Leucine Rich repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFP5_LEIDO

TriTrypDb:

LdBPK_320480.1 , LdCL_320009700 , LdCL_320009900 , LdCL_320010100 , LdCL_320010300 , LDHU3_32.0600

Length:

1054

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8

Expansion

Sequence features

A0A3Q8IFP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFP5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.360
CLV_C14_Caspase3-7	364	368	PF00656	0.745
CLV_C14_Caspase3-7	381	385	PF00656	0.593
CLV_C14_Caspase3-7	527	531	PF00656	0.476
CLV_C14_Caspase3-7	617	621	PF00656	0.636
CLV_C14_Caspase3-7	875	879	PF00656	0.411
CLV_NRD_NRD_1	1043	1045	PF00675	0.373
CLV_NRD_NRD_1	142	144	PF00675	0.424
CLV_NRD_NRD_1	409	411	PF00675	0.555
CLV_NRD_NRD_1	482	484	PF00675	0.426
CLV_NRD_NRD_1	504	506	PF00675	0.202
CLV_NRD_NRD_1	544	546	PF00675	0.418
CLV_NRD_NRD_1	549	551	PF00675	0.446
CLV_NRD_NRD_1	559	561	PF00675	0.481
CLV_NRD_NRD_1	573	575	PF00675	0.545
CLV_NRD_NRD_1	671	673	PF00675	0.411
CLV_NRD_NRD_1	68	70	PF00675	0.426
CLV_NRD_NRD_1	920	922	PF00675	0.418
CLV_PCSK_FUR_1	550	554	PF00082	0.405
CLV_PCSK_KEX2_1	1043	1045	PF00082	0.373
CLV_PCSK_KEX2_1	142	144	PF00082	0.424
CLV_PCSK_KEX2_1	242	244	PF00082	0.403
CLV_PCSK_KEX2_1	409	411	PF00082	0.566
CLV_PCSK_KEX2_1	482	484	PF00082	0.444
CLV_PCSK_KEX2_1	544	546	PF00082	0.429
CLV_PCSK_KEX2_1	549	551	PF00082	0.469
CLV_PCSK_KEX2_1	552	554	PF00082	0.498
CLV_PCSK_KEX2_1	573	575	PF00082	0.545
CLV_PCSK_KEX2_1	68	70	PF00082	0.426
CLV_PCSK_KEX2_1	920	922	PF00082	0.418
CLV_PCSK_KEX2_1	974	976	PF00082	0.363
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.403
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.517
CLV_PCSK_PC1ET2_1	974	976	PF00082	0.363
CLV_PCSK_PC7_1	545	551	PF00082	0.395
CLV_PCSK_SKI1_1	1038	1042	PF00082	0.403
CLV_PCSK_SKI1_1	275	279	PF00082	0.411
CLV_PCSK_SKI1_1	329	333	PF00082	0.548
CLV_PCSK_SKI1_1	432	436	PF00082	0.522
CLV_PCSK_SKI1_1	556	560	PF00082	0.525
CLV_PCSK_SKI1_1	673	677	PF00082	0.451
CLV_PCSK_SKI1_1	887	891	PF00082	0.504
CLV_Separin_Metazoa	557	561	PF03568	0.482
DEG_APCC_DBOX_1	427	435	PF00400	0.485
DEG_SCF_FBW7_2	94	99	PF00400	0.428
DEG_SPOP_SBC_1	606	610	PF00917	0.583
DOC_ANK_TNKS_1	693	700	PF00023	0.437
DOC_CKS1_1	929	934	PF01111	0.437
DOC_CYCLIN_RxL_1	861	872	PF00134	0.370
DOC_CYCLIN_RxL_1	974	985	PF00134	0.351
DOC_MAPK_DCC_7	994	1003	PF00069	0.426
DOC_MAPK_gen_1	272	282	PF00069	0.351
DOC_MAPK_gen_1	654	662	PF00069	0.368
DOC_MAPK_gen_1	683	693	PF00069	0.414
DOC_MAPK_MEF2A_6	106	113	PF00069	0.338
DOC_MAPK_MEF2A_6	592	599	PF00069	0.629
DOC_MAPK_MEF2A_6	994	1003	PF00069	0.554
DOC_PP1_RVXF_1	1036	1042	PF00149	0.365
DOC_PP1_RVXF_1	977	984	PF00149	0.388
DOC_PP2B_LxvP_1	126	129	PF13499	0.335
DOC_PP2B_LxvP_1	86	89	PF13499	0.357
DOC_USP7_MATH_1	1049	1053	PF00917	0.494
DOC_USP7_MATH_1	12	16	PF00917	0.522
DOC_USP7_MATH_1	127	131	PF00917	0.345
DOC_USP7_MATH_1	141	145	PF00917	0.343
DOC_USP7_MATH_1	152	156	PF00917	0.372
DOC_USP7_MATH_1	161	165	PF00917	0.273
DOC_USP7_MATH_1	2	6	PF00917	0.488
DOC_USP7_MATH_1	331	335	PF00917	0.640
DOC_USP7_MATH_1	361	365	PF00917	0.661
DOC_USP7_MATH_1	478	482	PF00917	0.412
DOC_USP7_MATH_1	49	53	PF00917	0.439
DOC_USP7_MATH_1	606	610	PF00917	0.583
DOC_USP7_MATH_1	697	701	PF00917	0.490
DOC_USP7_MATH_1	82	86	PF00917	0.356
DOC_USP7_MATH_2	853	859	PF00917	0.427
DOC_WW_Pin1_4	116	121	PF00397	0.399
DOC_WW_Pin1_4	355	360	PF00397	0.691
DOC_WW_Pin1_4	563	568	PF00397	0.551
DOC_WW_Pin1_4	602	607	PF00397	0.692
DOC_WW_Pin1_4	611	616	PF00397	0.605
DOC_WW_Pin1_4	741	746	PF00397	0.429
DOC_WW_Pin1_4	857	862	PF00397	0.541
DOC_WW_Pin1_4	92	97	PF00397	0.425
DOC_WW_Pin1_4	928	933	PF00397	0.498
LIG_14-3-3_CanoR_1	150	159	PF00244	0.406
LIG_14-3-3_CanoR_1	43	48	PF00244	0.443
LIG_14-3-3_CanoR_1	505	511	PF00244	0.362
LIG_14-3-3_CanoR_1	573	581	PF00244	0.608
LIG_14-3-3_CanoR_1	756	762	PF00244	0.495
LIG_14-3-3_CanoR_1	887	895	PF00244	0.475
LIG_14-3-3_CanoR_1	921	929	PF00244	0.422
LIG_Actin_WH2_2	452	470	PF00022	0.434
LIG_APCC_ABBA_1	714	719	PF00400	0.516
LIG_BIR_II_1	1	5	PF00653	0.510
LIG_BIR_III_2	356	360	PF00653	0.657
LIG_BRCT_BRCA1_1	1029	1033	PF00533	0.438
LIG_BRCT_BRCA1_1	565	569	PF00533	0.562
LIG_BRCT_BRCA1_1	625	629	PF00533	0.597
LIG_Clathr_ClatBox_1	1012	1016	PF01394	0.374
LIG_CSL_BTD_1	86	89	PF09270	0.382
LIG_CtBP_PxDLS_1	308	312	PF00389	0.548
LIG_deltaCOP1_diTrp_1	636	640	PF00928	0.518
LIG_deltaCOP1_diTrp_1	968	972	PF00928	0.398
LIG_FHA_1	102	108	PF00498	0.369
LIG_FHA_1	155	161	PF00498	0.353
LIG_FHA_1	287	293	PF00498	0.526
LIG_FHA_1	302	308	PF00498	0.422
LIG_FHA_1	489	495	PF00498	0.318
LIG_FHA_1	657	663	PF00498	0.370
LIG_FHA_1	682	688	PF00498	0.423
LIG_FHA_1	757	763	PF00498	0.469
LIG_FHA_1	929	935	PF00498	0.572
LIG_FHA_1	949	955	PF00498	0.222
LIG_FHA_2	198	204	PF00498	0.509
LIG_FHA_2	211	217	PF00498	0.297
LIG_FHA_2	283	289	PF00498	0.460
LIG_FHA_2	344	350	PF00498	0.744
LIG_FHA_2	385	391	PF00498	0.558
LIG_FHA_2	598	604	PF00498	0.635
LIG_FHA_2	675	681	PF00498	0.509
LIG_FHA_2	873	879	PF00498	0.527
LIG_FHA_2	888	894	PF00498	0.390
LIG_FHA_2	93	99	PF00498	0.419
LIG_GBD_Chelix_1	292	300	PF00786	0.373
LIG_GBD_Chelix_1	946	954	PF00786	0.382
LIG_Integrin_isoDGR_2	148	150	PF01839	0.457
LIG_LIR_Gen_1	1030	1041	PF02991	0.425
LIG_LIR_Gen_1	134	141	PF02991	0.392
LIG_LIR_Gen_1	484	494	PF02991	0.280
LIG_LIR_Gen_1	719	727	PF02991	0.417
LIG_LIR_Gen_1	737	748	PF02991	0.339
LIG_LIR_Gen_1	968	977	PF02991	0.398
LIG_LIR_Nem_3	134	139	PF02991	0.388
LIG_LIR_Nem_3	448	453	PF02991	0.475
LIG_LIR_Nem_3	484	489	PF02991	0.382
LIG_LIR_Nem_3	715	720	PF02991	0.451
LIG_LIR_Nem_3	737	743	PF02991	0.434
LIG_LIR_Nem_3	968	972	PF02991	0.398
LIG_NRBOX	430	436	PF00104	0.486
LIG_NRBOX	506	512	PF00104	0.390
LIG_NRBOX	881	887	PF00104	0.327
LIG_NRBOX	949	955	PF00104	0.381
LIG_PDZ_Class_1	1049	1054	PF00595	0.504
LIG_Pex14_1	87	91	PF04695	0.378
LIG_Pex14_2	1019	1023	PF04695	0.481
LIG_Pex14_2	66	70	PF04695	0.422
LIG_Pex14_2	983	987	PF04695	0.404
LIG_SH2_CRK	450	454	PF00017	0.467
LIG_SH2_SRC	914	917	PF00017	0.415
LIG_SH2_STAP1	590	594	PF00017	0.616
LIG_SH2_STAP1	788	792	PF00017	0.427
LIG_SH2_STAT3	777	780	PF00017	0.511
LIG_SH2_STAT5	479	482	PF00017	0.467
LIG_SH2_STAT5	740	743	PF00017	0.402
LIG_SH2_STAT5	786	789	PF00017	0.455
LIG_SH2_STAT5	914	917	PF00017	0.415
LIG_SH3_3	157	163	PF00018	0.339
LIG_SH3_3	643	649	PF00018	0.496
LIG_SH3_3	851	857	PF00018	0.477
LIG_SH3_3	937	943	PF00018	0.491
LIG_SH3_3	955	961	PF00018	0.412
LIG_SUMO_SIM_par_1	157	164	PF11976	0.429
LIG_SUMO_SIM_par_1	288	297	PF11976	0.411
LIG_SUMO_SIM_par_1	595	600	PF11976	0.632
LIG_SUMO_SIM_par_1	648	653	PF11976	0.543
LIG_SUMO_SIM_par_1	661	667	PF11976	0.313
LIG_SUMO_SIM_par_1	759	765	PF11976	0.405
LIG_SUMO_SIM_par_1	942	948	PF11976	0.370
LIG_TRAF2_1	393	396	PF00917	0.662
LIG_TRAF2_1	422	425	PF00917	0.416
LIG_TRAF2_1	518	521	PF00917	0.468
LIG_TRAF2_1	891	894	PF00917	0.387
LIG_TRAF2_1	896	899	PF00917	0.375
LIG_UBA3_1	174	182	PF00899	0.351
MOD_CDK_SPK_2	928	933	PF00069	0.328
MOD_CDK_SPxxK_3	857	864	PF00069	0.472
MOD_CK1_1	101	107	PF00069	0.382
MOD_CK1_1	144	150	PF00069	0.453
MOD_CK1_1	164	170	PF00069	0.310
MOD_CK1_1	177	183	PF00069	0.307
MOD_CK1_1	197	203	PF00069	0.394
MOD_CK1_1	210	216	PF00069	0.318
MOD_CK1_1	255	261	PF00069	0.525
MOD_CK1_1	341	347	PF00069	0.614
MOD_CK1_1	481	487	PF00069	0.437
MOD_CK1_1	605	611	PF00069	0.634
MOD_CK1_1	614	620	PF00069	0.574
MOD_CK1_1	760	766	PF00069	0.437
MOD_CK2_1	167	173	PF00069	0.403
MOD_CK2_1	210	216	PF00069	0.402
MOD_CK2_1	255	261	PF00069	0.535
MOD_CK2_1	263	269	PF00069	0.462
MOD_CK2_1	343	349	PF00069	0.633
MOD_CK2_1	375	381	PF00069	0.739
MOD_CK2_1	384	390	PF00069	0.592
MOD_CK2_1	484	490	PF00069	0.436
MOD_CK2_1	515	521	PF00069	0.485
MOD_CK2_1	532	538	PF00069	0.410
MOD_CK2_1	597	603	PF00069	0.635
MOD_CK2_1	607	613	PF00069	0.655
MOD_CK2_1	674	680	PF00069	0.429
MOD_CK2_1	887	893	PF00069	0.401
MOD_CMANNOS	637	640	PF00535	0.523
MOD_GlcNHglycan	1016	1019	PF01048	0.506
MOD_GlcNHglycan	143	146	PF01048	0.409
MOD_GlcNHglycan	163	166	PF01048	0.311
MOD_GlcNHglycan	188	191	PF01048	0.352
MOD_GlcNHglycan	196	199	PF01048	0.399
MOD_GlcNHglycan	210	213	PF01048	0.431
MOD_GlcNHglycan	254	257	PF01048	0.635
MOD_GlcNHglycan	333	336	PF01048	0.646
MOD_GlcNHglycan	377	380	PF01048	0.691
MOD_GlcNHglycan	39	42	PF01048	0.494
MOD_GlcNHglycan	483	486	PF01048	0.413
MOD_GlcNHglycan	53	56	PF01048	0.433
MOD_GlcNHglycan	577	580	PF01048	0.568
MOD_GlcNHglycan	626	629	PF01048	0.602
MOD_GlcNHglycan	700	703	PF01048	0.617
MOD_GlcNHglycan	798	801	PF01048	0.466
MOD_GlcNHglycan	905	908	PF01048	0.356
MOD_GSK3_1	1023	1030	PF00069	0.500
MOD_GSK3_1	150	157	PF00069	0.469
MOD_GSK3_1	174	181	PF00069	0.391
MOD_GSK3_1	2	9	PF00069	0.480
MOD_GSK3_1	221	228	PF00069	0.353
MOD_GSK3_1	276	283	PF00069	0.385
MOD_GSK3_1	343	350	PF00069	0.656
MOD_GSK3_1	357	364	PF00069	0.683
MOD_GSK3_1	484	491	PF00069	0.423
MOD_GSK3_1	49	56	PF00069	0.426
MOD_GSK3_1	575	582	PF00069	0.530
MOD_GSK3_1	602	609	PF00069	0.632
MOD_GSK3_1	620	627	PF00069	0.627
MOD_GSK3_1	664	671	PF00069	0.574
MOD_GSK3_1	756	763	PF00069	0.424
MOD_GSK3_1	778	785	PF00069	0.462
MOD_GSK3_1	829	836	PF00069	0.378
MOD_GSK3_1	924	931	PF00069	0.466
MOD_N-GLC_1	221	226	PF02516	0.343
MOD_N-GLC_1	280	285	PF02516	0.366
MOD_N-GLC_1	341	346	PF02516	0.613
MOD_N-GLC_1	49	54	PF02516	0.436
MOD_N-GLC_1	756	761	PF02516	0.434
MOD_N-GLC_1	82	87	PF02516	0.385
MOD_N-GLC_1	922	927	PF02516	0.405
MOD_NEK2_1	1005	1010	PF00069	0.569
MOD_NEK2_1	1023	1028	PF00069	0.370
MOD_NEK2_1	111	116	PF00069	0.397
MOD_NEK2_1	178	183	PF00069	0.395
MOD_NEK2_1	208	213	PF00069	0.537
MOD_NEK2_1	225	230	PF00069	0.343
MOD_NEK2_1	263	268	PF00069	0.556
MOD_NEK2_1	276	281	PF00069	0.340
MOD_NEK2_1	282	287	PF00069	0.263
MOD_NEK2_1	62	67	PF00069	0.384
MOD_NEK2_1	790	795	PF00069	0.529
MOD_NEK2_1	833	838	PF00069	0.354
MOD_NEK2_1	902	907	PF00069	0.446
MOD_NEK2_1	922	927	PF00069	0.405
MOD_NEK2_2	656	661	PF00069	0.434
MOD_PIKK_1	53	59	PF00454	0.394
MOD_PK_1	43	49	PF00069	0.444
MOD_PK_1	573	579	PF00069	0.565
MOD_PKA_1	573	579	PF00069	0.534
MOD_PKA_2	141	147	PF00069	0.488
MOD_PKA_2	186	192	PF00069	0.306
MOD_PKA_2	467	473	PF00069	0.533
MOD_PKA_2	481	487	PF00069	0.412
MOD_PKA_2	532	538	PF00069	0.448
MOD_PKA_2	572	578	PF00069	0.611
MOD_Plk_1	111	117	PF00069	0.331
MOD_Plk_1	2	8	PF00069	0.483
MOD_Plk_1	221	227	PF00069	0.429
MOD_Plk_1	287	293	PF00069	0.436
MOD_Plk_1	341	347	PF00069	0.817
MOD_Plk_1	49	55	PF00069	0.587
MOD_Plk_1	756	762	PF00069	0.422
MOD_Plk_1	82	88	PF00069	0.451
MOD_Plk_1	893	899	PF00069	0.409
MOD_Plk_1	98	104	PF00069	0.383
MOD_Plk_2-3	347	353	PF00069	0.723
MOD_Plk_2-3	384	390	PF00069	0.616
MOD_Plk_2-3	872	878	PF00069	0.420
MOD_Plk_2-3	893	899	PF00069	0.352
MOD_Plk_4	1008	1014	PF00069	0.369
MOD_Plk_4	135	141	PF00069	0.389
MOD_Plk_4	14	20	PF00069	0.454
MOD_Plk_4	174	180	PF00069	0.364
MOD_Plk_4	287	293	PF00069	0.418
MOD_Plk_4	488	494	PF00069	0.318
MOD_Plk_4	506	512	PF00069	0.410
MOD_Plk_4	712	718	PF00069	0.552
MOD_Plk_4	757	763	PF00069	0.467
MOD_Plk_4	782	788	PF00069	0.443
MOD_Plk_4	98	104	PF00069	0.408
MOD_Plk_4	982	988	PF00069	0.321
MOD_ProDKin_1	116	122	PF00069	0.405
MOD_ProDKin_1	355	361	PF00069	0.688
MOD_ProDKin_1	563	569	PF00069	0.555
MOD_ProDKin_1	602	608	PF00069	0.693
MOD_ProDKin_1	611	617	PF00069	0.605
MOD_ProDKin_1	741	747	PF00069	0.426
MOD_ProDKin_1	857	863	PF00069	0.527
MOD_ProDKin_1	92	98	PF00069	0.427
MOD_ProDKin_1	928	934	PF00069	0.497
MOD_SUMO_rev_2	234	244	PF00179	0.447
MOD_SUMO_rev_2	297	307	PF00179	0.474
MOD_SUMO_rev_2	399	408	PF00179	0.602
MOD_SUMO_rev_2	425	434	PF00179	0.411
TRG_AP2beta_CARGO_1	134	143	PF09066	0.367
TRG_DiLeu_BaEn_1	216	221	PF01217	0.397
TRG_DiLeu_BaEn_1	430	435	PF01217	0.574
TRG_DiLeu_BaEn_2	967	973	PF01217	0.393
TRG_DiLeu_BaEn_4	818	824	PF01217	0.382
TRG_DiLeu_BaEn_4	898	904	PF01217	0.435
TRG_DiLeu_BaLyEn_6	1035	1040	PF01217	0.361
TRG_DiLeu_LyEn_5	898	903	PF01217	0.440
TRG_ENDOCYTIC_2	450	453	PF00928	0.464
TRG_ENDOCYTIC_2	740	743	PF00928	0.345
TRG_ER_diArg_1	1042	1044	PF00400	0.382
TRG_ER_diArg_1	409	412	PF00400	0.554
TRG_ER_diArg_1	68	70	PF00400	0.426
TRG_ER_diArg_1	840	843	PF00400	0.380
TRG_ER_diArg_1	919	921	PF00400	0.415
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	676	680	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	802	807	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM54	Leptomonas seymouri	47%	100%
A4HK27	Leishmania braziliensis	77%	100%
A4I7L1	Leishmania infantum	99%	100%
D0A0B5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	96%
E9B2G8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q5N8	Leishmania major	93%	100%