MOD_CDK_SPxxK_3	188	195	PF00069	0.655
MOD_CDK_SPxxK_3	210	217	PF00069	0.600
MOD_CDK_SPxxK_3	244	251	PF00069	0.582
MOD_CDK_SPxxK_3	640	647	PF00069	0.551
MOD_CDK_SPxxK_3	712	719	PF00069	0.630
MOD_CK1_1	157	163	PF00069	0.628
MOD_CK1_1	165	171	PF00069	0.585
MOD_CK1_1	244	250	PF00069	0.643
MOD_CK1_1	266	272	PF00069	0.702
MOD_CK1_1	421	427	PF00069	0.652
MOD_CK1_1	559	565	PF00069	0.605
MOD_CK1_1	612	618	PF00069	0.604
MOD_CK1_1	634	640	PF00069	0.679
MOD_CK1_1	708	714	PF00069	0.671
MOD_CK1_1	78	84	PF00069	0.620
MOD_CK1_1	89	95	PF00069	0.566
MOD_CK2_1	169	175	PF00069	0.666
MOD_CK2_1	210	216	PF00069	0.656
MOD_CK2_1	264	270	PF00069	0.630
MOD_CK2_1	585	591	PF00069	0.710
MOD_CK2_1	662	668	PF00069	0.706
MOD_CK2_1	712	718	PF00069	0.674
MOD_CK2_1	81	87	PF00069	0.637
MOD_DYRK1A_RPxSP_1	188	192	PF00069	0.645
MOD_GlcNHglycan	104	107	PF01048	0.614
MOD_GlcNHglycan	171	174	PF01048	0.663
MOD_GlcNHglycan	270	273	PF01048	0.677
MOD_GlcNHglycan	323	326	PF01048	0.712
MOD_GlcNHglycan	349	352	PF01048	0.687
MOD_GlcNHglycan	363	366	PF01048	0.547
MOD_GlcNHglycan	421	424	PF01048	0.563
MOD_GlcNHglycan	435	440	PF01048	0.673
MOD_GlcNHglycan	444	447	PF01048	0.663
MOD_GlcNHglycan	468	471	PF01048	0.615
MOD_GlcNHglycan	478	481	PF01048	0.644
MOD_GlcNHglycan	498	501	PF01048	0.664
MOD_GlcNHglycan	575	578	PF01048	0.695
MOD_GlcNHglycan	606	609	PF01048	0.693
MOD_GlcNHglycan	611	614	PF01048	0.647
MOD_GlcNHglycan	618	621	PF01048	0.550
MOD_GlcNHglycan	636	639	PF01048	0.678
MOD_GlcNHglycan	673	676	PF01048	0.596
MOD_GSK3_1	113	120	PF00069	0.656
MOD_GSK3_1	12	19	PF00069	0.651
MOD_GSK3_1	154	161	PF00069	0.643
MOD_GSK3_1	165	172	PF00069	0.574
MOD_GSK3_1	196	203	PF00069	0.691
MOD_GSK3_1	264	271	PF00069	0.645
MOD_GSK3_1	315	322	PF00069	0.676
MOD_GSK3_1	371	378	PF00069	0.648
MOD_GSK3_1	435	442	PF00069	0.746
MOD_GSK3_1	476	483	PF00069	0.674
MOD_GSK3_1	490	497	PF00069	0.652
MOD_GSK3_1	548	555	PF00069	0.691
MOD_GSK3_1	556	563	PF00069	0.671
MOD_GSK3_1	583	590	PF00069	0.687
MOD_GSK3_1	612	619	PF00069	0.575
MOD_GSK3_1	656	663	PF00069	0.614
MOD_GSK3_1	704	711	PF00069	0.655
MOD_GSK3_1	86	93	PF00069	0.614
MOD_N-GLC_1	251	256	PF02516	0.659
MOD_N-GLC_1	286	291	PF02516	0.588
MOD_N-GLC_1	490	495	PF02516	0.650
MOD_N-GLC_1	556	561	PF02516	0.621
MOD_N-GLC_1	712	717	PF02516	0.689
MOD_N-GLC_2	263	265	PF02516	0.664
MOD_NEK2_1	113	118	PF00069	0.653
MOD_NEK2_1	167	172	PF00069	0.593
MOD_NEK2_1	382	387	PF00069	0.668
MOD_NEK2_1	529	534	PF00069	0.639
MOD_NEK2_1	578	583	PF00069	0.659
MOD_NEK2_1	604	609	PF00069	0.647
MOD_NEK2_1	693	698	PF00069	0.666
MOD_NEK2_1	703	708	PF00069	0.537
MOD_PIKK_1	291	297	PF00454	0.678
MOD_PIKK_1	382	388	PF00454	0.677
MOD_PIKK_1	490	496	PF00454	0.661
MOD_PIKK_1	524	530	PF00454	0.577
MOD_PIKK_1	680	686	PF00454	0.633
MOD_PK_1	682	688	PF00069	0.619
MOD_PK_1	698	704	PF00069	0.561
MOD_PKA_1	258	264	PF00069	0.663
MOD_PKA_1	341	347	PF00069	0.611
MOD_PKA_1	583	589	PF00069	0.643
MOD_PKA_1	704	710	PF00069	0.654
MOD_PKA_2	162	168	PF00069	0.587
MOD_PKA_2	341	347	PF00069	0.611
MOD_PKA_2	578	584	PF00069	0.721
MOD_PKA_2	625	631	PF00069	0.631
MOD_PKA_2	671	677	PF00069	0.697
MOD_Plk_1	130	136	PF00069	0.597
MOD_Plk_1	398	404	PF00069	0.605
MOD_Plk_1	456	462	PF00069	0.587
MOD_Plk_1	717	723	PF00069	0.669
MOD_Plk_1	734	740	PF00069	0.685
MOD_Plk_1	75	81	PF00069	0.585
MOD_Plk_1	86	92	PF00069	0.573
MOD_Plk_4	162	168	PF00069	0.632
MOD_Plk_4	538	544	PF00069	0.546
MOD_Plk_4	631	637	PF00069	0.720
MOD_Plk_4	698	704	PF00069	0.658
MOD_Plk_4	725	731	PF00069	0.608
MOD_ProDKin_1	104	110	PF00069	0.624
MOD_ProDKin_1	188	194	PF00069	0.664
MOD_ProDKin_1	198	204	PF00069	0.621
MOD_ProDKin_1	210	216	PF00069	0.599
MOD_ProDKin_1	233	239	PF00069	0.642
MOD_ProDKin_1	241	247	PF00069	0.611
MOD_ProDKin_1	270	276	PF00069	0.664
MOD_ProDKin_1	286	292	PF00069	0.616
MOD_ProDKin_1	304	310	PF00069	0.575
MOD_ProDKin_1	421	427	PF00069	0.678
MOD_ProDKin_1	439	445	PF00069	0.684
MOD_ProDKin_1	51	57	PF00069	0.686
MOD_ProDKin_1	62	68	PF00069	0.649
MOD_ProDKin_1	640	646	PF00069	0.614
MOD_ProDKin_1	662	668	PF00069	0.706
MOD_ProDKin_1	712	718	PF00069	0.630
MOD_ProDKin_1	81	87	PF00069	0.461
MOD_SUMO_rev_2	45	50	PF00179	0.626
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.665
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.622
TRG_ENDOCYTIC_2	166	169	PF00928	0.556
TRG_ENDOCYTIC_2	246	249	PF00928	0.653
TRG_ENDOCYTIC_2	709	712	PF00928	0.630
TRG_ER_diArg_1	274	276	PF00400	0.666
TRG_ER_diArg_1	300	302	PF00400	0.659
TRG_ER_diArg_1	33	35	PF00400	0.612
TRG_ER_diArg_1	339	342	PF00400	0.679
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HJK1	Leishmania braziliensis	46%	99%
A4I6Z8	Leishmania infantum	99%	100%
E9B219	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q642	Leishmania major	85%	100%