RNA pseudouridylate synthase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IFN9_LEIDO

TriTrypDb:

LdBPK_301940.1 , LdCL_300024700 , LDHU3_30.2670

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFN9

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006364	rRNA processing	8	8
GO:0006396	RNA processing	6	8
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009451	RNA modification	5	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0016072	rRNA metabolic process	7	8
GO:0034470	ncRNA processing	7	8
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034660	ncRNA metabolic process	6	8
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:0000154	rRNA modification	6	1
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	1
GO:0031118	rRNA pseudouridine synthesis	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0009982	pseudouridine synthase activity	4	10
GO:0016853	isomerase activity	2	10
GO:0016866	intramolecular transferase activity	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0106029	tRNA pseudouridine synthase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.648
CLV_C14_Caspase3-7	49	53	PF00656	0.570
CLV_NRD_NRD_1	11	13	PF00675	0.511
CLV_NRD_NRD_1	117	119	PF00675	0.462
CLV_NRD_NRD_1	182	184	PF00675	0.694
CLV_NRD_NRD_1	377	379	PF00675	0.215
CLV_NRD_NRD_1	438	440	PF00675	0.610
CLV_NRD_NRD_1	466	468	PF00675	0.489
CLV_PCSK_FUR_1	436	440	PF00082	0.551
CLV_PCSK_FUR_1	9	13	PF00082	0.480
CLV_PCSK_KEX2_1	11	13	PF00082	0.511
CLV_PCSK_KEX2_1	116	118	PF00082	0.437
CLV_PCSK_KEX2_1	181	183	PF00082	0.644
CLV_PCSK_KEX2_1	438	440	PF00082	0.610
CLV_PCSK_KEX2_1	466	468	PF00082	0.362
CLV_PCSK_SKI1_1	331	335	PF00082	0.269
CLV_PCSK_SKI1_1	341	345	PF00082	0.275
CLV_PCSK_SKI1_1	467	471	PF00082	0.329
CLV_PCSK_SKI1_1	486	490	PF00082	0.494
CLV_Separin_Metazoa	113	117	PF03568	0.415
CLV_Separin_Metazoa	279	283	PF03568	0.485
DEG_SCF_FBW7_2	417	422	PF00400	0.440
DOC_CYCLIN_RxL_1	462	473	PF00134	0.471
DOC_MAPK_gen_1	223	233	PF00069	0.369
DOC_MAPK_gen_1	264	272	PF00069	0.634
DOC_MAPK_MEF2A_6	438	447	PF00069	0.552
DOC_PP1_RVXF_1	339	346	PF00149	0.375
DOC_PP1_RVXF_1	472	478	PF00149	0.435
DOC_PP4_FxxP_1	477	480	PF00568	0.379
DOC_PP4_FxxP_1	65	68	PF00568	0.409
DOC_PP4_FxxP_1	71	74	PF00568	0.405
DOC_USP7_MATH_1	14	18	PF00917	0.487
DOC_USP7_MATH_1	153	157	PF00917	0.757
DOC_USP7_MATH_1	159	163	PF00917	0.631
DOC_USP7_MATH_1	193	197	PF00917	0.716
DOC_USP7_MATH_1	198	202	PF00917	0.716
DOC_USP7_MATH_1	235	239	PF00917	0.486
DOC_USP7_MATH_1	258	262	PF00917	0.560
DOC_USP7_MATH_1	271	275	PF00917	0.414
DOC_USP7_MATH_1	319	323	PF00917	0.525
DOC_USP7_MATH_1	348	352	PF00917	0.534
DOC_USP7_MATH_1	528	532	PF00917	0.651
DOC_USP7_MATH_1	74	78	PF00917	0.462
DOC_WW_Pin1_4	175	180	PF00397	0.738
DOC_WW_Pin1_4	204	209	PF00397	0.796
DOC_WW_Pin1_4	211	216	PF00397	0.562
DOC_WW_Pin1_4	415	420	PF00397	0.445
DOC_WW_Pin1_4	480	485	PF00397	0.523
DOC_WW_Pin1_4	490	495	PF00397	0.474
LIG_14-3-3_CanoR_1	129	133	PF00244	0.595
LIG_14-3-3_CanoR_1	474	478	PF00244	0.316
LIG_14-3-3_CanoR_1	486	491	PF00244	0.441
LIG_AP2alpha_2	442	444	PF02296	0.459
LIG_BIR_III_4	166	170	PF00653	0.639
LIG_BRCT_BRCA1_1	22	26	PF00533	0.499
LIG_BRCT_BRCA1_1	273	277	PF00533	0.570
LIG_BRCT_BRCA1_1	509	513	PF00533	0.432
LIG_eIF4E_1	106	112	PF01652	0.396
LIG_eIF4E_1	84	90	PF01652	0.472
LIG_EVH1_1	352	356	PF00568	0.435
LIG_EVH1_2	67	71	PF00568	0.384
LIG_FHA_1	137	143	PF00498	0.693
LIG_FHA_1	205	211	PF00498	0.574
LIG_FHA_1	226	232	PF00498	0.357
LIG_FHA_1	254	260	PF00498	0.455
LIG_FHA_1	291	297	PF00498	0.538
LIG_FHA_1	303	309	PF00498	0.403
LIG_FHA_1	497	503	PF00498	0.413
LIG_FHA_1	516	522	PF00498	0.452
LIG_FHA_1	86	92	PF00498	0.515
LIG_FHA_2	108	114	PF00498	0.406
LIG_FHA_2	132	138	PF00498	0.643
LIG_FHA_2	161	167	PF00498	0.630
LIG_FHA_2	274	280	PF00498	0.484
LIG_FHA_2	47	53	PF00498	0.424
LIG_KLC1_Yacidic_2	430	435	PF13176	0.514
LIG_LIR_Apic_2	4	10	PF02991	0.455
LIG_LIR_Apic_2	476	480	PF02991	0.322
LIG_LIR_Apic_2	70	74	PF02991	0.436
LIG_LIR_Gen_1	23	30	PF02991	0.450
LIG_LIR_Gen_1	274	285	PF02991	0.480
LIG_LIR_Gen_1	291	300	PF02991	0.481
LIG_LIR_Gen_1	303	312	PF02991	0.355
LIG_LIR_Gen_1	411	419	PF02991	0.456
LIG_LIR_Nem_3	23	29	PF02991	0.413
LIG_LIR_Nem_3	274	280	PF02991	0.477
LIG_LIR_Nem_3	291	295	PF02991	0.481
LIG_LIR_Nem_3	303	309	PF02991	0.355
LIG_LIR_Nem_3	411	417	PF02991	0.429
LIG_LIR_Nem_3	441	447	PF02991	0.530
LIG_LYPXL_yS_3	406	409	PF13949	0.348
LIG_SH2_CRK	292	296	PF00017	0.499
LIG_SH2_CRK	414	418	PF00017	0.337
LIG_SH2_CRK	7	11	PF00017	0.429
LIG_SH2_NCK_1	414	418	PF00017	0.337
LIG_SH2_SRC	84	87	PF00017	0.432
LIG_SH2_STAP1	292	296	PF00017	0.538
LIG_SH2_STAT5	106	109	PF00017	0.501
LIG_SH2_STAT5	124	127	PF00017	0.551
LIG_SH2_STAT5	21	24	PF00017	0.337
LIG_SH2_STAT5	28	31	PF00017	0.385
LIG_SH2_STAT5	292	295	PF00017	0.485
LIG_SH2_STAT5	414	417	PF00017	0.426
LIG_SH2_STAT5	433	436	PF00017	0.467
LIG_SH2_STAT5	55	58	PF00017	0.418
LIG_SH2_STAT5	7	10	PF00017	0.475
LIG_SH3_3	350	356	PF00018	0.525
LIG_SH3_3	401	407	PF00018	0.507
LIG_SH3_3	440	446	PF00018	0.548
LIG_SH3_3	518	524	PF00018	0.539
LIG_SUMO_SIM_anti_2	110	116	PF11976	0.399
LIG_SUMO_SIM_anti_2	227	235	PF11976	0.351
LIG_SUMO_SIM_anti_2	85	93	PF11976	0.432
LIG_SUMO_SIM_par_1	214	220	PF11976	0.398
LIG_SUMO_SIM_par_1	85	93	PF11976	0.407
LIG_TYR_ITIM	404	409	PF00017	0.349
LIG_UBA3_1	18	25	PF00899	0.486
LIG_WRC_WIRS_1	487	492	PF05994	0.420
LIG_WW_3	66	70	PF00397	0.471
MOD_CDC14_SPxK_1	178	181	PF00782	0.635
MOD_CDC14_SPxK_1	483	486	PF00782	0.493
MOD_CDK_SPxK_1	175	181	PF00069	0.634
MOD_CDK_SPxK_1	415	421	PF00069	0.513
MOD_CDK_SPxK_1	480	486	PF00069	0.468
MOD_CDK_SPxxK_3	175	182	PF00069	0.700
MOD_CK1_1	127	133	PF00069	0.571
MOD_CK1_1	177	183	PF00069	0.696
MOD_CK1_1	188	194	PF00069	0.755
MOD_CK1_1	240	246	PF00069	0.432
MOD_CK1_1	273	279	PF00069	0.422
MOD_CK1_1	511	517	PF00069	0.343
MOD_CK2_1	107	113	PF00069	0.428
MOD_CK2_1	131	137	PF00069	0.625
MOD_CK2_1	243	249	PF00069	0.469
MOD_CK2_1	273	279	PF00069	0.341
MOD_GlcNHglycan	191	194	PF01048	0.760
MOD_GlcNHglycan	195	198	PF01048	0.784
MOD_GlcNHglycan	227	231	PF01048	0.376
MOD_GlcNHglycan	239	242	PF01048	0.279
MOD_GlcNHglycan	448	454	PF01048	0.568
MOD_GSK3_1	124	131	PF00069	0.576
MOD_GSK3_1	132	139	PF00069	0.690
MOD_GSK3_1	140	147	PF00069	0.719
MOD_GSK3_1	173	180	PF00069	0.751
MOD_GSK3_1	185	192	PF00069	0.715
MOD_GSK3_1	198	205	PF00069	0.705
MOD_GSK3_1	20	27	PF00069	0.495
MOD_GSK3_1	249	256	PF00069	0.406
MOD_GSK3_1	284	291	PF00069	0.391
MOD_GSK3_1	486	493	PF00069	0.485
MOD_GSK3_1	507	514	PF00069	0.441
MOD_GSK3_1	515	522	PF00069	0.474
MOD_NEK2_1	29	34	PF00069	0.425
MOD_NEK2_1	366	371	PF00069	0.445
MOD_NEK2_1	380	385	PF00069	0.324
MOD_NEK2_1	413	418	PF00069	0.413
MOD_NEK2_1	470	475	PF00069	0.468
MOD_NEK2_1	90	95	PF00069	0.423
MOD_NEK2_2	153	158	PF00069	0.545
MOD_PIKK_1	29	35	PF00454	0.358
MOD_PIKK_1	325	331	PF00454	0.433
MOD_PIKK_1	511	517	PF00454	0.358
MOD_PK_1	284	290	PF00069	0.337
MOD_PKA_2	128	134	PF00069	0.632
MOD_PKA_2	473	479	PF00069	0.326
MOD_Plk_1	107	113	PF00069	0.431
MOD_Plk_1	14	20	PF00069	0.481
MOD_Plk_1	153	159	PF00069	0.701
MOD_Plk_1	302	308	PF00069	0.366
MOD_Plk_1	41	47	PF00069	0.398
MOD_Plk_1	507	513	PF00069	0.489
MOD_Plk_1	84	90	PF00069	0.494
MOD_Plk_4	107	113	PF00069	0.395
MOD_Plk_4	14	20	PF00069	0.445
MOD_Plk_4	302	308	PF00069	0.402
MOD_Plk_4	486	492	PF00069	0.496
MOD_Plk_4	508	514	PF00069	0.397
MOD_Plk_4	51	57	PF00069	0.496
MOD_Plk_4	85	91	PF00069	0.465
MOD_ProDKin_1	175	181	PF00069	0.740
MOD_ProDKin_1	204	210	PF00069	0.793
MOD_ProDKin_1	211	217	PF00069	0.551
MOD_ProDKin_1	415	421	PF00069	0.452
MOD_ProDKin_1	480	486	PF00069	0.524
MOD_ProDKin_1	490	496	PF00069	0.479
MOD_SUMO_rev_2	70	80	PF00179	0.385
TRG_DiLeu_BaEn_1	85	90	PF01217	0.470
TRG_DiLeu_BaEn_2	301	307	PF01217	0.357
TRG_DiLeu_BaEn_2	439	445	PF01217	0.484
TRG_ENDOCYTIC_2	292	295	PF00928	0.296
TRG_ENDOCYTIC_2	406	409	PF00928	0.348
TRG_ENDOCYTIC_2	414	417	PF00928	0.414
TRG_ER_diArg_1	115	118	PF00400	0.433
TRG_ER_diArg_1	181	183	PF00400	0.744
TRG_ER_diArg_1	370	373	PF00400	0.321
TRG_ER_diArg_1	436	439	PF00400	0.569
TRG_ER_diArg_1	9	12	PF00400	0.498
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME7	Leptomonas seymouri	48%	100%
A0A0S4JCR9	Bodo saltans	29%	89%
A0A3R7MB50	Trypanosoma rangeli	35%	100%
A4HIC8	Leishmania braziliensis	75%	100%
A4I5M1	Leishmania infantum	99%	100%
E9B0W6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q7A0	Leishmania major	90%	100%
V5DQK8	Trypanosoma cruzi	35%	100%