Roadblock/LC7 domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein-associated protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IFL9_LEIDO

TriTrypDb:

LdBPK_313280.1 , LdCL_310041100 , LDHU3_31.5540

Length:

123

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0005930	axoneme	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A0A3Q8IFL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFL9

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	29	33	PF00082	0.386
DEG_Nend_UBRbox_3	1	3	PF02207	0.739
DOC_PP1_RVXF_1	41	48	PF00149	0.411
DOC_PP1_RVXF_1	74	81	PF00149	0.319
DOC_PP2B_LxvP_1	97	100	PF13499	0.300
DOC_USP7_MATH_1	4	8	PF00917	0.559
LIG_14-3-3_CanoR_1	88	96	PF00244	0.324
LIG_deltaCOP1_diTrp_1	79	86	PF00928	0.319
LIG_FHA_1	105	111	PF00498	0.364
LIG_FHA_1	70	76	PF00498	0.404
LIG_FHA_1	91	97	PF00498	0.283
LIG_LIR_Gen_1	105	114	PF02991	0.324
LIG_LIR_Gen_1	83	94	PF02991	0.301
LIG_LIR_Nem_3	105	109	PF02991	0.313
LIG_LIR_Nem_3	46	50	PF02991	0.415
LIG_LIR_Nem_3	83	89	PF02991	0.345
LIG_SH2_CRK	106	110	PF00017	0.342
LIG_SH2_STAP1	106	110	PF00017	0.364
LIG_SH2_STAP1	60	64	PF00017	0.300
LIG_SH2_STAT5	106	109	PF00017	0.283
LIG_SH2_STAT5	34	37	PF00017	0.300
LIG_SUMO_SIM_anti_2	92	98	PF11976	0.366
LIG_SUMO_SIM_par_1	107	113	PF11976	0.296
LIG_WRC_WIRS_1	44	49	PF05994	0.444
MOD_CK1_1	90	96	PF00069	0.269
MOD_CK2_1	4	10	PF00069	0.557
MOD_CK2_1	50	56	PF00069	0.379
MOD_GlcNHglycan	6	9	PF01048	0.579
MOD_GSK3_1	70	77	PF00069	0.303
MOD_NEK2_1	50	55	PF00069	0.342
MOD_NEK2_1	70	75	PF00069	0.114
MOD_NEK2_2	60	65	PF00069	0.379
MOD_PKA_2	50	56	PF00069	0.390
MOD_PKA_2	87	93	PF00069	0.324
MOD_Plk_1	104	110	PF00069	0.405
MOD_Plk_1	18	24	PF00069	0.411
MOD_Plk_1	82	88	PF00069	0.300
MOD_Plk_4	104	110	PF00069	0.364
MOD_Plk_4	82	88	PF00069	0.316
TRG_ENDOCYTIC_2	106	109	PF00928	0.284
TRG_ENDOCYTIC_2	34	37	PF00928	0.300

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0K9	Leptomonas seymouri	74%	100%
A0A1X0NII5	Trypanosomatidae	46%	100%
A0A422NF11	Trypanosoma rangeli	50%	100%
A4HJW0	Leishmania braziliensis	88%	100%
A4I7C2	Leishmania infantum	99%	100%
C9ZMI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
C9ZWI3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B2B5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
P62627	Mus musculus	36%	100%
P62628	Rattus norvegicus	36%	100%
Q32P85	Bos taurus	36%	100%
Q3T140	Bos taurus	36%	100%
Q4Q5U1	Leishmania major	98%	100%
Q8TF09	Homo sapiens	36%	100%
Q9DAJ5	Mus musculus	36%	100%
Q9NP97	Homo sapiens	36%	100%