LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IFL6_LEIDO
TriTrypDb:
LdBPK_354890.1 , LdCL_350053900 , LDHU3_35.6420
Length:
389

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IFL6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IFL6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 114 118 PF00656 0.369
CLV_NRD_NRD_1 365 367 PF00675 0.603
CLV_NRD_NRD_1 40 42 PF00675 0.435
CLV_PCSK_KEX2_1 365 367 PF00082 0.630
CLV_PCSK_KEX2_1 40 42 PF00082 0.400
CLV_PCSK_SKI1_1 275 279 PF00082 0.466
CLV_PCSK_SKI1_1 317 321 PF00082 0.521
CLV_PCSK_SKI1_1 4 8 PF00082 0.470
DOC_CKS1_1 131 136 PF01111 0.448
DOC_CYCLIN_yCln2_LP_2 242 248 PF00134 0.472
DOC_MAPK_gen_1 188 196 PF00069 0.472
DOC_MAPK_MEF2A_6 188 196 PF00069 0.491
DOC_MAPK_MEF2A_6 74 81 PF00069 0.533
DOC_PP1_RVXF_1 2 8 PF00149 0.522
DOC_PP2B_LxvP_1 169 172 PF13499 0.447
DOC_PP2B_LxvP_1 279 282 PF13499 0.360
DOC_PP2B_PxIxI_1 191 197 PF00149 0.405
DOC_PP4_FxxP_1 312 315 PF00568 0.535
DOC_PP4_FxxP_1 7 10 PF00568 0.423
DOC_SPAK_OSR1_1 214 218 PF12202 0.389
DOC_USP7_MATH_1 267 271 PF00917 0.395
DOC_WW_Pin1_4 130 135 PF00397 0.443
DOC_WW_Pin1_4 188 193 PF00397 0.427
LIG_14-3-3_CanoR_1 365 369 PF00244 0.636
LIG_Actin_WH2_2 350 367 PF00022 0.640
LIG_APCC_ABBA_1 170 175 PF00400 0.375
LIG_BIR_III_4 59 63 PF00653 0.436
LIG_Clathr_ClatBox_1 86 90 PF01394 0.315
LIG_EH1_1 226 234 PF00400 0.408
LIG_FHA_1 189 195 PF00498 0.408
LIG_FHA_1 26 32 PF00498 0.539
LIG_FHA_1 359 365 PF00498 0.656
LIG_FHA_1 66 72 PF00498 0.477
LIG_FHA_1 94 100 PF00498 0.386
LIG_FHA_2 108 114 PF00498 0.361
LIG_FHA_2 131 137 PF00498 0.509
LIG_FHA_2 145 151 PF00498 0.298
LIG_FHA_2 353 359 PF00498 0.619
LIG_LIR_Apic_2 101 105 PF02991 0.387
LIG_LIR_Apic_2 310 315 PF02991 0.536
LIG_LIR_Apic_2 44 49 PF02991 0.579
LIG_LIR_Gen_1 255 265 PF02991 0.389
LIG_LIR_Gen_1 273 284 PF02991 0.336
LIG_LIR_Gen_1 306 315 PF02991 0.533
LIG_LIR_Gen_1 377 388 PF02991 0.519
LIG_LIR_Gen_1 95 105 PF02991 0.373
LIG_LIR_Nem_3 255 260 PF02991 0.369
LIG_LIR_Nem_3 273 279 PF02991 0.340
LIG_LIR_Nem_3 306 312 PF02991 0.584
LIG_LIR_Nem_3 377 383 PF02991 0.508
LIG_LIR_Nem_3 78 84 PF02991 0.393
LIG_LIR_Nem_3 95 100 PF02991 0.421
LIG_Pex14_2 142 146 PF04695 0.410
LIG_Rb_LxCxE_1 83 101 PF01857 0.401
LIG_SH2_CRK 102 106 PF00017 0.398
LIG_SH2_CRK 276 280 PF00017 0.339
LIG_SH2_CRK 284 288 PF00017 0.360
LIG_SH2_CRK 289 293 PF00017 0.380
LIG_SH2_CRK 46 50 PF00017 0.405
LIG_SH2_CRK 8 12 PF00017 0.438
LIG_SH2_CRK 84 88 PF00017 0.441
LIG_SH2_NCK_1 102 106 PF00017 0.398
LIG_SH2_STAP1 276 280 PF00017 0.315
LIG_SH2_STAP1 305 309 PF00017 0.523
LIG_SH2_STAT3 176 179 PF00017 0.377
LIG_SH3_3 180 186 PF00018 0.382
LIG_SH3_5 172 176 PF00018 0.431
LIG_TRAF2_1 253 256 PF00917 0.326
LIG_TYR_ITAM 273 292 PF00017 0.384
LIG_TYR_ITIM 6 11 PF00017 0.468
LIG_WRC_WIRS_1 104 109 PF05994 0.368
MOD_CDK_SPK_2 130 135 PF00069 0.512
MOD_CDK_SPxxK_3 130 137 PF00069 0.534
MOD_CK1_1 268 274 PF00069 0.476
MOD_CK1_1 352 358 PF00069 0.695
MOD_CK2_1 122 128 PF00069 0.358
MOD_CK2_1 220 226 PF00069 0.331
MOD_CK2_1 250 256 PF00069 0.358
MOD_CK2_1 267 273 PF00069 0.385
MOD_CK2_1 352 358 PF00069 0.621
MOD_GlcNHglycan 124 127 PF01048 0.366
MOD_GlcNHglycan 16 19 PF01048 0.539
MOD_GlcNHglycan 267 270 PF01048 0.412
MOD_GlcNHglycan 59 63 PF01048 0.463
MOD_GSK3_1 103 110 PF00069 0.331
MOD_GSK3_1 157 164 PF00069 0.402
MOD_GSK3_1 352 359 PF00069 0.594
MOD_GSK3_1 364 371 PF00069 0.528
MOD_N-GLC_1 161 166 PF02516 0.529
MOD_N-GLC_1 344 349 PF02516 0.671
MOD_NEK2_1 107 112 PF00069 0.455
MOD_NEK2_1 122 127 PF00069 0.294
MOD_NEK2_1 157 162 PF00069 0.420
MOD_NEK2_1 260 265 PF00069 0.451
MOD_NEK2_1 364 369 PF00069 0.576
MOD_PIKK_1 107 113 PF00454 0.483
MOD_PKA_2 364 370 PF00069 0.634
MOD_Plk_1 120 126 PF00069 0.379
MOD_Plk_1 161 167 PF00069 0.418
MOD_Plk_1 250 256 PF00069 0.351
MOD_Plk_4 260 266 PF00069 0.433
MOD_ProDKin_1 130 136 PF00069 0.446
MOD_ProDKin_1 188 194 PF00069 0.417
MOD_SUMO_for_1 187 190 PF00179 0.509
TRG_DiLeu_BaEn_1 95 100 PF01217 0.367
TRG_DiLeu_BaLyEn_6 27 32 PF01217 0.586
TRG_ENDOCYTIC_2 276 279 PF00928 0.401
TRG_ENDOCYTIC_2 289 292 PF00928 0.471
TRG_ENDOCYTIC_2 309 312 PF00928 0.376
TRG_ENDOCYTIC_2 8 11 PF00928 0.432
TRG_ENDOCYTIC_2 84 87 PF00928 0.441
TRG_ER_diArg_1 364 366 PF00400 0.605
TRG_ER_diArg_1 39 41 PF00400 0.432
TRG_NES_CRM1_1 114 128 PF08389 0.345
TRG_Pf-PMV_PEXEL_1 290 294 PF00026 0.382
TRG_Pf-PMV_PEXEL_1 366 370 PF00026 0.686

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDR1 Leptomonas seymouri 84% 82%
A0A0S4J7W9 Bodo saltans 50% 98%
A0A1X0P558 Trypanosomatidae 67% 84%
A4HNE7 Leishmania braziliensis 92% 100%
A4IC19 Leishmania infantum 100% 100%
C9ZYI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 85%
E9AFV8 Leishmania major 98% 100%
E9B711 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5BBH8 Trypanosoma cruzi 63% 84%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS