Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IFM8_LEIDO

TriTrypDb:

LdBPK_301750.1 , LdCL_300022800 , LDHU3_30.2440

Length:

165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IFM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.652
CLV_NRD_NRD_1	138	140	PF00675	0.437
CLV_NRD_NRD_1	43	45	PF00675	0.294
CLV_NRD_NRD_1	56	58	PF00675	0.359
CLV_PCSK_FUR_1	75	79	PF00082	0.515
CLV_PCSK_KEX2_1	68	70	PF00082	0.433
CLV_PCSK_KEX2_1	77	79	PF00082	0.473
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.433
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.473
CLV_PCSK_SKI1_1	153	157	PF00082	0.482
CLV_PCSK_SKI1_1	33	37	PF00082	0.577
DOC_CKS1_1	94	99	PF01111	0.728
DOC_PP1_RVXF_1	31	37	PF00149	0.375
DOC_USP7_MATH_1	18	22	PF00917	0.464
DOC_USP7_UBL2_3	140	144	PF12436	0.610
DOC_USP7_UBL2_3	153	157	PF12436	0.571
DOC_USP7_UBL2_3	68	72	PF12436	0.636
DOC_WW_Pin1_4	24	29	PF00397	0.377
DOC_WW_Pin1_4	93	98	PF00397	0.749
LIG_14-3-3_CanoR_1	33	43	PF00244	0.466
LIG_14-3-3_CanoR_1	75	84	PF00244	0.733
LIG_APCC_ABBA_1	1	6	PF00400	0.389
LIG_BIR_II_1	1	5	PF00653	0.387
LIG_FHA_1	35	41	PF00498	0.372
LIG_FHA_1	97	103	PF00498	0.639
LIG_LIR_Gen_1	131	137	PF02991	0.606
LIG_LIR_Gen_1	2	12	PF02991	0.375
LIG_LIR_Gen_1	37	46	PF02991	0.348
LIG_LIR_Nem_3	131	136	PF02991	0.606
LIG_LIR_Nem_3	2	7	PF02991	0.381
LIG_LIR_Nem_3	37	42	PF02991	0.292
LIG_NRP_CendR_1	162	165	PF00754	0.418
LIG_Pex14_1	49	53	PF04695	0.266
LIG_SH2_CRK	60	64	PF00017	0.567
LIG_SH2_PTP2	133	136	PF00017	0.604
LIG_SH2_SRC	111	114	PF00017	0.631
LIG_SH2_SRC	133	136	PF00017	0.604
LIG_SH2_STAP1	4	8	PF00017	0.413
LIG_SH2_STAT5	133	136	PF00017	0.609
LIG_SH2_STAT5	52	55	PF00017	0.304
LIG_SH3_3	91	97	PF00018	0.679
LIG_SUMO_SIM_anti_2	122	128	PF11976	0.591
LIG_WRC_WIRS_1	39	44	PF05994	0.215
MOD_CDK_SPK_2	93	98	PF00069	0.648
MOD_CK1_1	2	8	PF00069	0.413
MOD_CK1_1	79	85	PF00069	0.665
MOD_CK1_1	86	92	PF00069	0.660
MOD_GlcNHglycan	16	19	PF01048	0.544
MOD_GlcNHglycan	79	82	PF01048	0.460
MOD_GSK3_1	14	21	PF00069	0.359
MOD_GSK3_1	2	9	PF00069	0.483
MOD_GSK3_1	34	41	PF00069	0.285
MOD_GSK3_1	63	70	PF00069	0.686
MOD_GSK3_1	79	86	PF00069	0.627
MOD_GSK3_1	92	99	PF00069	0.682
MOD_NEK2_1	63	68	PF00069	0.726
MOD_PIKK_1	26	32	PF00454	0.413
MOD_PK_1	144	150	PF00069	0.636
MOD_PKA_1	68	74	PF00069	0.677
MOD_PKA_1	77	83	PF00069	0.633
MOD_PKA_2	68	74	PF00069	0.692
MOD_PKA_2	77	83	PF00069	0.644
MOD_ProDKin_1	24	30	PF00069	0.375
MOD_ProDKin_1	93	99	PF00069	0.747
MOD_SUMO_rev_2	135	142	PF00179	0.616
MOD_SUMO_rev_2	147	155	PF00179	0.590
MOD_SUMO_rev_2	79	89	PF00179	0.600
TRG_DiLeu_BaEn_1	151	156	PF01217	0.583
TRG_DiLeu_BaEn_2	37	43	PF01217	0.292
TRG_ENDOCYTIC_2	133	136	PF00928	0.604
TRG_ENDOCYTIC_2	4	7	PF00928	0.381
TRG_ENDOCYTIC_2	52	55	PF00928	0.335
TRG_ENDOCYTIC_2	60	63	PF00928	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9Q9	Leptomonas seymouri	63%	99%
A4HIB8	Leishmania braziliensis	79%	100%
A4I5K2	Leishmania infantum	98%	100%
E9B0U7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q7B9	Leishmania major	92%	100%