Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IFN0_LEIDO

TriTrypDb:

LdBPK_311940.1 , LdCL_310027300 , LDHU3_31.3510

Length:

849

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFN0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	448	452	PF00656	0.605
CLV_NRD_NRD_1	312	314	PF00675	0.783
CLV_NRD_NRD_1	478	480	PF00675	0.708
CLV_NRD_NRD_1	54	56	PF00675	0.679
CLV_NRD_NRD_1	626	628	PF00675	0.686
CLV_NRD_NRD_1	652	654	PF00675	0.713
CLV_NRD_NRD_1	68	70	PF00675	0.544
CLV_NRD_NRD_1	750	752	PF00675	0.700
CLV_NRD_NRD_1	759	761	PF00675	0.582
CLV_NRD_NRD_1	793	795	PF00675	0.685
CLV_NRD_NRD_1	798	800	PF00675	0.692
CLV_PCSK_FUR_1	650	654	PF00082	0.667
CLV_PCSK_KEX2_1	312	314	PF00082	0.783
CLV_PCSK_KEX2_1	478	480	PF00082	0.711
CLV_PCSK_KEX2_1	54	56	PF00082	0.679
CLV_PCSK_KEX2_1	625	627	PF00082	0.651
CLV_PCSK_KEX2_1	652	654	PF00082	0.799
CLV_PCSK_KEX2_1	673	675	PF00082	0.647
CLV_PCSK_KEX2_1	68	70	PF00082	0.544
CLV_PCSK_KEX2_1	752	754	PF00082	0.673
CLV_PCSK_KEX2_1	759	761	PF00082	0.557
CLV_PCSK_PC1ET2_1	625	627	PF00082	0.617
CLV_PCSK_PC1ET2_1	673	675	PF00082	0.584
CLV_PCSK_PC1ET2_1	752	754	PF00082	0.673
CLV_PCSK_PC1ET2_1	759	761	PF00082	0.557
CLV_PCSK_SKI1_1	277	281	PF00082	0.675
CLV_PCSK_SKI1_1	408	412	PF00082	0.749
CLV_PCSK_SKI1_1	41	45	PF00082	0.662
CLV_PCSK_SKI1_1	479	483	PF00082	0.720
CLV_PCSK_SKI1_1	627	631	PF00082	0.726
CLV_PCSK_SKI1_1	91	95	PF00082	0.691
CLV_Separin_Metazoa	733	737	PF03568	0.602
DEG_APCC_DBOX_1	478	486	PF00400	0.681
DEG_APCC_DBOX_1	673	681	PF00400	0.667
DEG_Nend_Nbox_1	1	3	PF02207	0.700
DEG_SCF_FBW7_2	185	192	PF00400	0.621
DEG_SPOP_SBC_1	372	376	PF00917	0.805
DOC_ANK_TNKS_1	446	453	PF00023	0.606
DOC_CKS1_1	186	191	PF01111	0.620
DOC_CKS1_1	365	370	PF01111	0.613
DOC_CYCLIN_yCln2_LP_2	632	638	PF00134	0.693
DOC_MAPK_gen_1	495	502	PF00069	0.659
DOC_MAPK_gen_1	52	61	PF00069	0.681
DOC_MAPK_gen_1	751	757	PF00069	0.535
DOC_PP1_RVXF_1	624	631	PF00149	0.658
DOC_PP4_FxxP_1	369	372	PF00568	0.564
DOC_PP4_FxxP_1	648	651	PF00568	0.628
DOC_USP7_MATH_1	17	21	PF00917	0.727
DOC_USP7_MATH_1	245	249	PF00917	0.640
DOC_USP7_MATH_1	256	260	PF00917	0.651
DOC_USP7_MATH_1	291	295	PF00917	0.647
DOC_USP7_MATH_1	473	477	PF00917	0.689
DOC_USP7_MATH_1	601	605	PF00917	0.763
DOC_USP7_MATH_1	704	708	PF00917	0.730
DOC_USP7_MATH_2	335	341	PF00917	0.663
DOC_USP7_UBL2_3	257	261	PF12436	0.774
DOC_WW_Pin1_4	185	190	PF00397	0.730
DOC_WW_Pin1_4	201	206	PF00397	0.641
DOC_WW_Pin1_4	241	246	PF00397	0.601
DOC_WW_Pin1_4	354	359	PF00397	0.803
DOC_WW_Pin1_4	364	369	PF00397	0.649
DOC_WW_Pin1_4	373	378	PF00397	0.535
DOC_WW_Pin1_4	461	466	PF00397	0.730
DOC_WW_Pin1_4	469	474	PF00397	0.762
DOC_WW_Pin1_4	483	488	PF00397	0.561
DOC_WW_Pin1_4	511	516	PF00397	0.761
DOC_WW_Pin1_4	655	660	PF00397	0.627
DOC_WW_Pin1_4	682	687	PF00397	0.756
LIG_14-3-3_CanoR_1	237	245	PF00244	0.754
LIG_14-3-3_CanoR_1	27	37	PF00244	0.700
LIG_14-3-3_CanoR_1	312	322	PF00244	0.759
LIG_14-3-3_CanoR_1	385	395	PF00244	0.721
LIG_14-3-3_CanoR_1	525	533	PF00244	0.558
LIG_14-3-3_CanoR_1	54	60	PF00244	0.712
LIG_14-3-3_CanoR_1	808	817	PF00244	0.595
LIG_Actin_WH2_2	318	336	PF00022	0.588
LIG_ActinCP_TwfCPI_2	648	657	PF01115	0.627
LIG_BRCT_BRCA1_1	203	207	PF00533	0.615
LIG_BRCT_BRCA1_1	590	594	PF00533	0.666
LIG_FHA_1	136	142	PF00498	0.675
LIG_FHA_1	16	22	PF00498	0.729
LIG_FHA_1	249	255	PF00498	0.624
LIG_FHA_1	484	490	PF00498	0.672
LIG_FHA_1	56	62	PF00498	0.650
LIG_FHA_1	563	569	PF00498	0.765
LIG_FHA_1	661	667	PF00498	0.729
LIG_FHA_2	149	155	PF00498	0.730
LIG_FHA_2	182	188	PF00498	0.727
LIG_FHA_2	300	306	PF00498	0.644
LIG_FHA_2	486	492	PF00498	0.719
LIG_FHA_2	825	831	PF00498	0.616
LIG_FHA_2	92	98	PF00498	0.645
LIG_LIR_Apic_2	321	327	PF02991	0.724
LIG_LIR_Apic_2	331	335	PF02991	0.596
LIG_LIR_Apic_2	367	372	PF02991	0.558
LIG_LIR_Gen_1	537	545	PF02991	0.689
LIG_LIR_Gen_1	743	750	PF02991	0.679
LIG_LIR_Nem_3	274	279	PF02991	0.594
LIG_LIR_Nem_3	537	541	PF02991	0.692
LIG_LIR_Nem_3	743	749	PF02991	0.695
LIG_LIR_Nem_3	76	82	PF02991	0.787
LIG_LIR_Nem_3	819	825	PF02991	0.652
LIG_LYPXL_yS_3	729	732	PF13949	0.782
LIG_LYPXL_yS_3	822	825	PF13949	0.432
LIG_MAD2	627	635	PF02301	0.663
LIG_MYND_3	225	229	PF01753	0.677
LIG_MYND_3	595	599	PF01753	0.614
LIG_PDZ_Class_1	844	849	PF00595	0.719
LIG_SH2_CRK	67	71	PF00017	0.706
LIG_SH2_CRK	746	750	PF00017	0.616
LIG_SH2_CRK	79	83	PF00017	0.680
LIG_SH2_NCK_1	566	570	PF00017	0.694
LIG_SH2_NCK_1	746	750	PF00017	0.616
LIG_SH2_STAP1	297	301	PF00017	0.700
LIG_SH2_STAP1	566	570	PF00017	0.694
LIG_SH2_STAP1	746	750	PF00017	0.616
LIG_SH2_STAT5	519	522	PF00017	0.671
LIG_SH2_STAT5	562	565	PF00017	0.593
LIG_SH3_1	501	507	PF00018	0.664
LIG_SH3_2	365	370	PF14604	0.713
LIG_SH3_2	620	625	PF14604	0.691
LIG_SH3_2	635	640	PF14604	0.559
LIG_SH3_3	175	181	PF00018	0.703
LIG_SH3_3	239	245	PF00018	0.604
LIG_SH3_3	362	368	PF00018	0.708
LIG_SH3_3	501	507	PF00018	0.747
LIG_SH3_3	509	515	PF00018	0.697
LIG_SH3_3	617	623	PF00018	0.765
LIG_SH3_3	632	638	PF00018	0.545
LIG_SH3_3	648	654	PF00018	0.594
LIG_SH3_3	656	662	PF00018	0.629
LIG_SH3_3	67	73	PF00018	0.699
LIG_SH3_3	729	735	PF00018	0.782
LIG_SH3_4	257	264	PF00018	0.774
LIG_SUMO_SIM_anti_2	319	324	PF11976	0.592
LIG_TRAF2_1	150	153	PF00917	0.640
LIG_TRAF2_1	404	407	PF00917	0.651
LIG_TYR_ITIM	65	70	PF00017	0.662
LIG_TYR_ITSM	742	749	PF00017	0.611
LIG_WRC_WIRS_1	273	278	PF05994	0.594
LIG_WW_3	733	737	PF00397	0.785
MOD_CDC14_SPxK_1	658	661	PF00782	0.629
MOD_CDK_SPxK_1	364	370	PF00069	0.713
MOD_CDK_SPxK_1	373	379	PF00069	0.758
MOD_CDK_SPxK_1	655	661	PF00069	0.629
MOD_CDK_SPxxK_3	373	380	PF00069	0.803
MOD_CK1_1	107	113	PF00069	0.751
MOD_CK1_1	121	127	PF00069	0.567
MOD_CK1_1	139	145	PF00069	0.541
MOD_CK1_1	240	246	PF00069	0.769
MOD_CK1_1	248	254	PF00069	0.661
MOD_CK1_1	259	265	PF00069	0.509
MOD_CK1_1	269	275	PF00069	0.608
MOD_CK1_1	354	360	PF00069	0.703
MOD_CK1_1	373	379	PF00069	0.594
MOD_CK1_1	386	392	PF00069	0.622
MOD_CK1_1	394	400	PF00069	0.672
MOD_CK1_1	474	480	PF00069	0.744
MOD_CK1_1	483	489	PF00069	0.617
MOD_CK1_1	703	709	PF00069	0.615
MOD_CK1_1	85	91	PF00069	0.723
MOD_CK2_1	386	392	PF00069	0.777
MOD_CK2_1	401	407	PF00069	0.551
MOD_CK2_1	429	435	PF00069	0.621
MOD_CK2_1	474	480	PF00069	0.767
MOD_CK2_1	485	491	PF00069	0.609
MOD_CK2_1	704	710	PF00069	0.738
MOD_DYRK1A_RPxSP_1	241	245	PF00069	0.601
MOD_GlcNHglycan	118	121	PF01048	0.764
MOD_GlcNHglycan	124	127	PF01048	0.663
MOD_GlcNHglycan	158	162	PF01048	0.706
MOD_GlcNHglycan	173	177	PF01048	0.594
MOD_GlcNHglycan	263	266	PF01048	0.706
MOD_GlcNHglycan	353	356	PF01048	0.718
MOD_GlcNHglycan	396	399	PF01048	0.729
MOD_GlcNHglycan	431	434	PF01048	0.684
MOD_GlcNHglycan	466	469	PF01048	0.730
MOD_GlcNHglycan	473	476	PF01048	0.695
MOD_GlcNHglycan	482	485	PF01048	0.625
MOD_GlcNHglycan	515	518	PF01048	0.726
MOD_GlcNHglycan	521	524	PF01048	0.621
MOD_GlcNHglycan	538	541	PF01048	0.609
MOD_GlcNHglycan	551	554	PF01048	0.581
MOD_GlcNHglycan	590	593	PF01048	0.678
MOD_GlcNHglycan	702	705	PF01048	0.620
MOD_GlcNHglycan	724	727	PF01048	0.586
MOD_GSK3_1	104	111	PF00069	0.737
MOD_GSK3_1	118	125	PF00069	0.540
MOD_GSK3_1	135	142	PF00069	0.551
MOD_GSK3_1	181	188	PF00069	0.639
MOD_GSK3_1	201	208	PF00069	0.642
MOD_GSK3_1	232	239	PF00069	0.790
MOD_GSK3_1	240	247	PF00069	0.671
MOD_GSK3_1	248	255	PF00069	0.532
MOD_GSK3_1	275	282	PF00069	0.692
MOD_GSK3_1	286	293	PF00069	0.608
MOD_GSK3_1	314	321	PF00069	0.691
MOD_GSK3_1	342	349	PF00069	0.779
MOD_GSK3_1	381	388	PF00069	0.768
MOD_GSK3_1	414	421	PF00069	0.611
MOD_GSK3_1	469	476	PF00069	0.738
MOD_GSK3_1	513	520	PF00069	0.690
MOD_GSK3_1	573	580	PF00069	0.658
MOD_GSK3_1	699	706	PF00069	0.618
MOD_GSK3_1	741	748	PF00069	0.622
MOD_GSK3_1	82	89	PF00069	0.722
MOD_LATS_1	378	384	PF00433	0.802
MOD_LATS_1	53	59	PF00433	0.646
MOD_LATS_1	806	812	PF00433	0.691
MOD_N-GLC_1	108	113	PF02516	0.769
MOD_N-GLC_1	135	140	PF02516	0.770
MOD_N-GLC_1	700	705	PF02516	0.625
MOD_N-GLC_1	74	79	PF02516	0.711
MOD_NEK2_1	104	109	PF00069	0.741
MOD_NEK2_1	171	176	PF00069	0.756
MOD_NEK2_1	227	232	PF00069	0.714
MOD_NEK2_1	279	284	PF00069	0.672
MOD_NEK2_1	346	351	PF00069	0.651
MOD_NEK2_1	415	420	PF00069	0.727
MOD_NEK2_1	536	541	PF00069	0.741
MOD_NEK2_1	666	671	PF00069	0.755
MOD_NEK2_1	712	717	PF00069	0.632
MOD_NEK2_2	17	22	PF00069	0.612
MOD_NEK2_2	741	746	PF00069	0.635
MOD_NEK2_2	775	780	PF00069	0.642
MOD_OFUCOSY	413	419	PF10250	0.662
MOD_PIKK_1	126	132	PF00454	0.686
MOD_PIKK_1	667	673	PF00454	0.615
MOD_PK_1	74	80	PF00069	0.679
MOD_PKA_1	312	318	PF00069	0.769
MOD_PKA_2	154	160	PF00069	0.733
MOD_PKA_2	171	177	PF00069	0.592
MOD_PKA_2	236	242	PF00069	0.739
MOD_PKA_2	312	318	PF00069	0.769
MOD_PKA_2	386	392	PF00069	0.753
MOD_PKA_2	524	530	PF00069	0.555
MOD_PKA_2	641	647	PF00069	0.764
MOD_PKA_2	660	666	PF00069	0.748
MOD_PKA_2	807	813	PF00069	0.686
MOD_PKA_2	86	92	PF00069	0.668
MOD_PKB_1	72	80	PF00069	0.709
MOD_Plk_1	135	141	PF00069	0.740
MOD_Plk_1	172	178	PF00069	0.760
MOD_Plk_1	299	305	PF00069	0.621
MOD_Plk_1	318	324	PF00069	0.581
MOD_Plk_1	391	397	PF00069	0.699
MOD_Plk_1	710	716	PF00069	0.724
MOD_Plk_1	74	80	PF00069	0.713
MOD_Plk_1	741	747	PF00069	0.628
MOD_Plk_4	136	142	PF00069	0.748
MOD_Plk_4	249	255	PF00069	0.637
MOD_Plk_4	318	324	PF00069	0.736
MOD_Plk_4	74	80	PF00069	0.716
MOD_Plk_4	741	747	PF00069	0.628
MOD_ProDKin_1	185	191	PF00069	0.732
MOD_ProDKin_1	201	207	PF00069	0.643
MOD_ProDKin_1	241	247	PF00069	0.600
MOD_ProDKin_1	354	360	PF00069	0.801
MOD_ProDKin_1	364	370	PF00069	0.654
MOD_ProDKin_1	373	379	PF00069	0.534
MOD_ProDKin_1	461	467	PF00069	0.731
MOD_ProDKin_1	469	475	PF00069	0.763
MOD_ProDKin_1	483	489	PF00069	0.560
MOD_ProDKin_1	511	517	PF00069	0.756
MOD_ProDKin_1	655	661	PF00069	0.629
MOD_ProDKin_1	682	688	PF00069	0.757
MOD_SUMO_rev_2	494	502	PF00179	0.573
TRG_DiLeu_BaEn_4	406	412	PF01217	0.652
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.617
TRG_ENDOCYTIC_2	67	70	PF00928	0.747
TRG_ENDOCYTIC_2	729	732	PF00928	0.789
TRG_ENDOCYTIC_2	746	749	PF00928	0.497
TRG_ENDOCYTIC_2	769	772	PF00928	0.569
TRG_ENDOCYTIC_2	79	82	PF00928	0.645
TRG_ENDOCYTIC_2	822	825	PF00928	0.681
TRG_ER_diArg_1	307	310	PF00400	0.769
TRG_ER_diArg_1	311	313	PF00400	0.745
TRG_ER_diArg_1	54	56	PF00400	0.679
TRG_ER_diArg_1	626	628	PF00400	0.677
TRG_ER_diArg_1	639	642	PF00400	0.612
TRG_ER_diArg_1	650	653	PF00400	0.631
TRG_ER_diArg_1	67	69	PF00400	0.568
TRG_NLS_MonoCore_2	750	755	PF00514	0.607
TRG_NLS_MonoExtN_4	622	629	PF00514	0.609
TRG_NLS_MonoExtN_4	751	756	PF00514	0.581
TRG_PTS1	846	849	PF00515	0.657

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HJH3	Leishmania braziliensis	49%	100%
A4I6W6	Leishmania infantum	99%	100%
E9B1Z0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	97%
Q4Q671	Leishmania major	82%	100%