G domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFN6_LEIDO

TriTrypDb:

LdBPK_355140.1 , LdCL_350057100 , LDHU3_35.6850

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFN6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	411	415	PF00656	0.397
CLV_NRD_NRD_1	130	132	PF00675	0.643
CLV_PCSK_KEX2_1	130	132	PF00082	0.643
CLV_PCSK_SKI1_1	178	182	PF00082	0.354
CLV_PCSK_SKI1_1	377	381	PF00082	0.475
CLV_PCSK_SKI1_1	93	97	PF00082	0.767
DOC_CKS1_1	137	142	PF01111	0.661
DOC_CKS1_1	226	231	PF01111	0.360
DOC_CKS1_1	66	71	PF01111	0.590
DOC_CYCLIN_RxL_1	175	184	PF00134	0.354
DOC_MAPK_gen_1	253	262	PF00069	0.498
DOC_MAPK_MEF2A_6	162	170	PF00069	0.467
DOC_MAPK_MEF2A_6	398	407	PF00069	0.361
DOC_PP1_RVXF_1	365	371	PF00149	0.325
DOC_PP2B_LxvP_1	171	174	PF13499	0.351
DOC_PP2B_LxvP_1	260	263	PF13499	0.371
DOC_PP4_FxxP_1	62	65	PF00568	0.576
DOC_USP7_MATH_1	23	27	PF00917	0.555
DOC_USP7_MATH_1	346	350	PF00917	0.398
DOC_USP7_MATH_1	354	358	PF00917	0.317
DOC_USP7_UBL2_3	251	255	PF12436	0.438
DOC_WW_Pin1_4	106	111	PF00397	0.651
DOC_WW_Pin1_4	136	141	PF00397	0.595
DOC_WW_Pin1_4	225	230	PF00397	0.364
DOC_WW_Pin1_4	266	271	PF00397	0.394
DOC_WW_Pin1_4	329	334	PF00397	0.431
DOC_WW_Pin1_4	56	61	PF00397	0.635
DOC_WW_Pin1_4	65	70	PF00397	0.652
LIG_14-3-3_CanoR_1	120	129	PF00244	0.773
LIG_14-3-3_CanoR_1	141	146	PF00244	0.607
LIG_14-3-3_CanoR_1	44	49	PF00244	0.598
LIG_14-3-3_CanoR_1	93	98	PF00244	0.567
LIG_APCC_ABBA_1	397	402	PF00400	0.365
LIG_BIR_III_2	330	334	PF00653	0.421
LIG_BRCT_BRCA1_1	151	155	PF00533	0.546
LIG_BRCT_BRCA1_1	58	62	PF00533	0.574
LIG_deltaCOP1_diTrp_1	290	300	PF00928	0.394
LIG_FHA_1	137	143	PF00498	0.540
LIG_FHA_1	163	169	PF00498	0.396
LIG_FHA_1	206	212	PF00498	0.443
LIG_FHA_1	284	290	PF00498	0.372
LIG_FHA_1	369	375	PF00498	0.371
LIG_FHA_1	383	389	PF00498	0.517
LIG_FHA_2	207	213	PF00498	0.401
LIG_FHA_2	336	342	PF00498	0.402
LIG_FHA_2	66	72	PF00498	0.662
LIG_LIR_Apic_2	59	65	PF02991	0.577
LIG_LIR_Gen_1	161	171	PF02991	0.432
LIG_LIR_Gen_1	222	229	PF02991	0.377
LIG_LIR_Gen_1	332	340	PF02991	0.343
LIG_LIR_Nem_3	222	226	PF02991	0.385
LIG_LIR_Nem_3	332	337	PF02991	0.378
LIG_LIR_Nem_3	45	51	PF02991	0.599
LIG_Pex14_1	294	298	PF04695	0.455
LIG_Pex14_1	300	304	PF04695	0.405
LIG_Pex14_2	62	66	PF04695	0.580
LIG_RPA_C_Fungi	80	92	PF08784	0.518
LIG_SH2_STAT5	233	236	PF00017	0.416
LIG_SH2_STAT5	316	319	PF00017	0.350
LIG_SH2_STAT5	369	372	PF00017	0.334
LIG_SH2_STAT5	67	70	PF00017	0.566
LIG_SH3_3	104	110	PF00018	0.519
LIG_SH3_3	134	140	PF00018	0.598
LIG_SH3_3	193	199	PF00018	0.487
LIG_SH3_3	54	60	PF00018	0.626
LIG_SH3_3	66	72	PF00018	0.737
LIG_SUMO_SIM_par_1	141	148	PF11976	0.531
LIG_TRAF2_1	123	126	PF00917	0.665
LIG_WRC_WIRS_1	295	300	PF05994	0.385
LIG_WW_1	64	67	PF00397	0.568
MOD_CDK_SPK_2	136	141	PF00069	0.660
MOD_CDK_SPK_2	56	61	PF00069	0.584
MOD_CK1_1	144	150	PF00069	0.754
MOD_CK1_1	231	237	PF00069	0.476
MOD_CK1_1	25	31	PF00069	0.556
MOD_CK1_1	319	325	PF00069	0.414
MOD_CK1_1	42	48	PF00069	0.601
MOD_CK1_1	5	11	PF00069	0.726
MOD_CK2_1	120	126	PF00069	0.763
MOD_CK2_1	15	21	PF00069	0.598
MOD_CK2_1	206	212	PF00069	0.419
MOD_DYRK1A_RPxSP_1	106	110	PF00069	0.603
MOD_DYRK1A_RPxSP_1	56	60	PF00069	0.525
MOD_GlcNHglycan	122	125	PF01048	0.688
MOD_GlcNHglycan	134	137	PF01048	0.602
MOD_GlcNHglycan	202	205	PF01048	0.549
MOD_GlcNHglycan	30	33	PF01048	0.608
MOD_GlcNHglycan	34	38	PF01048	0.616
MOD_GlcNHglycan	348	351	PF01048	0.460
MOD_GSK3_1	106	113	PF00069	0.766
MOD_GSK3_1	132	139	PF00069	0.639
MOD_GSK3_1	141	148	PF00069	0.499
MOD_GSK3_1	2	9	PF00069	0.502
MOD_GSK3_1	21	28	PF00069	0.543
MOD_GSK3_1	316	323	PF00069	0.419
MOD_GSK3_1	33	40	PF00069	0.568
MOD_LATS_1	118	124	PF00433	0.693
MOD_LATS_1	217	223	PF00433	0.434
MOD_N-GLC_1	190	195	PF02516	0.475
MOD_NEK2_1	181	186	PF00069	0.349
MOD_NEK2_1	205	210	PF00069	0.645
MOD_NEK2_1	320	325	PF00069	0.360
MOD_NEK2_1	379	384	PF00069	0.525
MOD_NEK2_1	388	393	PF00069	0.365
MOD_NEK2_1	6	11	PF00069	0.549
MOD_PIKK_1	408	414	PF00454	0.349
MOD_PK_1	141	147	PF00069	0.612
MOD_PKA_2	105	111	PF00069	0.609
MOD_PKA_2	145	151	PF00069	0.594
MOD_PKA_2	26	32	PF00069	0.614
MOD_PKA_2	84	90	PF00069	0.559
MOD_Plk_1	190	196	PF00069	0.483
MOD_Plk_1	77	83	PF00069	0.580
MOD_Plk_2-3	15	21	PF00069	0.558
MOD_Plk_4	176	182	PF00069	0.356
MOD_Plk_4	219	225	PF00069	0.414
MOD_Plk_4	228	234	PF00069	0.384
MOD_Plk_4	294	300	PF00069	0.505
MOD_Plk_4	316	322	PF00069	0.307
MOD_Plk_4	354	360	PF00069	0.350
MOD_Plk_4	99	105	PF00069	0.502
MOD_ProDKin_1	106	112	PF00069	0.655
MOD_ProDKin_1	136	142	PF00069	0.595
MOD_ProDKin_1	225	231	PF00069	0.365
MOD_ProDKin_1	266	272	PF00069	0.396
MOD_ProDKin_1	329	335	PF00069	0.426
MOD_ProDKin_1	56	62	PF00069	0.636
MOD_ProDKin_1	65	71	PF00069	0.651
TRG_DiLeu_BaEn_1	375	380	PF01217	0.442
TRG_ENDOCYTIC_2	163	166	PF00928	0.455
TRG_ER_diArg_1	129	131	PF00400	0.689
TRG_ER_diArg_1	300	303	PF00400	0.436
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5M5	Leptomonas seymouri	58%	100%
A4HNH9	Leishmania braziliensis	78%	100%
A4IC35	Leishmania infantum	100%	100%
E9AFZ0	Leishmania major	94%	100%
E9B743	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%