Peptidase m20/m25/m40 family-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

succinyl-diaminopimelate desuccinylase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IFP2_LEIDO

TriTrypDb:

LdBPK_312060.1 , LdCL_310028600 , LDHU3_31.3490

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 3
Pissara et al.	no	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFP2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0019538	protein metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	23
GO:0016787	hydrolase activity	2	23
GO:0005488	binding	1	1
GO:0005506	iron ion binding	6	1
GO:0016491	oxidoreductase activity	2	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0008233	peptidase activity	3	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	70	72	PF00675	0.428
CLV_PCSK_KEX2_1	453	455	PF00082	0.364
CLV_PCSK_KEX2_1	70	72	PF00082	0.411
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.364
CLV_PCSK_SKI1_1	19	23	PF00082	0.376
CLV_PCSK_SKI1_1	341	345	PF00082	0.299
CLV_PCSK_SKI1_1	453	457	PF00082	0.293
CLV_PCSK_SKI1_1	487	491	PF00082	0.287
CLV_PCSK_SKI1_1	551	555	PF00082	0.288
DEG_APCC_DBOX_1	18	26	PF00400	0.382
DEG_APCC_DBOX_1	340	348	PF00400	0.292
DOC_ANK_TNKS_1	205	212	PF00023	0.376
DOC_ANK_TNKS_1	307	314	PF00023	0.286
DOC_MAPK_FxFP_2	49	52	PF00069	0.444
DOC_MAPK_gen_1	279	287	PF00069	0.349
DOC_MAPK_gen_1	7	16	PF00069	0.386
DOC_MAPK_gen_1	70	78	PF00069	0.407
DOC_MAPK_JIP1_4	19	25	PF00069	0.379
DOC_MAPK_MEF2A_6	175	183	PF00069	0.375
DOC_MAPK_MEF2A_6	281	289	PF00069	0.300
DOC_MAPK_MEF2A_6	428	437	PF00069	0.291
DOC_MAPK_MEF2A_6	7	16	PF00069	0.386
DOC_MAPK_MEF2A_6	70	78	PF00069	0.407
DOC_PP1_RVXF_1	463	469	PF00149	0.314
DOC_PP2B_LxvP_1	26	29	PF13499	0.412
DOC_PP2B_LxvP_1	545	548	PF13499	0.271
DOC_PP4_FxxP_1	405	408	PF00568	0.364
DOC_PP4_FxxP_1	49	52	PF00568	0.444
DOC_PP4_FxxP_1	66	69	PF00568	0.406
DOC_USP7_MATH_1	242	246	PF00917	0.414
DOC_USP7_MATH_1	52	56	PF00917	0.446
DOC_USP7_MATH_1	90	94	PF00917	0.344
DOC_USP7_MATH_1	98	102	PF00917	0.313
DOC_USP7_UBL2_3	465	469	PF12436	0.419
DOC_WW_Pin1_4	1	6	PF00397	0.425
DOC_WW_Pin1_4	130	135	PF00397	0.384
DOC_WW_Pin1_4	173	178	PF00397	0.352
DOC_WW_Pin1_4	265	270	PF00397	0.364
DOC_WW_Pin1_4	38	43	PF00397	0.444
DOC_WW_Pin1_4	53	58	PF00397	0.408
DOC_WW_Pin1_4	565	570	PF00397	0.393
DOC_WW_Pin1_4	65	70	PF00397	0.407
LIG_14-3-3_CanoR_1	108	112	PF00244	0.369
LIG_14-3-3_CanoR_1	27	33	PF00244	0.402
LIG_14-3-3_CanoR_1	428	434	PF00244	0.310
LIG_APCC_ABBA_1	518	523	PF00400	0.286
LIG_BRCT_BRCA1_1	132	136	PF00533	0.466
LIG_EH1_1	525	533	PF00400	0.298
LIG_EVH1_1	39	43	PF00568	0.420
LIG_FHA_1	140	146	PF00498	0.436
LIG_FHA_1	174	180	PF00498	0.341
LIG_FHA_1	302	308	PF00498	0.289
LIG_FHA_1	334	340	PF00498	0.340
LIG_FHA_1	350	356	PF00498	0.223
LIG_FHA_1	430	436	PF00498	0.306
LIG_FHA_1	527	533	PF00498	0.307
LIG_FHA_1	552	558	PF00498	0.293
LIG_FHA_2	317	323	PF00498	0.300
LIG_FHA_2	354	360	PF00498	0.421
LIG_LIR_Apic_2	46	52	PF02991	0.437
LIG_LIR_Gen_1	124	134	PF02991	0.343
LIG_LIR_Gen_1	166	172	PF02991	0.427
LIG_LIR_Gen_1	176	184	PF02991	0.267
LIG_LIR_Gen_1	231	242	PF02991	0.330
LIG_LIR_Gen_1	295	303	PF02991	0.287
LIG_LIR_Gen_1	543	550	PF02991	0.300
LIG_LIR_Gen_1	92	102	PF02991	0.470
LIG_LIR_Nem_3	101	107	PF02991	0.364
LIG_LIR_Nem_3	124	129	PF02991	0.341
LIG_LIR_Nem_3	147	153	PF02991	0.405
LIG_LIR_Nem_3	166	170	PF02991	0.375
LIG_LIR_Nem_3	176	181	PF02991	0.265
LIG_LIR_Nem_3	231	237	PF02991	0.299
LIG_LIR_Nem_3	295	301	PF02991	0.287
LIG_LIR_Nem_3	467	471	PF02991	0.258
LIG_LIR_Nem_3	543	547	PF02991	0.300
LIG_LIR_Nem_3	92	97	PF02991	0.482
LIG_LRP6_Inhibitor_1	422	428	PF00058	0.372
LIG_MYND_1	203	207	PF01753	0.289
LIG_MYND_1	480	484	PF01753	0.300
LIG_NRBOX	21	27	PF00104	0.424
LIG_Pex14_2	136	140	PF04695	0.495
LIG_Pex14_2	380	384	PF04695	0.314
LIG_SH2_CRK	167	171	PF00017	0.375
LIG_SH2_PTP2	126	129	PF00017	0.356
LIG_SH2_SRC	126	129	PF00017	0.370
LIG_SH2_STAP1	234	238	PF00017	0.343
LIG_SH2_STAP1	298	302	PF00017	0.300
LIG_SH2_STAP1	367	371	PF00017	0.249
LIG_SH2_STAT3	502	505	PF00017	0.413
LIG_SH2_STAT5	126	129	PF00017	0.356
LIG_SH2_STAT5	24	27	PF00017	0.393
LIG_SH3_1	201	207	PF00018	0.289
LIG_SH3_3	201	207	PF00018	0.290
LIG_SH3_3	352	358	PF00018	0.330
LIG_SH3_3	37	43	PF00018	0.512
LIG_SH3_3	66	72	PF00018	0.410
LIG_SH3_3	80	86	PF00018	0.369
LIG_SUMO_SIM_par_1	256	261	PF11976	0.291
LIG_TRAF2_1	262	265	PF00917	0.285
LIG_TRFH_1	16	20	PF08558	0.381
LIG_TYR_ITIM	165	170	PF00017	0.405
LIG_UBA3_1	343	351	PF00899	0.364
LIG_WRC_WIRS_1	91	96	PF05994	0.349
LIG_WW_3	4	8	PF00397	0.388
MOD_CDC14_SPxK_1	4	7	PF00782	0.391
MOD_CDC14_SPxK_1	68	71	PF00782	0.420
MOD_CDK_SPK_2	565	570	PF00069	0.393
MOD_CDK_SPK_2	65	70	PF00069	0.401
MOD_CDK_SPxK_1	1	7	PF00069	0.422
MOD_CDK_SPxK_1	65	71	PF00069	0.425
MOD_CK1_1	323	329	PF00069	0.324
MOD_CK1_1	41	47	PF00069	0.429
MOD_CK1_1	93	99	PF00069	0.389
MOD_CK2_1	316	322	PF00069	0.300
MOD_CK2_1	342	348	PF00069	0.425
MOD_CK2_1	353	359	PF00069	0.358
MOD_GlcNHglycan	100	103	PF01048	0.464
MOD_GlcNHglycan	123	126	PF01048	0.403
MOD_GlcNHglycan	264	268	PF01048	0.300
MOD_GlcNHglycan	292	295	PF01048	0.298
MOD_GlcNHglycan	325	328	PF01048	0.295
MOD_GSK3_1	238	245	PF00069	0.444
MOD_GSK3_1	292	299	PF00069	0.360
MOD_GSK3_1	316	323	PF00069	0.428
MOD_GSK3_1	333	340	PF00069	0.280
MOD_GSK3_1	349	356	PF00069	0.323
MOD_GSK3_1	406	413	PF00069	0.442
MOD_GSK3_1	429	436	PF00069	0.310
MOD_GSK3_1	70	77	PF00069	0.424
MOD_GSK3_1	86	93	PF00069	0.544
MOD_N-GLC_1	130	135	PF02516	0.383
MOD_N-GLC_1	296	301	PF02516	0.378
MOD_N-GLC_2	475	477	PF02516	0.370
MOD_NEK2_1	296	301	PF00069	0.327
MOD_NEK2_1	303	308	PF00069	0.271
MOD_NEK2_1	320	325	PF00069	0.379
MOD_NEK2_1	410	415	PF00069	0.353
MOD_NEK2_1	498	503	PF00069	0.333
MOD_NEK2_1	526	531	PF00069	0.299
MOD_NEK2_1	553	558	PF00069	0.388
MOD_NEK2_2	464	469	PF00069	0.463
MOD_PIKK_1	296	302	PF00454	0.378
MOD_PIKK_1	31	37	PF00454	0.435
MOD_PIKK_1	41	47	PF00454	0.433
MOD_PKA_1	70	76	PF00069	0.384
MOD_PKA_2	107	113	PF00069	0.362
MOD_PKA_2	337	343	PF00069	0.413
MOD_PKA_2	70	76	PF00069	0.408
MOD_Plk_1	115	121	PF00069	0.363
MOD_Plk_1	296	302	PF00069	0.407
MOD_Plk_1	313	319	PF00069	0.439
MOD_Plk_1	353	359	PF00069	0.286
MOD_Plk_4	115	121	PF00069	0.356
MOD_Plk_4	189	195	PF00069	0.371
MOD_ProDKin_1	1	7	PF00069	0.422
MOD_ProDKin_1	130	136	PF00069	0.388
MOD_ProDKin_1	173	179	PF00069	0.348
MOD_ProDKin_1	265	271	PF00069	0.364
MOD_ProDKin_1	38	44	PF00069	0.443
MOD_ProDKin_1	53	59	PF00069	0.407
MOD_ProDKin_1	65	71	PF00069	0.407
MOD_SUMO_for_1	443	446	PF00179	0.286
MOD_SUMO_rev_2	345	352	PF00179	0.349
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.342
TRG_ENDOCYTIC_2	126	129	PF00928	0.356
TRG_ENDOCYTIC_2	167	170	PF00928	0.391
TRG_ENDOCYTIC_2	196	199	PF00928	0.289
TRG_ENDOCYTIC_2	234	237	PF00928	0.366
TRG_ENDOCYTIC_2	298	301	PF00928	0.300
TRG_ER_diArg_1	6	9	PF00400	0.385
TRG_ER_diArg_1	69	71	PF00400	0.394
TRG_NES_CRM1_1	280	292	PF08389	0.433
TRG_Pf-PMV_PEXEL_1	454	459	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q9	Leptomonas seymouri	75%	100%
A0A0N1PBD8	Leptomonas seymouri	77%	100%
A0A0S4JJE7	Bodo saltans	60%	100%
A0A1X0P1Q0	Trypanosomatidae	63%	100%
A0A381MQ29	Leishmania infantum	100%	100%
A0A3R7KSZ4	Trypanosoma rangeli	63%	100%
A0A3S7X4P6	Leishmania donovani	100%	100%
A0A3S7X6U2	Leishmania donovani	75%	100%
A4HJG9	Leishmania braziliensis	92%	100%
A4HJH1	Leishmania braziliensis	92%	100%
A4HJI4	Leishmania braziliensis	92%	100%
A4HLM2	Leishmania braziliensis	71%	100%
A4I933	Leishmania infantum	75%	100%
B2KZE7	Corynebacterium striatum	28%	100%
C9ZQ48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
D0A536	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9B201	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B3Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q426	Leishmania major	74%	100%
Q4Q660	Leishmania major	95%	100%
Q4Q673	Leishmania major	95%	100%
Q6Q0N1	Rattus norvegicus	27%	100%
Q9D1A2	Mus musculus	26%	100%
Q9P6I2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
V5BHA2	Trypanosoma cruzi	62%	100%