AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFP8_LEIDO

TriTrypDb:

LdBPK_302090.1 , LdCL_300026200 , LDHU3_30.2830

Length:

551

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFP8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	211	217	PF00089	0.286
CLV_NRD_NRD_1	289	291	PF00675	0.286
CLV_NRD_NRD_1	295	297	PF00675	0.286
CLV_NRD_NRD_1	374	376	PF00675	0.438
CLV_NRD_NRD_1	453	455	PF00675	0.600
CLV_NRD_NRD_1	524	526	PF00675	0.674
CLV_NRD_NRD_1	534	536	PF00675	0.613
CLV_PCSK_FUR_1	287	291	PF00082	0.286
CLV_PCSK_KEX2_1	289	291	PF00082	0.286
CLV_PCSK_KEX2_1	295	297	PF00082	0.286
CLV_PCSK_KEX2_1	374	376	PF00082	0.438
CLV_PCSK_KEX2_1	455	457	PF00082	0.535
CLV_PCSK_KEX2_1	524	526	PF00082	0.697
CLV_PCSK_KEX2_1	534	536	PF00082	0.633
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.577
CLV_PCSK_SKI1_1	224	228	PF00082	0.380
CLV_PCSK_SKI1_1	382	386	PF00082	0.410
CLV_PCSK_SKI1_1	456	460	PF00082	0.535
CLV_PCSK_SKI1_1	545	549	PF00082	0.497
DEG_APCC_DBOX_1	231	239	PF00400	0.383
DEG_MDM2_SWIB_1	74	81	PF02201	0.471
DEG_Nend_Nbox_1	1	3	PF02207	0.711
DEG_SCF_FBW7_1	260	266	PF00400	0.355
DEG_SPOP_SBC_1	34	38	PF00917	0.692
DOC_ANK_TNKS_1	181	188	PF00023	0.504
DOC_CKS1_1	260	265	PF01111	0.355
DOC_CYCLIN_RxL_1	443	453	PF00134	0.566
DOC_MAPK_gen_1	100	109	PF00069	0.444
DOC_MAPK_gen_1	12	20	PF00069	0.566
DOC_MAPK_gen_1	202	211	PF00069	0.374
DOC_MAPK_gen_1	402	411	PF00069	0.379
DOC_MAPK_HePTP_8	399	411	PF00069	0.411
DOC_MAPK_MEF2A_6	204	213	PF00069	0.362
DOC_MAPK_MEF2A_6	402	411	PF00069	0.407
DOC_PP2B_LxvP_1	165	168	PF13499	0.403
DOC_USP7_MATH_1	3	7	PF00917	0.711
DOC_USP7_MATH_1	34	38	PF00917	0.707
DOC_USP7_MATH_1	84	88	PF00917	0.469
DOC_WW_Pin1_4	1	6	PF00397	0.660
DOC_WW_Pin1_4	259	264	PF00397	0.455
DOC_WW_Pin1_4	308	313	PF00397	0.302
DOC_WW_Pin1_4	388	393	PF00397	0.406
LIG_14-3-3_CanoR_1	128	137	PF00244	0.582
LIG_14-3-3_CanoR_1	197	205	PF00244	0.440
LIG_14-3-3_CanoR_1	264	268	PF00244	0.408
LIG_14-3-3_CanoR_1	387	392	PF00244	0.425
LIG_14-3-3_CanoR_1	456	461	PF00244	0.412
LIG_14-3-3_CanoR_1	535	544	PF00244	0.560
LIG_14-3-3_CanoR_1	66	74	PF00244	0.518
LIG_Actin_WH2_2	11	29	PF00022	0.614
LIG_Actin_WH2_2	113	130	PF00022	0.380
LIG_APCC_ABBAyCdc20_2	404	410	PF00400	0.369
LIG_APCC_ABBAyCdc20_2	486	492	PF00400	0.516
LIG_BRCT_BRCA1_1	389	393	PF00533	0.425
LIG_CaM_IQ_9	288	303	PF13499	0.410
LIG_FHA_1	114	120	PF00498	0.424
LIG_FHA_1	168	174	PF00498	0.492
LIG_FHA_1	210	216	PF00498	0.286
LIG_FHA_1	244	250	PF00498	0.300
LIG_FHA_1	260	266	PF00498	0.233
LIG_FHA_2	138	144	PF00498	0.508
LIG_FHA_2	167	173	PF00498	0.502
LIG_FHA_2	264	270	PF00498	0.302
LIG_FHA_2	320	326	PF00498	0.286
LIG_FHA_2	381	387	PF00498	0.411
LIG_FHA_2	464	470	PF00498	0.565
LIG_FHA_2	486	492	PF00498	0.768
LIG_FHA_2	537	543	PF00498	0.558
LIG_LIR_Apic_2	386	392	PF02991	0.510
LIG_LIR_Gen_1	136	147	PF02991	0.389
LIG_LIR_Gen_1	311	321	PF02991	0.304
LIG_LIR_Gen_1	390	401	PF02991	0.424
LIG_LIR_Gen_1	491	500	PF02991	0.784
LIG_LIR_Gen_1	76	86	PF02991	0.434
LIG_LIR_Nem_3	103	107	PF02991	0.395
LIG_LIR_Nem_3	136	142	PF02991	0.381
LIG_LIR_Nem_3	143	149	PF02991	0.306
LIG_LIR_Nem_3	311	317	PF02991	0.304
LIG_LIR_Nem_3	390	396	PF02991	0.347
LIG_LIR_Nem_3	491	497	PF02991	0.783
LIG_LIR_Nem_3	541	547	PF02991	0.582
LIG_LIR_Nem_3	76	81	PF02991	0.364
LIG_NRBOX	347	353	PF00104	0.286
LIG_Pex14_1	201	205	PF04695	0.345
LIG_Pex14_2	74	78	PF04695	0.466
LIG_SH2_CRK	389	393	PF00017	0.450
LIG_SH2_CRK	494	498	PF00017	0.686
LIG_SH2_NCK_1	139	143	PF00017	0.453
LIG_SH2_NCK_1	389	393	PF00017	0.554
LIG_SH2_NCK_1	515	519	PF00017	0.643
LIG_SH2_PTP2	408	411	PF00017	0.392
LIG_SH2_SRC	218	221	PF00017	0.426
LIG_SH2_SRC	314	317	PF00017	0.333
LIG_SH2_SRC	408	411	PF00017	0.392
LIG_SH2_SRC	490	493	PF00017	0.612
LIG_SH2_STAP1	113	117	PF00017	0.471
LIG_SH2_STAP1	85	89	PF00017	0.502
LIG_SH2_STAT5	139	142	PF00017	0.514
LIG_SH2_STAT5	175	178	PF00017	0.520
LIG_SH2_STAT5	218	221	PF00017	0.321
LIG_SH2_STAT5	284	287	PF00017	0.426
LIG_SH2_STAT5	314	317	PF00017	0.332
LIG_SH2_STAT5	408	411	PF00017	0.348
LIG_SH2_STAT5	460	463	PF00017	0.540
LIG_SH2_STAT5	494	497	PF00017	0.732
LIG_SH2_STAT5	50	53	PF00017	0.405
LIG_SH3_3	257	263	PF00018	0.347
LIG_SH3_5	135	139	PF00018	0.406
LIG_Sin3_3	223	230	PF02671	0.302
LIG_SUMO_SIM_anti_2	234	239	PF11976	0.302
LIG_SUMO_SIM_par_1	234	239	PF11976	0.286
LIG_TRAF2_1	321	324	PF00917	0.383
LIG_TRAF2_1	370	373	PF00917	0.427
LIG_TRAF2_1	539	542	PF00917	0.523
LIG_UBA3_1	235	240	PF00899	0.357
LIG_UBA3_1	447	455	PF00899	0.477
LIG_WRC_WIRS_1	85	90	PF05994	0.471
MOD_CDK_SPK_2	259	264	PF00069	0.355
MOD_CK1_1	391	397	PF00069	0.456
MOD_CK1_1	482	488	PF00069	0.782
MOD_CK1_1	49	55	PF00069	0.572
MOD_CK1_1	506	512	PF00069	0.759
MOD_CK1_1	6	12	PF00069	0.653
MOD_CK1_1	70	76	PF00069	0.398
MOD_CK2_1	137	143	PF00069	0.444
MOD_CK2_1	267	273	PF00069	0.286
MOD_CK2_1	319	325	PF00069	0.302
MOD_CK2_1	367	373	PF00069	0.410
MOD_CK2_1	380	386	PF00069	0.427
MOD_CK2_1	439	445	PF00069	0.539
MOD_CK2_1	485	491	PF00069	0.768
MOD_CK2_1	536	542	PF00069	0.550
MOD_CK2_1	84	90	PF00069	0.442
MOD_Cter_Amidation	522	525	PF01082	0.681
MOD_GlcNHglycan	157	160	PF01048	0.548
MOD_GlcNHglycan	198	201	PF01048	0.483
MOD_GlcNHglycan	37	40	PF01048	0.718
MOD_GlcNHglycan	43	46	PF01048	0.570
MOD_GlcNHglycan	435	439	PF01048	0.477
MOD_GlcNHglycan	482	485	PF01048	0.728
MOD_GlcNHglycan	521	524	PF01048	0.739
MOD_GlcNHglycan	69	72	PF01048	0.518
MOD_GlcNHglycan	75	78	PF01048	0.494
MOD_GSK3_1	129	136	PF00069	0.443
MOD_GSK3_1	259	266	PF00069	0.370
MOD_GSK3_1	387	394	PF00069	0.568
MOD_GSK3_1	475	482	PF00069	0.665
MOD_GSK3_1	506	513	PF00069	0.778
MOD_GSK3_1	69	76	PF00069	0.411
MOD_GSK3_1	84	91	PF00069	0.370
MOD_N-GLC_1	20	25	PF02516	0.655
MOD_N-GLC_1	308	313	PF02516	0.302
MOD_N-GLC_1	377	382	PF02516	0.458
MOD_NEK2_1	209	214	PF00069	0.334
MOD_NEK2_1	236	241	PF00069	0.292
MOD_NEK2_1	243	248	PF00069	0.294
MOD_NEK2_1	339	344	PF00069	0.286
MOD_NEK2_1	46	51	PF00069	0.517
MOD_NEK2_2	113	118	PF00069	0.456
MOD_PIKK_1	129	135	PF00454	0.525
MOD_PIKK_1	330	336	PF00454	0.302
MOD_PKA_1	456	462	PF00069	0.417
MOD_PKA_2	155	161	PF00069	0.579
MOD_PKA_2	196	202	PF00069	0.378
MOD_PKA_2	231	237	PF00069	0.426
MOD_PKA_2	263	269	PF00069	0.426
MOD_PKA_2	485	491	PF00069	0.763
MOD_PKA_2	536	542	PF00069	0.661
MOD_PKB_1	375	383	PF00069	0.454
MOD_PKB_1	454	462	PF00069	0.410
MOD_Plk_1	434	440	PF00069	0.384
MOD_Plk_1	46	52	PF00069	0.560
MOD_Plk_2-3	319	325	PF00069	0.426
MOD_Plk_4	118	124	PF00069	0.345
MOD_Plk_4	231	237	PF00069	0.293
MOD_Plk_4	244	250	PF00069	0.273
MOD_Plk_4	263	269	PF00069	0.440
MOD_Plk_4	3	9	PF00069	0.644
MOD_Plk_4	380	386	PF00069	0.427
MOD_Plk_4	456	462	PF00069	0.596
MOD_Plk_4	46	52	PF00069	0.560
MOD_Plk_4	485	491	PF00069	0.763
MOD_Plk_4	492	498	PF00069	0.697
MOD_Plk_4	84	90	PF00069	0.546
MOD_ProDKin_1	1	7	PF00069	0.661
MOD_ProDKin_1	259	265	PF00069	0.455
MOD_ProDKin_1	308	314	PF00069	0.302
MOD_ProDKin_1	388	394	PF00069	0.409
MOD_SUMO_rev_2	499	504	PF00179	0.602
MOD_SUMO_rev_2	540	550	PF00179	0.598
TRG_DiLeu_BaEn_1	115	120	PF01217	0.315
TRG_DiLeu_BaEn_1	435	440	PF01217	0.526
TRG_ENDOCYTIC_2	139	142	PF00928	0.514
TRG_ENDOCYTIC_2	314	317	PF00928	0.302
TRG_ENDOCYTIC_2	408	411	PF00928	0.332
TRG_ENDOCYTIC_2	494	497	PF00928	0.689
TRG_ENDOCYTIC_2	544	547	PF00928	0.616
TRG_ENDOCYTIC_2	85	88	PF00928	0.499
TRG_ER_diArg_1	201	204	PF00400	0.397
TRG_ER_diArg_1	287	290	PF00400	0.286
TRG_ER_diArg_1	374	377	PF00400	0.468
TRG_ER_diArg_1	524	526	PF00400	0.726
TRG_ER_diArg_1	534	537	PF00400	0.691
TRG_NLS_MonoExtN_4	454	459	PF00514	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P0	Leptomonas seymouri	66%	98%
A0A0S4JQC6	Bodo saltans	53%	100%
A0A1X0P383	Trypanosomatidae	51%	100%
A0A422P3G0	Trypanosoma rangeli	62%	100%
A4HIE0	Leishmania braziliensis	81%	100%
A4I5N7	Leishmania infantum	100%	100%
C9ZR06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9B0Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q785	Leishmania major	93%	100%
V5DQJ7	Trypanosoma cruzi	63%	94%