Transmembrane 9 superfamily member

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endosomal integral membrane protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IFM1_LEIDO

TriTrypDb:

LdBPK_300360.1 , LdCL_300008700 , LDHU3_30.0500

Length:

642

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 4
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3Q8IFM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFM1

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0033036	macromolecule localization	2	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0072657	protein localization to membrane	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.216
CLV_NRD_NRD_1	166	168	PF00675	0.486
CLV_NRD_NRD_1	3	5	PF00675	0.557
CLV_NRD_NRD_1	309	311	PF00675	0.258
CLV_NRD_NRD_1	408	410	PF00675	0.318
CLV_NRD_NRD_1	93	95	PF00675	0.459
CLV_PCSK_KEX2_1	138	140	PF00082	0.500
CLV_PCSK_KEX2_1	166	168	PF00082	0.487
CLV_PCSK_KEX2_1	3	5	PF00082	0.505
CLV_PCSK_KEX2_1	309	311	PF00082	0.275
CLV_PCSK_KEX2_1	407	409	PF00082	0.316
CLV_PCSK_KEX2_1	93	95	PF00082	0.508
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.481
CLV_PCSK_SKI1_1	113	117	PF00082	0.484
CLV_PCSK_SKI1_1	119	123	PF00082	0.476
CLV_PCSK_SKI1_1	138	142	PF00082	0.444
CLV_PCSK_SKI1_1	18	22	PF00082	0.294
CLV_PCSK_SKI1_1	310	314	PF00082	0.254
CLV_PCSK_SKI1_1	498	502	PF00082	0.316
CLV_PCSK_SKI1_1	570	574	PF00082	0.225
CLV_PCSK_SKI1_1	597	601	PF00082	0.526
CLV_PCSK_SKI1_1	61	65	PF00082	0.597
CLV_PCSK_SKI1_1	633	637	PF00082	0.273
DEG_APCC_DBOX_1	17	25	PF00400	0.374
DEG_APCC_DBOX_1	376	384	PF00400	0.316
DEG_MDM2_SWIB_1	522	529	PF02201	0.256
DEG_SCF_FBW7_1	241	248	PF00400	0.225
DEG_SCF_FBW7_1	259	266	PF00400	0.268
DEG_SPOP_SBC_1	258	262	PF00917	0.234
DOC_CDC14_PxL_1	150	158	PF14671	0.268
DOC_CKS1_1	242	247	PF01111	0.203
DOC_CYCLIN_RxL_1	630	638	PF00134	0.437
DOC_MAPK_gen_1	143	150	PF00069	0.238
DOC_MAPK_gen_1	280	289	PF00069	0.305
DOC_MAPK_gen_1	338	348	PF00069	0.438
DOC_MAPK_gen_1	407	416	PF00069	0.425
DOC_MAPK_MEF2A_6	18	27	PF00069	0.365
DOC_MAPK_MEF2A_6	341	350	PF00069	0.456
DOC_MAPK_MEF2A_6	597	606	PF00069	0.364
DOC_PP1_RVXF_1	208	215	PF00149	0.225
DOC_PP1_RVXF_1	530	537	PF00149	0.139
DOC_PP1_RVXF_1	631	637	PF00149	0.464
DOC_PP2B_LxvP_1	156	159	PF13499	0.234
DOC_PP4_FxxP_1	337	340	PF00568	0.414
DOC_USP7_MATH_1	200	204	PF00917	0.237
DOC_USP7_MATH_1	245	249	PF00917	0.206
DOC_USP7_MATH_1	446	450	PF00917	0.260
DOC_USP7_MATH_1	549	553	PF00917	0.466
DOC_WW_Pin1_4	241	246	PF00397	0.305
DOC_WW_Pin1_4	259	264	PF00397	0.290
LIG_14-3-3_CanoR_1	127	136	PF00244	0.265
LIG_14-3-3_CanoR_1	250	256	PF00244	0.293
LIG_14-3-3_CanoR_1	407	412	PF00244	0.481
LIG_14-3-3_CanoR_1	532	537	PF00244	0.268
LIG_14-3-3_CanoR_1	73	78	PF00244	0.378
LIG_BRCT_BRCA1_1	124	128	PF00533	0.351
LIG_BRCT_BRCA1_1	247	251	PF00533	0.336
LIG_BRCT_BRCA1_1	362	366	PF00533	0.375
LIG_BRCT_BRCA1_1	38	42	PF00533	0.411
LIG_BRCT_BRCA1_1	627	631	PF00533	0.310
LIG_BRCT_BRCA1_1	74	78	PF00533	0.282
LIG_deltaCOP1_diTrp_1	256	264	PF00928	0.266
LIG_EH1_1	365	373	PF00400	0.266
LIG_eIF4E_1	189	195	PF01652	0.216
LIG_eIF4E_1	315	321	PF01652	0.516
LIG_eIF4E_1	557	563	PF01652	0.516
LIG_FHA_1	181	187	PF00498	0.216
LIG_FHA_1	206	212	PF00498	0.251
LIG_FHA_1	222	228	PF00498	0.269
LIG_FHA_1	397	403	PF00498	0.245
LIG_FHA_1	446	452	PF00498	0.179
LIG_FHA_1	53	59	PF00498	0.390
LIG_FHA_1	613	619	PF00498	0.262
LIG_FHA_2	102	108	PF00498	0.242
LIG_FHA_2	200	206	PF00498	0.311
LIG_FHA_2	242	248	PF00498	0.317
LIG_FHA_2	264	270	PF00498	0.218
LIG_GBD_Chelix_1	286	294	PF00786	0.445
LIG_LIR_Apic_2	335	340	PF02991	0.414
LIG_LIR_Gen_1	187	196	PF02991	0.289
LIG_LIR_Gen_1	39	48	PF02991	0.345
LIG_LIR_Gen_1	410	419	PF02991	0.535
LIG_LIR_Gen_1	431	442	PF02991	0.294
LIG_LIR_Gen_1	444	455	PF02991	0.262
LIG_LIR_Gen_1	502	511	PF02991	0.312
LIG_LIR_Gen_1	514	522	PF02991	0.302
LIG_LIR_Gen_1	555	565	PF02991	0.286
LIG_LIR_Gen_1	628	639	PF02991	0.340
LIG_LIR_Nem_3	187	192	PF02991	0.255
LIG_LIR_Nem_3	197	201	PF02991	0.197
LIG_LIR_Nem_3	232	238	PF02991	0.340
LIG_LIR_Nem_3	266	271	PF02991	0.218
LIG_LIR_Nem_3	326	332	PF02991	0.445
LIG_LIR_Nem_3	410	414	PF02991	0.420
LIG_LIR_Nem_3	431	437	PF02991	0.294
LIG_LIR_Nem_3	444	450	PF02991	0.262
LIG_LIR_Nem_3	502	506	PF02991	0.303
LIG_LIR_Nem_3	514	518	PF02991	0.245
LIG_LIR_Nem_3	520	525	PF02991	0.181
LIG_LIR_Nem_3	552	557	PF02991	0.272
LIG_LIR_Nem_3	628	634	PF02991	0.320
LIG_MAD2	210	218	PF02301	0.281
LIG_MYND_3	153	157	PF01753	0.316
LIG_NRBOX	379	385	PF00104	0.417
LIG_NRBOX	401	407	PF00104	0.416
LIG_NRBOX	449	455	PF00104	0.256
LIG_NRBOX	533	539	PF00104	0.139
LIG_Pex14_1	411	415	PF04695	0.422
LIG_Pex14_1	568	572	PF04695	0.414
LIG_Pex14_1	581	585	PF04695	0.249
LIG_Pex14_1	74	78	PF04695	0.362
LIG_Pex14_2	38	42	PF04695	0.374
LIG_Pex14_2	522	526	PF04695	0.226
LIG_SH2_CRK	531	535	PF00017	0.139
LIG_SH2_CRK	557	561	PF00017	0.434
LIG_SH2_CRK	585	589	PF00017	0.382
LIG_SH2_CRK	608	612	PF00017	0.428
LIG_SH2_PTP2	302	305	PF00017	0.310
LIG_SH2_PTP2	503	506	PF00017	0.385
LIG_SH2_PTP2	515	518	PF00017	0.411
LIG_SH2_STAP1	136	140	PF00017	0.259
LIG_SH2_STAP1	253	257	PF00017	0.218
LIG_SH2_STAT5	271	274	PF00017	0.281
LIG_SH2_STAT5	302	305	PF00017	0.285
LIG_SH2_STAT5	429	432	PF00017	0.251
LIG_SH2_STAT5	452	455	PF00017	0.394
LIG_SH2_STAT5	503	506	PF00017	0.269
LIG_SH2_STAT5	515	518	PF00017	0.331
LIG_SH2_STAT5	585	588	PF00017	0.284
LIG_SH3_1	488	494	PF00018	0.425
LIG_SH3_3	235	241	PF00018	0.314
LIG_SH3_3	333	339	PF00018	0.487
LIG_SH3_3	457	463	PF00018	0.266
LIG_SH3_3	488	494	PF00018	0.422
LIG_SH3_3	8	14	PF00018	0.540
LIG_SUMO_SIM_anti_2	291	297	PF11976	0.310
LIG_SUMO_SIM_anti_2	382	387	PF11976	0.279
LIG_SUMO_SIM_anti_2	615	620	PF11976	0.327
LIG_SUMO_SIM_par_1	291	297	PF11976	0.414
LIG_TYR_ITIM	196	201	PF00017	0.256
LIG_TYR_ITIM	300	305	PF00017	0.285
LIG_TYR_ITIM	427	432	PF00017	0.280
LIG_TYR_ITIM	529	534	PF00017	0.139
LIG_TYR_ITIM	588	593	PF00017	0.324
LIG_WRC_WIRS_1	533	538	PF05994	0.343
LIG_WW_3	338	342	PF00397	0.516
MOD_CDK_SPxK_1	259	265	PF00069	0.268
MOD_CK1_1	203	209	PF00069	0.317
MOD_CK1_1	276	282	PF00069	0.310
MOD_CK1_1	32	38	PF00069	0.331
MOD_CK1_1	373	379	PF00069	0.218
MOD_CK1_1	475	481	PF00069	0.501
MOD_CK1_1	520	526	PF00069	0.303
MOD_CK1_1	552	558	PF00069	0.354
MOD_CK1_1	62	68	PF00069	0.270
MOD_CK1_1	85	91	PF00069	0.289
MOD_CK1_1	92	98	PF00069	0.304
MOD_CK2_1	241	247	PF00069	0.323
MOD_CK2_1	311	317	PF00069	0.526
MOD_CK2_1	48	54	PF00069	0.372
MOD_CK2_1	511	517	PF00069	0.310
MOD_Cter_Amidation	1	4	PF01082	0.506
MOD_GlcNHglycan	106	110	PF01048	0.463
MOD_GlcNHglycan	124	127	PF01048	0.539
MOD_GlcNHglycan	202	205	PF01048	0.375
MOD_GlcNHglycan	325	329	PF01048	0.292
MOD_GlcNHglycan	574	577	PF01048	0.253
MOD_GSK3_1	101	108	PF00069	0.358
MOD_GSK3_1	199	206	PF00069	0.334
MOD_GSK3_1	217	224	PF00069	0.295
MOD_GSK3_1	241	248	PF00069	0.249
MOD_GSK3_1	259	266	PF00069	0.290
MOD_GSK3_1	32	39	PF00069	0.503
MOD_GSK3_1	436	443	PF00069	0.255
MOD_GSK3_1	471	478	PF00069	0.300
MOD_GSK3_1	48	55	PF00069	0.331
MOD_GSK3_1	517	524	PF00069	0.397
MOD_GSK3_1	549	556	PF00069	0.310
MOD_GSK3_1	568	575	PF00069	0.341
MOD_GSK3_1	80	87	PF00069	0.280
MOD_LATS_1	165	171	PF00433	0.190
MOD_N-GLC_1	175	180	PF02516	0.468
MOD_N-GLC_1	475	480	PF02516	0.304
MOD_NEK2_1	105	110	PF00069	0.245
MOD_NEK2_1	122	127	PF00069	0.256
MOD_NEK2_1	194	199	PF00069	0.231
MOD_NEK2_1	294	299	PF00069	0.268
MOD_NEK2_1	304	309	PF00069	0.254
MOD_NEK2_1	38	43	PF00069	0.426
MOD_NEK2_1	390	395	PF00069	0.250
MOD_NEK2_1	415	420	PF00069	0.287
MOD_NEK2_1	458	463	PF00069	0.308
MOD_NEK2_1	48	53	PF00069	0.384
MOD_NEK2_1	511	516	PF00069	0.290
MOD_NEK2_1	572	577	PF00069	0.263
MOD_NEK2_1	59	64	PF00069	0.290
MOD_NEK2_1	625	630	PF00069	0.275
MOD_NEK2_1	635	640	PF00069	0.505
MOD_NEK2_1	72	77	PF00069	0.318
MOD_NEK2_1	84	89	PF00069	0.237
MOD_NEK2_2	245	250	PF00069	0.257
MOD_NEK2_2	549	554	PF00069	0.387
MOD_NEK2_2	568	573	PF00069	0.551
MOD_PIKK_1	48	54	PF00454	0.328
MOD_PIKK_1	82	88	PF00454	0.327
MOD_PK_1	282	288	PF00069	0.173
MOD_PK_1	73	79	PF00069	0.288
MOD_PKA_1	407	413	PF00069	0.516
MOD_PKA_2	249	255	PF00069	0.321
MOD_PKA_2	376	382	PF00069	0.259
MOD_PKA_2	407	413	PF00069	0.516
MOD_PKA_2	72	78	PF00069	0.413
MOD_PKA_2	92	98	PF00069	0.122
MOD_Plk_1	475	481	PF00069	0.480
MOD_Plk_2-3	157	163	PF00069	0.234
MOD_Plk_2-3	311	317	PF00069	0.516
MOD_Plk_4	194	200	PF00069	0.321
MOD_Plk_4	282	288	PF00069	0.248
MOD_Plk_4	294	300	PF00069	0.213
MOD_Plk_4	344	350	PF00069	0.477
MOD_Plk_4	360	366	PF00069	0.218
MOD_Plk_4	379	385	PF00069	0.216
MOD_Plk_4	398	404	PF00069	0.428
MOD_Plk_4	446	452	PF00069	0.236
MOD_Plk_4	511	517	PF00069	0.272
MOD_Plk_4	521	527	PF00069	0.187
MOD_Plk_4	532	538	PF00069	0.228
MOD_Plk_4	549	555	PF00069	0.281
MOD_Plk_4	558	564	PF00069	0.434
MOD_Plk_4	625	631	PF00069	0.318
MOD_Plk_4	73	79	PF00069	0.288
MOD_ProDKin_1	241	247	PF00069	0.305
MOD_ProDKin_1	259	265	PF00069	0.290
MOD_SUMO_rev_2	273	281	PF00179	0.306
TRG_ENDOCYTIC_2	189	192	PF00928	0.281
TRG_ENDOCYTIC_2	198	201	PF00928	0.220
TRG_ENDOCYTIC_2	302	305	PF00928	0.216
TRG_ENDOCYTIC_2	429	432	PF00928	0.251
TRG_ENDOCYTIC_2	503	506	PF00928	0.389
TRG_ENDOCYTIC_2	515	518	PF00928	0.311
TRG_ENDOCYTIC_2	531	534	PF00928	0.151
TRG_ENDOCYTIC_2	557	560	PF00928	0.422
TRG_ENDOCYTIC_2	585	588	PF00928	0.255
TRG_ENDOCYTIC_2	589	592	PF00928	0.246
TRG_ENDOCYTIC_2	608	611	PF00928	0.160
TRG_ER_diArg_1	166	169	PF00400	0.297
TRG_ER_diArg_1	308	310	PF00400	0.475
TRG_ER_diArg_1	406	409	PF00400	0.481
TRG_NES_CRM1_1	205	217	PF08389	0.173
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P948	Leptomonas seymouri	28%	96%
A0A0N1I2B1	Leptomonas seymouri	57%	100%
A0A0N1I6Y7	Leptomonas seymouri	28%	100%
A0A0S4IV41	Bodo saltans	33%	100%
A0A0S4J9X2	Bodo saltans	30%	99%
A0A0S4JBB1	Bodo saltans	39%	100%
A0A0S4JCH7	Bodo saltans	30%	94%
A0A0S4JEU5	Bodo saltans	29%	100%
A0A0S4JIF4	Bodo saltans	35%	100%
A0A0S4JWZ9	Bodo saltans	30%	100%
A0A0S4JZ31	Bodo saltans	29%	100%
A0A1X0NJN3	Trypanosomatidae	24%	100%
A0A1X0NK64	Trypanosomatidae	34%	100%
A0A1X0NZX5	Trypanosomatidae	31%	99%
A0A1X0P2G3	Trypanosomatidae	45%	100%
A0A1X0PA12	Trypanosomatidae	32%	100%
A0A3Q8IBT4	Leishmania donovani	27%	100%
A0A3Q8IHT3	Leishmania donovani	28%	100%
A0A3R7MBZ3	Trypanosoma rangeli	31%	100%
A0A3S7X2L7	Leishmania donovani	30%	94%
A0A422NED2	Trypanosoma rangeli	30%	99%
A0A422NMS9	Trypanosoma rangeli	45%	98%
A0A422P482	Trypanosoma rangeli	25%	100%
A4H7C1	Leishmania braziliensis	22%	93%
A4HB85	Leishmania braziliensis	28%	100%
A4HHH4	Leishmania braziliensis	29%	100%
A4HHY3	Leishmania braziliensis	78%	100%
A4HVR6	Leishmania infantum	27%	100%
A4I4M3	Leishmania infantum	30%	100%
A4I563	Leishmania infantum	99%	100%
A4IAD3	Leishmania infantum	29%	100%
A4IFE9	Bos taurus	28%	100%
A5D7E2	Bos taurus	33%	100%
C9ZLB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	88%
C9ZLW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZUX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A6H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AE21	Leishmania major	29%	100%
E9ALR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9APG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	96%
E9B0G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B5F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
F4HW17	Arabidopsis thaliana	27%	100%
F4JRE0	Arabidopsis thaliana	31%	98%
F4KIB2	Arabidopsis thaliana	32%	99%
O15321	Homo sapiens	28%	100%
P32802	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	96%
P40071	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	91%
P58021	Mus musculus	31%	97%
Q04562	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	96%
Q4KLL4	Rattus norvegicus	31%	100%
Q4Q2H8	Leishmania major	28%	100%
Q4Q7S3	Leishmania major	92%	100%
Q4QG16	Leishmania major	23%	100%
Q54ZW0	Dictyostelium discoideum	26%	100%
Q55FP0	Dictyostelium discoideum	30%	100%
Q5R8F1	Pongo abelii	29%	100%
Q5R8Y6	Pongo abelii	32%	97%
Q5RDY2	Pongo abelii	33%	100%
Q66HF2	Rattus norvegicus	28%	100%
Q66HG5	Rattus norvegicus	31%	97%
Q7YTA6	Dictyostelium discoideum	25%	98%
Q8BH24	Mus musculus	32%	100%
Q8RWW1	Arabidopsis thaliana	33%	100%
Q92544	Homo sapiens	33%	100%
Q940G0	Arabidopsis thaliana	29%	100%
Q940S0	Arabidopsis thaliana	28%	100%
Q99805	Homo sapiens	32%	97%
Q9C5N2	Arabidopsis thaliana	32%	100%
Q9C720	Arabidopsis thaliana	33%	100%
Q9DBU0	Mus musculus	29%	100%
Q9ET30	Mus musculus	26%	100%
Q9FHT4	Arabidopsis thaliana	29%	100%
Q9FYQ8	Arabidopsis thaliana	31%	98%
Q9HD45	Homo sapiens	26%	100%
Q9LIC2	Arabidopsis thaliana	33%	100%
Q9Y819	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q9ZPS7	Arabidopsis thaliana	29%	100%
V5BCD5	Trypanosoma cruzi	45%	100%
V5BHS7	Trypanosoma cruzi	33%	100%
V5D9U0	Trypanosoma cruzi	30%	99%
V5DII3	Trypanosoma cruzi	24%	100%