Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IFN5_LEIDO

TriTrypDb:

LdBPK_320300.1 , LdCL_320007900 , LDHU3_32.0380

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3Q8IFN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFN5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.745
CLV_C14_Caspase3-7	217	221	PF00656	0.720
CLV_C14_Caspase3-7	233	237	PF00656	0.662
CLV_C14_Caspase3-7	279	283	PF00656	0.663
CLV_NRD_NRD_1	156	158	PF00675	0.418
CLV_NRD_NRD_1	303	305	PF00675	0.431
CLV_NRD_NRD_1	309	311	PF00675	0.364
CLV_PCSK_KEX2_1	142	144	PF00082	0.513
CLV_PCSK_KEX2_1	156	158	PF00082	0.366
CLV_PCSK_KEX2_1	303	305	PF00082	0.426
CLV_PCSK_KEX2_1	309	311	PF00082	0.362
CLV_PCSK_KEX2_1	62	64	PF00082	0.335
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.484
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.335
CLV_PCSK_SKI1_1	112	116	PF00082	0.370
CLV_PCSK_SKI1_1	303	307	PF00082	0.486
CLV_PCSK_SKI1_1	91	95	PF00082	0.307
DEG_APCC_DBOX_1	160	168	PF00400	0.649
DEG_Nend_UBRbox_1	1	4	PF02207	0.642
DEG_SPOP_SBC_1	198	202	PF00917	0.730
DOC_CYCLIN_RxL_1	109	119	PF00134	0.552
DOC_CYCLIN_yClb3_PxF_3	38	44	PF00134	0.618
DOC_MAPK_gen_1	13	22	PF00069	0.642
DOC_MAPK_gen_1	303	313	PF00069	0.547
DOC_MAPK_MEF2A_6	13	22	PF00069	0.642
DOC_PP1_RVXF_1	140	147	PF00149	0.635
DOC_PP4_FxxP_1	146	149	PF00568	0.627
DOC_PP4_FxxP_1	227	230	PF00568	0.687
DOC_USP7_MATH_1	183	187	PF00917	0.714
DOC_USP7_MATH_1	198	202	PF00917	0.647
DOC_USP7_MATH_1	256	260	PF00917	0.664
DOC_WW_Pin1_4	14	19	PF00397	0.654
DOC_WW_Pin1_4	177	182	PF00397	0.736
DOC_WW_Pin1_4	199	204	PF00397	0.830
LIG_14-3-3_CanoR_1	105	111	PF00244	0.652
LIG_14-3-3_CanoR_1	143	147	PF00244	0.763
LIG_14-3-3_CanoR_1	161	165	PF00244	0.573
LIG_CSL_BTD_1	36	39	PF09270	0.652
LIG_deltaCOP1_diTrp_1	35	44	PF00928	0.620
LIG_FHA_1	224	230	PF00498	0.785
LIG_FHA_1	3	9	PF00498	0.616
LIG_FHA_1	334	340	PF00498	0.409
LIG_FHA_2	108	114	PF00498	0.570
LIG_FHA_2	30	36	PF00498	0.641
LIG_LIR_Apic_2	145	149	PF02991	0.627
LIG_LIR_Apic_2	226	230	PF02991	0.686
LIG_LIR_Nem_3	108	114	PF02991	0.565
LIG_LIR_Nem_3	35	40	PF02991	0.667
LIG_MYND_1	38	42	PF01753	0.623
LIG_PDZ_Class_2	338	343	PF00595	0.436
LIG_Pex14_1	312	316	PF04695	0.469
LIG_Pex14_2	111	115	PF04695	0.559
LIG_Pex14_2	55	59	PF04695	0.528
LIG_Pex14_2	80	84	PF04695	0.538
LIG_SH2_CRK	298	302	PF00017	0.589
LIG_SH2_CRK	317	321	PF00017	0.369
LIG_SH2_NCK_1	76	80	PF00017	0.588
LIG_SH2_SRC	76	79	PF00017	0.543
LIG_SH2_STAP1	76	80	PF00017	0.541
LIG_SH2_STAT5	340	343	PF00017	0.549
LIG_SH3_3	15	21	PF00018	0.676
LIG_SH3_3	36	42	PF00018	0.616
LIG_SUMO_SIM_par_1	208	214	PF11976	0.692
LIG_SUMO_SIM_par_1	323	328	PF11976	0.268
LIG_TRAF2_1	128	131	PF00917	0.578
LIG_TRAF2_1	230	233	PF00917	0.669
LIG_TYR_ITIM	247	252	PF00017	0.563
LIG_WRC_WIRS_1	224	229	PF05994	0.604
LIG_WRC_WIRS_1	41	46	PF05994	0.498
MOD_CK1_1	104	110	PF00069	0.515
MOD_CK1_1	163	169	PF00069	0.570
MOD_CK1_1	177	183	PF00069	0.676
MOD_CK1_1	211	217	PF00069	0.646
MOD_CK1_1	255	261	PF00069	0.580
MOD_CK2_1	107	113	PF00069	0.443
MOD_CK2_1	20	26	PF00069	0.473
MOD_CK2_1	29	35	PF00069	0.549
MOD_GlcNHglycan	122	125	PF01048	0.416
MOD_GlcNHglycan	186	189	PF01048	0.720
MOD_GlcNHglycan	232	236	PF01048	0.637
MOD_GlcNHglycan	244	247	PF01048	0.528
MOD_GlcNHglycan	254	257	PF01048	0.566
MOD_GlcNHglycan	258	261	PF01048	0.591
MOD_GlcNHglycan	298	301	PF01048	0.498
MOD_GlcNHglycan	32	35	PF01048	0.480
MOD_GlcNHglycan	71	74	PF01048	0.527
MOD_GSK3_1	179	186	PF00069	0.670
MOD_GSK3_1	238	245	PF00069	0.576
MOD_GSK3_1	252	259	PF00069	0.569
MOD_GSK3_1	260	267	PF00069	0.591
MOD_LATS_1	140	146	PF00433	0.540
MOD_NEK2_1	252	257	PF00069	0.690
MOD_NEK2_1	29	34	PF00069	0.520
MOD_PIKK_1	20	26	PF00454	0.547
MOD_PKA_1	142	148	PF00069	0.532
MOD_PKA_2	104	110	PF00069	0.567
MOD_PKA_2	12	18	PF00069	0.654
MOD_PKA_2	142	148	PF00069	0.631
MOD_PKA_2	155	161	PF00069	0.451
MOD_PKA_2	192	198	PF00069	0.733
MOD_PKA_2	242	248	PF00069	0.565
MOD_PKA_2	260	266	PF00069	0.592
MOD_PKA_2	280	286	PF00069	0.573
MOD_Plk_1	107	113	PF00069	0.424
MOD_Plk_4	205	211	PF00069	0.604
MOD_ProDKin_1	14	20	PF00069	0.564
MOD_ProDKin_1	177	183	PF00069	0.676
MOD_ProDKin_1	199	205	PF00069	0.807
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.496
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.502
TRG_ENDOCYTIC_2	249	252	PF00928	0.560
TRG_ENDOCYTIC_2	317	320	PF00928	0.315
TRG_ENDOCYTIC_2	340	343	PF00928	0.688
TRG_ER_diArg_1	155	157	PF00400	0.511
TRG_ER_diArg_1	302	304	PF00400	0.524
TRG_ER_diArg_1	308	310	PF00400	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF27	Leptomonas seymouri	55%	100%
A4HK09	Leishmania braziliensis	81%	100%
A4I7J3	Leishmania infantum	100%	100%
E9B2F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q5Q6	Leishmania major	93%	100%